Deficits in geriatric assessment associate with disease activity and -burden in older patients with inflammatory bowel disease.

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We aimed to perform geriatric assessment in older inflammatory bowel disease (IBD) patients to evaluate which IBD characteristics associate with deficits in geriatric assessment and the impact of deficits on disease burden (health-related quality of life (HRQoL)).A prospective multicenter cohort study including 405 consecutive outpatient IBD patients aged ≥65 years. Somatic domain (comorbidity, polypharmacy, malnutrition), impairments in (instrumental) activities of daily living, physical capacity (handgrip strength, gait speed), mental (depressive symptoms, cognitive impairment), and social domain (life-partner) were assessed. Deficits in geriatric assessment were defined as ≥2 abnormal domains; 2-3 moderate and 4-5 severe deficits. Clinical (Harvey Bradshaw Index >4/partial Mayo Score >2) and biochemical (C-reactive protein ≥10 mg/L and/or calprotectin ≥250 μg/g) disease activity and disease burden (short Inflammatory Bowel Disease Questionnaire) were assessed.Somatic domain (51.6%) and activities of daily living (43.0%) were most frequently impaired. 160 (39.5%) patients had moderate deficits in their geriatric assessment, 32 (7.9%) severe. Clinical and biochemical disease activity associated with deficits (clinical: aOR 2.191, 95% CI 1.284-3.743, p=.004, biochemical: aOR 3.358, 95% CI 1.936-5.825, p

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Authors: Vera E R Asscher, Sanne N Waars, Andrea E van der Meulen-de Jong, Rogier J L Stuyt, A Martine C Baven-Pronk, Sander van der Marel, Rutger J Jacobs, Jeoffrey J L Haans, Lennart J Meijer, Jacqueline D Klijnsma-Slagboom, Marijn H Duin, Milou E R Peters, Felicia V Y L Lee-Kong, Nanda E Provoost, Femke Tijdeman, Kenan T van Dijk, Monse W M Wieland, Mirre G M Verstegen, Melissa E van der Meijs, Annemijn D I Maan, Floor J van Deudekom, Simon P Mooijaart, P W Jeroen Maljaars