The Latest Diabetes Medical Journal Articles

Keep up to date with the latest in diabetes. Check out the latest diabetes articles from leading medical journals in a single view, helping you discover relevant articles quickly and easily.

• Cardiovascular disease in patients with primary and secondary adrenal insufficiency and the role of comorbidities.15th February 2021
  Mortality studies have established that cardiovascular disease is the leading cause of death in patients with adrenal insufficiency and the risk is greater than that observed in individually-matched controls.Here we have performed a detailed analysis of cardiovascular morbidity and mortality, taking account of the role of co-morbidities.Retrospective cohort study.UK general practitioner database (CPRD).6821 patients with […]
• Genetic insight into sick sinus syndrome.13th February 2021
  The aim of this study was to use human genetics to investigate the pathogenesis of sick sinus syndrome (SSS) and the role of risk factors in its development.We performed a genome-wide association study of 6469 SSS cases and 1 000 187 controls from deCODE genetics, the Copenhagen Hospital Biobank, UK Biobank, and the HUNT study. Variants at […]
• Circulating chemerin level is associated with metabolic, biochemical, and hematological parameters – a population-based study.12th February 2021
  This study aims to analyze the association of chemerin levels with several metabolic, biochemical and hematological parameters in a large Taiwanese population with relative healthy status.Cross-sectional study.Data of 4101 healthy participants without history of hypertension, diabetes, dyslipidemia and renal insufficiency from Taiwan Biobank were analyzed. The demographic, biochemical and hematologic parameters were retrieved from the […]
• Efficacy and Safety of Imeglimin Monotherapy Versus Placebo in Japanese Patients With Type 2 Diabetes (TIMES 1): A Double-Blind, Randomized, Placebo-Controlled, Parallel-Group, Multicenter Phase 3 Trial.12th February 2021
  The aim of this study was to investigate the efficacy and safety of imeglimin, the first in a new class of oral antidiabetic agent, in Japanese patients with type 2 diabetes.This was a double-blind, randomized, parallel-group, placebo-controlled phase 3 trial in 30 sites in Japan. Eligible participants were individuals aged ≥20 years with type 2 […]
• Thresholds of Glycemia and the Outcomes of COVID-19 Complicated With Diabetes: A Retrospective Exploratory Study Using Continuous Glucose Monitoring.12th February 2021
  Although elevated glucose levels are reported to be associated with adverse outcomes of coronavirus disease 2019 (COVID-19), the optimal range of glucose in patients with COVID-19 and diabetes remains unknown. This study aimed to investigate the threshold of glycemia and its association with the outcomes of COVID-19.Glucose levels were assessed through intermittently scanned continuous glucose […]
• Chronic kidney disease detection, staging and treatment in cardiovascular disease prevention.11th February 2021
  Globally, nearly 10% of the population has chronic kidney disease (CKD), defined as a glomerular filtration rate less than 60 mL/min/1.73 m2 and/or a urinary albumin to creatinine ratio greater than 30 mg/g (3 mg/mmol). Persons with CKD have a substantially high risk of cardiovascular disease. Indeed, most persons with CKD are far more likely to develop a cardiovascular […]
• 2019 Health Care & Education Presidential Address: It’s All About Access!11th February 2021
  This article is adapted from a speech Ms. Youssef delivered as President, Health Care & Education, of the American Diabetes Association at its 79th Scientific Sessions in San Francisco, CA, on 8 June 2019.Diabetes care management and prevention are national priorities with significant health and economic consequences at the patient, provider, and system levels. Gretchen […]
• Changes in the Diagnosis and Management of Diabetes in Mexico City Between 1998-2004 and 2015-2019.11th February 2021
  To investigate the trends in diabetes prevalence, diagnosis, and management among Mexican adults who were participants in a long-term prospective study.From 1998 to 2004, 159,755 adults from Mexico City were recruited to a prospective study, and from 2015 to 2019, 10,144 survivors were resurveyed. Diabetes was defined as self-reported diagnosis, glucose-lowering medication use, or HbA1c […]
• DPP4 Activity, Hyperinsulinemia and Atherosclerosis.11th February 2021
