Fertility

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  • Male fertility before and after androgen abuse.
    Previous research has found that male users of androgens are diagnosed, approximately, twice as often with infertility. We therefore set out to investigate the fertility in men using androgens.The study includes the 545 males who were tested positive for androgens in an anti-doping test program in Danish fitness centers during the period January 3 rd, […]
  • Reproductive and perinatal outcomes in women with congenital adrenal hyperplasia – a population-based cohort study.
    Reduced fertility has been reported for women with congenital adrenal hyperplasia (CAH), especially for those with the salt-losing form. However, data are sparse on reproductive and perinatal outcomes in these women.To investigate reproductive and perinatal outcomes in women with CAH.Population-based and nationwide study using the National CAH Register, the Total Population Register and the Medical […]
  • Characterizing the clinical and genetic spectrum of polycystic ovary syndrome in electronic health records.
    Polycystic ovary syndrome (PCOS) is one of the leading causes of infertility, yet current diagnostic criteria are ineffective at identifying patients whose symptoms reside outside strict diagnostic criteria. As a result, PCOS is under diagnosed and its etiology is poorly understood.We aim to characterize the phenotypic spectrum of PCOS clinical features within and across racial […]
  • Baseline levels of seminal reactive oxygen species predict improvements in sperm function following anti-oxidant therapy in men with infertility.
    Poor sperm function is a major cause of infertility. There is no drug therapy to improve sperm function. Semen oxidative stress is a recently identified pathway for sperm damage. Commercial anti-oxidants such as L-carnitine and acetyl-L-carnitine (LAL) are commonly self-administered by infertile men. However, concerns have been raised whether inappropriate LAL therapy causes reductive stress-mediated […]
  • Testicular involvement is a hallmark of Apo A-I Leu75Pro mutation amyloidosis.
    Apo A-I Leu75Pro is a rare hereditary form of amyloidosis, that mainly involves the kidney, the liver, and the testis.To define the characteristics of organ damage and testis impairment in the largest cohort collected to date of men with Apo A-I Leu75Pro amyloidosis.Retrospective study from a prospectively collected database of 129 male subjects >18 years […]
  • Reproduction Function in Male Patients with Bardet Biedl Syndrome.
    Bardet-Biedl syndrome (BBS) is a ciliopathy with a wide spectrum of symptoms due to primary cilia dysfunction including genitourinary developmental anomalies as well as impaired reproduction particularly in males. Primary cilia are known to be required at the following steps of reproduction function: (1) genitourinary organogenesis, (2) in the fetal firing of hypothalamo-pituitary axe, (3) […]
  • The role of hormone stimulation in men with non-obstructive azoospermia undergoing surgical sperm retrieval.
    Non obstructive azoospermia, (NOA) is the most common cause of azoospermia. NOA is characterised by hypergonadotrophic hypogonadism, testicular failure, and impaired spermatogenesis. The recent development of surgical sperm retrieval techniques such as microsurgical testicular sperm extraction (mTESE) has, for the first time, allowed some men with NOA to father biological children. It is common practice […]
  • Fertility Options for the Transgender and Gender Non-binary Patient.
    Comprehensive care for transgender and gender non-binary patients has been a priority established by the World Professional Association for Transgender Health (WPATH). Because pubertal suppression, gender-affirming hormone therapy, and antiandrogen therapy used alone or in combination during medical transition can impact gonadal function, understanding the effects these treatments have on fertility potential is important for […]
  • Increased risk of metabolic dysfunction in children conceived by assisted reproductive technology.
    Assisted reproductive technology (ART) is the most widely used treatment for infertility and has resulted in millions of births worldwide. The safety of the offspring has been of the utmost concern. Previous studies suggested an increase in metabolic disorders in offspring later in life. The aim of the present study was to investigate metabolic changes […]
  • Fertility and pregnancy outcomes in women with polycystic ovary syndrome following bariatric surgery.
    Restoration of ovulation is quite common in women with polycystic ovary syndrome (PCOS) after surgically-induced weight loss. Whether or not this results in an improvement of PCOS-associated infertility is uncertain.To study fertility and gestational outcomes in women with PCOS after bariatric surgery.Unicenter cohort study.Academic hospital.Two-hundred sixteen premenopausal women were screened for PCOS before bariatric surgery. […]
  • Human Endometrial Stromal Cell Differentiation is Stimulated by PPARβ/δ Activation: New Targets for Infertility?
