Predicting response to topical non-steroidal anti-inflammatory drugs in osteoarthritis: an individual patient data meta-analysis of randomized controlled trials.

Bookmark(0)

No account yet? Register

To identify predictors of the specific (difference between treatment and placebo) and overall (change from baseline in treatment arm) treatment effects of topical NSAIDs in OA.Randomized controlled trials (RCTs) of […]

» Read more

Horizontal fissuring at the osteochondral interface: a novel and unique pathological feature in patients with obesity-related osteoarthritis.

Bookmark(0)

No account yet? Register

Obesity is a well-recognised risk factor for osteoarthritis (OA). Our aim is to characterise body mass index (BMI)-associated pathological changes in the osteochondral unit and determine if obesity is the […]

» Read more

Physical Therapy versus Glucocorticoid Injection for Osteoarthritis of the Knee.

Bookmark(0)

No account yet? Register

Both physical therapy and intraarticular injections of glucocorticoids have been shown to confer clinical benefit with respect to osteoarthritis of the knee. Whether the short-term and long-term effectiveness for relieving […]

» Read more

Subcutaneous tanezumab for osteoarthritis of the hip or knee: efficacy and safety results from a 24-week randomised phase III study with a 24-week follow-up period.

Bookmark(0)

No account yet? Register

Tanezumab, a nerve growth factor inhibitor, was investigated for osteoarthritis (OA) of the hip or knee in a study with 24-week treatment and 24-week safety follow-up.This double-blind, randomised, phase III […]

» Read more

Faecal microbiota transplantation from metabolically compromised human donors accelerates osteoarthritis in mice.

Bookmark(0)

No account yet? Register

Emerging evidence suggests that the microbiome plays an important role in the pathogenesis of osteoarthritis (OA). We aimed to test the two-hit model of OA pathogenesis and potentiation in which […]

» Read more

The Association of an Increasing Waist Circumference and Risk of Incident Low Physical Function in Adults with Knee Osteoarthritis.

Bookmark(0)

No account yet? Register

To investigate an eight-year change in waist circumference (WC) with the risk of incident low physical function over one-year in adults with or at risk of knee osteoarthritis (OA).Data from […]

» Read more

Five-year evolution patterns of physical activity and sedentary behavior in patients with lower-limb osteoarthritis and their sociodemographic and clinical correlates.

Bookmark(0)

No account yet? Register

The present study aimed to identify trajectories of physical activity (PA) components (frequency, duration, intensity, type) and screen-based sedentary behavior (SB) as well as baseline predictors of each trajectory in […]

» Read more

Metformin limits osteoarthritis development and progression through activation of AMPK signalling.

Bookmark(0)

No account yet? Register

In this study, we aim to determine the effect of metformin on osteoarthritis (OA) development and progression.Destabilisation of the medial meniscus (DMM) surgery was performed in 10-week-old wild type and […]

» Read more

Psychological and pain sensitisation characteristics are associated with patellofemoral osteoarthritis symptoms: The Multicenter Osteoarthritis Study.

Bookmark(0)

No account yet? Register

Determine the relation of symptomatic and structural features of patellofemoral osteoarthritis (PFOA) to psychological characteristics and measures of pain sensitisation, in older adults with or at risk of knee OA.1112 […]

» Read more

Opioid prescriptions in patients with osteoarthritis: a population-based cohort study.

Bookmark(0)

No account yet? Register

To examine the incidence, prevalence and trends for opioid prescriptions in patients with OA. Furthermore, types of opioids prescribed and long-term prescription rates were examined. Finally, the patient characteristics associated […]

» Read more

Statistical shape modelling provides a responsive measure of morphological change in knee osteoarthritis over 12 months.

Bookmark(0)

No account yet? Register

Responsive biomarkers are needed to assess the progression of OA and their lack has hampered previous clinical trials. Statistical shape modelling (SSM) from radiographic images identifies those at greatest risk […]

» Read more

Interleukin 1 receptor antagonist (IL1RN) gene variants predict radiographic severity of knee osteoarthritis and risk of incident disease.

Bookmark(0)

No account yet? Register

In these studies, we examined the association of single nucleotide polymorphisms (SNPs) of the IL1RN gene with radiographic severity of symptomatic knee osteoarthritis (SKOA) and the risk of incident OA. […]

» Read more

Health-related quality of life in patients with hand osteoarthritis from the general population and the outpatient clinic.

Bookmark(0)

No account yet? Register

To investigate the association of hand osteoarthritis and concurrent hand and knee osteoarthritis with health-related quality of life (HRQoL) in the general population, and in patients consulting a rheumatology outpatient […]

» Read more

Use of recommended non-surgical knee osteoarthritis management in patients prior to totalv knee arthroplasty: a cross-sectional study.

Bookmark(0)

No account yet? Register

Our aim was to assess prior use of core recommended non-surgical treatment among patients with knee osteoarthritis (OA) scheduled for total knee arthroplasty (TKA); and, to assess potential patient-level correlates […]

» Read more

Sleep quality is related to worsening knee pain in those with widespread pain: The Multicenter Osteoarthritis Study.

