Access to paediatric rheumatology care in juvenile idiopathic arthritis: what do we know? A systematic review.

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This review examines time to access appropriate care for JIA patients and analyses the referral pathway before the first paediatric rheumatology (PR) visit. We also describe factors associated with a […]

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CanVasc consensus recommendations for the management of antineutrophil cytoplasm antibody-associated vasculitis: 2020 update.

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In 2015, the Canadian Vasculitis Research Network (CanVasc) created recommendations for the management of antineutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV) in Canada. The current update aimed to revise existing recommendations […]

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Renal involvement in eosinophilic granulomatosis with polyangiitis (EGPA): a multicentric retrospective study of 63 biopsy-proven cases.

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Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic small-vessel vasculitis characterized by asthma, hypereosinophilia and ANCA positivity in 40% of patients. Renal involvement is rare and poorly described, leading to […]

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Renal involvement in eosinophilic granulomatosis with polyangiitis (EGPA): a multicentric retrospective study of 63 biopsy-proven cases.

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Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic small-vessel vasculitis characterized by asthma, hypereosinophilia and ANCA positivity in 40% of patients. Renal involvement is rare and poorly described, leading to […]

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Epidermal Neurite Density in Skin Biopsies from Patients with Juvenile Fibromyalgia.

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Fibromyalgia is defined by idiopathic, chronic, widespread musculoskeletal pain. In adults with fibromyalgia, meta-analysis of lower-leg skin biopsy demonstrated 45% pooled prevalence of abnormally low epidermal neurite density (END). END […]

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Association of systemic lupus erythematosus with peripheral arterial disease: a meta-analysis of literature studies.

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SLE patients have an increased cardiovascular morbidity and mortality. Contrasting data are available about the association between peripheral arterial disease (PAD) and SLE. We aimed to perform a meta-analysis of […]

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Outcomes Measured in Polymyalgia Rheumatica and Measurement Properties of Instruments Considered for the OMERACT Core Outcome Set: A Systematic Review.

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To systematically identify the outcome measures and instruments used in clinical studies of polymyalgia rheumatica (PMR) and to evaluate evidence about their measurement properties.Searches based on the MeSH term ‘polymyalgia […]

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Paradoxical gastrointestinal effects of interleukin-17 blockers.

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Secukinumab, ixekizumab and brodalumab are monoclonal antibody therapies that inhibit interleukin (IL)-17 activity and are widely used for the treatment of psoriasis, psoriatic arthritis and ankylosing spondylitis. The promising efficacy […]

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Comparative effectiveness of first-line tumour necrosis factor inhibitor versus non-tumour necrosis factor inhibitor biologics and targeted synthetic agents in patients with rheumatoid arthritis: results from a large US registry study.

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This study evaluated the comparative effectiveness of a tumour necrosis factor inhibitor (TNFi) versus a non-TNFi (biological disease-modifying antirheumatic drugs (bDMARDs) and targeted synthetic DMARDs (tsDMARDs)) as the first-line treatment […]

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Ultrasound for the diagnosis of gout-the value of gout lesions as defined by the Outcome Measures in Rheumatology ultrasound group.

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To evaluate ultrasound for diagnosing gout using consensus-based Outcome Measures in Rheumatology ultrasound definitions of gout lesions.Ultrasound was performed in patients with clinically suspected gout. Joints (28) and tendons (26) […]

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Axial articular manifestations in primary Sjögren’s syndrome: Association with spondyloarthritis.

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To assess the prevalence of axial articular manifestations (AAMs) in primary Sjögren’s syndrome (pSS) patients; to investigate whether these symptoms do reveal an associated spondyloarthritis (SpA); and to assess their […]

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Performance of the 2019 ACR/EULAR classification criteria for IgG4-related disease and clinical phenotypes in a Spanish multicentre registry (REERIGG4).

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Several IgG4-related disease (IgG4-RD) phenotypes have been proposed and the first set of classification criteria have been recently created. Our objectives were to assess the phenotype distribution and the performance […]

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Coexistence of systemic and localized scleroderma: a systematic literature review and observational cohort study.

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SSc and localized sclerosis (LoS) are considered clinically distinct entities. We describe herein the coexistence of SSc and LoS by both a systematic literature review and an observational cohort study […]

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Thoracic paravertebral involvement in patients with IgG4-related disease: CT and MR imaging findings.

