Finasteride use has been associated with a reduced incidence of bladder cancer (BCa). However, the majority of studies have been conducted primarily in East Asian or Caucasian populations. Given differences […]» Read more
MOSESTM Technology for Holmium Laser Enucleation of the Prostate: A Prospective Double-Blind Randomized Control Trial.
Holmium laser enucleation of the prostate (HoLEP) has proven to be efficacious and safe for the treatment of benign prostatic hyperplasia (BPH). New laser technologies, such as the MOSES™ Pulse […]» Read more
Prostatic Artery Embolisation Versus Transurethral Resection of the Prostate for Benign Prostatic Hyperplasia: 2-yr Outcomes of a Randomised, Open-label, Single-centre Trial.
Prostatic artery embolisation (PAE) for the treatment of lower urinary tract symptoms secondary to benign prostatic obstruction (LUTS/BPO) still remains under investigation.To compare the efficacy and safety of PAE and […]» Read more
Reliability of Serum Tumor Marker Measurement to Diagnose Recurrence in Patients with Clinical Stage I Nonseminomatous Germ Cell Tumors Undergoing Active Surveillance: A Systematic Review.
Men with nonseminomatous germ cell tumors (NSGCT) of the testicle without evidence of residual disease after radical orchiectomy (Clinical stage I; CS-I) are increasingly managed with active surveillance. The guideline-recommended […]» Read more
Restriction Spectrum Imaging (RSI-MRI) is a short duration enhanced diffusion weighted technique that seeks to standardize sequences and predict upgrading. We test this technology for active surveillance biopsies. Our objective […]» Read more
Risk-Based Selection for Active Surveillance: Results of the Movember Foundation’s Global Action Plan Prostate Cancer Active Surveillance (GAP3) Initiative.
To identify and validate known predictors of disease reclassification at 1 or 4 year(s) to support risk-based selection of patient suitable for AS.An individual participant data meta-analysis using data from […]» Read more
Robotic Salvage Lymph Node Dissection in Recurrent Prostate Cancer: Lessons Learned from 68 Cases and Implications for Future Clinical Management.
Salvage lymph node dissection (sLND) is a rescue treatment for patients with nodal recurrence after radical prostatectomy (RP). Very limited data are available on robotic sLND. Our purpose was to […]» Read more
Noninvasive tests that can accurately detect prostate cancer are urgently needed for prostate cancer diagnosis, surveillance, and prognosis. Exfoliated prostate cells captured in urine represent a promising resource for noninvasive […]» Read more
Surveillance Intensity in Intermediate Risk Nonmuscle Invasive Bladder Cancer: Revisiting the Optimal Timing and Frequency of Cystoscopy.
To determine the optimal cystoscopic interval for intermediate-risk nonmuscle invasive bladder cancer (IR-NMIBC).A retrospective analysis of IR-NMIBC patients (2010-2017) was performed and 3 hypothetical models of surveillance intensity applied: Model […]» Read more
Cardiac Failure Associated with Medical Therapy of Benign Prostatic Hyperplasia: A Population-Based Study.
Increased risk of cardiac failure with alpha blockers (AB) in hypertension studies and 5-alpha reductase inhibitors (5ARI) in prostate studies have raised safety concerns for long term management of benign […]» Read more
Salvage cystectomy is required for some patients with intravesical recurrence after trimodality therapy (TMT). We compared postoperative outcomes between salvage cystectomy post-TMT (SC), primary cystectomy (PC), and primary cystectomy with […]» Read more
Comparison of Conventional and Triple Bolus Computed Tomography Urography Protocols for Radiation Dose Reduction in Hematuria Evaluation: A Randomized Controlled Trial.
Computed tomography urography is the diagnostic tool of choice for evaluating hematuria. In keeping with the ALARA (as low as reasonably achievable) principle, we evaluated a triple bolus computed tomography […]» Read more
Dutasteride Improves Nocturia but Does Not Lead to Better Sleep: Results from the REDUCE Clinical Trial.
In men, complaints of nocturia causing poor sleep are often attributed to benign prostatic hyperplasia (BPH) and treated with BPH medications. We assessed whether treating lower urinary tract symptoms (LUTS) […]» Read more
Intraoperative Strategies to Reduce Catheter-Related Bladder Discomfort in the Early Postoperative Period after Robot-Assisted Radical Prostatectomy.
Catheter-related bladder discomfort (CRBD) occurs in up to 63% of patients following robot-assisted radical prostatectomy (RARP). The optimal intra-operative anesthesia regime to prevent patients from CRBD is unknown.A prospective cohort […]» Read more
Prevalence of Urinary Incontinence Among a Nationally Representative Sample of Adult Women, 2005-2016: Findings from the Urologic Diseases in America Project.