  Obesity and type 2 diabetes are associated with chronic hyperinsulinemia, elevated plasma levels of dipeptidyl peptidase-4 (DPP4), and a pro-atherosclerotic milieu.PubMed search of the term “insulin and atherosclerosis”, “hyperinsulinemia”, “atherosclerosis” or “cardiovascular outcomes” cross-referenced with “DPP4”. Relevant research and review articles were reviewed.DPP4 may represent a key link between central obesity, insulin resistance, and atherosclerosis. […]
• Examining the Relationship Between Delay Discounting, Delay Aversion, Diabetes Self-care Behaviors, and Diabetes Outcomes in U.S. Adults With Type 2 Diabetes.11th February 2021
  Delay discounting and delay aversion are emerging areas for understanding diabetes management; however, few data exist on their relationship with multiple diabetes self-care behaviors and diabetes outcomes.This cross-sectional study included 356 adults with type 2 diabetes across three racial/ethnic groups receiving care from two primary care clinics. The primary predictors were delay discounting and delay […]
• Impact of Type 1 Diabetes in the Developing Brain in Children: A Longitudinal Study.11th February 2021
  To assess whether previously observed brain and cognitive differences between children with type 1 diabetes and control subjects without diabetes persist, worsen, or improve as children grow into puberty and whether differences are associated with hyperglycemia.One hundred forty-four children with type 1 diabetes and 72 age-matched control subjects without diabetes (mean ± SD age at […]
• Saturated fatty acids entrap PDX1 in stress granules and impede islet beta cell function.11th February 2021
  Failure of pancreatic and duodenal homeobox factor 1 (PDX1) to localise in the nucleus of islet beta cells under high-fat diet (HFD) conditions may be an early functional defect that contributes to beta cell failure in type 2 diabetes; however, the mechanism of PDX1 intracellular mislocalisation is unclear. Stress granules (SGs) are membrane-less cytoplasmic structures […]
• Two decades since the fetal insulin hypothesis: what have we learned from genetics?11th February 2021
  In 1998 the fetal insulin hypothesis proposed that lower birthweight and adult-onset type 2 diabetes are two phenotypes of the same genotype. Since then, advances in research investigating the role of genetics affecting insulin secretion and action have furthered knowledge of fetal insulin-mediated growth and the biology of type 2 diabetes. In this review, we […]
• Insulin resistance in congenital adrenal hyperplasia is compensated for by reduced insulin clearance.9th January 2021
  Congenital Adrenal Hyperplasia (CAH) patients have potential normal longevity. However, a greater risk for cardiovascular disease has been reported. Insulin resistance and hyperinsulinemia have been described in CAH patients, whereas the prevalence of overt type 2 diabetes is not higher in CAH than in normal population.To examine the contributions of insulin secretion and of hepatic […]
• Plasma lipidomic profiles and risk of diabetes: two prospective cohorts of HIV-infected and HIV-uninfected individuals.9th January 2021
  Antiretroviral therapy (ART) use is associated with disrupted lipid and glucose metabolism in people with HIV-infection. We aimed to identify plasma lipid species associated with risk of diabetes in the context of HIV infection.We profiled 211 plasma lipid species in 491 HIV-infected and 203 HIV-uninfected participants aged 35-55 years from the Women’s Interagency HIV study […]
• Productivity Benefits of Preventing Type 2 Diabetes in Australia: A 10-Year Analysis.9th January 2021
  Diabetes imposes a heavy burden on both health and productivity. In this study, we sought to estimate the potential productivity gains associated with the prevention of type 2 diabetes over the next 10 years in Australia.Dynamic life table models were constructed to estimate years of life lived and productivity-adjusted life-years (PALYs) lived by Australians aged […]
• Thirty-year Trends in Complications in U.S. Adults With Newly Diagnosed Type 2 Diabetes.9th January 2021
  To assess the prevalence of and trends in complications among U.S. adults with newly diagnosed diabetes.We included 1,486 nonpregnant adults (aged ≥20 years) with newly diagnosed diabetes (diagnosed within the past 2 years) from the 1988-1994 and 1999-2018 National Health and Nutrition Examination Survey. We estimated trends in albuminuria (albumin-to-creatinine ratio ≥30 mg/g), reduced estimated […]
