The risk and trend of pulmonary embolism and deep vein thrombosis in rheumatoid arthritis: a general population-based study.

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To estimate the overall risk of venous thromboembolism (VTE), pulmonary embolism (PE) and deep vein thrombosis (DVT) among patients newly diagnosed with RA compared with the general population without RA; […]

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Biomechanical properties of common carotid arteries assessed by circumferential two-dimensional strain and beta stiffness index in patients with ankylosing spondylitis.

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Ankylosing spondylitis (AS) is associated with an elevated risk of cardiovascular disease (CVD) related to atherosclerosis, preceded by arterial stiffness. We aimed to examine common carotid artery (CCA) biomechanical properties […]

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Cardiovascular risk scores in axial spondyloarthritis versus the general population: A cross-sectional study.

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Cardiovascular (CV) morbidity and mortality are increased in axial spondyloarthritis (axSpA). We conducted a cross-sectional study evaluating the 10-year atherosclerotic cardiovascular disease (ASCVD) risk in axSpA compared to the general […]

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Cognitive dysfunction and serum levels of brain-derived neurotrophic factor (BDNF) in primary anti-phospholipid syndrome (PAPS).

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Cognitive dysfunction (CD) is a poorly understood non-stroke central neurological manifestation in anti-phospholipid syndrome (APS). Brain-derived neurotrophic factor (BDNF) is a neurotrophin that plays an important role in neural plasticity […]

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Propensity Score Methods in Rare Disease. A Demonstration Using Observational Data in Systemic Lupus Erythematosus.

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Observational studies allow researchers to understand the natural history of rheumatic conditions, risk factors for disease development, factors affecting important disease-related outcomes and estimate treatment effect from real world data. […]

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Sex differences in the clinical profile among patients with gout: cross-sectional analyses of an observational study.

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Research findings in gout result predominantly from studies among men, and might not be generalizable to women. To improve insight into sex differences, this study compared clinical characteristics and comorbidities […]

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Clinical characteristics and prognostic analysis of microscopic polyangiitis with diffuse alveolar haemorrhage.

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To analyse the clinical features and prognostic factors of microscopic polyangiitis (MPA) with diffuse alveolar haemorrhage (DAH).We conducted a retrospective study of 92 patients diagnosed with MPA with DAH at […]

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The iCanCope pain self-management application for adolescents with juvenile idiopathic arthritis: a pilot randomized controlled trial.

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To evaluate the feasibility and preliminary effectiveness of iCanCope with Pain (iCanCope), a smartphone-based pain self-management program, in adolescents with JIA. iCanCope featured symptom tracking, goal-setting, pain coping skills and […]

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“Unspoken Questions:” A Qualitative Study of Rheumatologists’ Perspectives on the Clinical Implementation of Patient-Reported Outcome Measures.

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To identify rheumatologists’ views on perceived barriers and facilitators to the clinical implementation of patient-reported outcome measures (PROMs).Semi-structured interviews were conducted with academically affiliated clinical rheumatologists. Interviews were audio-recorded and […]

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Health Care Utilization and Costs of Systemic Lupus Erythematosus by Disease Severity in the United States.

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To quantify health care utilization and costs by disease severity for patients with systemic lupus erythematosus (SLE) in the United States METHODS: We conducted descriptive analyses of Humedica electronic health […]

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Population characteristics as important contextual factors in rheumatological trials: an exploratory meta-epidemiological study from an OMERACT Working Group.

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To explore whether trial population characteristics modify treatment responses across various interventions, comparators and rheumatic conditions.In this meta-epidemiological study, we included trials from systematic reviews available from the Cochrane Musculoskeletal […]

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Quantitative analysis of pulmonary vasculature in systemic sclerosis at spirometry-gated chest CT.

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To prospectively investigate whether differences in pulmonary vasculature exist in systemic sclerosis (SSc) and how they are distributed in patients with different pulmonary function.Seventy-four patients with SSc undergoing chest CT […]

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Comparable or higher prevalence of comorbidities in antiphospholipid syndrome vs rheumatoid arthritis: a multicenter, case-control study.

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Evidence on comorbidity prevalence in antiphospholipid syndrome (APS) and its difference from high comorbidity burden rheumatic diseases is limited. Herein, we compare multiple comorbidities between APS and RA.A total of […]

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Identification of microRNAs and their target gene networks implicated in arterial wall remodelling in giant cell arteritis.

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To identify dysregulated microRNAs (miRNAs) and their gene targets in temporal arteries from GCA patients, and determine their association with GCA pathogenesis and related arterial wall remodelling.We included 93 formalin-fixed, […]

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TLR1/2 and 5 induce elevated cytokine levels from rheumatoid arthritis monocytes independent of ACPA or RF autoantibody status.

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RA is an autoimmune inflammatory joint disease. Both RF and ACPA are associated with more progressive disease and higher levels of systemic inflammation. Monocyte activation of toll-like receptors (TLRs) by […]

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Beneficial effect of Mediterranean diet on disease activity and cardiovascular risk in systemic lupus erythematosus patients: a cross-sectional study.

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To analyse the influence of the Mediterranean diet (Med Diet) on SLE activity, damage accrual and cardiovascular disease risk markers.A cross-sectional study was conducted on 280 patients with SLE [46.9 (12.85) years]. […]

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Arthritis autoantibodies in individuals without rheumatoid arthritis: follow-up data from a Dutch population-based cohort (Lifelines).

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To assess whether the presence of arthritis autoantibodies alongside IgG ACPA predicts clinically suspect arthralgia in ACPA-positive subjects without RA.In the population-based Lifelines cohort (n = 40 136), 308 IgG ACPA-positive individuals without […]

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Clinical course and outcome of COVID-19 in patients with rheumatic diseases: are all biological disease-modifying antirheumatic drugs alike? Response to: ‘Increased risk for severe COVID-19 in patients with inflammatory rheumatic diseases treated with rituximab’ by Schulze-Koops et al.

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Click here to read the full article @ Annals of the rheumatic diseases

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Clinical phenotypes of IgG4-related disease reflect different prognostic outcomes.

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Four clinical phenotypes of IgG4-related disease (IgG4-RD) have been recently identified by latent class analysis (LCA): pancreato-biliary (group 1); retroperitoneum/aortitis (group 2); head and neck limited (group 3); and Mikulicz/systemic […]

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Inflammatory hallmarks of lesser prominence in psoriatic arthritis patients starting biologics: a Nordic population-based cohort study.

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To assess secular trends in baseline characteristics of PsA patients initiating their first or subsequent biologic DMARD (bDMARD) therapy and to explore prescription patterns and treatment rates of bDMARDs from […]

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Effectiveness of secukinumab versus an alternative TNF inhibitor in patients with axial spondyloarthritis previously exposed to TNF inhibitors in the Swiss Clinical Quality Management cohort.

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To compare effectiveness of treatment with secukinumab (SEC) with that of alternative tumour necrosis factor inhibitors (TNFis) in patients with axial spondyloarthritis (axSpA) after withdrawal from one or more TNFis.Patients diagnosed […]

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