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Exogenous lipoid pneumonia (ELP) develops when lipid-containing substances enter the airways through aspiration or inhalation, and incite an inflammatory response. The diagnosis of ELP is often difficult as findings may […]
» Read moreSince COVID-19 was identified, its clinical and biological heterogeneity has been recognized. Identifying COVID-19 phenotypes might help guide basic, clinical, and translational research efforts.Does the clinical spectrum of patients with […]
» Read moreSurvivors of critical care may develop mental health disorders in the months after discharge.Which are risk factors for mental health disorders after ICU-discharge; and is there association between the burden […]
» Read moreAsthma differs from many other chronic conditions in that most key management decisions are made in non-specialist settings, such as general practitioner surgeries and accident and emergency departments. Diagnosis in […]
» Read moreTo develop and validate a prediction model of mortality in patients with COVID-19 attending hospital emergency rooms.Multivariable prognostic prediction model.127 Spanish hospitals.Derivation (DC) and external validation (VC) cohorts were obtained […]
» Read moreBronchiectasis is a well-recognised complication of primary antibody deficiency (PAD) syndromes. Previous data suggest that mortality in common variable immune deficiency (CVID) is not associated with isolated bronchiectasis. A retrospective […]
» Read moreThe optimal oxygenation in mechanically ventilated critically ill patients remains unclear.Randomised controlled trials investigating different oxygenation goal-directed mechanical ventilation in critically ill adult patients were eligible. The trinary classification classified […]
» Read moreThere is growing interest in the impact of greenness exposure on airway diseases, but the impact of greenness on lung function in children is limited. We aimed to investigate the […]
» Read moreAsthma in pregnancy is associated with respiratory diseases in the offspring.To investigate if maternal asthma is associated with lung function in early life.Data on lung function measured at 5-6 weeks of […]
» Read moreAirway inflammation plays a key role in asthma pathogenesis but is heterogeneous in nature. There has been significant scientific discovery with regard to type 2-driven, eosinophil-dominated asthma, with effective therapies […]
» Read moreEnd points that are repeatable and sensitive to change are important in pulmonary arterial hypertension (PAH) for clinical practice and trials of new therapies. In 42 patients with PAH, test-retest […]
» Read morePulmonary arterial hypertension (PAH) is a progressive disease predominantly targeting pre-capillary blood vessels. Adverse structural re-modelling and increased pulmonary vascular resistance result in cardiac hypertrophy and ultimately failure of the […]
» Read moreStudies of asthma and chronic obstructive pulmonary disease (COPD) typically focus on these diagnoses separately, limiting understanding of disease mechanisms and treatment options. NOVELTY is a global, 3-year, prospective observational […]
» Read moreEvidence suggests that vascular inflammation and thrombosis may be important drivers of poor clinical outcomes in patients with COVID-19. We hypothesized that a significant decrease in the percentage of blood […]
» Read moreSolriamfetol, a dopamine-norepinephrine reuptake inhibitor, is approved in the USA to improve wakefulness in adults with excessive daytime sleepiness (EDS) associated with obstructive sleep apnea (OSA) (37.5-150 mg/d).Does solriamfetol have […]
» Read moreThe prevalence of venous thromboembolic event (VTE) and arterial thromboembolic event (ATE) thromboembolic events in patients with COVID-19 remains largely unknown.In this meta-analysis, we systematically searched for observational studies describing […]
» Read moreAs mass vaccination campaigns against coronavirus disease 2019 (Covid-19) commence worldwide, vaccine effectiveness needs to be assessed for a range of outcomes across diverse populations in a noncontrolled setting. In […]
» Read moreInhalational exposures are increasingly recognized as contributing factors in interstitial lung disease (ILD). However, the characteristics of both exposures and exposed patients are not well understood. We hypothesized that domestic […]
» Read moreAtrial fibrillation (AF) with rapid ventricular response frequently complicates the management of critically ill patients with sepsis and may necessitate the initiation of medication to avoid hemodynamic compromise. However, the […]
» Read moreImmune checkpoint inhibitors (ICI) are standard treatments for advanced non-small cell lung cancer and have expanded use in small cell lung cancer. While generally better tolerated than traditional chemotherapy, immune-related […]
» Read moreMycobacterium abscessus-pulmonary disease (MABS-PD) is challenging to treat due to its resistance to antibiotics.What are the outcomes of treatment-naïve MABS-PD patients treated with inhaled amikacin-containing multidrug regimens?We identified 82 treatment-naïve […]
» Read moreSeverity of illness in COVID-19 is consistently lower in women. Focus on sex as a biologic factor may suggest a potential therapeutic intervention for this disease. We assessed whether adding […]
» Read moreStudies show uneven access to Medicare-approved lung cancer screening (LCS) programs across the US. The Veterans Health Administration (VA), the largest national US integrated health system, is potentially well-positioned to […]
» Read moreIndividuals diagnosed with cystic fibrosis (CF) as adults represent a rare but growing subset of the CF population; there are limited studies describing their lung function trajectories.What is the overall […]
» Read moreDespite the frequency and cost of hospitalizations for acute respiratory failure, there is a paucity of literature regarding the impact of hospital safety net burden on outcomes of these hospitalizations.How […]
» Read moreWhilst estimates of sub-optimal adherence to oral corticosteroids in asthma range from 30 to 50%, no ideal method for measurement exists; the impact of poor adherence in severe asthma is […]
» Read moreThe formulation of expert-opinion guidelines has several sources of bias that may adversely affect their quality. To minimize bias, guideline creators must employ rigorous methodology. There has been no appraisal […]
» Read moreSleep disordered breathing (SDB) is highly prevalent in adults and leads to significant cardiovascular and neurological sequelae. Intermittent hypoxia during sleep is a direct consequence of SDB. Nocturnal supplemental oxygen […]
» Read morePediatric pulmonary hypertension (PH) is a severe disease defined by sustained elevation of pulmonary artery pressures, and pulmonary vascular resistance (PVR). Noninvasive diagnostic and prognostic markers that are more pulmonary […]
» Read moreA relationship between inhalational exposure to materials in the environment and development of interstitial lung disease (ILD) is long recognized. Hypersensitivity pneumonitis (HP) is an environmentally induced diffuse parenchymal lung […]
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