    Implantation is a reproductive bottleneck in women, regulated by fluctuations in ovarian steroid hormone concentrations. However, other nuclear receptor ligands are modifiers of endometrial differentiation leading to successful pregnancy. In the current study we analyzed the effects of PPARβ/δ activation on established cellular biomarkers of human endometrial differentiation (decidualization).To test the effects of PPARβ/δ ligation […]
  • The Prevalence of Thyroid Dysfunction and Autoimmunity in Women With History of Miscarriage or Subfertility.
    To describe the prevalence of and factors associated with different thyroid dysfunction phenotypes in women who are asymptomatic preconception.Observational cohort study.A total of 49 hospitals across the United Kingdom between 2011 and 2016.Women aged 16 to 41years with history of miscarriage or subfertility trying for a pregnancy.Prevalences and 95% confidence intervals (CIs) were estimated using […]
  • Effects of IVF therapies on metabolic, endocrine and inflammatory status in IVF-conceived pregnancy.
    In vitro fertilization (IVF) is a common treatment for infertility. In mice, IVF is associated with development of glucose intolerance. However, human data are limited regarding the metabolic, endocrine and inflammatory effects of IVF therapy in IVF-conceived pregnancies.To explore effects of IVF therapies on metabolic, endocrine and inflammatory parameters in IVF-conceived pregnancy.12-week prospective observational study […]
  • Obesity, polycystic ovary syndrome and infertility: a new avenue for GLP-1 receptor agonists.
    Obesity is responsible for an increased risk of sub-fecundity and infertility. Obese women show poorer reproductive outcomes regardless of the mode of conception, and higher body mass index (BMI) is associated with poorer fertility prognosis. Polycystic ovary syndrome (PCOS) is one of the leading causes of infertility, and many women with PCOS are also overweight […]
  • Prospects for FSH Treatment of Male Infertility.
    Despite the new opportunities provided by assisted reproduction techniques, male infertility treatment is far from being optimized. One possibility, based on pathophysiological evidence, is to stimulate spermatogenesis with gonadotropins.We conducted a comprehensive systematic PubMed literature review, up to January 2020, of studies evaluating the genetic basis of FSH action, the role of FSH in spermatogenesis, […]
  • Burdens and awareness of adverse self-reported lifestyle factors in men with sub-fertility: a cross-sectional study in 1149 men.
    There are no current pharmacological therapies to improve sperm quality in men with sub-fertility. Reducing the exposure to lifestyle risk factor (LSF) is currently the only intervention for improving sperm quality in men with sub-fertility. No previous study has investigated what proportion of men with sub-fertility are exposed to adverse lifestyle factors. Furthermore, it is […]
  • A novel phenotype combining primary ovarian insufficiency growth retardation and pilomatricomas with MCM8 mutation.
    Primary Ovarian insufficiency (POI) affects 1% of women under 40 years and leads most often to definitive infertility with adverse health outcomes. Very recently, genes involved in DNA repair have been shown to cause POI.To identify the cause of a familial POI in a consanguineous Turkish family.Exome sequencing was performed in the proposita and her […]
  • CTG expansion in the DMPK gene: semen quality assessment and outcome of Preimplantation Genetic Diagnosis.
    Myotonic dystrophy (DM) is an autosomal dominant disorder characterized mainly by myotonia but also by primary hypogonadism. No study has reported on fertility management of patients affected by DM type 1.This study investigates the impact of CTG repeats in the DMPK gene on semen quality and preimplantation genetic diagnosis (PGD) outcome.This is a monocentric retrospective […]
  • Infertility, gravidity, and risk of diabetes among high-risk women in the Diabetes Prevention Program Outcomes Study.
    The extent to which infertility and pregnancy independently increase risk of diabetes and subclinical atherosclerosis is not known.We conducted a secondary analysis of Diabetes Prevention Program (DPP) and the DPP Outcomes Study over a 15-year period. We included women who answered questions about gravidity and infertility at baseline (n=2085). Infertility was defined as >1 year […]
  • Effect of Folic Acid and Zinc Supplementation in Men on Semen Quality and Live Birth Among Couples Undergoing Infertility Treatment: A Randomized Clinical Trial.
