COVID-19 and rheumatic musculoskeletal disease patients: infection rates, attitudes and medication adherence in an Irish population.

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To establish, amongst Irish rheumatic musculoskeletal disease (RMD) patients, rates of COVID-19 symptoms and positive tests, DMARD adherence and attitudes to virtual clinics.An online survey assessing COVID-19 status, RMD diagnoses, […]

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Points to consider for the treatment of immune-mediated inflammatory diseases with Janus kinase inhibitors: a consensus statement.

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Janus kinase inhibitors (JAKi) have been approved for use in various immune-mediated inflammatory diseases. With five agents licensed, it was timely to summarise the current understanding of JAKi use based […]

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Treatment of psoriatic arthritis with biologic and targeted synthetic DMARDs: British Society for Rheumatology guideline scope.

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The aim of this guideline is to provide an update on evidence-based recommendations for treatment of adult patients with PsA. The previous BSR guidelines for PsA were published in 2012 […]

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Medical Care of Adults With Down Syndrome: A Clinical Guideline.

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Down syndrome is the most common chromosomal condition, and average life expectancy has increased substantially, from 25 years in 1983 to 60 years in 2020. Despite the unique clinical comorbidities […]

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A narrative review on measurement properties of fixed-distance walk tests up to 40 meters for adults with knee osteoarthritis.

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Knee osteoarthritis (OA) is a serious disease and has no cure to date. Knee OA is a leading cause of functional limitation, e.g., difficulty walking. Walking speed is one method […]

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The prevalence of Rheumatoid Arthritis: A systematic review of population-based studies.

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To estimate the prevalence of Rheumatoid Arthritis (RA) from international population-based studies and investigate the influence of prevalence definition, data sources, classification criteria and geographical area on RA prevalence.A search […]

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EULAR recommendations for a core data set for pregnancy registries in rheumatology.

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There is an urgent need for robust data on the trajectories and outcomes of pregnancies in women with inflammatory rheumatic diseases (IRD). In particular when rare outcomes or rare diseases […]

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Towards consensus in defining and handling contextual factors within rheumatology trials: an initial qualitative study from an OMERACT working group.

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The Outcome Measures in Rheumatology Initiative established the Contextual Factors Working Group to guide the understanding, identification and handling of contextual factors for clinical trials. In clinical research, different uses […]

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Prevalence and impact of comorbidities in axial spondyloarthritis: systematic review and meta-analysis.

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Comorbidities are common in people with axial spondyloarthritis (axSpA). In this systematic review and meta-analysis, we aimed to: (i) describe the prevalence of commonly reported comorbidities, (ii) compare comorbidities between […]

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A Multicenter Study on Definitive Surgery for Isolated Hip Fracture within 24 Hours.

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Isolated hip fractures (IHFs) in the elderly are high frequency, life-altering events. Definitive surgery ≤ 24 hours of admission is associated with improved outcomes. An IHF process management guideline (IHF-PMG) […]

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Reporting items for capillaroscopy in clinical research on musculoskeletal diseases: a systematic review and international Delphi consensus.

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The level of detail included when describing nailfold videocapillaroscopy (NVC) methods varies among research studies, making interpretation and comparison of results challenging. The overarching objective of the present study was […]

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Access to paediatric rheumatology care in juvenile idiopathic arthritis: what do we know? A systematic review.

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This review examines time to access appropriate care for JIA patients and analyses the referral pathway before the first paediatric rheumatology (PR) visit. We also describe factors associated with a […]

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CanVasc consensus recommendations for the management of antineutrophil cytoplasm antibody-associated vasculitis: 2020 update.

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In 2015, the Canadian Vasculitis Research Network (CanVasc) created recommendations for the management of antineutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV) in Canada. The current update aimed to revise existing recommendations […]

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Renal involvement in eosinophilic granulomatosis with polyangiitis (EGPA): a multicentric retrospective study of 63 biopsy-proven cases.

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Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic small-vessel vasculitis characterized by asthma, hypereosinophilia and ANCA positivity in 40% of patients. Renal involvement is rare and poorly described, leading to […]

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Renal involvement in eosinophilic granulomatosis with polyangiitis (EGPA): a multicentric retrospective study of 63 biopsy-proven cases.

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Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic small-vessel vasculitis characterized by asthma, hypereosinophilia and ANCA positivity in 40% of patients. Renal involvement is rare and poorly described, leading to […]

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Epidermal Neurite Density in Skin Biopsies from Patients with Juvenile Fibromyalgia.

