The summary presented herein represents Part II of the two-part series dedicated to Advanced Prostate Cancer: AUA/ASTRO/SUO Guideline discussing prognostic and treatment recommendations for patients with castration-resistant disease. Please refer […]» Read more
The summary presented herein represents Part I of the two-part series dedicated to Advanced Prostate Cancer: AUA/ASTRO/SUO Guideline discussing prognostic and treatment recommendations for patients with biochemical recurrence without metastatic […]» Read more
Surgical Management and Outcomes of Renal Tumors Arising from Horseshoe Kidneys: Results from an International Multicenter Collaboration.
Despite being the most frequent renal fusion anomaly, tumors arising from horseshoe kidneys (HSKs) are extremely rare and management guidance is lacking.To evaluate the perioperative, oncological, and functional outcomes of […]» Read more
Hybrid Indocyanine Green-99mTc-nanocolloid for Single-photon Emission Computed Tomography and Combined Radio- and Fluorescence-guided Sentinel Node Biopsy in Penile Cancer: Results of 740 Inguinal Basins Assessed at a Single Institution.
Sentinel node (SN) biopsy in penile cancer (PeCa) is typically performed using 99mTc-nanocolloid and blue dye. Recent reports suggested that the hybrid (radioactive and fluorescent) tracer indocyanine green (ICG)-99mTc-nanocolloid may […]» Read more
We previously reported that olaparib led to significantly longer imaging-based progression-free survival than the physician’s choice of enzalutamide or abiraterone among men with metastatic castration-resistant prostate cancer who had qualifying […]» Read more
Technical Refinements in Superextended Robot-assisted Radical Prostatectomy for Locally Advanced Prostate Cancer Patients at Multiparametric Magnetic Resonance Imaging.
The feasibility and efficacy of robot-assisted radical prostatectomy (RARP) in locally advanced prostate cancer (PCa) patients with iT3 lesion at magnetic resonance imaging (MRI) are currently not explored.To describe our […]» Read more
Biopsy Cell Cycle Proliferation Score Predicts Adverse Surgical Pathology in Localized Renal Cell Carcinoma.
Active surveillance (AS) is an accepted management strategy for some patients with renal cell carcinoma, but limited tools are available to identify optimal AS candidates. While renal mass biopsy provides […]» Read more
A Systematic Review and Meta-Analysis of the Significance of Body Mass Index on Kidney Cancer Outcomes.
Obesity is a well-known risk factor for kidney cancer incidence. However, a number of studies have demonstrated more favorable kidney cancer prognosis in patients with elevated body mass index (BMI) […]» Read more
The incidence of UTIs is seasonal, peaking in summer months. One possible mechanism for the observed seasonality of UTIs is warmer weather.We identified all UTI cases located in approximately 400 […]» Read more
Rates and Patterns of Recurrences, and Survival Outcomes after Robot-Assisted Radical Cystectomy: Results from the International Robotic Cystectomy Consortium.
There have been concerns about higher incidence of local and retroperitoneal recurrences after robot-assisted radical cystectomy (RARC) compared to open radical cystectomy. We sought to report and detail relapses following […]» Read more
Efficacy of Daily Intake of Dried Cranberry 500 mg in Women with Overactive Bladder: A Randomized, Double-Blind, Placebo-Controlled Study.
To determine the efficacy of dried cranberry on reducing symptoms of overactive bladder in women.Eligible women aged 18 or older with overactive bladder were randomized to either daily dried cranberry […]» Read more
A Urine Exosome Gene Expression Panel Distinguishes Between Indolent and Aggressive Prostate Cancers at Biopsy.
Prostate cancer is predominantly indolent at diagnosis with a small fraction (15-25%) representing aggressive subtype [Gleason score (GS) 7-10], which is prone to metastatic progression. It is critical to explore […]» Read more
Final Overall Survival Results from a Phase 3 Study to Compare Tivozanib to Sorafenib as Third- or Fourth-line Therapy in Subjects with Metastatic Renal Cell Carcinoma.
Tivozanib is a potent and selective inhibitor of the VEGF receptor. In an open-label, randomized phase 3 trial, we compared tivozanib to sorafenib in patients with metastatic renal cell carcinoma […]» Read more
The Impact of Ureteroscopy following Computed Tomography Urography in the Management of Upper Tract Urothelial Carcinoma.
The aim of the study is to report the reliability of computed tomography urography (CTU) and ureteroscopy (URS) in the diagnosis and management of UTUC.From 2015 to 11/2018, we prospectively […]» Read more
Detection Rate of Prostate-Specific Membrane Antigen Tracers for Positron Emission Tomography/Computed Tomography in Prostate Cancer Biochemical Recurrence: A Systematic Review and Network Meta-Analysis.