    Dietary supplements marketed for male fertility commonly contain folic acid and zinc based on limited prior evidence for improving semen quality. However, no large-scale trial has examined the efficacy of this therapy for improving semen quality or live birth.To determine the effect of daily folic acid and zinc supplementation on semen quality and live birth.The […]
  • Fertility Considerations in Adolescent Klinefelter Syndrome: Current Practice Patterns.
    Click here to read the full article @ The Journal of clinical endocrinology and metabolism
  • Association Between Fertility Treatment and Cancer Risk in Children.
    An increasing number of children worldwide are born after the use of fertility treatment, although it remains unclear whether the treatment affects the risk of childhood cancer and whether any associations observed are due to the use of specific drugs, the use of specific procedures, or the underlying infertility.To examine the association between different types […]
  • BMPR1A and BMPR1B missense mutations cause primary ovarian insufficiency.
    Primary ovarian insufficiency (POI) is a frequently occurring disorder affecting ~1% of women under 40 years of age. POI, which is characterized by the premature depletion of ovarian follicles and elevated plasma levels of FSH, leads to infertility. Although various etiological factors have been described, including chromosomal abnormalities and gene mutations, most cases remain idiopathic.To […]
  • Low Circulating Levels of miR-451a in Girls with Polycystic Ovary Syndrome: Different Effects of Randomized Treatments.
    Polycystic ovary syndrome (PCOS) is a prevalent disorder in adolescent girls, purportedly driven by hepato-visceral fat excess, and often followed by subfertility and type 2 diabetes.we studied the baseline miRNA profile of girls with PCOS, and the effects of a randomized treatment with an oral contraceptive (OC) or with spironolactone-pioglitazone-metformin (SPIOMET, aiming at loss of […]
  • Human Endometrial Transcriptome and Progesterone Receptor Cistrome Reveal Important Pathways and Epithelial Regulators.
    Poor uterine receptivity is one major factor leading to pregnancy loss and infertility. Understanding the molecular events governing successful implantation is hence critical in combating infertility.To define PGR-regulated molecular mechanisms and epithelial roles in receptivity.RNA-seq and PGR-ChIP-seq were conducted in parallel to identify PGR-regulated pathways during the WOI in endometrium of fertile women.Endometrial biopsies from […]
  • Fertility and pregnancy in women with hypopituitarism: a systematic literature review.
    Human reproduction is mainly governed from the hypothalamic-adrenal-gonadal (HPG) axis, which controls both ovarian morphology and function. Disturbances in the secretion of other anterior pituitary hormones (and their respective endocrine axes) interfere with HPG activity and have been linked to fertility problems. In normal pregnancy, maintenance of homeostasis is associated with continuous changes in pituitary […]
  • Diabetes: a metabolic and reproductive disorder in women.
    Reproductive dysfunction is a common but little studied complication of diabetes. The spectrum of reproductive health problems in diabetes is broad, and encompasses delayed puberty and menarche, menstrual cycle abnormalities, subfertility, adverse pregnancy outcomes, and potentially early menopause. Depending on the age at diagnosis of diabetes, reproductive problems can manifest early on in puberty, emerge […]
  • Fertility in Adolescents with Klinefelter Syndrome: A Survey of Current Clinical Practice.
    Abstract: Progress has been made in determining the fertility timeline and potential in adolescents with Klinefelter Syndrome; however, medical professionals are currently left without protocols to guide treatment.To evaluate the current practices regarding fertility and andrology care in adolescent males with Klinefelter Syndrome.A 24 question survey was developed to elicit practitioner background/expertise and management practices. […]
  • Regulation of Insulin-Like Growth Factor 2 by Oocyte-Secreted Factors in Primary Human Granulosa Cells.
    Abstract: Human granulosa cells (hGCs) produce and respond to insulin-like growth factor 2 (IGF2) but whether the oocyte participates in IGF2 regulation in humans is unknown.To determine the role of oocyte-secreted factors (OSFs) such as growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) in IGF2 production by hGCs.Primary human cumulus GCs in […]
  • Associations between anti-mullerian hormone and cardio-metabolic health in reproductive age women are explained by body mass index.
    Abstract: The relationship between reproductive and cardio-metabolic aging is unclear. It is unknown if the relationship differs across different clinical populations.To determine whether markers of ovarian reserve are associated with cardio-metabolic risk in reproductive aged women with unexplained infertility (UI), polycystic ovary syndrome (PCOS) and regularly cycling women (OVA).Cross sectional data from 8 US-based academic […]
  • Infertility and Mortality.
