To evaluate the association between psychological factors and pain exacerbations in people with hip OA.Eligible participants with symptomatic hip OA were instructed to complete online questionnaires every 10 days over a […]» Read more
Recently, necroptosis has attracted increasing attention in arthritis research; however, it remains unclear whether its regulation is involved in osteoarthritis (OA) pathogenesis. Since receptor-interacting protein kinase-3 (RIP3) plays a pivotal […]» Read more
Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration.
To identify OA subtypes based on cartilage transcriptomic data in cartilage tissue and characterize their underlying pathophysiological processes and/or clinically relevant characteristics.This study includes n = 66 primary OA patients (41 knees […]» Read more
To study the incidence, time-trends and outcomes of serious infections in people with osteoarthritis.We used the 1998-2016 U.S. National Inpatient Sample data. We examined the epidemiology of five hospitalized, i.e., […]» Read more
Joint inflammation is present in the majority of OA patients and pro-inflammatory mediators, such as IL-6, are actively involved in disease progression. Increased levels of IL-6 in serum or synovial […]» Read more
Multicenter validation of the DETAIL questionnaire for the screening of spondyloarthritis in patients with inflammatory bowel diseases.
Spondyloarthritis (SpA) is among the most frequent extra-intestinal manifestations in inflammatory bowel diseases (IBD). In this study, we aimed to validate the DETection of Arthritis in Inflammatory bowel diseases (DETAIL) […]» Read more
Previous work has established that the deacetylase sirtuin-1 (SIRT1) is cleaved by cathepsin B in chondrocytes subjected to proinflammatory stress, yielding a stable but inactive N-terminal (NT) polypeptide (75SIRT1) and […]» Read more
Effect of laser moxibustion for knee osteoarthritis: a multi-site double-blind randomized controlled trial.
To examine the effects of laser moxibustion on pain and function in patients with knee osteoarthritis.A double-blind randomized clinical trial (4-week treatment, 20-week follow-up) was conducted. A total of 392 […]» Read more
To examine trends in the initial prescription of commonly-prescribed analgesics and patient- as well as practice-level factors related to their selection in incident OA.Patients consulting with incident clinical OA between […]» Read more
Statin use and risk of joint replacement due to osteoarthritis and rheumatoid arthritis: a propensity-score matched longitudinal cohort study.
Click here to read the full article @ Rheumatology (Oxford, England)» Read more
A Decline in Walking Speed is Associated with Incident Knee Replacement in Adults with and at Risk for Knee Osteoarthritis.
To determine if a one-year change in walking speed is associated with receiving an incident knee replacement during the following year in adults with and at risk for knee osteoarthritis […]» Read more
The inverse OARSI-OMERACT criteria is a valid indicator of the clinical worsening of knee osteoarthritis: data from the Osteoarthritis Initiative.
We assessed if the inverse OARSI-OMERACT criteria relate to concurrent radiographic knee osteoarthritis (KOA) progression and decline in walking speed as well as future knee replacement.We conducted knee-based analyses of […]» Read more
To what extent is severe osteoarthritis preventable? Occupational and non-occupational risk factors for knee and hip osteoarthritis.
To explore the relative contribution of cumulative physical workload, sociodemographic and lifestyle factors, as well as prior injury to hospitalization due to knee and hip OA.We examined a nationally representative […]» Read more
An international, multicentre, double-blind, randomized study (DISSCO): effect of diacerein vs celecoxib on symptoms in knee osteoarthritis.
The objective of this study was to investigate whether diacerein has comparable efficacy with celecoxib in pain reduction for treatment in symptomatic knee OA patients.This randomized double-blind multicentre non-inferiority trial […]» Read more
Patients with osteoarthritis and ankylosing spondylitis have lower cancer-related mortality than the general population. We examined risks of solid cancers at 16 sites in elderly patients with knee or hip […]» Read more
Incidence trend of five common musculoskeletal disorders from 1990 to 2017 at the global, regional and national level: results from the global burden of disease study 2017.
