The appropriate number of systematic biopsy cores to retrieve during Magnetic Resonance Imaging (MRI)-targeted prostate biopsy is not well defined. We aimed to demonstrate a biopsy sampling approach that reduces […]» Read more
The Impact of Upper Tract Urothelial Carcinoma Diagnostic Modality on Intravesical Recurrence after Radical Nephroureterectomy: A Single Institution Series and Updated meta-Analysis.
Diagnostic ureteroscopic biopsy for upper tract urothelial carcinoma (UTUC) has been hypothesized to increase intravesical recurrence of urothelial carcinoma after radical nephroureterectomy (RNU). Moreover, the impact of ureteroscopy without biopsy […]» Read more
Atezolizumab Versus Chemotherapy in Patients with Platinum-treated Locally Advanced or Metastatic Urothelial Carcinoma: A Long-term Overall Survival and Safety Update from the Phase 3 IMvigor211 Clinical Trial.
Atezolizumab is an anti-PD-L1 immune checkpoint inhibitor recommended for the treatment of locally advanced or metastatic urothelial carcinoma (mUC) after prior platinum-containing chemotherapy, regardless of PD-L1 status, among other treatment […]» Read more
To review the available evidence regarding health disparities in kidney stone disease and identify knowledge gaps in this area.A literature search was conducted using PubMed, Embase, and Scopus, limited to […]» Read more
Distinct Response to Platinum-Based Chemotherapy Among Patients With Metastatic Castration-Resistant Prostate Cancer Harboring Alterations in Genes Involved in Homologous Recombination.
To explore the association between genomic status and clinical outcome of platinum-based chemotherapy among patients with metastatic castration resistant prostate cancer (mCRPC).We conducted a retrospective study of 55 patients with […]» Read more
Genome Wide Association Study Identifies Two Novel Loci Associated with Female Stress and Urgency Urinary Incontinence.
Genome-wide association studies (GWAS) have not identified replicable genetic risk loci for stress or urgency urinary incontinence.We carried out a discovery stage case control GWAS in three independent discovery cohorts […]» Read more
To assess the literature around post-treatment asymptomatic residual stone fragments, and to perform a meta-analysis. The main outcomes were intervention rate and disease progression.We searched Ovid Medline, Embase, Cochrane library […]» Read more
Peri- and Postoperative Outcomes of Robot-Assisted Radical Prostatectomy in Prostate Cancer Patients with Prior Transurethral Subvesical Deobstruction: Results of a High-Volume Center.
Prostate cancer patients, who are scheduled for robot-assisted radical prostatectomy (RARP), often have a history of transurethral resection or laser enucleation of the prostate (TUR/LE-P) as treatment of benign prostate […]» Read more
Historically, open techniques have been favored over minimally invasive approaches for complex surgeries. We aimed to identify differences in perioperative outcomes, surgical footprints, and complication rates in patients undergoing either […]» Read more
Residual Benign Prostate Glandular Tissue after Radical Prostatectomy is Not Associated with the Development of Detectable Postoperative Serum PSA.
To determine if benign glandular tissue at the surgical margin (BGM) is associated with detectable PSA and/or biochemical recurrence (BCR) after radical prostatectomy (RP).Participants underwent RP for localized prostate cancer […]» Read more
The Duration of Antibiotics Prophylaxis at the Time of Catheter Removal after Radical Prostatectomy: Clinically-Integrated, Cluster, Randomized Trial.
Prophylactic antibiotics are routinely given at the time of catheter removal post radical prostatectomy (RP). The low rate of infectious complications entails that large sample sizes are required for randomized […]» Read more
Previous studies have elucidated the unique macroscopic and histologic properties of buccal mucosa that make it a viable and durable graft for urethral augmentation. However, no prior literature has directly […]» Read more
The Prognostic Association of Prostate MRI PI-RADS v2 Assessment Category and Risk of Biochemical Recurrence after Definitive Local Therapy for Prostate Cancer: A Systematic Review and Meta-analysis.
Although the Prostate Imaging-Reporting and Data System version 2 (PI-RADS v2) is a reliable diagnostic tool for significant prostate cancer (PCa), less is known about the prognostic significance of the […]» Read more
Association Between Lesion Location and Oncological Outcomes after Focal Therapy for Localized Prostate Cancer Using Either High Intensity Focused Ultrasound or Cryotherapy.
To assess whether PCa location might affect oncological outcomes after focal therapy (FT) for prostate cancer (PCa).We identified 274 men receiving FT for prostate cancer (PCa) using either HIFU or […]» Read more
Features of Various Bladder Lesions and Their Impact on Clinical Symptoms and Recurrence in Interstitial Cystitis.
We aimed to investigate the impact of various bladder lesions on the clinical symptoms and recurrence of interstitial cystitis (IC).IC patients who underwent transurethral resection and cauterization (TURC) for Hunner […]» Read more
Impact of Pathogenic Germline DNA Damage Repair alterations on Response to Intense Neoadjuvant Androgen Deprivation Therapy in High-risk Localized Prostate Cancer.
Intense neoadjuvant androgen deprivation therapy (ADT) before radical prostatectomy (RP) is an investigational approach to reduce recurrence rates in men with high-risk localized prostate cancer (PCa). The impact of germline […]» Read more
A Comparison of Image-Guided Targeted Prostate Biopsy Outcomes by PI-RADS Score and Ethnicity in a Diverse, Multiethnic Population.