    Abstract: Infertility affects 1 in 10 American reproductive-age women. The impact of this disease beyond the reproductive years is largely unknown.To determine the association of infertility history with all-cause and cause-specific mortality.This secondary analysis of a multicenter randomized clinical trial included 75,784 women (age 55-74) prospectively enrolled in the Prostate, Lung, Colorectal, and Ovarian (PLCO) […]
  • Reduced uterine volume after induction of puberty in women with hypogonadism.
    Abstract: Adequate uterine growth is an essential component of pubertal induction with exogenous oestradiol in those with hypogonadism. Poor uterine development will render the individual vulnerable in the context of fertility. We assessed uterine size using ultrasound in those who had undergone pubertal induction treatment compared to a reference group who had experienced spontaneous puberty.This […]
  • Psychiatric Aspects of Infertility.
    Abstract: Abstract empty Click here to read full article on original source website
  • Fertility preservation in Turner Syndrome: karyotype doesn’t predict ovarian response to stimulation.
    Abstract: Turner syndrome (TS) is responsible for gonadal dysgenesis with high risk of premature ovarian insufficiency. Little is known about fertility preservation (FP) strategies is this population.Data from TS women consulting with a fertility specialist in our FP center from 2014 to 2018 were retrospectively collected.Total number of mature oocytes cryopreserved using vitrification.Nine TS women […]
  • Pregnancy and live birth in women with pathogenic LHCGR variants using their own oocytes.
    Abstract: The luteinizing hormone/chorionic gonadotropin receptor (LHCGR) is mainly expressed in gonads and plays important roles in estradiol production, ovulation and luteal formation. Women with pathogenic LHCGR variants suffer from infertility, and successful fertility treatments for such women have never been reported.The purpose of this study was to determine whether women with pathogenic LHCGR variants […]
  • Lipid Profiling of Peri-implantation Endometrium in Patients with Premature Progesterone Rise in the Late Follicular Phase.
    Abstract: Late follicular phase elevation in serum progesterone (P) during controlled ovarian hyperstimulation (COH) negatively affects the outcome of assisted reproductive technology (ART) by contributing to endometrial-embryo asynchrony. There are still no data on lipid metabolite alterations during this process.To investigate alterations in the lipid profile during the window of implantation in patients with premature […]
  • Fertility Preservation Outcomes and Considerations in Transgender and Gender-Diverse Youth.
    Abstract: Abstract empty Click here to read full article on original source website
  • Fertility Preservation Outcomes in Adolescent and Young Adult Feminizing Transgender Patients.
    Abstract: Fertility preservation enables patients undergoing gonadotoxic therapies to retain the potential for biological children and now has broader implications in the care of transgender individuals. Multiple medical societies recommend counseling on fertility preservation before initiating therapy for gender dysphoria; however, outcome data pre- and posttreatment are limited in feminizing transgender adolescents and young adults.The […]
  • Reproducibility of the Endometriosis Fertility Index: a prospective inter/intra-rater agreement study.
    To evaluate the reproducibility of the EFI (Endometriosis Fertility Index).Single-cohort prospective observational study.University hospital.Women undergoing laparoscopic resection of any rASRM-stage endometriosis.Details of pre- and per-operative findings were collected into a coded research file. EFI-scoring was performed ‘en-bloc’ by three different raters (expert-1 (C.T.), expert-2 (C.M.), junior (C.B.)). Required sample size: 71. Definitions used for agreement: clinical (scores within same range: 0-4, 5-6, 7-10) and numerical (difference ? 1 EFI-point).Primary outcome: rate of clinical agreement between two experts.expert numerical agreement, clinical and numerical agreement between expert-1 and junior and within expert-1 (intra-observer), agreement of rASRM-score and -stage.A near-to-perfect ‘inter-expert’ clinical agreement rate (1.000 (95% CI 0.956-1.000), p=0.0149) was observed. The numerical agreement between two experts was also high (0.988 (95% CI 0.934-1.000)); similarly high agreement rates were observed for both ‘junior-expert’ comparison (clinical 0 .963 (95% CI 0.897-0.992), numerical 0.988 (95% CI 0.934-1.000) and ‘intra-expert’ comparisons (clinical 0.988 (95% CI 0.934-1.000); numerical 1.000 (95% CI 0.956-1.000)). Reasons for disagreements were different scoring of the least-function score and disagreements in rASRM-scores. The reproducibility of the rASRM-score was clearly inferior to that of the EFI for all comparisons.The EFI can be reproduced reliably by different raters, further supporting its use in daily clinical practice as the principal clinical tool for postoperative fertility counselling/management of women with endometriosis. This article is protected by copyright. All rights reserved.
