Impact of visceral fat area in patients with chronic kidney disease.

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Longitudinal studies evaluating the association between visceral fat area (VFA) and kidney function decline in patients with chronic kidney disease (CKD) are limited, and little is known about VFA interactions contributing to the kidney prognosis (e.g. interactions between VFA ≥ 100 cm2 and age, sex, and CKD category). In this study, we stratified patients with CKD according to VFA category, as well as age, sex, CKD category, hyperglycemia, and diabetes mellitus, and determined the ability of obesity-related indicators (body mass index, waist circumference, subcutaneous fat area, visceral-to-subcutaneous fat ratio) to predict the renal prognosis. Kidney outcomes (≥ 50% estimated glomerular filtration rate decline or end-stage kidney disease) were examined in 200 patients with CKD (median follow-up, 12.3 years). On multivariable Cox analysis, an increase in VFA (10-cm2 increase) was significantly associated with kidney outcomes in the entire cohort, and VFA was significantly associated with kidney disease progression even in the VFA 

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Authors: Shun Manabe, Hiroshi Kataoka, Toshio Mochizuki, Kazuhiro Iwadoh, Yusuke Ushio, Keiko Kawachi, Kentaro Watanabe, Saki Watanabe, Taro Akihisa, Shiho Makabe, Masayo Sato, Naomi Iwasa, Rie Yoshida, Yukako Sawara, Norio Hanafusa, Ken Tsuchiya, Kosaku Nitta