The association between psychological factors and pain exacerbations in hip osteoarthritis.

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To evaluate the association between psychological factors and pain exacerbations in people with hip OA.Eligible participants with symptomatic hip OA were instructed to complete online questionnaires every 10 days over a […]

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TRIM24-RIP3 axis perturbation accelerates osteoarthritis pathogenesis.

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Recently, necroptosis has attracted increasing attention in arthritis research; however, it remains unclear whether its regulation is involved in osteoarthritis (OA) pathogenesis. Since receptor-interacting protein kinase-3 (RIP3) plays a pivotal […]

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Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration.

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To identify OA subtypes based on cartilage transcriptomic data in cartilage tissue and characterize their underlying pathophysiological processes and/or clinically relevant characteristics.This study includes n = 66 primary OA patients (41 knees […]

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Multicenter validation of the DETAIL questionnaire for the screening of spondyloarthritis in patients with inflammatory bowel diseases.

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Spondyloarthritis (SpA) is among the most frequent extra-intestinal manifestations in inflammatory bowel diseases (IBD). In this study, we aimed to validate the DETection of Arthritis in Inflammatory bowel diseases (DETAIL) […]

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Effect of laser moxibustion for knee osteoarthritis: a multi-site double-blind randomized controlled trial.

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To examine the effects of laser moxibustion on pain and function in patients with knee osteoarthritis.A double-blind randomized clinical trial (4-week treatment, 20-week follow-up) was conducted. A total of 392 […]

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The inverse OARSI-OMERACT criteria is a valid indicator of the clinical worsening of knee osteoarthritis: data from the Osteoarthritis Initiative.

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We assessed if the inverse OARSI-OMERACT criteria relate to concurrent radiographic knee osteoarthritis (KOA) progression and decline in walking speed as well as future knee replacement.We conducted knee-based analyses of […]

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To what extent is severe osteoarthritis preventable? Occupational and non-occupational risk factors for knee and hip osteoarthritis.

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To explore the relative contribution of cumulative physical workload, sociodemographic and lifestyle factors, as well as prior injury to hospitalization due to knee and hip OA.We examined a nationally representative […]

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An international, multicentre, double-blind, randomized study (DISSCO): effect of diacerein vs celecoxib on symptoms in knee osteoarthritis.

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The objective of this study was to investigate whether diacerein has comparable efficacy with celecoxib in pain reduction for treatment in symptomatic knee OA patients.This randomized double-blind multicentre non-inferiority trial […]

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Risks of solid cancers in elderly persons with osteoarthritis or ankylosing spondylitis.

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Patients with osteoarthritis and ankylosing spondylitis have lower cancer-related mortality than the general population. We examined risks of solid cancers at 16 sites in elderly patients with knee or hip […]

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Incidence trend of five common musculoskeletal disorders from 1990 to 2017 at the global, regional and national level: results from the global burden of disease study 2017.

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To assess cause-specific incidence and its trend of musculoskeletal (MSK) disorders at global, regional and national levels.Data on MSK disorders were downloaded from the Global Burden of Disease 2017 study […]

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Are OMERACT knee osteoarthritis ultrasound scores associated with pain severity, other symptoms, radiographic and MRI findings?

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To investigate the associations of Outcome Measures in Rheumatology (OMERACT) ultrasound scores for knee osteoarthritis (OA) with pain severity, other symptoms, and OA severity on radiographs and magnetic resonance imaging […]

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Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017.

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To report the level and trends of prevalence, incidence and years lived with disability (YLDs) for osteoarthritis (OA) in 195 countries and territories from 1990 to 2017 by age, sex […]

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Trajectory analysis combining pain and physical function in individuals with knee and hip osteoarthritis: results from the French KHOALA cohort.

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The aims of this study were to identify homogeneous subgroups of knee and/or hip OA patients with distinct trajectories of the combination of pain and physical function (PF) over time […]

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Expression of granulocyte macrophage-colony stimulating factor and its receptor in the synovium of osteoarthritis patients is negatively correlated with pain.

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The crosstalk between the immune and nervous system in the regulation of OA pain is increasingly becoming evident. GM-CSF signals in both systems and might be a new treatment target […]

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Phenylalanine is a novel marker for radiographic knee osteoarthritis progression: the MOST study.

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To identify plasma markers associated with an increased risk of radiographic knee osteoarthritis (OA) progression using a metabolomics approach.Study participants were from the Multicenter Osteoarthritis Study (MOST) and were categorized […]

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Association between disease progression and depression onset in persons with radiographic knee osteoarthritis.

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Osteoarthritis (OA) disease progression may lead to deteriorating psychosocial function, but it is unclear what aspects of disease severity are related to the onset of depression. This study assessed which […]

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Effect of Intravenous Zoledronic Acid on Tibiofemoral Cartilage Volume Among Patients With Knee Osteoarthritis With Bone Marrow Lesions: A Randomized Clinical Trial.

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A proof-of-principle study suggested that intravenous zoledronic acid may reduce knee pain and the size of bone marrow lesions in people with knee osteoarthritis, but data from large trials are […]

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The contribution of age and obesity to the number of painful joint sites in individuals reporting osteoarthritis: a population-based study.

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To investigate the association of OA risk factors with number of painful joint sites in a representative population sample.Analysis of the 2009 Survey on Living with Chronic Diseases in Canada […]

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Predicting response to topical non-steroidal anti-inflammatory drugs in osteoarthritis: an individual patient data meta-analysis of randomized controlled trials.

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To identify predictors of the specific (difference between treatment and placebo) and overall (change from baseline in treatment arm) treatment effects of topical NSAIDs in OA.Randomized controlled trials (RCTs) of […]

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Horizontal fissuring at the osteochondral interface: a novel and unique pathological feature in patients with obesity-related osteoarthritis.

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Obesity is a well-recognised risk factor for osteoarthritis (OA). Our aim is to characterise body mass index (BMI)-associated pathological changes in the osteochondral unit and determine if obesity is the […]

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