Reliability of detection of ultrasound and MRI features of hand osteoarthritis: a systematic review and meta-analysis.

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To systematically review the literature on inter- and intra-rater reliability of scoring ultrasound and MRI changes in hand osteoarthritis (OA).Medline, EMBASE, CINHAL, Web of Science and AMED were searched from […]

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circPDE4B prevents articular cartilage degeneration and promotes repair by acting as a scaffold for RIC8A and MID1.

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Circular RNAs (circRNAs) have emerged as significant biological regulators. Herein, we aimed to elucidate the role of an unidentified circRNA (circPDE4B) that is reportedly downregulated in osteoarthritis (OA) tissues.The effects […]

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Knee joint distraction results in MRI cartilage thickness increase up to ten years after treatment.

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Knee joint distraction (KJD) has shown long-term clinical improvement and short-term cartilage restoration in young osteoarthritis (OA) patients. The current objective was to evaluate MRI cartilage thickness up to ten […]

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Long-term structural and symptomatic effects of intra-articular sprifermin in patients with knee osteoarthritis: 5-year results from the FORWARD study.

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The FORWARD (FGF-18 Osteoarthritis Randomized Trial with Administration of Repeated Doses) trial assessed efficacy and safety of the potential disease-modifying osteoarthritis drug (DMOAD) sprifermin in patients with knee osteoarthritis. Here, […]

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Linking chondrocyte and synovial transcriptional profile to clinical phenotype in osteoarthritis.

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To determine how gene expression profiles in osteoarthritis joint tissues relate to patient phenotypes and whether molecular subtypes can be reproducibly captured by a molecular classification algorithm.We analysed RNA sequencing […]

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Towards sex-specific osteoarthritis risk models: evaluation of risk factors for knee osteoarthritis in males and females.

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The aim of this study was to identify sex-specific prevalence and strength of risk factors for the incidence of radiographic knee osteoarthritis (incRKOA).Our study population consisted of 10,958 Rotterdam Study […]

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The impact of comorbidities on health-related quality of life of people with osteoarthritis over ten years.

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To investigate the impact of total number and patterns of comorbidities on health-related quality of life (HRQoL) and identify the most prevalent and influential comorbidity patterns in people with osteoarthritis […]

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Reduction of Smad2 caused by oxidative stress leads to necrotic death of hypertrophic chondrocytes associated with an endemic osteoarthritis.

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The occurrence and development of an endemic osteoarthritis Kashin-Beck Disease (KBD) is closely related to oxidative stress induced by free radicals. The aim of the study was to find the […]

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Multifocal Calcific Periarthritis with Distinctive Clinical and Radiological Features in Patients with CD73 Deficiency.

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Arterial calcification due to deficiency of CD73 (ACDC) is a hereditary autosomal recessive ectopic mineralization syndrome caused by loss-of-function mutations in the 5′-nucleotidase Ecto (NT5E) gene. Periarticular calcification has been […]

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β-blocker prescription is associated with lower cumulative risk of knee osteoarthritis and knee pain consultations in primary care: a propensity score matched cohort study.

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To examine the association between β-blocker prescription and first primary-care consultation for knee osteoarthritis (OA), hip OA, knee pain and hip pain.Data source: Clinical Practice Research Datalink. Participants aged ≥40 years […]

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Factors associated with longitudinal change of meniscal extrusion in overweight women without clinical signs of osteoarthritis.

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To identify variables associated with longitudinal change in meniscal extrusion, which might be used as possible targets for knee osteoarthritis (KOA) prevention.In a high-risk population of middle-aged overweight women, meniscal […]

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Relationship between the dynamics of telomere loss in peripheral blood leukocytes from osteoarthritis patients and mitochondrial DNA haplogroup.

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The evaluation of the evolution of telomere length from peripheral blood leukocytes (PBL) in subjects from the Osteoarthritis Initiative (OAI) cohort in relation to the incidence of osteoarthritis (OA) and […]

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Osteoarthritis and risk of hospitalization for ambulatory care sensitive conditions: A general population-based cohort study.

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To determine the association between osteoarthritis (OA) and risk of hospitalization for ambulatory care sensitive conditions (HACSCs).We included all individuals aged 40-85 years who resided in Skåne, Sweden on 31st December […]

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Effect of High-Intensity Strength Training on Knee Pain and Knee Joint Compressive Forces Among Adults With Knee Osteoarthritis: The START Randomized Clinical Trial.

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Thigh muscle weakness is associated with knee discomfort and osteoarthritis disease progression. Little is known about the efficacy of high-intensity strength training in patients with knee osteoarthritis or whether it […]

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Associations of blood pressure and arterial stiffness with knee cartilage volume in patients with knee osteoarthritis.

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To describe the associations of blood pressure and arterial stiffness with knee cartilage volume in patients with knee osteoarthritis (OA).A secondary analysis was performed on the data from participants of […]

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Characteristics associated between the incidence of hip osteoarthritis and early hip complaints (CHECK study) within 10 years.

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To determine which baseline characteristics, especially clinically variables like pain, stiffness, physical functioning and disease variables, are associated with incident hip osteoarthritis (OA) within 10-years in first presenters with hip […]

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Low rate of subsequent surgery and serious complications following intra-articular steroid injection for base of thumb osteoarthritis: national cohort analysis.

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Intra-articular steroid injection is commonly used to treat base of thumb osteoarthritis (BTOA), despite a lack of large scale data on safety and effectiveness. We estimate the incidence of serious […]

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The role of inflammation in mesenchymal stromal cell therapy in osteoarthritis, perspectives for post-traumatic osteoarthritis: a review.

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Osteoarthritis (OA) is a complex and highly prevalent degenerative disease affecting the whole joint, in which factors like genetic predisposition, gender, age, obesity and traumas contribute to joint destruction. ∼50-80% […]

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Base of thumb osteoarthritis (BTOA) in UK interface services-a cohort and survey based study to assess current practice.

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Base of thumb osteoarthritis (BTOA) is a common age-related disease which has a significant negative impact upon quality of life, while little is known about structure and pathways of interface […]

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Relationship between motion, using the GaitSmartTM system, and radiographic knee osteoarthritis: an explorative analysis in the IMI-APPROACH cohort.

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To assess underlying domains measured by GaitSmartTMparameters and whether these are additional to established OA markers including patient reported outcome measures (PROMs) and radiographic parameters, and to evaluate if GaitSmart […]

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Mediation of the association between obesity and osteoarthritis by blood pressure, vessel wall stiffness and subclinical atherosclerosis.

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We investigated the role of blood pressure, vessel wall stiffness [pulse wave velocity (PWV)] and subclinical atherosclerosis markers [carotid intima-media thickness (cIMT), popliteal vessel wall thickness (pVWT)] as mediators of […]

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The clinical and cost effectiveness of splints for thumb base osteoarthritis: a randomized controlled clinical trial.

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To investigate the clinical effectiveness, efficacy and cost effectiveness of splints (orthoses) in people with symptomatic basal thumb joint OA (BTOA).A pragmatic, multicentre parallel group randomized controlled trial at 17 […]

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The association between change in bone marrow lesion size and change in tibiofemoral cartilage volume and knee symptoms.

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To describe the association between change in subchondral bone marrow lesions (BMLs) and change in tibiofemoral cartilage volume and knee symptoms in patients with symptomatic knee OA.In total, 251 participants […]

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Towards developing diagnostic criteria for early knee osteoarthritis: data from the CHECK study.

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There is a general consensus that a shift in focus towards early diagnosis and treatment of knee OA is warranted. However, there are no validated and widely accepted diagnostic criteria […]

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