Cut-off value to identify a flare using the Flare Assessment in Rheumatoid Arthritis (FLARE-RA) questionnaire: analysis of the TOSCA study.

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The Flare Assessment in Rheumatoid Arthritis (FLARE-RA) self-administered questionnaire aims to identify patients who had flare in the interval between 2 consultations. This study aimed to establish a threshold for […]

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ABATACEPT IN MONOTHERAPY VERSUS COMBINED IN INTERSTITIAL LUNG DISEASE OF RHEUMATOID ARTHRITIS. MULTICENTER STUDY OF 263 CAUCASIAN PATIENTS.

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To assess the efficacy and safety of abatacept (ABA) in monotherapy (ABAMONO) versus combined-ABA, ABA plus methotrexate (ABAMTX) or ABA plus non-MTX conventional-DMARDs (ABANON-MTX), in Rheumatoid Arthritis (RA) patients with […]

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MTX optimization or adding bDMARD equally improve disease activity in rheumatoid arthritis: results from the prospective study STRATEGE.

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The STRATEGE study aimed to describe treatment strategies in current practice in RA bDMARD-naive patients with an inadequate response to MTX therapy, and to compare clinical efficacy of the different […]

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Long-term persistence of rituximab in patients with rheumatoid arthritis: an evaluation of the UCL cohort from 1998 to 2020.

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B cell depletion therapy based on rituximab in patients with rheumatoid arthritis (RA) was pioneered at UCLH/UCL in 1998. The objective of this study was to evaluate long-term persistence of […]

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Using Bayesian Networks to identify musculoskeletal symptoms influencing the risk of developing Psoriatic Arthritis in people with psoriasis.

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To explore Bayesian networks (BNs) in understanding the relationships between musculoskeletal symptoms and the development of PsA in people with psoriasis.Incident cases of psoriasis were identified between 1998 and 2015 […]

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Circulating blood metabolite trajectories and risk of rheumatoid arthritis among military personnel in the Department of Defense Biorepository.

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We sought to identify metabolic changes potentially related to rheumatoid arthritis (RA) pathogenesis occurring in the blood prior to its diagnosis.In a US military biorepository, serum samples collected at two […]

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Are neutrophil extracellular traps the link for the cross-talk between periodontitis and rheumatoid arthritis physiopathology?

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Neutrophil extracellular traps (NETs) play a role in the pathogenesis of periodontitis and rheumatoid arthritis (RA). However, it remains poorly understood whether NETs participate in the cross-talk between periodontitis and […]

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Doppler ultrasound predicts successful discontinuation of biological DMARDs in rheumatoid arthritis patients in clinical remission.

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To assess the ability of ultrasound to predict successful tapering and successful discontinuation of biological disease-modifying anti-rheumatic drugs (bDMARDs) at 2-year follow-up in rheumatoid arthritis (RA) patients in sustained remission.Patients […]

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Risk of venous thromboembolism associated with tofacitinib in patients with rheumatoid arthritis: a population-based cohort study.

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To evaluate the risk of venous thromboembolism (VTE) with tofacitinib compared to tumor necrosis factor inhibitors (TNFIs) in patients with rheumatoid arthritis (RA).RA patients initiating tofacitinib or a TNFI without […]

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What influences patients’ opinion of remission and low disease activity in psoriatic arthritis? Principal component analysis of an international study of 424 patients.

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In psoriatic arthritis (PsA), the treatment objective is remission (REM) or low disease activity (LDA), but patients’ perception of REM is poorly studied. This analysis aimed to identify factors associated […]

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JAK selectivity and the implications for clinical inhibition of pharmacodynamic cytokine signalling by filgotinib, upadacitinib, tofacitinib and baricitinib.

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Janus kinase inhibitors (JAKinibs) are efficacious in rheumatoid arthritis (RA) with variable reported rates of adverse events, potentially related to differential JAK family member selectivity. Filgotinib was compared with baricitinib, […]

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Rituximab plus leflunomide in rheumatoid arthritis: a randomized, placebo-controlled, investigator-initiated clinical trial (AMARA study).