Restaging of prostate cancer in patients with biochemical recurrence (BCR) after radical treatment remains a challenging clinical scenario as current imaging modalities are suboptimal. To date, PSMA PET/CT seems to […]» Read more
Robotic Kidney Transplantation with Regional Hypothermia Versus Open Kidney Transplantation for Patients with End-Stage Renal Disease: An Ideal Stage 2B Study.
To report on comparative effectiveness of minimally invasive versus traditional open kidney transplantation.We undertook a prospective cohort study of 654 patients who underwent open or robotic kidney transplantation at a […]» Read more
Erectile Dysfunction in a Sample of Sexually Active Young Adult Men from a US Cohort: Demographic, Metabolic, and Mental Health Correlates.
Little is understood about physiologic and psychologic correlates of erectile dysfunction (ED) among younger men. This study examined prevalence and correlates of ED in a large US sample of 18-31 […]» Read more
Sequencing of PD-1/L1 Inhibitors and Carboplatin-Based Chemotherapy for Cisplatin-Ineligible Metastatic Urothelial Carcinoma.
Current first-line treatment options in patients with metastatic urothelial carcinoma (mUC) unfit to receive cisplatin-containing chemotherapy include PD-1/L1 inhibitors and carboplatin-containing chemotherapy. However, the optimal sequencing of these therapies remains […]» Read more
psychological intervention with parents improves treatment results and reduces punishment in enuretic children: a randamized clinical trial.
This study aims to evaluate the impact of psychological intervention with parents of enuretic children on treatment outcome.Sixty-six enuretic children were randomized into two groups. All children received urotherapy orientation […]» Read more
Association of Lower Urinary Tract Symptom Severity with Kidney Function Among Community-Dwelling Older Men.
Most international practice guidelines recommend screening for chronic kidney disease among older men with lower urinary tract symptoms. However, prior studies supporting these guidelines are insufficient due to incomplete assessments […]» Read more
The relationship between fluid intake and lower urinary tract symptoms (LUTS) in individuals with neurogenic bladder is unknown. We aimed to investigate the association between fluid intake and urinary symptoms […]» Read more
Regimented Phosphodiesterase Type 5 Inhibitor Use Reduces Emergency Department Visits for Recurrent Ischemic Priapism.
To evaluate the real-world effectiveness of regimented phosphodiesterase type 5 inhibitor (regPDE5i) dosing on recurrent ischemic priapism (RIP) outcomes, using emergency department (ED) visits as a proxy for therapeutic control […]» Read more
Comparative Effectiveness of Surveillance, Primary Chemotherapy, Radiotherapy, and Retroperitoneal Lymph Node Dissection for the Management of Early-Stage Testicular Germ Cell Tumors: A Systematic Review.
Cancer-specific survival for men with early-stage (Stage I-IIB) testicular germ cell tumors (TGCT) is greater than 90% with any management strategy. The data regarding the comparative effectiveness of surveillance, primary […]» Read more
The phase 3 SPARTAN study evaluated apalutamide versus placebo in patients with nonmetastatic castration-resistant prostate cancer (nmCRPC) and prostate-specific antigen doubling time of ≤10 mo. At primary analysis, apalutamide improved […]» Read more
Racial differences in urinary incontinence prevalence, overactive bladder and associated bother among men: The Multi-Ethnic Study of Atherosclerosis.
To examine the association of race/ethnicity with urinary incontinence subtypes and overactive bladder and associated bother in older men.This cross-sectional analysis utilized data from Multi-Ethnic Study of Atherosclerosis, an observational […]» Read more
Patient-Reported vs. Claims-Based Measures of Health for Modeling Life Expectancy in Men with Prostate Cancer.
Life expectancy has become a core consideration in prostate cancer care. While multiple prediction tools exist to support decision-making, their discriminative ability remains modest, which hamper usage and utility. We […]» Read more
Darolutamide is a structurally distinct androgen-receptor inhibitor that is approved for the treatment of nonmetastatic, castration-resistant prostate cancer. In the planned primary analysis of a phase 3 trial, the median […]» Read more
Mid Urethral Slings for the Treatment of Urodynamic Stress Incontinence in Overweight and Obese Women: Surgical Outcomes and Preoperative Predictors of Failure.
We evaluated mid urethral sling outcomes in overweight and obese patients compared to normal weight patients and identified risk factors for failure in this population.Records of 688 women between January […]» Read more
High Intensity Focused Ultrasound Hemigland Ablation for Prostate Cancer: Initial Outcomes of a United States Series.
We report outcomes of hemigland high intensity focused ultrasound ablation as primary treatment for localized prostate cancer in the United States.A total of 100 consecutive men underwent hemigland high intensity […]» Read more
Ascending testes has been documented to be descended in scrotum within the first year of life and then re-ascended. The aim of the study was to investigate to what extend […]» Read more