Performance Characteristics of Spirometry with Negative Bronchodilator Response and Methacholine Challenge Testing and Implications for Asthma Diagnosis.

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In patients with a history suggestive of asthma, diagnosis is usually confirmed by spirometry with bronchodilator response (BDR) or confirmatory methacholine challenge testing (MCT).We examined the proportion of participants with […]

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Development and clinical application of a prednisolone/cortisol assay to determine adherence to maintenance oral prednisolone in severe asthma.

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Non-adherence to oral prednisolone is an important driver of poor control in severe asthma, and its detection is warranted to guide management.to study the utility of liquid chromatography and tandem […]

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Mepolizumab in a population with severe eosinophilic asthma and corticosteroid dependence: results from a French early access programme.

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Mepolizumab was available in France as part of an early access programme for patients with severe eosinophilic asthma (nominative Temporary Use Authorisation [nATU]) before its commercialisation. This study aimed to […]

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Decreasing antibiotic use, the gut microbiota, and asthma incidence in children: evidence from population-based and prospective cohort studies.

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Childhood asthma incidence is decreasing in some parts of Europe and North America. Antibiotic use in infancy has been associated with increased asthma risk. In the present study, we tested […]

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Crucial role for lung iron level and regulation in the pathogenesis and severity of asthma.

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Accumulating evidence highlights links between iron regulation and respiratory disease. Here, we assessed the relationship between iron levels and regulatory responses in clinical and experimental asthma.We show that cell-free iron […]

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Maternal distress during pregnancy and recurrence in early childhood predicts atopic dermatitis and asthma in childhood.

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Using data from a provincial newborn screen and healthcare database for 12,587 children born in 2004, maternal distress was defined as: prenatal, and self-limiting, recurrent or late-onset postpartum. Atopic dermatitis […]

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Predictive value of blood eosinophils and exhaled nitric oxide in adults with mild asthma: a prespecified subgroup analysis of an open-label, parallel-group, randomised controlled trial.

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Whether blood eosinophil counts and exhaled nitric oxide (FeNO) are associated with important outcomes in mild asthma is unclear. In this prespecified subgroup analysis of a previously published open-label clinical […]

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Using fractional exhaled nitric oxide to guide step down treatment decisions in patients with asthma: a systematic review and individual patient data meta-analysis.

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High fractional exhaled nitric oxide (FeNO) levels are associated with greater risk of asthma exacerbations. However, it is not clear how FeNO can be used to guide safe reductions in […]

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Effect of fixed-dose subcutaneous reslizumab on asthma exacerbations in patients with severe uncontrolled asthma and corticosteroid sparing in patients with oral corticosteroid-dependent asthma: results from two phase 3, randomised, double-blind, placebo-controlled trials.

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Reslizumab 3 mg/kg administered intravenously is approved for the treatment of severe eosinophilic asthma. We assessed the safety and efficacy of subcutaneous reslizumab 110 mg in two trials in patients […]

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Adherence to Corticosteroids and Clinical Outcomes in Mepolizumab Therapy for Severe Asthma.

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Inhaled corticosteroids (ICS) achieve disease control in the majority of asthmatics, although adherence to prescribed ICS is often poor. Patients with severe eosinophilic asthma (SEA) may require treatment with oral […]

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Patient preferences for symptom-driven or regular preventer treatment in mild to moderate asthma – findings from the PRACTICAL study, a randomised clinical trial.

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Symptom-driven low-dose inhaled corticosteroid-formoterol is safe and effective in mild asthma and has been recommended as one of the preferred treatment regimens at steps 1 and 2 in the 2019 […]

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Bronchodilator response assessed using the forced oscillation technique identifies poor asthma control with greater sensitivity than spirometry.

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Persistent bronchodilator response (BDR) following diagnosis of asthma is an under-recognized treatable trait, associated with worse lung function and asthma control. The forced oscillation technique (FOT) measures respiratory system impedance […]

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Managing Chronic Cough due to Asthma and NAEB in Adults and Adolescents: CHEST Guideline and Expert Panel Report.

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Asthma and non-asthmatic eosinophilic bronchitis (NAEB) are among the commonest causes of chronic cough in adults. We sought to determine the role of non-invasive measurements of airway inflammation including induced […]

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Inducible epithelial resistance against acute Sendai virus infection prevents chronic asthma-like lung disease in mice.

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Respiratory viral infections play central roles in the initiation, exacerbation and progression of asthma in humans. An acute paramyxoviral infection in mice can cause a chronic lung disease that resembles […]

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Overuse of short-acting β2-agonists in asthma is associated with increased risk of exacerbation and mortality: A nationwide cohort study of the global SABINA programme.

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Overuse of short-acting β2 agonists (SABA) may indicate poor asthma control and adverse health outcomes. Contemporary population-based data on use, risk factors and impact of SABA (over)use on asthma exacerbations […]

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