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To investigate the efficacy and safety of rituximab + LEF in patients with RA.In this investigator-initiated, randomized, double-blind, placebo-controlled phase 3 trial, patients with an inadequate response to LEF who […]

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Ultrasound, magnetic resonance imaging and radiography of the finger joints in psoriatic arthritis patients.

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To report the discrepancies and agreements between ultrasound (US), magnetic resonance imaging (MRI) and radiography of the hand in psoriatic arthritis (PsA), and to compare the sensitivity and specificity of […]

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Retention rate and effectiveness of secukinumab vs TNF inhibitor in ankylosing spondylitis patients with prior TNF inhibitor exposure.

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The choice of second-line biologics for ankylosing spondylitis (AS) patients previously treated with a tumour necrosis factor inhibitor (TNFi) remains unclear. Here, we compared drug retention and clinical efficacy between […]

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Secukinumab Efficacy on Enthesitis in Patients with Ankylosing Spondylitis: Pooled Analysis of Four Pivotal Phase 3 Studies.

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To assess the efficacy of secukinumab on axial and peripheral enthesitis in patients with ankylosing spondylitis (AS) using pooled data from randomized controlled phase 3 studies.In this post-hoc analysis, data […]

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COMPARING COST-UTILITY OF DMARDs IN AUTOANTIBODY-NEGATIVE RHEUMATOID ARTHRITIS PATIENTS.

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To evaluate the 1-year cost-effectiveness between three different initial treatment strategies in autoantibody-negative rheumatoid arthritis(RA-) patients, according to 2010 criteria.For this analysis we selected all RA- patients within the intermediate […]

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Meaningful change thresholds for Patient-Reported Outcomes Measurement Information System (PROMIS) fatigue and pain interference scores in patients with rheumatoid arthritis.

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We estimated meaningful change thresholds (MCTs) for Patient-Reported Outcomes Measurement Information System (PROMIS®) Fatigue and Pain Interference in rheumatoid arthritis (RA).The responsiveness of several patient-reported outcomes (PROs) was assessed among […]

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Psoriasis and Psoriatic Arthritis in the Context of the COVID-19 Pandemic: A Plenary Session From the GRAPPA 2020 Annual Meeting.

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The coronavirus disease 2019 (COVID-19; caused by SARS-CoV-2) pandemic has affected the healthcare system on a global scale, and we utilized the Group for Research and Assessment of Psoriasis and […]

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Summarising current Refractory Disease definitions in Rheumatoid Arthritis and Polyarticular Juvenile Idiopathic Arthritis: Systematic review.

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To identify how refractory disease (or relevant terminology variations) in Rheumatoid Arthritis (RA) and Polyarticular Juvenile Idiopathic Arthritis (PolyJIA) is defined and establish the key components of such definitions.Searches were […]

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The burden of psoriatic arthritis in the biological era: data from the Belgian Epidemiological Psoriatic Arthritis Study (BEPAS).

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To characterize the frequency of PsA subtypes, as well as to estimate the severity based on damage and inflammation, and to estimate the impact of PsA on patients’ health-related quality […]

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The influence of the SARS-CoV-2 lockdown on patients with inflammatory rheumatic diseases on their adherence to immunomodulatory medication – a cross sectional study over 3 months in Germany.

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To evaluate the influence of the SARS-CoV-2 pandemic on the adherence of patients with inflammatory rheumatic diseases (IRD) to their immunomodulatory medication during the three-months lockdown in Germany.From March 16th […]

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TNF is a homoeostatic regulator of distinct epigenetically primed human osteoclast precursors.

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Circulating myeloid precursors are responsible for post-natal osteoclast (OC) differentiation and skeletal health, although the exact human precursors have not been defined. Enhanced osteoclastogenesis contributes to joint destruction in rheumatoid […]

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Characteristics of patients with difficult-to-treat rheumatoid arthritis in real-world.

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To investigate the clinical characteristics of patients with difficult-to-treat rheumatoid arthritis (D2T RA) and the usefulness of switching drugs with different mode of action in the real world.We reviewed all […]

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