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To assess non-invasive imaging for detection and quantification of gland structure, inflammation and function in patients with primary Sjogren’s syndrome (pSS) using PET-CT with 11C-Methionine (11C-MET; radiolabelled amino acid), and […]
» Read moreTo carry out a review of clinical characteristics, laboratory profiles, management and outcomes of patients with Kawasaki disease (KD) and macrophage activation syndrome (MAS).Medical records of patients treated for KD […]
» Read moreChronic glucocorticoid use is complicated by osteoporosis and increases the risk of fragility fractures. EULAR guidelines on SLE management recommend reducing chronic glucocorticoid dosage to ≤7.5 mg/day to minimize this risk. […]
» Read moreYttrium-90 (90Y) is approved in several countries as a radiosynoviorthesis agent in the intra-articular treatment of synovitis, however, no such radiopharmaceuticals are approved in Canada. The aim of this Health […]
» Read moreTo identify cytokines, markers of endothelial activation [soluble vascular cell adhesion molecule-1 (sVCAM-1)] and myocyte strain [soluble ST2 (sST2)] associated with myocardial injury (MInj) in SLE, classified by cardiac magnetic […]
» Read moreThis two-sample Mendelian randomization study aimed to delve into the effects of genetically predicted adipokine levels on OA.Summary statistic data for OA originated from a meta-analysis of a genome-wide association […]
» Read moreCalcitonin gene-related peptide alpha (αCGRP) represents an immunomodulatory neuropeptide implicated in pain perception. αCGRP also functions as a critical regulator of bone formation and is overexpressed in patients with rheumatoid […]
» Read moreTo summarize evidence regarding efficacy of anti-TNFα in childhood chronic uveitis, refractory to common DMARDs.An updated systematic search was conducted between November 2012 and January 2020. Studies investigating the efficacy […]
» Read moreTo estimate the incidence and strength of association of extra-articular manifestations [EAMs, here: anterior uveitis (AU), IBD and psoriasis] in patients with AS, undifferentiated SpA (uSpA) and PsA, compared with […]
» Read moreAltered homeostasis of salivary gland (SG) epithelial cells in Sjögren’s syndrome (SS) could be the initiating factor that leads to inflammation, secretory dysfunction and autoimmunity. Autophagy is an important homeostatic […]
» Read morePneumomediastinum (PnM) is a rare but life-threatening complication of DM. The present study aims to characterize the long-term prognosis and prognostic factors of DM-associated PnM.Inpatients with DM-associated PnM were retrospectively […]
» Read moreResearch on spatial variability of the incidence of IgA vasculitis (IgAV) in children and its potential implications for elucidation of the multifactorial aetiology and pathogenesis is limited. We intended to […]
» Read moreNo immunomodulatory drug has been approved for primary Sjögren’s syndrome, a systemic autoimmune disease affecting 0.1% of the population. To demonstrate the efficacy of targeting interleukin 6 receptor in patients […]
» Read moreAnti-centromere antibodies (ACAs) are detected in patients with various autoimmune diseases such as Sjögren’s syndrome (SS), systemic sclerosis (SSc) and primary biliary cholangitis (PBC). However, the targeted antigens of ACAs […]
» Read moreCommunity screening and therapeutic prevention strategies may reduce the incidence of falls in older people. The effects of these measures on the incidence of fractures, the use of health resources, […]
» Read moreFrequent monitoring of forced vital capacity at home may be of added value in patients with SSc-associated interstitial lung disease (SSc-ILD) to monitor disease progression and guide treatment decisions. The […]
» Read moreWe developed and tested a robust case ascertainment strategy within the Clinical Practice Research Datalink (CPRD), with the aim of assessing the incidence, prevalence, mortality and delay in diagnosis of […]
» Read moreTo compare the efficacy and safety of citrate mixture and sodium bicarbonate on urine alkalization in gout patients under benzbromarone treatment.A prospective, randomized, parallel controlled trial was conducted among 200 […]
» Read moreThe aim of this study was to compare the clinical characteristics of IgG4-related disease (IgG4-RD) among different age groups.We conducted a prospective study of 737 patients who were newly diagnosed […]
» Read moreTo study the efficacy and safety of fasinumab in moderate-to-severe, chronic low back pain (CLBP).In this phase II/III, double-blind, placebo-controlled study, patients with CLBP aged ≥35 years with inadequate pain […]
» Read moreTo analyse the risk of incident vertebral and non-vertebral fracture in men with DISH.In 782 men ages 50-85 years, DISH was diagnosed using Resnick’s criteria. In men followed prospectively for 7.5 years, […]
» Read moreTo investigate the clinical significance of serum IL-18 levels for the diagnosis of systemic JIA (s-JIA) and to predict the disease course of s-JIA.Overall, 116 patients with s-JIA, 151 with […]
» Read moreEpigenetic modifications are dynamic and influence cellular disease activity. The aim of this study was to investigate global DNA methylation in peripheral blood mononuclear cells (PBMCs) of RA patients to […]
» Read morePMR is an inflammatory rheumatic disease of elderly people characterized by pain and stiffness in the neck, shoulder and pelvic girdles. No specific diagnostic confirmatory tests exist and clinical symptoms, […]
» Read moreConnective tissue disease-related thrombocytopenia (CTD-TP) is a problematic disorder in clinical practice. Because the first-line therapy of glucocorticoid and/or immunosuppressants is not effective for refractory cases, alternative treatment approaches are […]
» Read moreTo evaluate the long-term efficacy of once-daily baricitinib 4 mg in patients with active RA who were either naïve to DMARDs or who had inadequate response (IR) to MTX.Analyses of data […]
» Read moreTherapeutic response was evaluated among new apremilast, methotrexate, or biologic disease-modifying anti-rheumatic drug (bDMARD) initiators with oligoarticular psoriatic arthritis (PsA).Patients with oligoarticular PsA in the Corrona PsA/Spondyloarthritis Registry initiating treatment […]
» Read moreThe current crisis COVID-19 has affected the already challenging management of rheumatic diseases. Since no evidence-based approach is yet available, this survey was conducted to explore the Iraqi rheumatologists’ attitude […]
» Read moreTo assess concerns and healthcare-related behaviors of patients with autoimmune rheumatic diseases during the COVID-19 pandemic.Adults from the United States with rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), […]
» Read moreTo establish a new predictive score for the diagnosis of septic arthritis (SA) according to different synovial fluid (SF) variables.First, we analysed the different clinical, biological and SF variables associated […]
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