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Mepolizumab was available in France as part of an early access programme for patients with severe eosinophilic asthma (nominative Temporary Use Authorisation [nATU]) before its commercialisation. This study aimed to […]
» Read moreNoninvasive ventilation (NIV) is standard of care for chronic hypercapnic respiratory failure but indications, devices and ventilatory modes are in constant evolution.To describe changes in prevalence, and indications for NIV […]
» Read moreTachycardia and atrial fibrillation frequently occur in patients being treated for sepsis or septic shock and have a poor prognosis. Treatments for tachyarrhythmias are often ineffective or contraindicated in this […]
» Read moreThere remains uncertainty in the optimal prognostication and management of patients with intermediate-risk PE. Transthoracic echocardiography can identify right ventricular (RV) dysfunction to recognise intermediate-high risk patients.The aim of this […]
» Read moreWhether hydrocortisone, vitamin C, and thiamine treatment can reduce the mortality of patients with sepsis is controversial.To evaluate the efficacy and safety of hydrocortisone, vitamin C, and thiamine combination treatment […]
» Read moreAs global awareness of air pollution rises, so does the imperative to provide evidence-based recommendations for strategies to mitigate its impact. While public policy has a central role in reducing […]
» Read moreIn animal models of pulmonary arterial hypertension (PAH), angiotensin converting enzyme type 2 (ACE2) and Angiotensin 1-7 [Ang-(1-7)] have been shown to have vasodilatory, anti-proliferative, anti-fibrotic and anti-hypertrophic properties. However, […]
» Read moreOutcomes for adults with community-acquired pneumonia (CAP) admitted to hospital at the weekend were compared with those admitted during weekdays using data from the British Thoracic Society national CAP audits. […]
» Read morePulmonary cysts and spontaneous pneumothorax are presented in most patients with Birt-Hogg-Dubé (BHD) syndrome, which is caused by loss of function mutations in the folliculin (FLCN) gene. The pathogenic mechanisms […]
» Read moreAdmission to high-acuity intensive care units (ICUs) has been associated with improved outcomes compared to low-acuity ICUs, although the mechanism for these findings is unclear.Do high-acuity ICUs more effectively implement […]
» Read moreChronic lung disease is a common cause of mortality, yet little is known about where individuals with chronic lung disease die.What are the trends and factors associated with place of […]
» Read moreChronic pulmonary aspergillosis (CPA) is often poorly responsive to antifungal treatment; secondary infections increase morbidity/mortality, particularly in progressive cases. Interferon gamma (IFNγ) has been implicated in not only Aspergillus control […]
» Read morePatients with chronic obstructive pulmonary disease (COPD) in advanced disease stage who need long-term home oxygen therapy (LTHOT) have difficulty participating in outpatient pulmonary rehabilitation (PR) programs due to the […]
» Read morePulmonary rehabilitation (PR) is an effective, key standard treatment for people with COPD. Nevertheless, low participant uptake, insufficient attendance and high drop-out rates are reported. Investigation is warranted of the […]
» Read moreChildren with congenital heart disease (CHD) have an increased risk of neurocognitive impairment. No prior studies have evaluated the role of obstructive sleep apnea (OSA), which is associated with neurocognitive […]
» Read moreChildhood asthma incidence is decreasing in some parts of Europe and North America. Antibiotic use in infancy has been associated with increased asthma risk. In the present study, we tested […]
» Read morePulmonary involvement in lymphatic anomalies (LA) is associated with significant morbidity and mortality. Recently described Dynamic Contrast Enhanced Magnetic Resonance lymphangiography (DCMRL) is capable of imaging the lymphatic system in […]
» Read moreThe World Health Organization (WHO) recommends tuberculosis (TB) preventive treatment for high-risk groups. Isoniazid preventive therapy (IPT) has been used globally for this purpose for many years, including in pregnancy. […]
» Read moreAcute exacerbations of chronic obstructive pulmonary disease (COPD) are associated with a significant mortality, health and economic burden. Their diagnosis, assessment and management remain suboptimal and unchanged for decades. Recent […]
» Read moreAlthough erythropoiesis is impaired and anaemia frequent in neonates born preterm, haematopoiesis in adults born preterm has not been previously studied.We, thus, aimed to evaluate haemoglobin and erythropoietin levels in […]
» Read moreIn this randomised, crossover trial, 22 patients with severe chronic obstructive pulmonary disease climbed six flights of stairs (108 steps) twice, under two test conditions: (1) energy conservation technique (ECT): […]
» Read moreIsolated PE is associated with a higher burden of atherosclerotic disease than other manifestations of venous thromboembolism (VTE).We hypothesized that the presence of isolated PE may signal a chronically elevated […]
» Read moreObesity hypoventilation syndrome (OHS) is treated with either non-invasive ventilation (NIV) or CPAP, but there are no long-term cost-effectiveness studies comparing the two treatment modalities.We performed a large, multicentre, randomised, […]
» Read moreRSV bronchiolitis is the most common cause of infant hospital admissions, but there is limited understanding of the mechanisms of disease and no specific anti-viral treatment. Using a novel in […]
» Read moreThe use of thoracic CT for patients presenting with a unilateral pleural effusion is well established. However, there is no consensus with regard to the inclusion of the entire abdomen […]
» Read moreWe used data from the INBUILD and INPULSIS trials to investigate the natural history of progressive fibrosing interstitial lung diseases (ILDs).Subjects in the two INPULSIS trials had a clinical diagnosis […]
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