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SLE is a severe autoimmune disease characterized by autoreactive B cells and IC formation, which causes systemic inflammation. B cell-targeted therapy could be a promising treatment strategy in SLE patients; nevertheless, […]
» Read moreTo investigate the long-term efficacy and safety of the IL-6 receptor antibody tocilizumab in patients with Takayasu arteritis (TAK).Patients completing the randomized, double-blind, placebo-controlled period of the TAKT (Takayasu arteritis […]
» Read moreBidirectional relationships between some autoimmune diseases and non- Hodgkin’s lymphoma (NHL) may exist. We conducted this nationwide populationbased study in Taiwan to investigate whether there is a bidirectional relationship between […]
» Read moreComorbidity burden and obesity may affect treatment response in patients with rheumatoid arthritis (RA). Few real-world studies have evaluated the impact of comorbidity burden or obesity on the effectiveness of […]
» Read moreMental health problems are prevalent in youth with rheumatologic disease. Gaps in knowledge exist regarding their impact, as well as strategies for detection and effective treatment. To address these gaps, […]
» Read moreResponsive biomarkers are needed to assess the progression of OA and their lack has hampered previous clinical trials. Statistical shape modelling (SSM) from radiographic images identifies those at greatest risk […]
» Read moreSSc is an autoimmune disease characterized by microvascular damage, endothelial dysfunction and fibrosis of the skin and the internal organs. Cardiac manifestation in patients with SSc is one of the […]
» Read moreTargeting the IL-17-axis is efficacious in psoriasis (PsO) and spondyloarthritis (SpA) but not in rheumatoid arthritis (RA). We investigated potential differences in tissue expression and function of IL-17A and IL-17F […]
» Read moreTo investigate fetal/perinatal and maternal outcomes from a large multicentre cohort of women diagnosed with UCTD.This multicentre retrospective cohort study describes the outcomes of 224 pregnancies in 133 consecutive women […]
» Read moreTo evaluate selection methods among published single-nucleotide polymorphisms (SNPs) associated with RA to construct predictive genetic risk scores (GRSs) in a population-based setting.The Nord-Trøndelag Health (HUNT) Study is a prospective […]
» Read moreRapidly progressive interstitial lung disease (RPILD) is a major cause of death in patients with DM. Although clinically amyopathic DM (CADM) represents risk for RPILD, the incidence rate of RPILD […]
» Read moreTo identify early predictors of disease activity at 18 months in JIA using clinical and biomarker profiling.Clinical and biomarker data were collected at JIA diagnosis in a prospective longitudinal inception cohort […]
» Read moreThe favourable long-term results of early treatment in patients with classified rheumatoid arthritis have resulted in an increasing interest in the diseases phases preceding clinical arthritis. The hypothesis to test […]
» Read moreUsing a reversible multistate model, we prospectively examined neuropsychiatric (NP) events for attribution, outcome and association with health-related quality of life (HRQoL), in an international, inception cohort of systemic lupus […]
» Read moreMesenchymal stem cells (MSCs) are considered potential therapeutic agents for treating autoimmune disease because of their immunomodulatory capacities and anti-inflammatory effects. However, several studies have shown that there is no […]
» Read moreTo study two neutrophil activation markers, myeloid-related protein (MRP) 8/14 and neutrophil elastase (NE), for their ability to predict treatment response and flare in patients with JIA.Using samples from two […]
» Read moreUltrasound of temporal and axillary arteries may reveal vessel wall inflammation in patients with giant cell arteritis (GCA). We developed a ultrasound scoring system to quantify the extent of vascular […]
» Read moreClinical diagnosis of SLE is currently challenging due to its heterogeneity. Many autoantibodies are associated with SLE and are considered potential diagnostic markers, but systematic screening and validation of such […]
» Read moreTo examine secular trends in the progression of clinical and patient-reported outcomes in early RA.A total of 2701 patients recruited to the Early Rheumatoid Arthritis Study or Early Rheumatoid Arthritis […]
» Read moreAnti-citrullinated protein antibodies (ACPAs) form immune complexes with citrullinated proteins binding toll-like receptor (TLR) 4, which has been proposed as a mediator of rheumatoid arthritis (RA). NI-0101 is a first-in-class […]
» Read moreCherry concentrate has been suggested to reduce serum urate (SU) and gout flares. The aims of this study were to determine the magnitude of the effect of tart cherry concentrate […]
» Read moreLay descriptions of mild, moderate and severe disease states have been utilized in Global Burden of Disease studies in the calculation of years lived with disability, and may be a […]
» Read moreAnti-transcription intermediary factor 1 (TIF1)-γ autoantibodies are robustly linked with cancer-associated DM in adults. This review aims to give an overview of the physiological context of TIF1-γ and to determine […]
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