A real-life comparative effectiveness study into the addition of antibiotics to the management of asthma exacerbations in primary care.

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Asthma exacerbations are major contributors to asthma morbidity and mortality. They are usually managed with bronchodilators and oral corticosteroids (OCS), but clinical trial evidence suggests antibiotics could be beneficial. We […]

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Screening for pulmonary arterial hypertension in adults carrying a BMPR2 mutation.

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Heritable pulmonary arterial hypertension (PAH) is most commonly due to heterozygous mutations of the BMPR2 gene. Based on expert consensus, guidelines recommend annual screening echocardiography in asymptomatic BMPR2 mutation carriers. […]

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Risk factors, management, and outcomes of legionella pneumonia in a large nationally-representative sample.

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ATS/IDSA guidelines recommend against routine Legionella pneumophila testing but that hospitalized patients with community-acquired pneumonia (CAP) receive empiric treatment covering Legionella. Testing, empiric treatment, and outcomes for patients with Legionella […]

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Endobronchial Valves for the Treatment of Advanced Emphysema.

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Bronchoscopic lung volume reduction with one-way endobronchial valves is a guideline treatment option for patients with advanced emphysema, supported by extensive scientific data. Patients limited by severe hyperinflation, with a […]

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Clinical characteristics and 3-month outcomes in cancer patients with incidental versus clinically-suspected and confirmed pulmonary embolism.

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Current guidelines suggest treating cancer patients with incidental pulmonary embolism (PE) similar to those with clinically-suspected and confirmed PE. However, the natural history of these presentations has not been thoroughly […]

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Long-term exposure to low-level air pollution and incidence of asthma: the ELAPSE project.

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Long-term exposure to ambient air pollution has been linked to childhood-onset asthma, while evidence is still insufficient. Within the multicentre project “Effects of Low-Level Air Pollution: A Study in Europe” […]

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Targeting Cystic Fibrosis Inflammation in the Age of CFTR Modulators: Focus on Macrophages.

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Cystic fibrosis is a life-shortening, multiorgan, autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The most prominent clinical manifestation in CF is the […]

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Performance of Risk factor-based Guidelines and Model-based Chest CT Lung Cancer Screening in World Trade Center Exposed Fire Department Rescue/Recovery Workers.

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Lung cancer is a leading cause of cancer incidence and death in the US. Risk factor-based guidelines and risk model-based strategies are used to identify patients who could benefit from […]

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Top 10 research priorities for people living with pulmonary fibrosis, their caregivers, healthcare professionals and researchers.

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People with pulmonary fibrosis (PF) experience a high symptom burden, reduced quality of life and a shortened lifespan. Treatment options are limited and little is known about what patients, caregivers […]

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Managing Asthma in Adolescents and Adults: 2020 Asthma Guideline Update From the National Asthma Education and Prevention Program.

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Asthma is a major public health problem worldwide and is associated with excess morbidity, mortality, and economic costs associated with lost productivity. The National Asthma Education and Prevention Program has […]

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World Health Organization recommendations on the treatment of drug-resistant tuberculosis, 2020 update.

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Antimicrobial resistance is a major public health problem globally. Likewise, forms of tuberculosis (TB) resistant to first- and second-line TB medicines present a major challenge for patients, health care workers […]

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Low-tidal volume mechanical ventilation against no ventilation during cardiopulmonary bypass in heart surgery (MECANO): a randomized controlled trial.

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Postoperative pulmonary complications are common after cardiac surgery and have been related to lung collapsus during cardiopulmonary bypass (CPB). There is no consensus on the effects of maintaining mechanical ventilation […]

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Trajectories of asthma and allergies from 7 years to 53 years and associations with lung function and extrapulmonary comorbidity profiles: a prospective cohort study.

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Longitudinal trajectories of asthma and allergies from childhood to adulthood might be differentially associated with lung function and chronic obstructive pulmonary disease (COPD), but associations with extrapulmonary comorbidities have not […]

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Sepsis, the Administration of Intravenous Fluids and Respiratory failure: A Retrospective analysis – SAIFR Study.

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Although resuscitation with intravenous fluids (IVF) is the cornerstone of sepsis management, consensus regarding their association with improvement in clinical outcomes is lacking.Is there a difference in the incidence of […]

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Association of asthma severity and educational attainment at age 6-7 years in a birth cohort: population-based record-linkage study.

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There is conflicting research about the association between asthma and poor educational attainment that may be due to asthma definitions. Our study creates seven categories of current chronic and acute […]

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Accuracy of UK Rapid Test Consortium (UK-RTC) “AbC-19 Rapid Test” for detection of previous SARS-CoV-2 infection in key workers: test accuracy study.

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To assess the accuracy of the AbC-19 Rapid Test lateral flow immunoassay for the detection of previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.Test accuracy study.Laboratory based evaluation.2847 key […]

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Eosinophilic inflammation in COPD: from an inflammatory marker to a treatable trait.

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The heterogeneity of chronic obstructive pulmonary disease (COPD) creates many diagnostic, prognostic, treatment and management challenges, as the pathogenesis of COPD is highly complex and the underlying cellular and molecular […]

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Tuberculosis prevention in children: A prospective community based study in South Africa.

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Tuberculosis preventive therapy reduces tuberculosis risk in children. However, the effectiveness of tuberculosis preventive therapy in children living in high burden settings is unclear.In a prospective observational community-based cohort study […]

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How I Do It: Managing M. avium complex lung disease with a little help from my friend.

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Management of Mycobacterium avium complex (MAC) lung disease is complicated, frequently unsuccessful and frustrating to patients and clinicians. The initial treatment effort may not be solely directed at MAC infection, […]

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Timing of thromboprophylaxis in patients with blunt abdominal solid organ injuries undergoing nonoperative management.

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Decision-making regarding the optimal timing for initiating thromboprophylaxis in patients with blunt abdominal solid organ injuries (BSOIs) remains ill-defined, with no guidelines defining optimal timing. In this study, we aimed […]

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Essential Components of an Interstitial Lung Disease Clinic: Results from a Delphi Survey and Patient Focus Group Analysis.

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Management of patients with interstitial lung disease (ILD) requires subspecialized, comprehensive, multidisciplinary care. The Pulmonary Fibrosis Foundation established the Care Center Network (CCN) in 2013 with identified criteria to become […]

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Trends in mediastinal nodal staging and its impact on unforeseen N2 and survival in lung cancer.

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Guidelines for invasive mediastinal nodal staging in resectable NSCLC have changed over the years. The aims of this study were to describe trends in invasive staging and unforeseen N2 (uN2) […]

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