Real World Practice Patterns and Predictors of Continuous versus Intermittent ADT Use for Prostate Cancer in Older Men.

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Phase-III RCT evidence suggests intermittent ADT (IADT) is not significantly inferior to continuous ADT for prostate cancer (PC) patients. However, clinical practice and guidelines differ in their recommendations. We evaluate […]

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A Predictive Pre- and Post-operative Nomogram for Post-operative Potency Recovery after Robot-Assisted Radical Prostatectomy.

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Prediction of potency recovery following RARP is useful for better patient counselling and post-operative treatment strategies. In this study we propose a pre-operative and post-operative nomogram to predict post-operative potency […]

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Cardiovascular Proteomics: A Post-hoc Analysis from a Phase II Randomized Clinical Trial Comparing GnRH Antagonist Vs GnRH Agonist Among Men with Advanced Prostate Cancer.

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Recent studies demonstrated reduced cardiovascular risk with GnRH antagonist, yet the underlying mechanism remains undetermined. The objective of this study was to examine longitudinal changes over time in established cardiovascular […]

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Disparate Practice Patterns and Survival Outcomes: The Impact of Centralization of Cancer Care for Adrenocortical Carcinoma in the United States.

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Adrenocortical carcinoma is a rare but aggressive malignancy. While centralization of care to referral centers improves outcomes across common urologic malignancies, there exists a paucity of data for low-incidence cancers. […]

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Overall Survival of Men with Metachronous Metastatic Hormone-sensitive Prostate Cancer Treated with Enzalutamide and Androgen Deprivation Therapy.

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Men who initially present with localized prostate cancer and later develop metachronous metastases have a better prognosis than men with de novo metastatic disease and often have a low burden […]

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Interstitial Cystitis/Bladder Pain Syndrome’s Correlations with Pregnancy and Neonatal Outcomes: A Study of a Population Database.

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To evaluate the associations with interstitial cystitis during pregnancy using a United States inpatient database.We conducted a retrospective cohort study utilizing the Nationwide Inpatient Sample database from the Healthcare Cost […]

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One-Stage Buccal Mucosal Graft Urethroplasty for Lichen Sclerosus Related Urethral Stricture Disease: A Systematic Review and Pooled Proportional Meta-Analysis.

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Performing one-stage urethroplasty in patients with urethral strictures caused by lichen sclerosis (LS) is hotly debated among reconstructive urologists due to conflicting reports of success. Therefore, the objective of this […]

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Pathologic Downstaging and Survival Outcomes Associated with Neoadjuvant Chemotherapy for Variant Histology Muscle Invasive Bladder Cancer.

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Patients with muscle invasive bladder cancer (MIBC) of variant histology have a poor prognosis. It is unclear if neoadjuvant chemotherapy prior to radical cystectomy is associated with pathologic downstaging or […]

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External Validation and Addition of Prostate-specific Membrane Antigen Positron Emission Tomography to the Most Frequently Used Nomograms for the Prediction of Pelvic Lymph-node Metastases: an International Multicenter Study.

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Different nomograms exist for the preoperative prediction of pelvic lymph-node metastatic disease in individual patients with prostate cancer (PCa). These nomograms do not incorporate modern imaging techniques such as prostate-specific […]

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Pretreatment Risk Stratification for Endoscopic Kidney-sparing Surgery in Upper Tract Urothelial Carcinoma: An International Collaborative Study.

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Several groups have proposed features to identify low-risk patients who may benefit from endoscopic kidney-sparing surgery in upper tract urothelial carcinoma (UTUC).To evaluate standard risk stratification features, develop an optimal […]

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Impact of the Implementation of the EAU Guidelines Recommendation on Reporting and Grading of Complications in Patients Undergoing Robot-assisted Radical Cystectomy: A Systematic Review.

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In 2012, the European Association of Urology (EAU) Ad Hoc Panel proposed a standardised methodology on reporting and grading complications after urological surgical procedures. The aim of the current study […]

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Reliability of Serial Prostate Magnetic Resonance Imaging to Detect Prostate Cancer Progression During Active Surveillance: A Systematic Review and Meta-analysis.

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Although magnetic resonance imaging (MRI) is broadly implemented into active surveillance (AS) protocols, data on the reliability of serial MRI in order to help guide follow-up biopsy are inconclusive.To assess […]

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Timing of Androgen Deprivation Treatment for Men with Biochemical Recurrent Prostate Cancer in the Context of Novel Therapies.

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There were three recent FDA approvals for drugs to be used in non-metastatic castration resistant prostate cancer, a state that arises from the unproven start of continuous androgen deprivation therapy […]

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Digital Frozen Sections with Fluorescence Confocal Microscopy During Robot-assisted Radical Prostatectomy: Surgical Technique.

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Robot-assisted radical prostatectomy (RARP) involves a tradeoff between oncological control and functional outcomes. Intraoperative control of surgical margins (SMs) may help in ensuring the safety of the dissection. Fluorescence confocal […]

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A Systematic Review of the Impact of Surgeon and Hospital Caseload Volume on Oncological and Nononcological Outcomes After Radical Prostatectomy for Nonmetastatic Prostate Cancer.

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The impact of surgeon and hospital volume on outcomes after radical prostatectomy (RP) for localised prostate cancer (PCa) remains unknown.To perform a systematic review on the association between surgeon or […]

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Female Sexual Function following Sling Surgery: A Prospective Parallel Cohort, Multi-Center Study of the Solyx™ Single Incision Sling System Vs. the Obtryx™ II Sling System (FDA- Mandated 522 Results at 36 Months).

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Limited data exist regarding sexual function after single incision sling surgery. We compared sexual function 36 months postoperatively between patients undergoing single incision and transobturatorsling for treatment of stress urinary […]

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Long-Term Outcomes of Whole Gland Salvage Cryotherapy for Locally Recurrent Prostate Cancer Following Radiation Therapy: A Combined Analysis of Two Centers.

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Radiation refractory prostate cancer (RRPCa) is common and salvage cryotherapy for RRPCa is emerging as a viable local treatment option. However, there is a paucity of long-term data. The purpose […]

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