• Insulinemic and Inflammatory Dietary Patterns Show Enhanced Predictive Potential for Type 2 Diabetes Risk in Postmenopausal Women.9th January 2021
  The empirical dietary index for hyperinsulinemia (EDIH) and empirical dietary inflammatory pattern (EDIP) scores assess the insulinemic and inflammatory potentials of habitual dietary patterns, irrespective of the macronutrient content, and are based on plasma insulin response or inflammatory biomarkers, respectively. The glycemic index (GI) and glycemic load (GL) assess postprandial glycemic potential based on dietary […]
• Survival and risk of recurrence of takotsubo syndrome.9th January 2021
  The goal of this study is to evaluate the long-term outcomes of patients with takotsubo syndrome and assess factors associated with death or recurrence.This is a retrospective population-based cohort study of consecutive patients who presented to an integrated health system in Southern California with takotsubo syndrome between 2006 and 2016. Medical records were manually reviewed […]
• Lessons learnt from the variation across 6741 family/general practices in England in the use of treatments for hypogonadism.8th January 2021
  We have previously reported rates of diagnosis of male hypogonadism in United Kingdom (UK) general practices. We aimed to identify factors associated with testosterone prescribing in UK general practice.We determined for 6741 general practices in England, the level of testosterone prescribing in men and the relation between volume of testosterone prescribing and 1) demographic characteristics […]
• Association of T-wave abnormalities with major cardiovascular events in diabetes: the ACCORD trial.8th January 2021
  T-wave abnormalities (TWA) are often found on ECG and signify abnormal ventricular repolarisation. While TWA have been shown to be associated with subclinical atherosclerosis, the relationship between TWA and hard cardiovascular endpoints is less clear and may differ in the presence of diabetes, so we sought to explore these associations in participants from the Action […]
• Generation of β cells from iPSC of a MODY8 patient with a novel mutation in the carboxyl ester lipase (CEL) gene.8th January 2021
  MODY8 is a rare form of monogenic diabetes characterized by a mutation in CEL (carboxyl-ester-lipase) gene, which leads to exocrine pancreas dysfunction, followed by β cell failure. Induced pluripotent stem cells can differentiate into functional β cells. Thus, β cells from MODY8 patients can be generated in vitro and used for disease modelling and cell […]
• The Effect of BMI and Type 2 Diabetes on Socioeconomic Status: A Two-Sample Multivariable Mendelian Randomization Study.8th January 2021
  To assess the independent causal effect of BMI and type 2 diabetes (T2D) on socioeconomic outcomes by applying two-sample Mendelian randomization (MR) analysis.We performed univariable and multivariable two-sample MR to jointly assess the effect BMI and T2D on socioeconomic outcomes. We used overlapping genome-wide significant single nucleotide polymorphisms for BMI and T2D as instrumental variables. […]
• Serum Galectin-3 and Subsequent Risk of Coronary Heart Disease in Subjects With Childhood-Onset Type 1 Diabetes: A Cohort Study.7th January 2021
  To study whether serum galectin-3 and other biomarkers of inflammation predict coronary heart disease (CHD) in subjects with long-standing childhood-onset type 1 diabetes.A population-based nationwide cohort of 299 subjects with type 1 diabetes diagnosed in Norway at <15 years of age during 1973-1982. They were examined in 2002-2003 at a mean age of 33 years […]
• Full Inequities in Diabetic Ketoacidosis among Patients with Type 1 diabetes and COVID-19: Data from 52 US Clinical Centers.7th January 2021
  We examined whether diabetic ketoacidosis (DKA), a serious complication of type 1 diabetes (T1D) was more prevalent among Non-Hispanic (NH) Black and Hispanic patients with T1D and laboratory-confirmed COVID-19 compared to NH Whites.This is a cross-sectional study of patients with T1D and laboratory-confirmed COVID-19 from 52 clinical sites in the US, data was collected April […]
• Risk of type 2 diabetes mellitus in women with prior hypertensive disorders of pregnancy: a systematic review and meta-analysis.7th January 2021
  The association between a history of hypertensive disorders of pregnancy (HDP) and subsequent type 2 diabetes (referred to throughout as diabetes) remains inconclusive. We reviewed the most recent evidence to quantify the association of previous HDP with incident diabetes.A systematic search of MEDLINE, Embase and CINAHL was performed up to 17 February 2020 to identify […]
