To examine the incidence, prevalence and trends for opioid prescriptions in patients with OA. Furthermore, types of opioids prescribed and long-term prescription rates were examined. Finally, the patient characteristics associated […]» Read more
Statistical shape modelling provides a responsive measure of morphological change in knee osteoarthritis over 12 months.
Responsive biomarkers are needed to assess the progression of OA and their lack has hampered previous clinical trials. Statistical shape modelling (SSM) from radiographic images identifies those at greatest risk […]» Read more
Lay descriptions of mild, moderate and severe disease states have been utilized in Global Burden of Disease studies in the calculation of years lived with disability, and may be a […]» Read more
Interleukin 1 receptor antagonist (IL1RN) gene variants predict radiographic severity of knee osteoarthritis and risk of incident disease.
In these studies, we examined the association of single nucleotide polymorphisms (SNPs) of the IL1RN gene with radiographic severity of symptomatic knee osteoarthritis (SKOA) and the risk of incident OA. […]» Read more
Hip osteoarthritis (OA) is a common cause of pain and disability.To identify the clinical findings that are most strongly associated with hip OA.Systematic search of MEDLINE, PubMed, EMBASE, and CINAHL […]» Read more
Health-related quality of life in patients with hand osteoarthritis from the general population and the outpatient clinic.
To investigate the association of hand osteoarthritis and concurrent hand and knee osteoarthritis with health-related quality of life (HRQoL) in the general population, and in patients consulting a rheumatology outpatient […]» Read more
Sleep quality is related to worsening knee pain in those with widespread pain: The Multicenter Osteoarthritis Study.
We examined the association between sleep and odds of developing knee pain, and whether this relationship varied by status of widespread pain (WSP).At the 60-month visit of the Multicenter Osteoarthritis […]» Read more
Use of recommended non-surgical knee osteoarthritis management in patients prior to totalv knee arthroplasty: a cross-sectional study.
Our aim was to assess prior use of core recommended non-surgical treatment among patients with knee osteoarthritis (OA) scheduled for total knee arthroplasty (TKA); and, to assess potential patient-level correlates […]» Read more
Correction: Mitochondrial DNA haplogroups influence the risk of incident knee osteoarthritis in OAI and CHECK cohorts. A meta-analysis and functional study.
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Abstract: Osteoarthritis (OA) is the most prevalent of the musculoskeletal conditions and represents a significant public health burden. While degeneration of articular cartilage is a key feature, it is now […]» Read more
Effect of Intra-Articular Sprifermin vs Placebo on Femorotibial Joint Cartilage Thickness in Patients With Osteoarthritis: The FORWARD Randomized Clinical Trial.
Abstract: Sprifermin is under investigation as a disease-modifying osteoarthritis drug.To evaluate the effects of sprifermin on changes in total femorotibial joint cartilage thickness in the more symptomatic knee of patients […]» Read more
The bulge sign – a simple physical examination for identifying progressive knee osteoarthritis: data from the Osteoarthritis Initiative.
Abstract: To examine whether the presence of bulge sign or patellar tap was associated with frequent knee pain, progression of radiographic OA (ROA) and total knee replacement (TKR).This study included […]» Read more
Abstract: Globally, hip fractures are among the top 10 causes of disability in adults. For displaced femoral neck fractures, there remains uncertainty regarding the effect of a total hip arthroplasty […]» Read more
Self-reported painful joint count and assessor-reported tender joint count as instruments to assess pain in hand osteoarthritis.
Abstract: To evaluate self-reported and assessor-reported joint counts for pain and their value in measuring pain and joint activity in hand OA patients.A total of 524 patients marked painful joints […]» Read more
Knee osteoarthritis risk in non-industrial societies undergoing an energy balance transition: evidence from the indigenous Tarahumara of Mexico.
Abstract: Here, we propose that knee osteoarthritis is one such disease for which susceptibility is amplified by this energy balance transition.Support for our hypothesis comes from comparisons of knee radiographs, […]» Read more
Discovery of an autoantibody signature for the early diagnosis of knee osteoarthritis: data from the Osteoarthritis Initiative.
Abstract: To find autoantibodies (AAbs) in serum that could be useful to predict incidence of radiographic knee osteoarthritis (KOA).A Nucleic-acid Programmable Protein Arrays (NAPPA) platform was used to screen AAbs […]» Read more
Top down or bottom up? An observational investigation of improvement in fibromyalgia symptoms following hip and knee replacement.