To assess cause-specific incidence and its trend of musculoskeletal (MSK) disorders at global, regional and national levels.Data on MSK disorders were downloaded from the Global Burden of Disease 2017 study […]» Read more
Are OMERACT knee osteoarthritis ultrasound scores associated with pain severity, other symptoms, radiographic and MRI findings?
To investigate the associations of Outcome Measures in Rheumatology (OMERACT) ultrasound scores for knee osteoarthritis (OA) with pain severity, other symptoms, and OA severity on radiographs and magnetic resonance imaging […]» Read more
TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.
FBXO6, a component of the ubiquitin E3 ligases, has been shown to bind high mannose N-linked glycoproteins and act as ubiquitin ligase subunits. Most proteins in the secretory pathway, such […]» Read more
Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017.
To report the level and trends of prevalence, incidence and years lived with disability (YLDs) for osteoarthritis (OA) in 195 countries and territories from 1990 to 2017 by age, sex […]» Read more
Effect of Biomechanical Footwear on Knee Pain in People With Knee Osteoarthritis: The BIOTOK Randomized Clinical Trial.
Individually calibrated biomechanical footwear therapy may improve pain and physical function in people with symptomatic knee osteoarthritis, but the benefits of this therapy are unclear.To assess the effect of a […]» Read more
Although treatment development in osteoarthritis (OA) focuses on chondroprotection, it is unclear how much preventing cartilage loss reduces joint pain. It is also unclear how nociceptive tissues may be involved.Using […]» Read more
BCP crystals promote chondrocyte hypertrophic differentiation in OA cartilage by sequestering Wnt3a.
Calcification of cartilage with basic calcium phosphate (BCP) crystals is a common phenomenon during osteoarthritis (OA). It is directly linked to the severity of the disease and known to be […]» Read more
Trajectory analysis combining pain and physical function in individuals with knee and hip osteoarthritis: results from the French KHOALA cohort.
The aims of this study were to identify homogeneous subgroups of knee and/or hip OA patients with distinct trajectories of the combination of pain and physical function (PF) over time […]» Read more
Expression of granulocyte macrophage-colony stimulating factor and its receptor in the synovium of osteoarthritis patients is negatively correlated with pain.
The crosstalk between the immune and nervous system in the regulation of OA pain is increasingly becoming evident. GM-CSF signals in both systems and might be a new treatment target […]» Read more
To identify plasma markers associated with an increased risk of radiographic knee osteoarthritis (OA) progression using a metabolomics approach.Study participants were from the Multicenter Osteoarthritis Study (MOST) and were categorized […]» Read more
Association between disease progression and depression onset in persons with radiographic knee osteoarthritis.
Osteoarthritis (OA) disease progression may lead to deteriorating psychosocial function, but it is unclear what aspects of disease severity are related to the onset of depression. This study assessed which […]» Read more
Effect of Intravenous Zoledronic Acid on Tibiofemoral Cartilage Volume Among Patients With Knee Osteoarthritis With Bone Marrow Lesions: A Randomized Clinical Trial.
A proof-of-principle study suggested that intravenous zoledronic acid may reduce knee pain and the size of bone marrow lesions in people with knee osteoarthritis, but data from large trials are […]» Read more
The contribution of age and obesity to the number of painful joint sites in individuals reporting osteoarthritis: a population-based study.
To investigate the association of OA risk factors with number of painful joint sites in a representative population sample.Analysis of the 2009 Survey on Living with Chronic Diseases in Canada […]» Read more
Predicting response to topical non-steroidal anti-inflammatory drugs in osteoarthritis: an individual patient data meta-analysis of randomized controlled trials.
To identify predictors of the specific (difference between treatment and placebo) and overall (change from baseline in treatment arm) treatment effects of topical NSAIDs in OA.Randomized controlled trials (RCTs) of […]» Read more
Horizontal fissuring at the osteochondral interface: a novel and unique pathological feature in patients with obesity-related osteoarthritis.
Obesity is a well-recognised risk factor for osteoarthritis (OA). Our aim is to characterise body mass index (BMI)-associated pathological changes in the osteochondral unit and determine if obesity is the […]» Read more