Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort.

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We previously described the contributions of increased total airway mucin concentrations to the pathogenesis and diagnosis of the chronic bronchitic component of chronic obstructive pulmonary disease (COPD). Here, we investigated […]

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Emphysema progression and lung function decline among angiotensin converting enzyme inhibitors (ACEi) and angiotensin-receptor blockade (ARB) users in the COPDGene® Cohort.

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Attenuation of transforming growth factor-β by blocking angiotensin II has been shown to reduce emphysema in a murine model. General population studies have demonstrated use of angiotensin converting enzyme inhibitors […]

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Comparative effectiveness and safety of different types of LABA/LAMA versus LABA/ICS fixed-dose combinations in COPD: a propensity score-inverse probability of treatment weighting cohort study.

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Despite multiple available fixed-dose combinations (FDCs) of inhaled long-acting β2-agonists (LABAs)/long-acting muscarinic antagonists (LAMAs) and LABA/inhaled corticosteroids (ICSs) in chronic obstructive pulmonary disease (COPD), uncertainty remains in their comparative effects.Can […]

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Personalised Variable vs Fixed Dose Systemic Corticosteroid Therapy in Hospitalized Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Prospective, Multicentered, Randomised, Open-Label Clinical Trial.

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Systemic corticosteroids for treatment of chronic obstructive pulmonary disease (COPD) exacerbations decrease treatment failure and shorten the length of hospitalization. However, the optimal dose is unclear.Is personalized-dose corticosteroid by a […]

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Bronchial gene expression signature associated with rate of subsequent FEV1 decline in individuals with and at risk of COPD.

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COPD is characterised by progressive lung function decline. Leveraging prior work demonstrating bronchial airway COPD-associated gene expression alterations, we sought to determine if there are alterations associated with differences in […]

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Kidney function and obstructive lung disease: a bidirectional Mendelian randomisation study.

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Additional study is warranted to investigate the causal effects between kidney function and obstructive lung disease.This study was a bidirectional two-sample Mendelian randomisation (MR) analysis. The CKDGen genome-wide association study […]

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The coexistence of asthma and COPD: risk factors, clinical history and lung function trajectories.

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Patients with concomitant features of asthma and chronic obstructive pulmonary disease (COPD) have a heavy disease burden.Using data collected prospectively in the European Community Respiratory Health Survey, we compared the […]

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Nasal versus oronasal masks for home non-invasive ventilation in patients with chronic hypercapnia: a systematic review and individual participant data meta-analysis.

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The optimal interface for the delivery of home non-invasive ventilation (NIV) to treat chronic respiratory failure has not yet been determined. The aim of this individual participant data (IPD) meta-analysis […]

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Association between pre-existing respiratory disease and its treatment, and severe COVID-19: a population cohort study.

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Previous studies suggested that the prevalence of chronic respiratory disease in patients hospitalised with COVID-19 was lower than its prevalence in the general population. The aim of this study was […]

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Decrease in hospital admissions for respiratory diseases during the COVID-19 pandemic: a nationwide claims study.

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Non-pharmaceutical interventions (NPIs) have been widely implemented to mitigate the spread of COVID-19. We assessed the effect of NPIs on hospitalisations for pneumonia, influenza, COPD and asthma. This retrospective, ecological […]

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Multi-omics links IL-6 trans-signalling with neutrophil extracellular trap formation and Haemophilus infection in COPD.

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IL-6 trans-signalling (IL-6TS) is emerging as a pathogenic mechanism in chronic respiratory diseases, however the drivers of IL-6TS in the airways and the phenotypic characteristic of patients with increased IL-6TS […]

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Efficacy of unsupervised exercise in adults with obstructive lung disease: a systematic review and meta-analysis.

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The benefits of unsupervised exercise programmes in obstructive lung disease are unclear. The aim of this systematic review was to synthesise evidence regarding the efficacy of unsupervised exercise versus non-exercise-based […]

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COPD discharge bundle and pulmonary rehabilitation referral and uptake following hospitalisation for acute exacerbation of COPD.

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Pulmonary rehabilitation (PR) following hospitalisations for acute exacerbation of COPD (AECOPD) is associated with improved exercise capacity and quality of life, and reduced readmissions. However, referral for, and uptake of, […]

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Heterogeneity within and between physician-diagnosed asthma and/or COPD: NOVELTY cohort.

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Studies of asthma and chronic obstructive pulmonary disease (COPD) typically focus on these diagnoses separately, limiting understanding of disease mechanisms and treatment options. NOVELTY is a global, 3-year, prospective observational […]

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