Evaluation of Cardiac Troponin I and N-Terminal pro B – Type Natriuretic Peptide Serum Levels in Patients with Alopecia Areata.
Alopecia areata (AA) is a recurrent, immune mediated, hair loss disorder. It is associated with other autoimmune disorders which carry high risk of cardiovascular diseases (CVDs). However, cardiovascular comorbidity associated with AA was poorly investigated. Cardiac troponin I (cTnI) is a biomarker of myocardial ischemia and inflammation. N-terminal pro B- type natriuretic peptide (NT pro BNP) is used in diagnose of congestive heart failure. This study was conducted to assess serum level of both markers by enzyme linked immune-sorbent assay in 44 AA patients compared to 44 control subjects. All participants didn’t suffer from CVDs or risk factors or other diseases associated with elevation of both markers. The study revealed that serum levels of both markers were significantly higher in AA patients compared to controls (P< 0.001). Thus, the inflammatory milieu encountered in AA may be associated with subtle myocardial inflammation that causes elevation of levels of both markers.