• Association between diabetes and haematological malignancies: a population-based study.7th January 2021
  Contemporary data for the association of diabetes with haematological malignancies are lacking. We evaluated the risk of developing haematological malignancies and subsequent mortality in individuals with diabetes compared with those without diabetes.We conducted a population-based observational study using healthcare databases from Ontario, Canada. All Ontario residents 30 years of age or older free of cancer and […]
• Plasma concentrations of lipoproteins and risk of lower-limb peripheral artery disease in people with type 2 diabetes: the SURDIAGENE study.7th January 2021
  The lipid profile has not been fully investigated in individuals with peripheral artery disease (PAD). We aimed to evaluate the relationship between plasma concentrations of lipoproteins and the prevalence of lower-limb PAD at baseline and its incidence during follow-up in people with type 2 diabetes.Plasma concentrations of total cholesterol, HDL-cholesterol, triacylglycerol and apolipoprotein (Apo) A-I, […]
• First-appearing islet autoantibodies for type 1 diabetes in young children: maternal life events during pregnancy and the child’s genetic risk.6th January 2021
  Psychological stress has long been considered a possible trigger of type 1 diabetes, although prospective studies examining the link between psychological stress or life events during pregnancy and the child’s type 1 diabetes risk are rare. The objective of this study was to examine the association between life events during pregnancy and first-appearing islet autoantibodies […]
• Reducing intergenerational obesity and diabetes risk.6th January 2021
  To address the intergenerational transmission of obesity and diabetes, strategies promoting the health of women of reproductive age appear to be urgently needed. In this narrative review, we summarise what has been learned from many prenatal clinical trials, discuss the emerging evidence from preconception clinical trials and highlight persistent gaps and critical future directions. Most […]
• Lower insulin clearance is associated with increased risk of type 2 diabetes in Native Americans.6th January 2021
  Impaired insulin clearance is implicated in the pathogenesis of type 2 diabetes, but prospective evidence remains limited. Therefore, we sought to identify factors associated with the metabolic clearance rate of insulin (MCRI) and to investigate whether lower MCRI is associated with increased risk of incident type 2 diabetes.From a longitudinal cohort, 570 adult Native Americans […]
• Carbamylated HDL and Mortality Outcomes in Type 2 Diabetes.6th January 2021
  Carbamylation is part of the aging process and causes adverse changes in the structure and function of proteins. Lipoproteins are subjected to carbamylation. We investigated the usefulness of carbamylated HDL as a prognostic indicator of survival in patients with type 2 diabetes and the association with mortality outcomes.Baseline plasma carbamylated HDL was measured by ELISA […]
• Impact of Obesity on Measures of Cardiovascular and Kidney Health in Youth With Type 1 Diabetes as Compared With Youth With Type 2 Diabetes.6th January 2021
  Insulin resistance and obesity are independently associated with type 1 diabetes (T1D) and are known risk factors for cardiovascular and kidney diseases, the leading causes of death in T1D. We evaluated the effect of BMI on cardiovascular and kidney outcomes in youth with T1D versus control youth with normal weight or obesity and youth with […]
• Multicenter, Head-to-Head, Real-World Validation Study of Seven Automated Artificial Intelligence Diabetic Retinopathy Screening Systems.6th January 2021
  With rising global prevalence of diabetic retinopathy (DR), automated DR screening is needed for primary care settings. Two automated artificial intelligence (AI)-based DR screening algorithms have U.S. Food and Drug Administration (FDA) approval. Several others are under consideration while in clinical use in other countries, but their real-world performance has not been evaluated systematically. We […]
• Structural and functional polarisation of human pancreatic beta cells in islets from organ donors with and without type 2 diabetes.5th January 2021
