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The impact of ECG presentations of acute myocardial infarction (AMI) in cardiogenic shock is unknown.In myocardial infarction with cardiogenic shock, is there a difference in the outcomes and effect of […]
» Read moreWhile the performance of the emPHasis-10 (e10) score has been evaluated against limited patient characteristics within the United Kingdom, there is an unmet need for exploring the performance of the […]
» Read moreWe aimed to develop a deep-learning algorithm detecting 10 common abnormalities (DLAD-10) on chest radiographs and to evaluate its impact in diagnostic accuracy, timeliness of reporting, and workflow efficacy.DLAD-10 was […]
» Read moreSmall airways disease (SAD) is a key component of COPD and is a main contributing factor to lung function decline.Is small airways disease a key feature of frequent COPD exacerbators […]
» Read moreRespiratory complaints like swimming induced pulmonary edema (SIPE) are a common feature of United States Navy Special Warfare (NSW) training. We designed a study to evaluate the incidence and clinical […]
» Read moreThere is currently limited understanding of the genetic aetiology of obstructive sleep apnoea (OSA). We aimed at identifying genetic loci associated with OSA risk and to test if OSA and […]
» Read moreInfluenza epidemics remain a leading cause of morbidity and mortality worldwide. In the current study, we investigated the impact of chronological aging on tryptophan metabolism in response to influenza infection. […]
» Read moreAntimicrobial resistance is a major public health problem globally. Likewise, forms of tuberculosis (TB) resistant to first- and second-line TB medicines present a major challenge for patients, health care workers […]
» Read moreAlthough delamanid has been approved for the treatment of multidrug-resistant tuberculosis (MDR-TB) in numerous regions, in areas where it is not yet registered, it can be accessed as part of […]
» Read moreTo examine the association between gestational age at birth and hospital admissions to age 10 years and how admission rates change throughout childhood.Population based, record linkage, cohort study in England.NHS […]
» Read moreRecent Bayesian reanalyses of prominent trials in critical illness have generated controversy by contradicting the initial conclusions based on conventional frequentist analyses. Many clinicians might be sceptical that Bayesian analysis, […]
» Read moreRecent reports of COVID-19 patients developing pneumothorax mainly correspond to case reports in mechanically-ventilated patients. The real incidence, clinical characteristics and outcome of spontaneous pneumothorax (SP) as a form of […]
» Read moreRecent reports of COVID-19 patients developing pneumothorax mainly correspond to case reports in mechanically-ventilated patients. The real incidence, clinical characteristics and outcome of spontaneous pneumothorax (SP) as a form of […]
» Read moreWorldwide, healthcare professionals are experiencing unprecedented stress related to the COVID-19 pandemic. Responding to a new virus for which there is no effective treatment yet and no vaccine, is beyond […]
» Read moreThe World Health Organization (WHO) recommends following up passengers following possible exposure to a case of infectious tuberculosis (TB) during air travel. This is known to be time consuming and […]
» Read moreObstructive sleep apnea (OSA) is associated with an increased prevalence of aortic aneurysms, and it has also been suggested that severe OSA furthers aneurysm expansion in the abdomen. We evaluated […]
» Read moreLongitudinal trajectories of asthma and allergies from childhood to adulthood might be differentially associated with lung function and chronic obstructive pulmonary disease (COPD), but associations with extrapulmonary comorbidities have not […]
» Read moreLittle is known about whether DNA methylation (DNAm) of cytosine-phosphate-guanine (CpG) sites at birth predicts patterns of lung function development. We used heel prick DNAm from the F1-generation of Isle […]
» Read moreClinical heterogeneity in bronchiectasis remains a challenge to improve the appropriate targeting of therapies and patient management. Antimicrobial peptides (AMPs) have been linked to disease severity and phenotype.Can we identify […]
» Read morePhysiological and symptom responses at the ventilatory threshold (Tvent) during incremental cardiopulmonary exercise testing (CPET) can provide important prognostic information.This study aimed to develop an updated normative reference set for […]
» Read moreFibroblastic foci represent the cardinal pathogenic lesion in idiopathic pulmonary fibrosis (IPF) and comprise activated fibroblasts and myofibroblasts, the key effector cells responsible for dysregulated extracellular matrix deposition in multiple […]
» Read moreIn the evaluation of community-acquired pneumonia, 30-60% of cases remain undiagnosed, despite extensive conventional microbiologic testing (CMT). Clinical metagenomics (CM) is an unbiased pathogen detection method that can increase diagnostic […]
» Read morePostoperative pulmonary complications are common after cardiac surgery and have been related to lung collapsus during cardiopulmonary bypass (CPB). There is no consensus on the effects of maintaining mechanical ventilation […]
» Read moreFibroblastic foci represent the cardinal pathogenic lesion in idiopathic pulmonary fibrosis (IPF) and comprise activated fibroblasts and myofibroblasts, the key effector cells responsible for dysregulated extracellular matrix deposition in multiple […]
» Read morePrior reports on a possible female survival advantage in both surgical and non-surgical cohorts of patients with lung cancer are conflicting. Previously reported differences in survival following lung cancer surgery […]
» Read moreThe main goal of management in patients with NSCLC and MPE is palliation. PVatients with MPE and actionable mutations, because their disease is expected to quickly and markedly respond to […]
» Read moreEpigenetic mechanisms represent potential molecular routes which could bridge the gap between genetic background and environmental risk factors contributing to the pathogenesis of pulmonary diseases. In patients with chronic obstructive […]
» Read moreGalectin-3 (Gal-3) is a pro-fibrotic β-galactoside-binding lectin that plays a key role in the pathogenesis of idiopathic pulmonary fibrosis (IPF) and IPF exacerbations. TD139 is a novel and potent small […]
» Read moreLung function is an important predictor of health and a marker of physical functioning at older ages. This study aimed to quantify the years of lung function lost according to […]
» Read moreThe clinical activities regarding sleep disordered breathing (SDB) have been sharply interrupted during the initial phase of the COVID-19 epidemic throughout Europe. In the last months, activities have gradually restarted, […]
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