  • Quantitative differences in TGF-? family members measured in small antral follicle fluids from women with or without PCO.
    Members of the Transforming-Growth-Factor-? (TGF-?) family have been implicated in aberrant follicle development in women with polycystic ovaries (PCO).Are there quantitative differences in the concentrations of TGF-? family members in fluid from small antral follicles (hSAF) from women with or without PCO?& Follicle fluids (FF) were collected from 4-11 mm hSAF obtained from women undergoing ovarian tissue cryopreservation for fertility preservation.FFs from 16 women with PCO (FF=93) and 33 women without PCO (FF=92).Intrafollicular concentrations of Growth-Differentiation-Factor-9 (GDF9), Anti-Müllerian-Hormone (AMH), inhibin-A and -B, total inhibin, activin-A, -B and -AB, follistatin, follistatin-like-3, estradiol, and testosterone.Activin-B concentrations are reported for the first time in hSAF and concentrations were 10 times higher than activin-A and -AB. Activin-B showed significant associations to other growth factors. Concentrations of inhibin-A and -B were significantly lower in FF from women with PCO, especially in hSAF below 8 mm in diameter. AMH concentrations did not differ between the groups in hSAF below 8 mm, however, AMH remained high in hSAF above 8 mm in PCO but decreased in non-PCO women. Estradiol was significantly lower in FF from women with PCO and showed significant associations with AMH. Concentrations of GDF9 are reported for the first time showing significantly higher concentrations in PCO FF of follicles above 6 mm.Altered concentrations of TGF-? family members in hSAF from women with PCO highlight altered growth factor signaling as a potential mechanism for follicle growth arrest.
  • Gene expression in granulosa cells from small antral follicles from women with or without polycystic ovaries.
    Polycystic ovary syndrome (PCOS) is the commonest cause of anovulation. A key feature of PCOS is arrest of follicles at the small-medium sized antral stage.To provide further insight into the mechanism of follicle arrest in PCOS, we profiled; (1) gonadotropin receptors; (2) characteristics of aberrant steroidogenesis, and (3) expression of anti-Mullerian hormone (AMH) and its receptor in granulosa cells (GCs) from unstimulated, human small antral follicles (hSAFs) and from granulosa-lutein cells (GLCs).GCs from hSAFs were collected at the time of cryopreservation of ovarian tissue for fertility preservation and GLCs collected during oocyte aspiration before IVF/ICSI.hSAF GCs were collected from 31 women (98 follicles), 10 with polycystic ovaries (PCO) and 21 without. GLCs were collected from 6 women with PCOS and 6 controls undergoing IVF.Expression of the following genes: LHCGR, FSHR, AR, INSR, HSD3B2, CYP11A1, CYP19, STAR, AMH, AMHR2, FST, INHBA, INHBB in GCs and GLCs were compared between women with PCO and controls.GCs in hSAFs from PCO women showed higher expression of LHCGR in a subset (20%) of follicles. Expression of FSHR (p<0.05), AR (p<0.05), CYP11A1 (P<0.05) was lower, and expression of CYP19A1 (p<0.05), STAR (p<0.05), HSD3B2 (ns), INHBA (p<0.05) higher in PCO GCs. Gene expression in GL cells differed between women with and without PCOS but also differed from that in GCs.Follicle arrest in PCO is characterised in GCs by differential regulation of key genes involved in follicle growth and function.
  • Effect of hyperinsulinemia and IR on endocrine, metabolic, and fertility outcomes in women with polycystic ovary syndrome undergoing ovulation induction.
    Abstract: The aim of this study was to evaluate the effects of hyperinsulinemia and insulin resistance (IR) on reproductive and metabolic disorders and fertility in women with polycystic ovary syndrome (PCOS).This was a multicenter, randomized controlled trial involving a total of 1,000 women diagnosed with PCOS according to the modified Rotterdam criteria at 21 sites […]