EmPHasis-10 as a Measure of Health-Related Quality of Life in Pulmonary Arterial Hypertension: data from PHAR.

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While the performance of the emPHasis-10 (e10) score has been evaluated against limited patient characteristics within the United Kingdom, there is an unmet need for exploring the performance of the […]

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Development and validation of a deep learning algorithm detecting 10 common abnormalities on chest radiographs.

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We aimed to develop a deep-learning algorithm detecting 10 common abnormalities (DLAD-10) on chest radiographs and to evaluate its impact in diagnostic accuracy, timeliness of reporting, and workflow efficacy.DLAD-10 was […]

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World Health Organization recommendations on the treatment of drug-resistant tuberculosis, 2020 update.

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Antimicrobial resistance is a major public health problem globally. Likewise, forms of tuberculosis (TB) resistant to first- and second-line TB medicines present a major challenge for patients, health care workers […]

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Gestational age and hospital admissions during childhood: population based, record linkage study in England (TIGAR study).

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To examine the association between gestational age at birth and hospital admissions to age 10 years and how admission rates change throughout childhood.Population based, record linkage, cohort study in England.NHS […]

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Clinical trials in critical care: can a Bayesian approach enhance clinical and scientific decision making?

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Recent Bayesian reanalyses of prominent trials in critical illness have generated controversy by contradicting the initial conclusions based on conventional frequentist analyses. Many clinicians might be sceptical that Bayesian analysis, […]

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Frequency, risk factors, clinical characteristics and outcomes of spontaneous pneumothorax in patients with Covid-19: A case-control, emergency medicine-based multicenter study.

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Recent reports of COVID-19 patients developing pneumothorax mainly correspond to case reports in mechanically-ventilated patients. The real incidence, clinical characteristics and outcome of spontaneous pneumothorax (SP) as a form of […]

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Frequency, risk factors, clinical characteristics and outcomes of spontaneous pneumothorax in patients with Covid-19: A case-control, emergency medicine-based multicenter study.

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Recent reports of COVID-19 patients developing pneumothorax mainly correspond to case reports in mechanically-ventilated patients. The real incidence, clinical characteristics and outcome of spontaneous pneumothorax (SP) as a form of […]

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Trajectories of asthma and allergies from 7 years to 53 years and associations with lung function and extrapulmonary comorbidity profiles: a prospective cohort study.

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Longitudinal trajectories of asthma and allergies from childhood to adulthood might be differentially associated with lung function and chronic obstructive pulmonary disease (COPD), but associations with extrapulmonary comorbidities have not […]

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Normative cardiopulmonary exercise test responses at the ventilatory threshold in Canadian adults aged 40-80 years.

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Physiological and symptom responses at the ventilatory threshold (Tvent) during incremental cardiopulmonary exercise testing (CPET) can provide important prognostic information.This study aimed to develop an updated normative reference set for […]

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Transcriptome analysis of IPF fibroblastic foci identifies key pathways involved in fibrogenesis.

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Fibroblastic foci represent the cardinal pathogenic lesion in idiopathic pulmonary fibrosis (IPF) and comprise activated fibroblasts and myofibroblasts, the key effector cells responsible for dysregulated extracellular matrix deposition in multiple […]

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Added Diagnostic Utility Of Clinical Metagenomics For The Diagnosis Of Pneumonia In Immunocompromised Adults.

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In the evaluation of community-acquired pneumonia, 30-60% of cases remain undiagnosed, despite extensive conventional microbiologic testing (CMT). Clinical metagenomics (CM) is an unbiased pathogen detection method that can increase diagnostic […]

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Low-tidal volume mechanical ventilation against no ventilation during cardiopulmonary bypass in heart surgery (MECANO): a randomized controlled trial.

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Postoperative pulmonary complications are common after cardiac surgery and have been related to lung collapsus during cardiopulmonary bypass (CPB). There is no consensus on the effects of maintaining mechanical ventilation […]

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Transcriptome analysis of IPF fibroblastic foci identifies key pathways involved in fibrogenesis.

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Fibroblastic foci represent the cardinal pathogenic lesion in idiopathic pulmonary fibrosis (IPF) and comprise activated fibroblasts and myofibroblasts, the key effector cells responsible for dysregulated extracellular matrix deposition in multiple […]

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Risk Factors for and Time to Recurrence of Symptomatic Malignant Pleural Effusion in Patients with Metastatic Non-Small Cell Lung Cancer with EGFR or ALK Mutations.

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The main goal of management in patients with NSCLC and MPE is palliation. PVatients with MPE and actionable mutations, because their disease is expected to quickly and markedly respond to […]

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Epigenetics and pulmonary diseases in the horizon of precision medicine: a review.

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Epigenetic mechanisms represent potential molecular routes which could bridge the gap between genetic background and environmental risk factors contributing to the pathogenesis of pulmonary diseases. In patients with chronic obstructive […]

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Target-inhibition of Galectin-3 by Inhaled TD139 in Patients with Idiopathic Pulmonary Fibrosis.

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Galectin-3 (Gal-3) is a pro-fibrotic β-galactoside-binding lectin that plays a key role in the pathogenesis of idiopathic pulmonary fibrosis (IPF) and IPF exacerbations. TD139 is a novel and potent small […]

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