Urinary incontinence (UI) is frequently underreported and underdiagnosed in the clinical setting. We analyzed 12 years of data from a large, nationally representative sample of women in the United States […]» Read more
Little is known about health-related quality of life (HRQOL) following treatment for bladder cancer (BC).To determine this, we undertook a cross-sectional survey covering 10% of the English population.Participants 1-10 yr from […]» Read more
Androgen Receptor Splice Variant 7 Predicts Shorter Response in Patients with Metastatic Hormone-sensitive Prostate Cancer Receiving Androgen Deprivation Therapy.
Whether AR-V7 expression can predict the response in patients with metastatic hormone-sensitive prostate cancer (mHSPC) who receive androgen deprivation therapy (ADT) remains to be explored.To evaluate the predictive value of […]» Read more
Smoking cessation after a urologic cancer diagnosis significantly benefits patients. It is not well known how often patients quit after diagnosis or how urologists intervene to support patients’ smoking cessation […]» Read more
Little is known about the role of the genitourinary and gastrointestinal microbiota in the pathogenesis of male infertility.To compare the taxonomic and functional profiles of the gut, semen, and urine […]» Read more
Micro-Ultrasound-guided Versus Multiparametric Magnetic Resonance Imaging-Targeted Biopsy in the Detection of Prostate Cancer: A Systematic Review and Meta-Analysis.
Micro-ultrasound is a novel, high-resolution, ultrasound technology, aiming to improve prostate imaging and, consequently, the diagnostic accuracy of ultrasound-guided prostate biopsy (PB). Micro-ultrasound-guided PB may present comparable detection rates to, […]» Read more
Robotic-assisted Versus Laparoscopic Surgery: Outcomes from the First Multicentre, Randomised, Patient-blinded Controlled Trial in Radical Prostatectomy (LAP-01).
The LAP-01 trial was designed to address the lack of high-quality literature comparing robotic-assisted (RARP) and laparoscopic (LRP) radical prostatectomy.To compare the functional and oncological outcomes between RARP and LRP […]» Read more
The Clinical Significance of Bone Mineral Density Changes Following Long Term Androgen Deprivation Therapy in Localized Prostate Cancer Patients.
Long-term androgen deprivation therapy (LT-ADT) has been associated with decreased bone mineral density (BMD) in men with prostate cancer (PCa). Some evidence suggests that there is no impact on fracture […]» Read more
Antimicrobial Prophylaxis (AMP) in Transurethral Resection of the Prostate (TURP): Results of a Randomized Trial.
To determine whether omitting antimicrobial prophylaxis (AMP) in TURP is safe in patients undergoing TURP without pre-operative pyuria and a pre-operative catheter.A multi-centered randomized controlled trial (RCT) from 17-09-2017 until […]» Read more
Collaborative Review: Factors Influencing Treatment Decisions for Patients with a Localized Solid Renal Mass.
With the addition of active surveillance and thermal ablation (TA) to the urologist’s established repertoire of partial (PN) and radical nephrectomy (RN) as first-line management options for localized renal cell […]» Read more
Robot-assisted Radical Prostatectomy Using the Novel Urethral Fixation Technique Versus Standard Vesicourethral Anastomosis.
Urinary continence recovery after radical prostatectomy is a major issue even in the robotic era. Surgical techniques aimed at improving earlier return to continence are continuously sought.To describe our novel […]» Read more
Outcomes of a Noninferiority Randomised Controlled Trial of Surgery for Men with Urodynamic Stress Incontinence After Prostate Surgery (MASTER).
Stress urinary incontinence (SUI) is common after radical prostatectomy and likely to persist despite conservative treatment. The sling is an emerging operation for persistent SUI, but randomised controlled trial (RCT) […]» Read more
Cystoscopy and Systematic Bladder Tissue Sampling in Predicting pT0 Bladder Cancer: A Prospective Trial.
Concern for discordance between clinical staging and final pathology drives current management of patients deemed appropriate candidates for radical cystectomy (RC). Thus, we set out to prospectively investigate reliability and […]» Read more
Changes in Clinical Presentation and Renal Outcomes Among Children with Febrile Urinary Tract Infection: 2005 vs 2015.
Recent studies have demonstrated trends of decreasing voiding cystourethrogram (VCUG) utilization rates and delayed vesico-ureteral reflux (VUR) diagnosis in some children. It is possible that such delays could lead to […]» Read more
Temporal Relationships Between Pain, Mood and Urinary Symptoms in Urologic Chronic Pelvic Pain Syndrome (UCPPS): A MAPP Network Study.
To determine the time-lagged, bidirectional relationships among clinical variables of pelvic pain, urinary symptoms, negative mood, non-pelvic pain and quality of life (QOL) in men and women with UCPPS, incorporating […]» Read more
Regional Lymph Node Metastasis on PSMA PET Correlates with Decreased BCR-Free and Therapy-free Survival after Radical Prostatectomy: A Retrospective Single-Center Single-Arm Observational Study.
To address the impact of preoperative PSMA PET (prostate specific membrane antigen positron emission tomography) findings prior to radical prostatectomy (RP) and pelvic lymph node dissection (PLND) on biochemical recurrence […]» Read more