Studies suggest an increased all-cause mortality among adults with asthma. We aimed to study the relationship between asthma in children and young adults and all-cause mortality, and investigate differences in […]» Read more
Lung-Protective Ventilation and Associated Outcomes and Costs Among Patients Receiving Invasive Mechanical Ventilation in the Emergency Department.
Invasive mechanical ventilation is often initiated in the Emergency Department (ED), and mechanically ventilated patients may be kept in the ED for hours prior to intensive care unit (ICU) transfer. […]» Read more
Pulmonary exacerbations in adults with cystic fibrosis – a grown-up issue in a changing CF landscape.
Pulmonary exacerbations (PEx) are significant life events in people with cystic fibrosis (CF), associated with declining lung function, reduced quality of life (QoL), hospitalisations and decreased survival. The adult CF […]» Read more
Osimertinib is standard-of-care therapy for previously untreated epidermal growth factor receptor (EGFR) mutation-positive advanced non-small-cell lung cancer (NSCLC). The efficacy and safety of osimertinib as adjuvant therapy are unknown.In this […]» Read more
There is increasing interest in the effects of sleep and sleep disturbances on the brain, particularly in relation to aging and neurodegenerative processes. Parkinson’s disease (PD) is the second most […]» Read more
Emotional intelligence (EI) has become widely appreciated as an important leadership attribute, in business, education and, increasingly, in healthcare. Defined as “the capacity to understand your own and others’ emotions […]» Read more
With the advancement of cardio-respiratory interventions, the survival rate among patients with Duchenne muscular dystrophy has increased. Subsequently, pneumothorax has become a significant problem in patients with prolonged ventilatory support.We […]» Read more
The coronavirus pandemic has disrupted clinical practice, healthcare organizations, and life. In the context that “a crisis is a terrible thing to waste,” as disruptive as the pandemic has been […]» Read more
In the context that leadership matters and that leadership competencies differ from those needed to practice medicine or conduct research, developing leadership competencies for physicians is important. Indeed, effective leadership […]» Read more
“A National Survey of Burnout and Depression Among Fellows Training in Pulmonary and Critical Care Medicine: A Special Report by the APCCMPD.
The prevalence of burnout and depressive symptoms is high among physician trainees.What is the burden of burnout and depressive symptoms among fellows training in pulmonary and critical care medicine (PCCM) […]» Read more
No therapies for targeting KRAS mutations in cancer have been approved. The KRAS p.G12C mutation occurs in 13% of non-small-cell lung cancers (NSCLCs) and in 1 to 3% of colorectal […]» Read more
Effect of aspirin on deaths associated with sepsis in healthy older people (ANTISEPSIS): a randomised, double-blind, placebo-controlled primary prevention trial.
Sepsis is a serious global health issue and a major cause of death and disability. The availability of a simple, community-based preventive strategy could substantially reduce the burden of sepsis. […]» Read more
Chronic tobacco smoke exposure results in a broad range of lung pathologies including emphysema, airway disease and parenchymal fibrosis as well as a multitude of extra-pulmonary comorbidities. Prior work using […]» Read more
Patient-derived malignant pleural mesothelioma cell cultures: a tool to advance biomarker-driven treatments.
Malignant pleural mesothelioma (MPM) is an aggressive cancer, associated with poor prognosis. We assessed the feasibility of patient-derived cell cultures to serve as an ex vivo model of MPM. Patient-derived […]» Read more
Exposure to tobacco content in films is a cause of smoking uptake in young people. In an earlier study, we reported that tobacco content occurred in 70% of UK box […]» Read more
Sarcoidosis and tuberculosis are granulomatous pulmonary diseases characterised by heightened immune reactivity to Mycobacterium tuberculosis (M.tb.) antigens. We hypothesised that an unsupervised analysis comparing the molecular characteristics of granulomas formed […]» Read more
Are long-term Household Air Pollutions (HAPs) associated with asthma and lung function decline in middle-aged adults, and whether these associations were modified by GST gene variants, ventilation and atopy.Prospective data […]» Read more
In patients with chronic fibrosing interstitial lung disease (ILD), a progressive fibrosing phenotype (PF-ILD) may develop, but information on the frequency and characteristics of this population outside clinical trials is […]» Read more
Obesity is a common co-morbidity in asthma and associated with poorer asthma control, more frequent/severe exacerbations, and reduced response to asthma pharmacotherapy.This review aims to compare use of all classes […]» Read more
The Self-fulfilling Prophecy of Pulmonary Fibrosis: A Selective Inspection of Pathologic Signaling Loops.
Pulmonary fibrosis is a devastating, progressive disease and carries a prognosis worse than most cancers. Despite ongoing research, the mechanism(s) which underlie disease pathogenesis remain only partially understood. However, the […]» Read more
Aspirin reduces cardiovascular events in patients with pneumonia: a prior event rate ratio analysis in a large primary care database.
Ischaemic stroke and myocardial infarction (MI) are common after pneumonia and are associated with long-term mortality. Aspirin may attenuate this risk and should be explored as a therapeutic option.We extracted […]» Read more
Effects of Random Measurement Error on Lung Cancer Screening Decisions:: A Retrospective-Cohort-Based Microsimulation Study.
Self-reported tobacco pack-year history plays a large role in decisions about low-dose computed tomography (CT) lung cancer screening yet is challenging to measure accurately.To what extent does random measurement error […]» Read more
Characteristics of critically ill adults with coronavirus disease 2019 (COVID-19) in an academic safety net hospital and the effect of evidence-based practices in these patients are unknown.What are the outcomes […]» Read more
Long-term oxygen therapy improves survival in patients with chronic obstructive pulmonary disease (COPD) and chronic severe daytime hypoxemia. However, the efficacy of oxygen therapy for the management of isolated nocturnal […]» Read more
Association between nutritional profiles of foods underlying Nutri-Score front-of-pack labels and mortality: EPIC cohort study in 10 European countries.
To determine if the Food Standards Agency nutrient profiling system (FSAm-NPS), which grades the nutritional quality of food products and is used to derive the Nutri-Score front-of-packet label to guide […]» Read more
Pulmonary hemodynamics during exercise may reveal early pulmonary vascular disease and be of clinical and prognostic relevance in systemic sclerosis (SSc). We aimed to assess the prognostic relevance of exercise […]» Read more
A behaviour change intervention aimed at increasing physical activity improves clinical control in adults with asthma: a randomised controlled trial.
Higher levels of physical activity have been associated with better asthma clinical control.Does a behaviour change intervention aimed at increasing physical activity change asthma clinical control, physical activity, sedentary time, […]» Read more
Behavioral and regional brain responses to inhalation of capsaicin modified by painful conditioning in humans.
Cough is a defense mechanism that protects the airways and lungs in response to airway irritation. The sensory neurons involved in detecting airway irritants and the neural pathways mediating cough […]» Read more
The COVID-19 pandemic has severely impacted Intensive Care Units (ICUs) and Critical Care Healthcare Providers (HCPs) worldwide.How do regional differences and perceived lack of ICU resources affect critical care resource […]» Read more
Maxim Integrated Smartphone Sensor with App Meets FDA/ISO Standards for Clinical Pulse Oximetry and can be Reliably Utilized by a Wide Range of Patients.
Millions of smartphones contain a photoplethysmography (PPG) bio-sensor (Maxim Integrated, San Jose CA) that accurately measures pulse oximetry. No clinical use of these embedded sensors is currently being made, despite […]» Read more