Exposure to household air pollution over 10 years is related to asthma and lung function decline.

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Are long-term Household Air Pollutions (HAPs) associated with asthma and lung function decline in middle-aged adults, and whether these associations were modified by GST gene variants, ventilation and atopy.Prospective data […]

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A behaviour change intervention aimed at increasing physical activity improves clinical control in adults with asthma: a randomised controlled trial.

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Higher levels of physical activity have been associated with better asthma clinical control.Does a behaviour change intervention aimed at increasing physical activity change asthma clinical control, physical activity, sedentary time, […]

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Efficacy and safety of once-daily single-inhaler triple therapy (FF/UMEC/VI) versus FF/VI in patients with inadequately controlled asthma (CAPTAIN): a double-blind, randomised, phase 3A trial.

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Despite inhaled corticosteroid plus long-acting β2-agonist (ICS/LABA) therapy, 30-50% of patients with moderate or severe asthma remain inadequately controlled. We investigated the safety and efficacy of single-inhaler fluticasone furoate plus […]

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Composite type-2 biomarker strategy versus a symptom-risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial.

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Asthma treatment guidelines recommend increasing corticosteroid dose to control symptoms and reduce exacerbations. This approach is potentially flawed because symptomatic asthma can occur without corticosteroid responsive type-2 (T2)-driven eosinophilic inflammation, […]

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Allergen inhalation generates pro-inflammatory oxidised phosphatidylcholine associated with airway dysfunction.

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Oxidised phosphatidylcholines (OxPC) are produced under conditions of elevated oxidative stress and can contribute to human disease pathobiology. However, their role in allergic asthma is unexplored.Characterise the OxPC profile in […]

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Effect of Vitamin D3 Supplementation on Severe Asthma Exacerbations in Children With Asthma and Low Vitamin D Levels: The VDKA Randomized Clinical Trial.

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Severe asthma exacerbations cause significant morbidity and costs. Whether vitamin D3 supplementation reduces severe childhood asthma exacerbations is unclear.To determine whether vitamin D3 supplementation improves the time to a severe […]

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Real-world mepolizumab in the prospective severe asthma REALITI-A study – initial analysis.

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Efficacy of mepolizumab, an anti-interleukin-5 monoclonal antibody, was demonstrated in randomised, controlled trials; data on its real-world impact in routine clinical practice are starting to emerge. We assessed the effectiveness […]

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Self-management interventions to reduce healthcare use and improve quality of life among patients with asthma: systematic review and network meta-analysis.

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To compare the different self-management models (multidisciplinary case management, regularly supported self-management, and minimally supported self-management) and self-monitoring models against usual care and education to determine which are most effective […]

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Air pollution and family related determinants of asthma onset and persistent wheezing in children: nationwide case-control study.

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To identify risk factors (air pollution and family related) for the onset of asthma and persistent wheezing in children.Nationwide case-control study.Denmark.All Danish children born from 1997 to 2014 and followed […]

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Long-term trends of asthma, allergic rhinitis and atopic eczema in Finnish young men: a retrospective analysis, 1926‒2017.

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To assess the long-term time trends of the prevalence of asthma, allergic rhinitis and atopic eczema in Finnish young men.A retrospective analysis of cross-sectional data using statistics and reports of […]

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Assessing the strength of evidence for a causal effect of respiratory syncytial virus lower respiratory tract infections on subsequent wheezing illness: a systematic review and meta-analysis.

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Although a positive association has been established, it is unclear whether lower respiratory tract infections (LRTIs) with respiratory syncytial virus (RSV) cause chronic wheezing illnesses. If RSV-LRTI were causal, we […]

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Incidence of osteoporosis and fragility fractures in asthma: a UK population-based matched cohort study.

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Osteoporosis and fragility fractures (FF) are associated with corticosteroids which are the mainstay treatment for asthma; however, these bone comorbidities within asthma need to be better described.A matched cohort study […]

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Chlamydia trachomatis during pregnancy and childhood asthma-related morbidity: a population-based prospective cohort.

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Chlamydia trachomatis is the most commonly reported sexually transmitted disease and although infection during pregnancy is associated with neonatal complications, long-term respiratory consequences are unknown. We aimed to determine whether […]

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