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To retrospectively evaluate CT and magnetic resonance (MR) imaging thoracic paravertebral findings at baseline and follow-up in patients with IgG4-related disease.The study consisted of 36 patients with IgG4-related disease involving […]

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Bacterial citrullinated epitopes generated by Porphyromonas gingivalis infection-a missing link for ACPA production.

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Porphyromonas gingivalis (P.g.) is discussed to be involved in triggering self-reactive immune responses. The aim of this study was to investigate the autocitrullinated prokaryotic peptidylarginine deiminase (PPAD) from P.g. CH2007 […]

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EULAR recommendations for the management of psoriatic arthritis with pharmacological therapies: 2019 update.

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To update the European League Against Rheumatism (EULAR) recommendations for the pharmacological treatment of psoriatic arthritis (PsA).According to the EULAR standardised operating procedures, a systematic literature review was followed by […]

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Novel and reliable DACTylitis glObal Sonographic (DACTOS) score in psoriatic arthritis.

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Dactylitis is one of the most typical features of psoriatic arthritis (PsA), with a high lifetime prevalence and inclusion in PsA clinical indices. Musculoskeletal ultrasonography (Msk-US) can readily detect inflammatory […]

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Pathophysiology, Clinical Presentation, and Treatment of Psoriasis: A Review.

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Approximately 125 million people worldwide have psoriasis. Patients with psoriasis experience substantial morbidity and increased rates of inflammatory arthritis, cardiometabolic diseases, and mental health disorders.Plaque psoriasis is the most common […]

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Mixed methods study of clinicians’ perspectives on barriers to implementation of treat to target in psoriatic arthritis.

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In treat to target (T2T), the patient is treated to reach and maintain specified and sequentially measured goals, such as remission or low disease activity. T2T in psoriatic arthritis (PsA) […]

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Clinical practice guidelines and recommendations for the management of patients with systemic lupus erythematosus: a critical comparison.

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SLE has a great clinical heterogeneity and low prevalence, thus making the development of recommendations or clinical practice guidelines (CPG) based on high-quality evidence difficult. In the last few years, […]

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An update on the epidemiology of ANCA-associated vasculitis.

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ANCA-associated vasculitis (AAV) includes granulomatosis with polyangiitis, microscopic polyangiitis and eosinophilic granulomatosis with polyangiitis. Epidemiological studies in AAV are important in understanding possible aetiologic mechanisms and facilitating healthcare planning. However, […]

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Real-world evidence of TNF inhibition in axial spondyloarthritis: can we generalise the results from clinical trials?

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Management guidelines assume that results from clinical trials can be generalised, although seldom is data available to test this assumption. We aimed to determine the proportion of patients commencing tumour […]

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EULAR points to consider for the diagnosis and management of rheumatic immune-related adverse events due to cancer immunotherapy with checkpoint inhibitors.

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Rheumatic and musculoskeletal immune-related adverse events (irAEs) are observed in about 10% of patients with cancer receiving checkpoint inhibitors (CPIs). Given the recent emergence of these events and the lack […]

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Pilot study of the juvenile dermatomyositis consensus treatment plans: a CARRA Registry study.

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To determine the feasibility of comparing the Childhood Arthritis and Rheumatology Research Alliance (CARRA) consensus treatment plans (CTPs) in treating new-onset, moderate juvenile dermatomyositis (JDM) using the CARRA registry, and […]

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Association Between Uncemented vs Cemented Hemiarthroplasty and Revision Surgery Among Patients With Hip Fracture.

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Consensus guidelines and systematic reviews have suggested that cemented fixation is more effective than uncemented fixation in hemiarthroplasty for displaced femoral neck fractures. Given that these recommendations are based on […]

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Rituximab and Cyclophosphamide in anti-synthetase syndrome (ASyS)-related ILD: an observational retrospective study.

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Anti-synthetase syndrome (ASyS)-related interstitial lung disease (ILD) has a poor prognosis. Intravenous cyclophosphamide (CYC) and rituximab (RTX) are the main treatments currently used for moderate to severe ILD. We compare […]

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Impact of the new American College of Cardiology/American Heart Association definition of hypertension on atherosclerotic vascular events in systemic lupus erythematosus.

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The 2017 American College of Cardiology/American Heart Association guidelines defined hypertension at ≥130/80 mm Hg. Studies on patients with connective tissue diseases were not considered. Our aim was to assess the […]

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