Developmental Delay and School Performance Among Retinoblastoma Survivors: Development/school morbidity among retinoblastoma survivors.
To describe the academic performance of childhood retinoblastoma (RB) survivors.Retrospective cohort study METHODS: Retrospective chart review of children followed in a survivorship clinic.Seventy-three patients with retinoblastoma (median age at diagnosis 9.97 months [range 0.29, 65.1]) were followed for a median of 6.4 years (0.2, 1.76). Forty-eight (65.8%) had unilateral RB. Forty-three (63.0%) received systemic chemotherapy, 57 (78.1%) enucleation. At last follow-up, 5 (6.8%) children had bilateral visual acuity (VA) <20/70. Seventeen (23.3%) reported school difficulties and 10 (13.7%) had an individualized education program (IEP). Multivariable analysis revealed that a history of receiving chemotherapy was associated with self-reported school difficulties (OR 5.44 [1.36, 21.69], p=0.016), and possessing an individualized education program (IEP) (OR 11.47 [1.34, 98.16], p=0.03). Degree of visual impairment and history of enucleation did not influence the risk of self-reported school difficulties or the implementation of an IEP. Among unilateral RB patients, chemotherapy was an independent risk factor for self-reported school difficulties (OR 12.8 [1.45, 113], p=0.009) and implementation of an IEP (OR 15.2 [0.78, 292], p=0.02).Academic difficulties in childhood RB survivors are associated with chemotherapy treatment, a risk factor independent of VA.
Authors: Margaret Reynolds, Gregg Lueder, Mae Gordon, Robert J Hayashi