Osimertinib in Resected EGFR-Mutated Non-Small-Cell Lung Cancer.

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Osimertinib is standard-of-care therapy for previously untreated epidermal growth factor receptor (EGFR) mutation-positive advanced non-small-cell lung cancer (NSCLC). The efficacy and safety of osimertinib as adjuvant therapy are unknown.In this […]

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“A National Survey of Burnout and Depression Among Fellows Training in Pulmonary and Critical Care Medicine: A Special Report by the APCCMPD.

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The prevalence of burnout and depressive symptoms is high among physician trainees.What is the burden of burnout and depressive symptoms among fellows training in pulmonary and critical care medicine (PCCM) […]

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Effect of aspirin on deaths associated with sepsis in healthy older people (ANTISEPSIS): a randomised, double-blind, placebo-controlled primary prevention trial.

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Sepsis is a serious global health issue and a major cause of death and disability. The availability of a simple, community-based preventive strategy could substantially reduce the burden of sepsis. […]

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Phagosome-regulated mTOR Signalling during Sarcoidosis Granuloma Biogenesis.

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Sarcoidosis and tuberculosis are granulomatous pulmonary diseases characterised by heightened immune reactivity to Mycobacterium tuberculosis (M.tb.) antigens. We hypothesised that an unsupervised analysis comparing the molecular characteristics of granulomas formed […]

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Exposure to household air pollution over 10 years is related to asthma and lung function decline.

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Are long-term Household Air Pollutions (HAPs) associated with asthma and lung function decline in middle-aged adults, and whether these associations were modified by GST gene variants, ventilation and atopy.Prospective data […]

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The Self-fulfilling Prophecy of Pulmonary Fibrosis: A Selective Inspection of Pathologic Signaling Loops.

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Pulmonary fibrosis is a devastating, progressive disease and carries a prognosis worse than most cancers. Despite ongoing research, the mechanism(s) which underlie disease pathogenesis remain only partially understood. However, the […]

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Aspirin reduces cardiovascular events in patients with pneumonia: a prior event rate ratio analysis in a large primary care database.

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Ischaemic stroke and myocardial infarction (MI) are common after pneumonia and are associated with long-term mortality. Aspirin may attenuate this risk and should be explored as a therapeutic option.We extracted […]

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Effects of Random Measurement Error on Lung Cancer Screening Decisions:: A Retrospective-Cohort-Based Microsimulation Study.

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Self-reported tobacco pack-year history plays a large role in decisions about low-dose computed tomography (CT) lung cancer screening yet is challenging to measure accurately.To what extent does random measurement error […]

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Association between nutritional profiles of foods underlying Nutri-Score front-of-pack labels and mortality: EPIC cohort study in 10 European countries.

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To determine if the Food Standards Agency nutrient profiling system (FSAm-NPS), which grades the nutritional quality of food products and is used to derive the Nutri-Score front-of-packet label to guide […]

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A behaviour change intervention aimed at increasing physical activity improves clinical control in adults with asthma: a randomised controlled trial.

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Higher levels of physical activity have been associated with better asthma clinical control.Does a behaviour change intervention aimed at increasing physical activity change asthma clinical control, physical activity, sedentary time, […]

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Maxim Integrated Smartphone Sensor with App Meets FDA/ISO Standards for Clinical Pulse Oximetry and can be Reliably Utilized by a Wide Range of Patients.

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Millions of smartphones contain a photoplethysmography (PPG) bio-sensor (Maxim Integrated, San Jose CA) that accurately measures pulse oximetry. No clinical use of these embedded sensors is currently being made, despite […]

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