Composite type-2 biomarker strategy versus a symptom-risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial.

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Asthma treatment guidelines recommend increasing corticosteroid dose to control symptoms and reduce exacerbations. This approach is potentially flawed because symptomatic asthma can occur without corticosteroid responsive type-2 (T2)-driven eosinophilic inflammation, […]

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Progressive fibrosing interstitial lung disease: clinical uncertainties, consensus recommendations, and research priorities.

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Within the spectrum of fibrosing interstitial lung diseases (ILDs) is a subset of patients who have inexorable progression of pulmonary fibrosis despite treatment, which is known as the progressive fibrotic […]

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International perspective on the new 2019 ATS/IDSA CAP guideline – a critical appraisal by a global expert panel.

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In 2019, the American Thoracic Society (ATS) / Infectious Diseases Society of America (IDSA) issued a substantial revision of the 2007 guideline on community-acquired pneumonia (CAP). Despite generalization of infectious […]

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International perspective on the new 2019 ATS/IDSA CAP guideline – a critical appraisal by a global expert panel.

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In 2019, the American Thoracic Society (ATS) / Infectious Diseases Society of America (IDSA) issued a substantial revision of the 2007 guideline on community-acquired pneumonia (CAP). Despite generalization of infectious […]

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Computed Tomography Imaging and Comorbidities in Chronic Obstructive Pulmonary Disease: Beyond Lung Cancer Screening.

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Comorbidities significantly contribute to morbidity, mortality, and health care costs in individuals with chronic obstructive pulmonary disease (COPD). Comorbidity prevalence does not always correlate with lung disease severity and the […]

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Efficacy and safety of sildenafil added to pirfenidone in patients with advanced idiopathic pulmonary fibrosis and risk of pulmonary hypertension: a double-blind, randomised, placebo-controlled, phase 2b trial.

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The benefit of sildenafil in patients with advanced idiopathic pulmonary fibrosis (IPF) at risk of poor outcomes from pulmonary hypertension, whether already present or likely to develop, is uncertain. We […]

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Transbronchial cryobiopsy increases diagnostic confidence in interstitial lung disease: a prospective multicenter trial.

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The accurate diagnosis of individual interstitial lung diseases (ILD) is often challenging, but is a critical determinant of appropriate management. If a diagnosis cannot be made after multidisciplinary team discussion […]

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Determination of Brain Death/Death by Neurologic Criteria: The World Brain Death Project.

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There are inconsistencies in concept, criteria, practice, and documentation of brain death/death by neurologic criteria (BD/DNC) both internationally and within countries.To formulate a consensus statement of recommendations on determination of […]

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Evidence-based practices for acute respiratory failure and acute respiratory distress syndrome: A systematic review of reviews.

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The recent pandemic highlights the essential nature of optimizing the use of invasive mechanical ventilation (IMV) in complex critical care settings. This review of reviews maps evidence-based practices (EBPs) associated […]

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Epidemiological, comorbidity factors with severity and prognosis of COVID-19: a systematic review and meta-analysis.

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A systematic review and meta-analysis was conducted in an attempt to systematically collect and evaluate the associations of epidemiological, comorbidity factors with the severity and prognosis of coronavirus disease 2019 […]

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Management of Allergic Patients During the COVID-19 Pandemic in Asia.

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Although a viral infection is a major triggering factor of asthma and allergic diseases, asthma is suggested to be not a predisposing condition for coronavirus disease 2019 (COVID-19) infection. However, […]

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Treatment of nontuberculous mycobacterial pulmonary disease: an official ATS/ERS/ESCMID/IDSA clinical practice guideline.

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Nontuberculous mycobacteria (NTM) represent over 190 species and subspecies, some of which can produce disease in humans of all ages and can affect both pulmonary and extrapulmonary sites. This guideline […]

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Mixed Venous Oxygen Saturation is a Better Prognosticator than Cardiac Index in Pulmonary Arterial Hypertension.

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European Society of Cardiology and European Respiratory Society (ESC/ERS) guidelines include thermodilution cardiac index (TDCI) and mixed venous oxygen saturation (SvO2) as two of the three hemodynamic determinations used in […]

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Nonoperating room anesthesia for patients with serious comorbidities.

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To provide aids to deal with increasing amount of several comorbidities in nonoperating room anesthesia (NORA).New indexes for assessment of comorbidities are described and guidelines for the care of patients […]

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Recommended physical activity and all cause and cause specific mortality in US adults: prospective cohort study.

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To determine the association between recommended physical activity according to the 2018 physical activity guidelines for Americans and all cause and cause specific mortality using a nationally representative sample of […]

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SARS-CoV-2 pneumonia in hospitalized asthmatic patients did not induce severe exacerbation.

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Viral infections are known to exacerbate asthma in adults. Previous studies have found few asthmatics among SARS-CoV-2 pneumonia cases. However, the relationship between SARS-CoV-2 infection and severe asthma exacerbation is […]

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Epidemic and pandemic viral infections: impact on tuberculosis and the lung. A consensus by the World Association for Infectious Diseases and Immunological Disorders (WAidid), Global Tuberculosis Network (GTN) and members# of ESCMID Study Group for Mycobacterial Infections (ESGMYC).

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Major epidemics including some that qualify as pandemics, such as Severe Acute Respiratory Syndrome (SARS), Middle-Eastern Respiratory Syndrome (MERS), Human Immunodeficiency Virus, pandemic H1N1/09 and most recently COVID-19 affect the […]

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