Core cerebrospinal fluid biomarker profile in anti-LGI1 encephalitis.

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To compare CSF biomarkers’ levels in patients suffering from anti-Leucine-rich Glioma-Inactivated 1 (LGI1) encephalitis to neurodegenerative [Alzheimer’s disease (AD), Creutzfeldt-Jakob’s disease (CJD)] and primary psychiatric (PSY) disorders.Patients with LGI1 encephalitis were retrospectively selected from the French Reference Centre database between 2010 and 2019 and enrolled if CSF was available for biomarkers analysis including total tau (T-tau), phosphorylated tau (P-tau), amyloid-beta Aβ1-42, and neurofilaments light chains (Nf L). Samples sent for biomarker determination as part of routine practice, and formally diagnosed as AD, CJD, and PSY, were used as comparators.Twenty-four patients with LGI1 encephalitis were compared to 39 AD, 20 CJD and 20 PSY. No significant difference was observed in T-tau, P-tau, and Aβ1-42 levels between LGI1 encephalitis and PSY patients. T-Tau and P-Tau levels were significantly lower in LGI1 encephalitis (231 and 43 ng/L) than in AD (621 and 90 ng/L, p 

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Authors: Pierre Lardeux, Anthony Fourier, Elise Peter, Aline Dorey, Sergio Muñiz-Castrillo, Alberto Vogrig, Géraldine Picard, Véronique Rogemond, Mathieu Verdurand, Maité Formaglio, Bastien Joubert, Caroline Froment Tilikete, Jérôme Honnorat, Isabelle Quadrio, Virginie Desestret