  We hypothesised that human beta cells are structurally and functional polarised with respect to the islet capillaries. We set out to test this using confocal microscopy to map the 3D spatial arrangement of key proteins and live-cell imaging to determine the distribution of insulin granule fusion around the cells.Human pancreas samples were rapidly fixed and […]
• Involvement of circHIPK3 in the pathogenesis of diabetic cardiomyopathy in mice.5th January 2021
  In a mouse model of diabetic cardiomyopathy (DCM) the expression of the circular RNA circHIPK3 was found to be significantly increased. This study aimed to discover the molecular mechanisms linking circHIPK3 to the pathogenesis of DCM.The diabetic mouse model was established by i.p. injection of streptozotocin, which led to the development of DCM. Echocardiographic measurements […]
• Efficacy and Safety of Dulaglutide 3.0 mg and 4.5 mg Versus Dulaglutide 1.5 mg in Metformin-Treated Patients With Type 2 Diabetes in a Randomized Controlled Trial (AWARD-11).5th January 2021
  To compare efficacy and safety of dulaglutide at doses of 3.0 and 4.5 mg versus 1.5 mg in patients with type 2 diabetes inadequately controlled with metformin.Patients were randomly assigned to once-weekly dulaglutide 1.5 mg, 3.0 mg, or 4.5 mg for 52 weeks. The primary objective was determining superiority of dulaglutide 3.0 mg and/or 4.5 […]
• Fully Closed Loop Glucose Control With a Bihormonal Artificial Pancreas in Adults With Type 1 Diabetes: An Outpatient, Randomized, Crossover Trial.5th January 2021
  To demonstrate the performance and safety of a bihormonal (insulin and glucagon) artificial pancreas (AP) in adults with type 1 diabetes.In this outpatient, randomized, crossover trial, 2-week fully closed loop glucose control (AP therapy) was compared with 2-week open loop control (patient’s normal insulin pump therapy with a glucose sensor if they had one).A total […]
• C-C motif chemokine receptor 9 regulates obesity-induced insulin resistance via inflammation of the small intestine in mice.5th January 2021
  Accumulation of adipose tissue macrophages is considered pivotal in the development of obesity-associated inflammation and insulin resistance. In addition, recent studies suggest an involvement of the intestine as the primary organ in inducing hyperglycaemia and insulin resistance. We have reported that the C-C motif chemokine receptor (CCR) CCR9 is associated with intestinal immunity and has […]
• A prospective study of endometriosis and risk of type 2 diabetes.5th January 2021
  The objective of this study was to investigate the association between laparoscopically confirmed endometriosis and risk of type 2 diabetes.We used data from the Nurses’ Health Study II, a prospective cohort of female nurses followed for >25 years (N = 112,037). We used Cox proportional hazards models to estimate the HRs and 95% CIs of incident, confirmed type […]
• Impact of Baseline Right Bundle Branch Block on Outcomes after Pulmonary Vein Isolation in Patients with Atrial Fibrillation.1st January 2021
  Right bundle branch block (RBBB) is one of the most frequent alterations of the electrocardiogram. Several studies have shown that RBBB is a risk factor of cardiovascular diseases. However, the clinical outcomes after pulmonary vein isolation (PVI) in patients with RBBB remain unclear. We enrolled consecutive atrial fibrillation (AF) patients who underwent PVI from the […]
• Reduced Muscle Strength Associates with Insulin Resistance in Type 2 Diabetes Patients with Osteoarthritis.31st December 2020
  Type 2 diabetes associates with greater risk for musculoskeletal disorders, yet its impact on joint function remains unclear.We hypothesized that patients with type 2 diabetes and osteoarthritis would exhibit musculoskeletal impairment, which would associate with insulin resistance and distinct microRNA profiles.Participants of the German Diabetes Study with type 2 diabetes (T2D, n=39) or normal glucose […]
• Congenital Glucagon-like peptide-1 deficiency in the pathogenesis of protracted diarrhea in Mitchell Riley syndrome.31st December 2020
  Mitchell Riley syndrome (MRS) due to RFX6 gene mutations is characterized by neonatal diabetes and protracted diarrhea. RFX6 gene encodes a transcription factor involved in enteroendocrine cell differentiation required for beta-cell maturation. In contrast to the pathway by which RFX6 mutations leads to diabetes, the mechanisms underlying protracted diarrhea are unknown.To assess whether glucagon-like peptide-1 […]
• A Panel of Six Biomarkers Significantly Improves the Prediction of Type 2 Diabetes in the MONICA/KORA Study Population.31st December 2020
