Hypothyroidism and its Association with Sleep Apnea Among Adults in The United States: NHANES 2007-2008.


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The association between hypothyroidism and sleep apnea (SA) has been previously studied, but results are discrepant and mostly based on small population studies.To determine whether there is a positive association between hypothyroidism and SA in the U.S. population.Cross-sectional study.U.S. National Health and Nutrition Examination Survey (NHANES), 2007-2008.We included all subjects above the age of 18 years who met inclusion criteria. Participants not on antithyroid medication with a thyroid stimulating hormone (TSH) >5.6 mIU/L and those on thyroid hormone replacement regardless of TSH were categorized as hypothyroid. Participants not on thyroid hormone replacement with a TSH<0.34 mIU/L and those on antithyroid medications regardless of TSH were categorized as hyperthyroid. Participants not on thyroid hormone replacement or antithyroid medication who had a TSH?0.34 and ?5.6 mIU/L were categorized as euthyroid. The diagnosis of SA was based on participants' response when asked if they had been diagnosed with SA by their doctors.None.Multivariate logistic regression analyses were performed to determine the association between hypothyroidism and SA.5,515 adults were included for data analysis. The prevalence of hypothyroidism and hyperthyroidism were calculated at 9.47% and 1.19%, respectively. Multivariate logistic regression analysis adjusted for demographics, health care access, body mass index, socioeconomic factor, alcohol use, smoking, and other comorbidities demonstrated a significant association between hypothyroidism and SA (OR=1.88, 95% CI: 1.24-2.84, P<0.01).Hypothyroidism is associated with SA after adjustment for potential confounding variables. Click here to read full article on original source website