Abstract: The proportion of the efficacy of high dose inhaled corticosteroids (ICS) in oral corticosteroid-dependent asthma that is due to systemic effects is uncertain. This study aimed to estimate the […]» Read more
European Respiratory Society guideline on long term management of children with bronchopulmonary dysplasia.
Abstract: This document provides recommendations for monitoring and treatment of children in whom bronchopulmonary dysplasia (BPD) has been established and were discharged from the hospital, or who were older than […]» Read more
Abstract: This document provides clinical recommendations for the management of severe asthma. Comprehensive evidence syntheses, including meta-analyses, were performed to summarise all available evidence relevant to the Task Force’s questions. […]» Read more
Abstract: Asthma is a common respiratory disorder with a highly heterogeneous nature that remains poorly understood. The objective was to identify regions of common genetic variation contributing to lung function […]» Read more
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Abstract: Acute pollutant-related lung function changes among children varies across pollutants and lag periods. We examined whether short-term air pollutant fluctuations were related to daily lung function among a panel […]» Read more
Abstract: The economic impact of multimorbidity in severe or difficult-to-treat asthma has not been comprehensively investigated.To estimate the incremental healthcare costs of coexisting chronic conditions (comorbidities) in patients with severe […]» Read more
Abstract: The randomized clinical trials of bronchial thermoplasty (BT) were conducted in patients with a baseline FEV1 greater than 50%. There is a paucity of data regarding BT in patients […]» Read more
Abstract: Asthma pathobiology can be broadly classified by endotypes of type 2-high and type 2-low disease, with a significant percentage of asthmatics having a type 2-low endotype that is poorly […]» Read more
Abstract: Relative enlargement of the pulmonary artery (PA) on chest computed tomography (CT) is associated with respiratory exacerbations in patients with chronic obstructive pulmonary disease or cystic fibrosis. We sought […]» Read more
Abstract: The number of deaths from asthma in England and Wales has not changed significantly over the last decade. This lack of improvement has received attention from both national asthma […]» Read more
Abstract: These guidelines incorporate the recent advances in chronic cough pathophysiology, diagnosis and treatment. The concept of cough hypersensitivity has allowed an umbrella term that explains the exquisite sensitivity of […]» Read more
Abstract: Severe obstructive lung disease, which encompasses patients with asthma, chronic obstructive pulmonary disease (COPD) or features of both, remains a considerable global health problem and burden on healthcare resources. […]» Read more
Abstract: Asthma is a common cause of emergency care attendance in low and middle-income countries (LMICs). While few prospective studies of predictors for emergency care attendance have been undertaken in […]» Read more
Increased Mortality in Patients with Corticosteroid-dependent Asthma: A Nationwide Population-based Study.
Abstract: Chronic systemic corticosteroid (CS) therapy is associated with an increased risk of mortality in patients with many chronic diseases. However, it has not been elucidated whether chronic, systemic CS […]» Read more
Abstract: Asthma is a heterogeneous condition, characterised by chronic inflammation of the airways, typically managed with inhaled bronchodilators and corticosteroids. In case of uncontrolled asthma, oral corticosteroids (OCSs) are often […]» Read more
Abstract: There are little data on the usefulness of different tests to diagnose asthma in children.We assessed the contribution of a detailed history and a variety of diagnostic tests for […]» Read more
Does maintenance azithromycin reduce asthma exacerbations? An individual participant data meta-analysis.
Abstract: Preventing exacerbations is an important goal of asthma treatment. Long-term treatment with azithromycin may help achieve this. Our aim was to conduct a systematic review and individual participant data […]» Read more
Abstract: Individual susceptibility to exacerbations in chronic obstructive pulmonary disease (COPD) is likely influenced by genetic factors; however, most such variance is unexplained. We hypothesised that ?2-adrenergic receptor genotypes, Gly16Arg […]» Read more
Clinical effect on uncontrolled asthma using a novel digital automated self-management solution: a physician-blinded randomised controlled crossover trial.
Abstract: AsthmaTuner is a novel self-management system consisting of a patient app, a cloud-based storage solution and a healthcare interface. Patients use Bluetooth spirometers to measure lung function (FEV1) and […]» Read more
Abstract: Airway remodelling is a characteristic feature of asthma and is thought to play an important role in the pathogenesis of airway hyperresponsiveness. Myofibroblasts are key structural cells involved in […]» Read more
ERS/EAACI Statement on severe exacerbations in asthma in adult: facts, priorities and key research questions.
Abstract: Despite the use of effective medications to control asthma, severe exacerbations in asthma are still a major health risk and require urgent action on the part of the patient […]» Read more
Bronchial thermoplasty decreases airway remodelling by blocking epithelium-derived heat shock protein 60 (HSP60) secretion and protein arginine methyltransferase 1 (PRMT1) in fibroblasts.
Abstract: Bronchial thermoplasty (BT) is to date the only therapy, which lastingly reduces airway wall remodelling. However, the mechanism of action of BT is not well understood. This study aimed […]» Read more
The Role of the 17q21 Genotype in the Prevention of Early Childhood Asthma and Recurrent Wheeze by Vitamin D.
Abstract: Evidence suggests vitamin D has preventive potential for asthma, however, not all children benefit from this intervention. This study aims to investigate whether variation in the functional 17q21 SNP; […]» Read more
Abstract: Information on the clinical traits associated to bronchial neutrophilia in asthma is scant, preventing its recognition and adequate treatment. We aimed to assess the clinical, functional and biological features […]» Read more
Allergic Diseases and Long Term Risk of Autoimmune Disorders: longitudinal cohort study and cluster analysis.
Abstract: The association between allergic diseases (ADs) and autoimmune disorders (AIDs) is not well established.To determine incidence rates of AIDs in allergic rhinitis/conjunctivitis (ARC), atopic eczema (AE) and asthma, and […]» Read more
Abstract: A 63-year-old woman presented with a 2-year history of nonproductive cough. She denied the presence of shortness of breath, chest pain, arthralgia, muscle weakness, weight loss, night sweats, and […]» Read more
Abstract: Patients with asthma are at risk of hospitalisation with influenza, but the reasons for this predisposition are unknown.A prospective observational study of adults with PCR-confirmed influenza in 11 UK […]» Read more
Abstract: Emerging evidence suggests that air pollution may contribute to childhood asthma development. We estimated the burden of incident childhood asthma that may be attributable to outdoor NO2, PM2.5 and […]» Read more
Abstract: The Winter Meeting of the British Thoracic Society (BTS) is a platform for the latest clinical and scientific research in respiratory medicine. This review summarises some key symposia and […]» Read more