  Improved strategies to identify persons at high risk of type 2 diabetes are important to target costly preventive efforts to those who will benefit most.To assess whether novel biomarkers improve the prediction of type 2 diabetes beyond non-invasive standard clinical risk factors alone or in combination with HbA1c.We used a population-based case-cohort study for discovery […]
• Association of Cognitive Function and Retinal Neural and Vascular Structure in Type 1 Diabetes.30th December 2020
  Cognitive dysfunction is a growing and understudied public health issue in the aging type 1 diabetic population and is difficult and time-consuming to diagnose. Studies in long duration type 1 diabetes have reported the presence of proliferative diabetic retinopathy (PDR) was associated with cognitive dysfunction.This study assessed whether structural and vascular abnormalities of the retina, […]
• Fasting Glucose Variation Predicts Microvascular Risk in ACCORD and VADT.28th December 2020
  The association of glycemic variability with microvascular disease complications in type 2 diabetes (T2D) has been understudied and remains unclear. We investigated this relationship using both Action to Control Cardiovascular Risk in Diabetes (ACCORD) and the Veteran Affairs Diabetes Trial (VADT).In ACCORD, fasting plasma glucose (FPG) was measured 1-3 times/year for up to 84 months […]
• Continuous Glucose Monitoring in the Intensive Care Unit During the COVID-19 Pandemic.28th December 2020
  Real-time continuous glucose monitoring (rtCGM) in critically ill hospitalized patients holds promise; however, real-world data are needed.We placed Dexcom G6 CGM on intensive care unit (ICU) patients at Montefiore Medical Center with confirmed coronavirus disease 2019 (COVID-19) infection and glycemic variability. We analyzed inpatient CGM accuracy using point-of-care (POC) glucose-CGM matched pairs and included patients […]
• Effects of empagliflozin on estimated extracellular volume, estimated plasma volume, and measured glomerular filtration rate in patients with heart failure (Empire HF Renal): a prespecified substudy of a double-blind, randomised, placebo-controlled trial.28th December 2020
  SGLT2 inhibitors are a promising treatment option in patients with heart failure and reduced ejection fraction. We aimed to investigate the effects of empagliflozin on estimated extracellular volume, estimated plasma volume, and measured glomerular filtration rate (GFR) in patients with heart failure and reduced ejection fraction.Empire HF Renal was a prespecified substudy of the investigator-initiated, […]
• Dapagliflozin and the Incidence of Type 2 Diabetes in Patients With Heart Failure and Reduced Ejection Fraction: An Exploratory Analysis From DAPA-HF.23rd December 2020
  The sodium-glucose cotransporter 2 inhibitor dapagliflozin reduced the risk of cardiovascular mortality and worsening heart failure in the Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure (DAPA-HF) trial. This report explores the effect of dapagliflozin on incident type 2 diabetes (T2D) in the cohort without diabetes enrolled in the trial.The subgroup of 2,605 patients […]
• Exercise During the First Trimester of Pregnancy and the Risks of Abnormal Screening and Gestational Diabetes Mellitus.23rd December 2020
  To estimate the effects of exercise during the first trimester on the risks of abnormal screening and gestational diabetes mellitus (GDM).Data come from PETALS, a prospectively followed pregnancy cohort (n = 2,246, 79% minorities) receiving care at Kaiser Permanente Northern California. A Pregnancy Physical Activity Questionnaire was used to assess exercise. Glucose testing results for […]
• Extended Use of the Control-IQ Closed-Loop Control System in Children With Type 1 Diabetes.23rd December 2020
  To further evaluate the safety and efficacy of the Control-IQ closed-loop control (CLC) system in children with type 1 diabetes.After a 16-week randomized clinical trial (RCT) comparing CLC with sensor-augmented pump (SAP) therapy in 101 children age 6-13 years old with type 1 diabetes, 22 participants in the SAP group initiated use of the CLC […]
• Advanced Liver Fibrosis Is Common in Patients With Type 2 Diabetes Followed in the Outpatient Setting: The Need for Systematic Screening.23rd December 2020
  Assess the prevalence of nonalcoholic fatty liver disease (NAFLD) and of liver fibrosis associated with nonalcoholic steatohepatitis in unselected patients with type 2 diabetes mellitus (T2DM).A total of 561 patients with T2DM (age: 60 ± 11 years; BMI: 33.4 ± 6.2 kg/m2; and HbA1c: 7.5 ± 1.8%) attending primary care or endocrinology outpatient clinics and […]
