Advanced imaging for quantification of abnormalities in the salivary glands of patients with primary Sjögren’s syndrome.

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To assess non-invasive imaging for detection and quantification of gland structure, inflammation and function in patients with primary Sjogren’s syndrome (pSS) using PET-CT with 11C-Methionine (11C-MET; radiolabelled amino acid), and […]

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Macrophage activation syndrome in children with Kawasaki disease: an experience from a tertiary care hospital in northwest India.

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To carry out a review of clinical characteristics, laboratory profiles, management and outcomes of patients with Kawasaki disease (KD) and macrophage activation syndrome (MAS).Medical records of patients treated for KD […]

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Proinflammatory and bone protective role of calcitonin gene-related peptide alpha in collagen antibody-induced arthritis.

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Calcitonin gene-related peptide alpha (αCGRP) represents an immunomodulatory neuropeptide implicated in pain perception. αCGRP also functions as a critical regulator of bone formation and is overexpressed in patients with rheumatoid […]

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Changing evidence over time: updated meta-analysis regarding anti-TNF efficacy in childhood chronic uveitis.

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To summarize evidence regarding efficacy of anti-TNFα in childhood chronic uveitis, refractory to common DMARDs.An updated systematic search was conducted between November 2012 and January 2020. Studies investigating the efficacy […]

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Incidence of extra-articular manifestations in ankylosing spondylitis, psoriatic arthritis and undifferentiated spondyloarthritis: results from a national register-based cohort study.

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To estimate the incidence and strength of association of extra-articular manifestations [EAMs, here: anterior uveitis (AU), IBD and psoriasis] in patients with AS, undifferentiated SpA (uSpA) and PsA, compared with […]

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Tofacitinib counteracts IL-6 overexpression induced by deficient autophagy: implications in Sjögren’s syndrome.

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Altered homeostasis of salivary gland (SG) epithelial cells in Sjögren’s syndrome (SS) could be the initiating factor that leads to inflammation, secretory dysfunction and autoimmunity. Autophagy is an important homeostatic […]

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The long-term prognosis of pneumomediastinum associated with dermatomyositis: a two-centre retrospective cohort study.

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Pneumomediastinum (PnM) is a rare but life-threatening complication of DM. The present study aims to characterize the long-term prognosis and prognostic factors of DM-associated PnM.Inpatients with DM-associated PnM were retrospectively […]

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Interleukin 6 receptor inhibition in primary Sjögren syndrome: a multicentre double-blind randomised placebo-controlled trial.

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No immunomodulatory drug has been approved for primary Sjögren’s syndrome, a systemic autoimmune disease affecting 0.1% of the population. To demonstrate the efficacy of targeting interleukin 6 receptor in patients […]

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Anti-centromere antibodies target centromere-kinetochore macrocomplex: a comprehensive autoantigen profiling.

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Anti-centromere antibodies (ACAs) are detected in patients with various autoimmune diseases such as Sjögren’s syndrome (SS), systemic sclerosis (SSc) and primary biliary cholangitis (PBC). However, the targeted antigens of ACAs […]

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The efficacy and safety of citrate mixture vs sodium bicarbonate on urine alkalization in Chinese primary gout patients with benzbromarone: a prospective, randomized controlled study.

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To compare the efficacy and safety of citrate mixture and sodium bicarbonate on urine alkalization in gout patients under benzbromarone treatment.A prospective, randomized, parallel controlled trial was conducted among 200 […]

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Efficacy and safety of fasinumab in patients with chronic low back pain: a phase II/III randomised clinical trial.

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To study the efficacy and safety of fasinumab in moderate-to-severe, chronic low back pain (CLBP).In this phase II/III, double-blind, placebo-controlled study, patients with CLBP aged ≥35 years with inadequate pain […]

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Relationship between diffuse idiopathic skeletal hyperostosis and fragility vertebral fracture: a prospective study in older men.

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To analyse the risk of incident vertebral and non-vertebral fracture in men with DISH.In 782 men ages 50-85 years, DISH was diagnosed using Resnick’s criteria. In men followed prospectively for 7.5 years, […]

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Clinical significance of interleukin-18 for the diagnosis and prediction of disease course in systemic juvenile idiopathic arthritis.

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To investigate the clinical significance of serum IL-18 levels for the diagnosis of systemic JIA (s-JIA) and to predict the disease course of s-JIA.Overall, 116 patients with s-JIA, 151 with […]

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Peripheral blood mononuclear cells are hypomethylated in active rheumatoid arthritis and methylation correlates with disease activity.

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Epigenetic modifications are dynamic and influence cellular disease activity. The aim of this study was to investigate global DNA methylation in peripheral blood mononuclear cells (PBMCs) of RA patients to […]

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Sirolimus for patients with connective tissue disease-related refractory thrombocytopenia: a single-arm, open-label clinical trial.

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Connective tissue disease-related thrombocytopenia (CTD-TP) is a problematic disorder in clinical practice. Because the first-line therapy of glucocorticoid and/or immunosuppressants is not effective for refractory cases, alternative treatment approaches are […]

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Efficacy of baricitinib in patients with moderate-to-severe rheumatoid arthritis with 3 years of treatment: results from a long-term study.

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To evaluate the long-term efficacy of once-daily baricitinib 4 mg in patients with active RA who were either naïve to DMARDs or who had inadequate response (IR) to MTX.Analyses of data […]

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Descriptive Comparisons of the Impact of Apremilast and Methotrexate Monotherapy in Oligoarticular Psoriatic Arthritis: the Corrona Psoriatic Arthritis/Spondyloarthritis Registry Results.

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Therapeutic response was evaluated among new apremilast, methotrexate, or biologic disease-modifying anti-rheumatic drug (bDMARD) initiators with oligoarticular psoriatic arthritis (PsA).Patients with oligoarticular PsA in the Corrona PsA/Spondyloarthritis Registry initiating treatment […]

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Attitude of Iraqi Rheumatologists While Managing Rheumatic Diseases in the Era of COVID-19: An Online Survey.

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The current crisis COVID-19 has affected the already challenging management of rheumatic diseases. Since no evidence-based approach is yet available, this survey was conducted to explore the Iraqi rheumatologists’ attitude […]

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Concerns, healthcare use, and treatment interruptions in patients with common autoimmune rheumatic diseases during the COVID-19 pandemic.

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To assess concerns and healthcare-related behaviors of patients with autoimmune rheumatic diseases during the COVID-19 pandemic.Adults from the United States with rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), […]

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Elaboration of a new synovial predictive score of septic origin for acute arthritis on the native joint (RESAS).

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To establish a new predictive score for the diagnosis of septic arthritis (SA) according to different synovial fluid (SF) variables.First, we analysed the different clinical, biological and SF variables associated […]

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