Abstract: Many patients with osteoarthritis have comorbid symptoms of FM, but it is unknown how these symptoms respond to surgical procedures that address nociceptive input in the periphery, such as […]» Read more
Human osteoarthritic synovial fluid increases excitability of mouse dorsal root ganglion sensory neurons: an in-vitro translational model to study arthritic pain.
Abstract: Knee OA is a leading global cause of morbidity. This study investigates the effects of knee SF from patients with OA on the activity of dorsal root ganglion sensory […]» Read more
Comorbid conditions and emergency department treat and release utilization in multimorbid persons with cognitive impairment.
There is an increasing focus in the emergency department (ED) on addressing the needs of persons with cognitive impairment, most of whom have multiple chronic conditions. We investigated which common comorbidities among multimorbid persons with cognitive impairment conferred increased risk for ED treat and release utilization.We examined the association of 16 chronic conditions on use of ED treat and release visit utilization among 1006 adults with cognitive impairment and???2 comorbidities using the nationally-representative National Health and Aging Trends Study merged with Fee-For-Service Medicare claims data, 2011-2015.At baseline, 28.5% had ?6 conditions and 35.4% were???85?years old. After controlling for sex, age, race, education, urban-living, number of disabled activities of daily living, and sampling strata, we found significantly increased adjusted risk ratios (aRR) of ED treat and release visits for persons with depression (aRR 1.38 95% CI 1.15-1.65) representing 78/100 person-years, and osteoarthritis or rheumatoid arthritis (aRR 1.32 95% CI 1.12-1.57) representing 71/100 person-years. At baseline 93.9% had ?1 informal caregiver and 69.7% had a caregiver that helped with medications or attended physician visits.These results show that multimorbid cognitively impaired older adults with depression or osteoarthritis or rheumatoid arthritis are at higher risk of ED treat and release visits. Future ED research with multimorbid cognitively impaired persons may explore behavioral aspects of depression and/or pain and flairs associated with osteoarthritis or rheumatoid arthritis, as well as the role of informal caregivers in the care of these conditions.» Read more
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Effect of Tanezumab on Joint Pain, Physical Function, and Patient Global Assessment of Osteoarthritis Among Patients With Osteoarthritis of the Hip or Knee: A Randomized Clinical Trial.
Abstract: Patients with osteoarthritis (OA) may remain symptomatic with traditional OA treatments.To assess 2 subcutaneous tanezumab dosing regimens for OA.A randomized, double-blind, multicenter trial from January 2016 to May 14, […]» Read more
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Development and validation of risk stratification trees for incident slow gait speed in persons at high risk for knee osteoarthritis.
Abstract: Disability prevention strategies are more achievable before osteoarthritis disease drives impairment. It is critical to identify high-risk groups, for strategy implementation and trial eligibility. An established measure, gait speed […]» Read more
Abstract: Osteoarthritis (OA) is the most common degenerative joint disease in aged population and its development is significantly influenced by aberrant epigenetic modifications of numerous OA susceptible genes; however, the […]» Read more
Arthritis self-efficacy beliefs and functioning among osteoarthritis and rheumatoid arthritis patients: a meta-analytic review.
Abstract: The Arthritis Self-Efficacy Scale (ASES) is a widely used self-report measure of beliefs reflecting confidence in one’s capacity to function despite pain and control pain or other symptoms of […]» Read more
The simultaneous analysis of mesenchymal stem cells and early osteocytes accumulation in osteoarthritic femoral head sclerotic bone.
Abstract: OA subchondral bone is a key target for therapy development. Osteocytes, the most abundant bone cell, critically regulate bone formation and resorption. Their progenitors, mesenchymal stem cells (MSCs), display […]» Read more
Abstract: Vascular pathology (changes in blood vessels) and osteoarthritis are both common chronic conditions associated with ageing and obesity, but whether vascular pathology is a risk factor for osteoarthritis is […]» Read more
Canadian Rheumatology Association Meeting Fairmont The Queen Elizabeth Montreal, Quebec, Canada February – March 2, 2019.
Abstract: The 73rd Annual Meeting of The Canadian Rheumatology Association was held at the Fairmont The Queen Elizabeth, Montreal, Quebec, Canada February 27 – March 2, 2019. The program consisted […]» Read more