Mesangial C3 deposition and serum C3 levels predict renal outcome in IgA nephropathy.

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Complement activation plays an important role in the pathogenesis of IgA nephropathy (IgAN). We aimed to evaluate the relationship between mesangial C3 deposition and histologic lesions and to investigate the role of mesangial C3 deposition and serum C3 reduction in predicting renal outcome in IgAN children.We performed a retrospective cohort study in children with biopsy-proven IgAN. Mesangial C3 deposition (

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Authors: Dan Wu, Xueqian Li, Xingfeng Yao, Nan Zhang, Lei Lei, Hejia Zhang, Mengmeng Tang, Jie Ni, Chen Ling, Zhi Chen, Xiangmei Chen, Xiaorong Liu