Advanced chronic kidney disease (CKD) carries an increased risk for progression to end-stage renal disease (ESRD). We aimed to determine the rate of progression and the factors that drive the […]» Read more
Tobacco smoking is a major threat to health. There is no doubt about the need to promote and support cessation at every opportunity. Smoking has a clear role in RA, […]» Read more
Burnout among physicians is common and has important implications. We assessed the extent of burnout among rheumatology practitioners and its associations.128 attendees at the 2019 Rheumatology Winter Clinical Symposium were […]» Read more
Well-designed randomized controlled trials (RCTs) mitigate bias and confounding, but prior evaluations of rheumatology trials found high rates of methodological flaws. Outside of rheumatoid arthritis, no studies in the modern […]» Read more
Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients.
Genome-wide meta-analyses of clinically defined gout were performed to identify subtype-specific susceptibility loci. Evaluation using selection pressure analysis with these loci was also conducted to investigate genetic risks characteristic of […]» Read more
Improving Hydroxychloroquine Dosing and Toxicity Screening at a Tertiary Care Ambulatory Centre: A Quality Improvement Initiative.
Hydroxychloroquine (HCQ) is a commonly used weight-based medication with a risk of retinal toxicity when prescribed at doses above 5 mg/kg/day. The objectives of our study were: (1) To characterize […]» Read more
Subcutaneous tanezumab for osteoarthritis of the hip or knee: efficacy and safety results from a 24-week randomised phase III study with a 24-week follow-up period.
Tanezumab, a nerve growth factor inhibitor, was investigated for osteoarthritis (OA) of the hip or knee in a study with 24-week treatment and 24-week safety follow-up.This double-blind, randomised, phase III […]» Read more
The renal resistive index, a new biomarker for the follow up of vascular modifications in Systemic Sclerosis.
The aim of the present retrospective observational study was to evaluate in SSc patients the change of renal resistive index (RRI) over the time (ΔRRI) and under treatment as well […]» Read more
Long-term safety and effectiveness of tacrolimus in lupus nephritis patients: 5- year interim post-marketing surveillance study in Japan (TRUST).
To assess the long-term safety and effectiveness of tacrolimus for treating lupus nephritis (LN) in the real-world clinical setting.This is an ongoing, open-label, non-comparative, observational, post-marketing surveillance study conducted across […]» Read more
Utility of the Brief Illness Perception Questionnaire to Monitor Patient Beliefs in Systemic Vasculitis.
To assess the validity and clinical utility of the Brief Illness Perception Questionnaire (BIPQ) to measure illness perceptions in multiple forms of vasculitis.Patients with giant cell arteritis (GCA), Takayasu’s arteritis […]» Read more
To compare colour duplex ultrasonography (CDU) findings with axillary 18F-fluorodeoxyglucose (FDG) PET/CT findings and to compare the diagnostic performance of temporal and axillary artery CDU with temporal artery CDU alone.Patients […]» Read more
To determine the feasibility of comparing the Childhood Arthritis and Rheumatology Research Alliance (CARRA) consensus treatment plans (CTPs) in treating new-onset, moderate juvenile dermatomyositis (JDM) using the CARRA registry, and […]» Read more
Impact of disease activity on organ damage progression in systemic lupus erythematosus: University of Toronto Lupus Clinic Cohort.
To examine the role of disease activity on organ damage over 5 years in patients with active systemic lupus erythematosus (SLE) despite standard of care.This analysis of the University of […]» Read more
Diagnostic value of optical spectral transmission in rheumatoid arthritis: associations with clinical characteristics and comparison with joint ultrasonography.
To examine the value of optical spectral transmission (OST) in detecting joint inflammation in patients with rheumatoid arthritis (RA) and to evaluate whether OST correlates with certain patient characteristics.OST measurements […]» Read more
Negative associations for fasting blood glucose, cholesterol and triglyceride levels with the development of giant cell arteritis.
