Association of asthma severity and educational attainment at age 6-7 years in a birth cohort: population-based record-linkage study.

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There is conflicting research about the association between asthma and poor educational attainment that may be due to asthma definitions. Our study creates seven categories of current chronic and acute […]

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Accuracy of UK Rapid Test Consortium (UK-RTC) “AbC-19 Rapid Test” for detection of previous SARS-CoV-2 infection in key workers: test accuracy study.

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To assess the accuracy of the AbC-19 Rapid Test lateral flow immunoassay for the detection of previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.Test accuracy study.Laboratory based evaluation.2847 key […]

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Eosinophilic inflammation in COPD: from an inflammatory marker to a treatable trait.

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The heterogeneity of chronic obstructive pulmonary disease (COPD) creates many diagnostic, prognostic, treatment and management challenges, as the pathogenesis of COPD is highly complex and the underlying cellular and molecular […]

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Tuberculosis prevention in children: A prospective community based study in South Africa.

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Tuberculosis preventive therapy reduces tuberculosis risk in children. However, the effectiveness of tuberculosis preventive therapy in children living in high burden settings is unclear.In a prospective observational community-based cohort study […]

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How I Do It: Managing M. avium complex lung disease with a little help from my friend.

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Management of Mycobacterium avium complex (MAC) lung disease is complicated, frequently unsuccessful and frustrating to patients and clinicians. The initial treatment effort may not be solely directed at MAC infection, […]

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Timing of thromboprophylaxis in patients with blunt abdominal solid organ injuries undergoing nonoperative management.

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Decision-making regarding the optimal timing for initiating thromboprophylaxis in patients with blunt abdominal solid organ injuries (BSOIs) remains ill-defined, with no guidelines defining optimal timing. In this study, we aimed […]

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Essential Components of an Interstitial Lung Disease Clinic: Results from a Delphi Survey and Patient Focus Group Analysis.

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Management of patients with interstitial lung disease (ILD) requires subspecialized, comprehensive, multidisciplinary care. The Pulmonary Fibrosis Foundation established the Care Center Network (CCN) in 2013 with identified criteria to become […]

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Trends in mediastinal nodal staging and its impact on unforeseen N2 and survival in lung cancer.

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Guidelines for invasive mediastinal nodal staging in resectable NSCLC have changed over the years. The aims of this study were to describe trends in invasive staging and unforeseen N2 (uN2) […]

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Composite type-2 biomarker strategy versus a symptom-risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial.

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Asthma treatment guidelines recommend increasing corticosteroid dose to control symptoms and reduce exacerbations. This approach is potentially flawed because symptomatic asthma can occur without corticosteroid responsive type-2 (T2)-driven eosinophilic inflammation, […]

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Progressive fibrosing interstitial lung disease: clinical uncertainties, consensus recommendations, and research priorities.

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Within the spectrum of fibrosing interstitial lung diseases (ILDs) is a subset of patients who have inexorable progression of pulmonary fibrosis despite treatment, which is known as the progressive fibrotic […]

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Effectiveness of proton pump inhibitors in idiopathic pulmonary fibrosis: a population-based cohort study.

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Gastroesophageal reflux disease is a common co-morbidity in idiopathic pulmonary fibrosis (IPF) and may contribute to its progression. Anti-acid therapy, such as proton pump inhibitors (PPIs), has been considered as […]

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Diagnosis and Treatment of Pulmonary Embolism During the COVID-19 Pandemic: A Position Paper from the National PERT Consortium.

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The co-existence of COVID-19 and PE, two life threatening illnesses, in the same patient presents a unique challenge. Recent guidelines have delineated how best to diagnose and manage patients with […]

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International perspective on the new 2019 ATS/IDSA CAP guideline – a critical appraisal by a global expert panel.

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In 2019, the American Thoracic Society (ATS) / Infectious Diseases Society of America (IDSA) issued a substantial revision of the 2007 guideline on community-acquired pneumonia (CAP). Despite generalization of infectious […]

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International perspective on the new 2019 ATS/IDSA CAP guideline – a critical appraisal by a global expert panel.

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In 2019, the American Thoracic Society (ATS) / Infectious Diseases Society of America (IDSA) issued a substantial revision of the 2007 guideline on community-acquired pneumonia (CAP). Despite generalization of infectious […]

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Computed Tomography Imaging and Comorbidities in Chronic Obstructive Pulmonary Disease: Beyond Lung Cancer Screening.

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Comorbidities significantly contribute to morbidity, mortality, and health care costs in individuals with chronic obstructive pulmonary disease (COPD). Comorbidity prevalence does not always correlate with lung disease severity and the […]

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Efficacy and safety of sildenafil added to pirfenidone in patients with advanced idiopathic pulmonary fibrosis and risk of pulmonary hypertension: a double-blind, randomised, placebo-controlled, phase 2b trial.

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The benefit of sildenafil in patients with advanced idiopathic pulmonary fibrosis (IPF) at risk of poor outcomes from pulmonary hypertension, whether already present or likely to develop, is uncertain. We […]

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Transbronchial cryobiopsy increases diagnostic confidence in interstitial lung disease: a prospective multicenter trial.

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The accurate diagnosis of individual interstitial lung diseases (ILD) is often challenging, but is a critical determinant of appropriate management. If a diagnosis cannot be made after multidisciplinary team discussion […]

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How I Do It: The PERT Concept: A Step-by-Step Approach to Managing PE.

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Pulmonary embolism (PE) is a major source of morbidity and mortality. The presentation of acute PE varies, ranging from few or no symptoms to sudden death. Patient outcome depends upon […]

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Determination of Brain Death/Death by Neurologic Criteria: The World Brain Death Project.

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There are inconsistencies in concept, criteria, practice, and documentation of brain death/death by neurologic criteria (BD/DNC) both internationally and within countries.To formulate a consensus statement of recommendations on determination of […]

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Evidence-based practices for acute respiratory failure and acute respiratory distress syndrome: A systematic review of reviews.

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The recent pandemic highlights the essential nature of optimizing the use of invasive mechanical ventilation (IMV) in complex critical care settings. This review of reviews maps evidence-based practices (EBPs) associated […]

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Epidemiological, comorbidity factors with severity and prognosis of COVID-19: a systematic review and meta-analysis.

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A systematic review and meta-analysis was conducted in an attempt to systematically collect and evaluate the associations of epidemiological, comorbidity factors with the severity and prognosis of coronavirus disease 2019 […]

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