Health-related quality of life and economic burden of prurigo nodularis.

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Prurigo nodularis (PN) is an understudied, pruritic inflammatory skin disease. Little is known about the effect of PN on quality of life (QoL) and its associated economic burden.To quantify QoL impact and economic implications of PN.A cohort study of PN patients (n=36) was performed using the Health Utilities Index Mark 3 (HUI3) questionnaire. Control data from US adults (n=4,187) were obtained from the 2002-2003 Joint Canada/United States Survey of Health. Quality-adjusted life-year (QALY) loss and economic costs were estimated by comparing HUI3 scores of PN patients to controls.PN patients had lower overall health performance compared to controls, (mean±SE, 0.52±0.06 vs. 0.86±0.003, p<0.001). In multivariable regression, PN was associated with worse health performance (coefficient -0.34, 95% CI [-0.46 to -0.23]), most prominent in the pain subdomain (coefficient -0.24, [-0.35 to -0.13]). This correlated to 6.5 average lifetime QALYs lost per patient, translating to an individual lifetime economic burden of $323,292 and a societal burden of $38.8 billion.These results demonstrate PN is associated with significant QoL impairment, similar to the level of other chronic systemic conditions. PN also has substantial individual economic burden, emphasizing the necessity of research into effective treatment options.

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Authors: Katherine A Whang, Thomas K Le, Raveena Khanna, Kyle A Williams, Youkyung Sophie Roh, Nishadh Sutaria, Justin Choi, Sylvie Gabriel, Rajeev Chavda, Yevgeniy Semenov, Shawn G Kwatra