To investigate metabolic features that may predispose to GCA in a nested case-control study.Individuals who developed GCA after inclusion in a population-based health survey (the Malmö Preventive Medicine Project; N = 33 346) […]» Read more
Click here to read the full article @ The Journal of rheumatology» Read more
The utility of magnetic resonance imaging lesion combinations in the sacroiliac joints for diagnosing patients with axial spondyloarthritis. A prospective study of 204 participants including post-partum women, patients with disc herniation, cleaning staff, runners and healthy persons.
To investigate the diagnostic utility of different combinations of SI joint MRI lesions for differentiating patients with axial SpA (axSpA) from other conditions with and without buttock/pelvic pain.A prospective cross-sectional […]» Read more
Clinical characteristics of pediatric patients with acne fulminans associated to chronic non-bacterial osteomyelitis.
Acne fulminans (AF) is a rare, explosive systemic form of acne. Chronic non-bacterial osteomyelitis (CNO) or chronic recurrent multifocal osteomyelitis (CRMO) is a primarily pediatric autoinflammatory disorder characterized by sterile […]» Read more
Tumour Necrosis Factor Inhibitor monotherapy versus combination therapy for the treatment of psoriatic arthritis: combined analysis of European biologics databases.
To investigate whether tumour necrosis factor inhibitor (TNFi) combination therapy with conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) is more effective for psoriatic arthritis (PsA) and/or improves TNFi drug survival compared […]» Read more
To investigate peripheral lymphopenia, a frequent finding in primary Sjögren’s syndrome (pSS) associated with higher disease activity and increased mortality.Prospective, cross-sectional study of consecutive patients with pSS (n = 66) and healthy […]» Read more
Prognostic factors of pulmonary hypertension associated with connective tissue disease: pulmonary artery size measured by chest CT.
Pulmonary artery enlargement is a common manifestation of chest CT in patients with pulmonary arterial hypertension (PAH). The exact clinical significance of this phenomenon has not been clarified in connective […]» Read more
Association between depression and anxiety with skin and musculoskeletal clinical phenotypes in systemic lupus erythematosus.
To study the clinical phenotypes, determined based on cumulative disease activity manifestations, and sociodemographic factors associated with depression and anxiety in SLE.Patients attending a single centre were assessed for depression […]» Read more
2019 Update of the Joint European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of lupus nephritis.
To update the 2012 EULAR/ERA-EDTA recommendations for the management of lupus nephritis (LN).Following the EULAR standardised operating procedures, a systematic literature review was performed. Members of a multidisciplinary Task Force […]» Read more
Click here to read the full article @ Rheumatology (Oxford, England)» Read more
Response to: ‘Immune-mediated necrotizing myopathies and interstitial lung disease are predominant characteristics in anti-Ku positive patients with idiopathic inflammatory myopathies’ by Yang et al.
Click here to read the full article @ Annals of the rheumatic diseases» Read more
Response to: ‘Can sexual dimorphism in rheumatoid arthritis be attributed to the different abundance of Gardnerella?’ by Liu et al.
Click here to read the full article @ Annals of the rheumatic diseases» Read more
Hyperspectral imaging (HSI) is a novel technology for obtaining quantitative measurements from transcutaneous spatial and spectral information. In patients with SSc, the severity of skin tightness is associated with internal […]» Read more
Takayasu’s arteritis (TAK) is a large vessel vasculitis with important infiltration of proinflammatory T cells in the aorta and its main branches, but its aetiology is still unknown. Our work […]» Read more
To assess Doppler ultrasound (US) and tenosynovial fluid (TSF) characteristics in tenosynovitis within common rheumatic conditions, as well as their diagnostic utility.Subjects with tenosynovitis underwent Doppler US and US-guided TSF […]» Read more
Immunosuppression and the risk of readmission and mortality in patients with rheumatoid arthritis undergoing hip fracture, abdominopelvic and cardiac surgery.
The impact of immunosuppression on postoperative outcomes has primarily been studied in patients undergoing joint replacement surgery. We aimed to evaluate the impact of biologics and glucocorticoids on outcomes after […]» Read more