Bookmark(0)

No account yet? Register

We examined the association between sleep and odds of developing knee pain, and whether this relationship varied by status of widespread pain (WSP).At the 60-month visit of the Multicenter Osteoarthritis […]

» Read more

Effect of Intra-Articular Sprifermin vs Placebo on Femorotibial Joint Cartilage Thickness in Patients With Osteoarthritis: The FORWARD Randomized Clinical Trial.

Bookmark(0)

No account yet? Register

Abstract: Sprifermin is under investigation as a disease-modifying osteoarthritis drug.To evaluate the effects of sprifermin on changes in total femorotibial joint cartilage thickness in the more symptomatic knee of patients […]

» Read more

The bulge sign – a simple physical examination for identifying progressive knee osteoarthritis: data from the Osteoarthritis Initiative.

Bookmark(0)

No account yet? Register

Abstract: To examine whether the presence of bulge sign or patellar tap was associated with frequent knee pain, progression of radiographic OA (ROA) and total knee replacement (TKR).This study included […]

» Read more

Self-reported painful joint count and assessor-reported tender joint count as instruments to assess pain in hand osteoarthritis.

Bookmark(0)

No account yet? Register

Abstract: To evaluate self-reported and assessor-reported joint counts for pain and their value in measuring pain and joint activity in hand OA patients.A total of 524 patients marked painful joints […]

» Read more

Knee osteoarthritis risk in non-industrial societies undergoing an energy balance transition: evidence from the indigenous Tarahumara of Mexico.

Bookmark(0)

No account yet? Register

Abstract: Here, we propose that knee osteoarthritis is one such disease for which susceptibility is amplified by this energy balance transition.Support for our hypothesis comes from comparisons of knee radiographs, […]

» Read more

Discovery of an autoantibody signature for the early diagnosis of knee osteoarthritis: data from the Osteoarthritis Initiative.

Bookmark(0)

No account yet? Register

Abstract: To find autoantibodies (AAbs) in serum that could be useful to predict incidence of radiographic knee osteoarthritis (KOA).A Nucleic-acid Programmable Protein Arrays (NAPPA) platform was used to screen AAbs […]

» Read more

Top down or bottom up? An observational investigation of improvement in fibromyalgia symptoms following hip and knee replacement.

Bookmark(0)

No account yet? Register

Abstract: Many patients with osteoarthritis have comorbid symptoms of FM, but it is unknown how these symptoms respond to surgical procedures that address nociceptive input in the periphery, such as […]

» Read more

Human osteoarthritic synovial fluid increases excitability of mouse dorsal root ganglion sensory neurons: an in-vitro translational model to study arthritic pain.

Bookmark(0)

No account yet? Register

Abstract: Knee OA is a leading global cause of morbidity. This study investigates the effects of knee SF from patients with OA on the activity of dorsal root ganglion sensory […]

» Read more

Comorbid conditions and emergency department treat and release utilization in multimorbid persons with cognitive impairment.

Bookmark(0)

No account yet? Register

There is an increasing focus in the emergency department (ED) on addressing the needs of persons with cognitive impairment, most of whom have multiple chronic conditions. We investigated which common comorbidities among multimorbid persons with cognitive impairment conferred increased risk for ED treat and release utilization.We examined the association of 16 chronic conditions on use of ED treat and release visit utilization among 1006 adults with cognitive impairment and???2 comorbidities using the nationally-representative National Health and Aging Trends Study merged with Fee-For-Service Medicare claims data, 2011-2015.At baseline, 28.5% had ?6 conditions and 35.4% were???85?years old. After controlling for sex, age, race, education, urban-living, number of disabled activities of daily living, and sampling strata, we found significantly increased adjusted risk ratios (aRR) of ED treat and release visits for persons with depression (aRR 1.38 95% CI 1.15-1.65) representing 78/100 person-years, and osteoarthritis or rheumatoid arthritis (aRR 1.32 95% CI 1.12-1.57) representing 71/100 person-years. At baseline 93.9% had ?1 informal caregiver and 69.7% had a caregiver that helped with medications or attended physician visits.These results show that multimorbid cognitively impaired older adults with depression or osteoarthritis or rheumatoid arthritis are at higher risk of ED treat and release visits. Future ED research with multimorbid cognitively impaired persons may explore behavioral aspects of depression and/or pain and flairs associated with osteoarthritis or rheumatoid arthritis, as well as the role of informal caregivers in the care of these conditions.

» Read more

Effect of Tanezumab on Joint Pain, Physical Function, and Patient Global Assessment of Osteoarthritis Among Patients With Osteoarthritis of the Hip or Knee: A Randomized Clinical Trial.

Bookmark(0)

No account yet? Register

Abstract: Patients with osteoarthritis (OA) may remain symptomatic with traditional OA treatments.To assess 2 subcutaneous tanezumab dosing regimens for OA.A randomized, double-blind, multicenter trial from January 2016 to May 14, […]

» Read more
1 2