Category: Respiratory
Results of an Expert Consensus Survey on the Treatment of Pulmonary Arterial Hypertension with Oral Prostacyclin Pathway Agents.
Treatment of pulmonary arterial hypertension (PAH) has evolved substantially over the past two decades and varies according to etiology, functional class (FC), hemodynamic parameters, and other clinical factors. Current guidelines […]
» Read moreUS States confront oil and gas drilling health hazards.
Acute ventilatory support during whole-body hybrid rowing in patients with high-level spinal cord injury: a randomized controlled cross-over trial.
High-level spinal cord injury (SCI) results in profound spinal and supraspinal deficits, leading to substantial ventilatory limitation during whole-body hybrid functional electrical stimulation (FES)-rowing, a form of exercise that markedly […]
» Read moreSensitivity of Radial Endobronchial Ultrasound Guided Bronchoscopy for Lung Cancer in Patients with Peripheral Pulmonary Lesions: An Updated Meta-Analysis.
Registry trials have found r-EBUS sensitivity to vary between institutions, suggesting that in clinical practice r-EBUS sensitivity may be lower than reported in clinical trials. We performed meta-analysis to update […]
» Read moreBurkholderia cenocepacia ET12 transmission in adults with cystic fibrosis.
This report describes transmission of a Burkholderia cenocepacia ET12 strain (ET12-Bc) at the Toronto Adult Cystic Fibrosis (CF) Centre occurring from 2008 to 2017. Epidemiological and genomic data from 11 […]
» Read moreBedaquiline, moxifloxacin, pretomanid, and pyrazinamide during the first 8 weeks of treatment of patients with drug-susceptible or drug-resistant pulmonary tuberculosis: a multicentre, open-label, partially randomised, phase 2b trial.
New anti-tuberculosis regimens that are shorter, simpler, and less toxic than those that are currently available are needed as part of the global effort to address the tuberculosis epidemic. We […]
» Read moreAre pretomanid-containing regimens for tuberculosis a victory or a victory narrative?
Neutrophils in community-acquired pneumonia: parallels in dysfunction at the extremes of age.
“Science means constantly walking a tight rope” Heinrich Rohrer, physicist, 1933. Community-acquired pneumonia (CAP) is the leading cause of death from infectious disease worldwide and disproportionately affects older adults and […]
» Read moreValidation of the COPD Assessment Test (CAT) as an outcome measure in bronchiectasis.
Objective assessment of symptoms in bronchiectasis is important for research and in clinical practice. The COPD Assessment Test (CAT) is a short, simple assessment tool widely used in chronic obstructive […]
» Read moreCaring for people with untreated pectus excavatum: An international online survey.
Pectus excavatum is a chest-wall deformity with no known cause and no standardized guidelines for evaluation or management. There is a pressing need to characterize the symptoms that these individuals […]
» Read moreAssociation between particulate matter air pollution and lung cancer.
Long-term exposure to particulate matter 2.5 μm (PM2.5) air pollution is associated with an increased risk of lung cancer. However, the evidence is limited in low-income and middle-income countries. We […]
» Read morePrevalence and clinical associations of Staphylococcus aureus small-colony variant respiratory infection in children with cystic fibrosis (SCVSA): a multicentre, observational study.
Staphylococcus aureus is the bacterium cultured most often from respiratory secretions of people with cystic fibrosis. Both meticillin-susceptible S aureus and meticillin-resistant S aureus (MRSA) can adapt to form slow-growing, […]
» Read moreMicrobiological outliers in cystic fibrosis: resolving uncertainty.
Grant Writing for Clinicians in Training: An Important Career Development Exercise.
Current perspectives on the role of Interleukin-1 signaling in the pathogenesis of Asthma and COPD.
Asthma and chronic obstructive pulmonary disease (COPD) cause significant morbidity and mortality worldwide. In the context of disease pathogenesis, both asthma and COPD involve chronic inflammation of the lung and […]
» Read moreViral Infection Increases the Risk of Idiopathic Pulmonary Fibrosis: A Meta-analysis.
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic lung disease with a poor prognosis. Although many factors have been identified to possibly trigger or aggravate IPF, such as viral […]
» Read moreClinical implications of incidental venous thromboembolism in cancer patients.
In cancer patients, current guidance suggests similar treatment for incidental and symptomatic venous thromboembolism (VTE), mainly based on retrospective data. We aimed to evaluate anticoagulant therapy in cancer patients with […]
» Read moreThe Impact of Gravity versus Suction-driven Therapeutic Thoracentesis on Pressure-related Complications: the GRAVITAS Multicenter Randomized Controlled Trial.
Thoracentesis can be accomplished by active aspiration or drainage with gravity. We investigated whether gravity drainage could protect against negative-pressure related complications, such as chest discomfort, re-expansion pulmonary edema or […]
» Read moreE-cigarette, or vaping, product use associated lung injury (EVALI): case series and diagnostic approach.
Since June, 2019, more than 1000 new cases of e-cigarette, or vaping, product use associated lung injury (EVALI) have been reported in the USA. Patients presented with dyspnoea, cough, and […]
» Read moreAirway Management in Critical Illness: An Update.
Expertise in airway management is a vital skill for any provider caring for critically ill patients. A growing body of literature has identified the stark difference in peri-procedural outcomes of […]
» Read moreVentilation inhomogeneity and bronchial basement membrane changes in chronic neutrophilic airway inflammation.
Bronchial epithelial reticular basement membrane (RBM) thickening occurs in diseases with both eosinophilic [allergic bronchial asthma (AB)] and neutrophilic [cystic fibrosis (CF), primary ciliary dyskinesia (PCD)] chronic airway inflammation; however, […]
» Read moreE-cigarette regulation: getting it wrong costs lives.
Extracorporeal membrane oxygenation for severe ARDS due to immune diffuse alveolar hemorrhage: a retrospective observational study.
WHO global progress report on tuberculosis elimination.
How I Do It: An Algorithmic Approach to the Interpretation of Diffuse Lung Disease on Chest CT Imaging.
Healthcare system encounters before COPD diagnosis: a registry-based longitudinal cohort study.
There is high interest in strategies for improving early detection of chronic obstructive pulmonary disease (COPD). These strategies often rely on opportunistic encounters between patients with undiagnosed COPD and the […]
» Read moreReturn to work after critical illness: a systematic review and meta-analysis.
Survivors of critical illness often experience poor outcomes after hospitalisation, including delayed return to work, which carries substantial economic consequences.To conduct a systematic review and meta-analysis of return to work […]
» Read moreERS/TSANZ Task Force Statement on the Management of Reproduction and Pregnancy in Women with Airways Diseases.
This Statement outlines a review of the literature and expert opinion concerning management of reproduction and pregnancy in women with airways diseases. The Statement represents the first collaboration of the […]
» Read moreCarbon footprint impact of the choice of inhalers for asthma and COPD.
In the 1990s, metered dose inhalers (MDIs) containing chlorofluorocarbons were replaced with dry-powder inhalers (DPIs) and MDIs containing hydrofluorocarbons (HFCs). While HFCs are not ozone depleting, they are potent greenhouse […]
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