• Association of Serum Bile Acids Profile and Pathway Dysregulation With the Risk of Developing Diabetes among Normoglycemic Chinese Adults: Findings From the 4C Study.23rd December 2020
  Comprehensive assessment of serum bile acids (BAs) aberrations before diabetes onset remains inconclusive. We examined the association of serum BA profile and coregulation with the risk of developing type 2 diabetes mellitus (T2DM) among normoglycemic Chinese adults.We tested 23 serum BA species in subjects with incident diabetes (n = 1,707) and control subjects (n = […]
• Metabolic profiling of angiopoietin-like protein 3 and 4 inhibition: a drug-target Mendelian randomization analysis.22nd December 2020
  Angiopoietin-like protein 3 (ANGPTL3) and 4 (ANGPTL4) inhibit lipoprotein lipase (LPL) and represent emerging drug targets to lower circulating triglycerides and reduce cardiovascular risk. To investigate the molecular effects of genetic mimicry of ANGPTL3 and ANGPTL4 inhibition and compare them to the effects of genetic mimicry of LPL enhancement.Associations of genetic variants in ANGPTL3 (rs11207977-T), […]
• Early prediction of gestational diabetes mellitus in the Chinese population via advanced machine learning.22nd December 2020
  Accurate methods for early gestational diabetes mellitus (GDM) (during the first trimester of pregnancy) prediction in Chinese and other populations are lacking.Establishing effective models to predict early GDM.Pregnancy data for 73 variables during the first trimester were extracted from the electronic medical record system.Based on a machine learning (ML) driven feature selection method, 17 variables […]
• Effect of empagliflozin on exercise ability and symptoms in heart failure patients with reduced and preserved ejection fraction, with and without type 2 diabetes.22nd December 2020
  The EMPERIAL (Effect of EMPagliflozin on ExeRcise ability and HF symptoms In patients with chronic heArt faiLure) trials evaluated the effects of empagliflozin on exercise ability and patient-reported outcomes in heart failure (HF) with reduced and preserved ejection fraction (EF), with and without type 2 diabetes (T2D), reporting, for the first time, the effects of […]
• Plasma bile acids more closely align with insulin resistance, visceral and hepatic adiposity than total adiposity.21st December 2020
  The etiological mechanism of bile acid (BA) effects on insulin resistance and obesity is unknown.To determine if plasma BA are elevated in human obesity and/or insulin resistance.Observational study.Academic research center.71 adult volunteers formed four groups: lean insulin-sensitive (BMI≤25kg/m 2, HOMA-IR<2.0, n=19), overweight/obese non-diabetic who were either insulin-sensitive (Obsensitive, BMI>25kg/m 2, HOMA-IR<1.5, n=11), or insulin-resistant (Obresistant, […]
• Plasma Creatine and Incident Type 2 Diabetes in a General Population-Based Cohort: The PREVEND Study.21st December 2020
  Type 2 diabetes is associated with both impaired insulin action at target tissues and impaired insulin secretion in pancreatic beta-cells. Mitochondrial dysfunction may play a role in both insulin resistance and impaired insulin secretion. Plasma creatine has been proposed as a potential marker for mitochondrial dysfunction. We aimed to investigate the association between plasma creatine […]
• Maternal health, in-utero, and perinatal exposures and risk of thyroid cancer in offspring: a Nordic population-based nested case-control study.21st December 2020
  Thyroid cancer tends to be diagnosed at a younger age (median age 51 years) compared with most other malignancies (such as breast cancer [62 years] or lung cancer [71 years]). The incidence of thyroid cancer is higher in women than men diagnosed from early adolescence. However, few in-utero and early life risk exposures associated with […]
• Pulmonary Arterial Hypertension in Hospitalized Patients with Polycythemia Vera (From the National Inpatient Database).21st December 2020
  The prevalence and pathophysiology of pulmonary arterial hypertension (PAH) in myeloproliferative neoplasms (MPN) is poorly understood and have not been evaluated on larger scale studies. These reports generally focus on all MPN rather than each disease individually. We aim to establish the prevalence and association of PAH in patients with polycythemia vera (P. vera) using […]