Non-Hispanic Black (NHB) and Hispanic/Afro-Caribbean men have the highest risk for prostate cancer (PCa) compared to non-Hispanic White (NHW) men. However, ethnicity-specific outcomes of targeted fusion biopsy (FB) for the […]» Read more
Deep Learning Improves Speed and Accuracy of Prostate Gland Segmentations on MRI for Targeted Biopsy.
Targeted biopsy improves prostate cancer diagnosis. Accurate prostate segmentation on MRI is critical for accurate biopsy. Manual gland segmentation is tedious and time-consuming. We sought to develop a deep learning […]» Read more
Expression Analysis of Same-Patient Metachronous and Synchronous Upper-Tract and Bladder Urothelial Carcinoma.
To compare upper-tract urothelial carcinoma (UTUC) and bladder urothelial carcinoma (BUC) in same-patient metachronous-(m) and synchronous-(s) UTUC and BUC using next generation sequencing.Consecutive untreated same-patient samples of UTUC and BUC […]» Read more
Risk Factors for Intravesical Recurrence After Minimally Invasive Nephroureterctomy for Upper Tract Urothelial Cancer (Robuust Collaboration).
Intravesical recurrence (IVR) after radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC) has an incidence of approximately 20-50%. Studies to date have been composed of mixed treatment cohorts – […]» Read more
This study investigated the association between Dietary Inflammatory Index and sex hormones in a large, nationally representative adult male sample.We utilized data from the 2013-2014 and 2015-2016 National Health and […]» Read more
Free Graft Augmentation Urethroplasty for Bulbar Urethral Strictures: Which Technique Is Best? A Systematic Review.
Four techniques for graft placement in one-stage bulbar urethroplasty have been reported: dorsal onlay (DO), ventral onlay (VO), dorsolateral onlay (DLO), and dorsal inlay (DI). There is currently no systematic […]» Read more
Cardiovascular Events in Men with Prostate Cancer Receiving Hormone Therapy: An Analysis of the FDA Adverse Event Reporting System (FAERS).
The comparative cardiovascular risk profiles of available hormone therapies for the treatment of prostate cancer is not known.We queried the FDA Adverse Event Reporting System (FAERS), a retrospective, pharmacovigilance database, […]» Read more
Contemporary Rates of Gynecologic Organ Involvement in Females With Muscle Invasive Bladder Cancer: A Retrospective Review of Women Undergoing Radical Cystectomy Following Neoadjuvant Chemotherapy.
According to the AUA/ASCO/ASTRO/SUO Guideline on treatment of nonmetastatic muscle-invasive bladder cancer (MIBC), females requiring radical cystectomy (RC) should undergo concomitant anterior pelvic exenteration despite low rates of malignant involvement […]» Read more
Final 5-Year Outcomes of the Multicenter Randomized Sham-Controlled Trial of Rezūm Water Vapor Thermal Therapy for Treatment of Moderate-To-Severe Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia.
To present final 5-year outcomes of the multicenter randomized sham-controlled trial of Rezum water vapor therapy for treatment of moderate-to-severe LUTS due to BPH.Total of 197 subjects >50 years of […]» Read more
The primary aim of our study was to evaluate relief of chronic scrotal content pain after a series of spermatic cord blocks with a combination of local anesthetic and a […]» Read more
A Single-arm, Multicenter, Phase 2 Study of Lenvatinib Plus Everolimus in Patients with Advanced Non-Clear Cell Renal Cell Carcinoma.
Non-clear cell renal cell carcinoma (nccRCC) accounts for ≤20% of RCC cases. Lenvatinib (a multitargeted tyrosine kinase inhibitor) in combination with everolimus (an mTOR inhibitor) is approved for the treatment […]» Read more
Clinical Outcomes in Clinical N0 (cN0) Squamous Cell Carcinoma (SCC) of the Penis according to Nodal Management: Early, Delayed or Selective (following Dynamic Sentinel Node Biopsy – DSNB) Inguinal Lymph-Node Dissection (ILND).
We evaluated the oncologic efficacy of early inguinal lymph-node dissection (ILND), observation or dynamic sentinel node biopsy (DSNB) followed by delayed or selective ILND in cN0 patients with penile squamous […]» Read more
Prostate-specific Membrane Antigen and Fluciclovine Transporter Genes are Associated with Variable Clinical Features and Molecular Subtypes of Primary Prostate Cancer.
18F-Fluciclovine-based positron emission tomography (PET) imaging is recommended in the USA for biochemical recurrence (BCR) after prostate cancer treatment. However, prostate-specific membrane antigen (PSMA)-based PET imaging is more common worldwide, […]» Read more
A Systematic Review and Meta-analysis of the Effectiveness and Toxicities of Lutetium-177-labeled Prostate-specific Membrane Antigen-targeted Radioligand Therapy in Metastatic Castration-Resistant Prostate Cancer.
Castration-resistant prostate cancer (CRPC) treatment is an evolving challenge. Prostate-specific membrane antigen (PSMA)-targeted endoradiotherapy/radioligand therapy (PRLT) with small-molecule, urea-based agents labeled with the β-particle-emitting radionuclide lutetium-177 (177Lu) is a promising […]» Read more