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Fibromyalgia is defined by idiopathic, chronic, widespread musculoskeletal pain. In adults with fibromyalgia, meta-analysis of lower-leg skin biopsy demonstrated 45% pooled prevalence of abnormally low epidermal neurite density (END). END […]

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Association of systemic lupus erythematosus with peripheral arterial disease: a meta-analysis of literature studies.

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SLE patients have an increased cardiovascular morbidity and mortality. Contrasting data are available about the association between peripheral arterial disease (PAD) and SLE. We aimed to perform a meta-analysis of […]

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Outcomes Measured in Polymyalgia Rheumatica and Measurement Properties of Instruments Considered for the OMERACT Core Outcome Set: A Systematic Review.

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To systematically identify the outcome measures and instruments used in clinical studies of polymyalgia rheumatica (PMR) and to evaluate evidence about their measurement properties.Searches based on the MeSH term ‘polymyalgia […]

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Paradoxical gastrointestinal effects of interleukin-17 blockers.

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Secukinumab, ixekizumab and brodalumab are monoclonal antibody therapies that inhibit interleukin (IL)-17 activity and are widely used for the treatment of psoriasis, psoriatic arthritis and ankylosing spondylitis. The promising efficacy […]

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Comparative effectiveness of first-line tumour necrosis factor inhibitor versus non-tumour necrosis factor inhibitor biologics and targeted synthetic agents in patients with rheumatoid arthritis: results from a large US registry study.

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This study evaluated the comparative effectiveness of a tumour necrosis factor inhibitor (TNFi) versus a non-TNFi (biological disease-modifying antirheumatic drugs (bDMARDs) and targeted synthetic DMARDs (tsDMARDs)) as the first-line treatment […]

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Ultrasound for the diagnosis of gout-the value of gout lesions as defined by the Outcome Measures in Rheumatology ultrasound group.

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To evaluate ultrasound for diagnosing gout using consensus-based Outcome Measures in Rheumatology ultrasound definitions of gout lesions.Ultrasound was performed in patients with clinically suspected gout. Joints (28) and tendons (26) […]

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Axial articular manifestations in primary Sjögren’s syndrome: Association with spondyloarthritis.

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To assess the prevalence of axial articular manifestations (AAMs) in primary Sjögren’s syndrome (pSS) patients; to investigate whether these symptoms do reveal an associated spondyloarthritis (SpA); and to assess their […]

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Performance of the 2019 ACR/EULAR classification criteria for IgG4-related disease and clinical phenotypes in a Spanish multicentre registry (REERIGG4).

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Several IgG4-related disease (IgG4-RD) phenotypes have been proposed and the first set of classification criteria have been recently created. Our objectives were to assess the phenotype distribution and the performance […]

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Coexistence of systemic and localized scleroderma: a systematic literature review and observational cohort study.

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SSc and localized sclerosis (LoS) are considered clinically distinct entities. We describe herein the coexistence of SSc and LoS by both a systematic literature review and an observational cohort study […]

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Thoracic paravertebral involvement in patients with IgG4-related disease: CT and MR imaging findings.

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To retrospectively evaluate CT and magnetic resonance (MR) imaging thoracic paravertebral findings at baseline and follow-up in patients with IgG4-related disease.The study consisted of 36 patients with IgG4-related disease involving […]

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Bacterial citrullinated epitopes generated by Porphyromonas gingivalis infection-a missing link for ACPA production.

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Porphyromonas gingivalis (P.g.) is discussed to be involved in triggering self-reactive immune responses. The aim of this study was to investigate the autocitrullinated prokaryotic peptidylarginine deiminase (PPAD) from P.g. CH2007 […]

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EULAR recommendations for the management of psoriatic arthritis with pharmacological therapies: 2019 update.

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To update the European League Against Rheumatism (EULAR) recommendations for the pharmacological treatment of psoriatic arthritis (PsA).According to the EULAR standardised operating procedures, a systematic literature review was followed by […]

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Novel and reliable DACTylitis glObal Sonographic (DACTOS) score in psoriatic arthritis.

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Dactylitis is one of the most typical features of psoriatic arthritis (PsA), with a high lifetime prevalence and inclusion in PsA clinical indices. Musculoskeletal ultrasonography (Msk-US) can readily detect inflammatory […]

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