The burden of mental illness among survivors of critical care – risk factors and impact on quality of life: a multicenter prospective cohort study.

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Survivors of critical care may develop mental health disorders in the months after discharge.Which are risk factors for mental health disorders after ICU-discharge; and is there association between the burden […]

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Development and validation of a prediction model for 30-day mortality in hospitalised patients with COVID-19: the COVID-19 SEIMC score.

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To develop and validate a prediction model of mortality in patients with COVID-19 attending hospital emergency rooms.Multivariable prognostic prediction model.127 Spanish hospitals.Derivation (DC) and external validation (VC) cohorts were obtained […]

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Classification and effectiveness of different oxygenation goals in mechanically ventilated critically ill patients: network meta-analysis of randomised controlled trials.

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The optimal oxygenation in mechanically ventilated critically ill patients remains unclear.Randomised controlled trials investigating different oxygenation goal-directed mechanical ventilation in critically ill adult patients were eligible. The trinary classification classified […]

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The pathophysiological role of novel pulmonary arterial hypertension gene SOX17.

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Pulmonary arterial hypertension (PAH) is a progressive disease predominantly targeting pre-capillary blood vessels. Adverse structural re-modelling and increased pulmonary vascular resistance result in cardiac hypertrophy and ultimately failure of the […]

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Heterogeneity within and between physician-diagnosed asthma and/or COPD: NOVELTY cohort.

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Studies of asthma and chronic obstructive pulmonary disease (COPD) typically focus on these diagnoses separately, limiting understanding of disease mechanisms and treatment options. NOVELTY is a global, 3-year, prospective observational […]

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Randomized Controlled Trial of Solriamfetol for Excessive Daytime Sleepiness in Obstructive Sleep Apnea: An Analysis of Subgroups Adherent or Nonadherent to Obstructive Sleep Apnea Treatment.

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Solriamfetol, a dopamine-norepinephrine reuptake inhibitor, is approved in the USA to improve wakefulness in adults with excessive daytime sleepiness (EDS) associated with obstructive sleep apnea (OSA) (37.5-150 mg/d).Does solriamfetol have […]

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Characteristics and Prevalence of Domestic and Occupational Inhalational Exposures Across Interstitial Lung Diseases.

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Inhalational exposures are increasingly recognized as contributing factors in interstitial lung disease (ILD). However, the characteristics of both exposures and exposed patients are not well understood. We hypothesized that domestic […]

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Immune checkpoint inhibitor-related pneumonitis in lung cancer: real-world incidence, risk factors, and management practices across six health care centers in North Carolina.

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Immune checkpoint inhibitors (ICI) are standard treatments for advanced non-small cell lung cancer and have expanded use in small cell lung cancer. While generally better tolerated than traditional chemotherapy, immune-related […]

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Outcomes of inhaled amikacin-containing multidrug regimens for Mycobacterium abscessus pulmonary disease.

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Mycobacterium abscessus-pulmonary disease (MABS-PD) is challenging to treat due to its resistance to antibiotics.What are the outcomes of treatment-naïve MABS-PD patients treated with inhaled amikacin-containing multidrug regimens?We identified 82 treatment-naïve […]

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Progesterone in Addition to Standard of Care Versus Standard of Care Alone in the Treatment of Men Hospitalized with Moderate to Severe COVID-19: A Randomized, Controlled Pilot Trial.

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Severity of illness in COVID-19 is consistently lower in women. Focus on sex as a biologic factor may suggest a potential therapeutic intervention for this disease. We assessed whether adding […]

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Access to lung cancer screening in the Veterans Health Administration: Does geographic distribution match need in the population?

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Studies show uneven access to Medicare-approved lung cancer screening (LCS) programs across the US. The Veterans Health Administration (VA), the largest national US integrated health system, is potentially well-positioned to […]

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Clinical characteristics associated with lung function decline in individuals with adult-diagnosed cystic fibrosis: Contemporary analysis of the Canadian CF Registry.

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Individuals diagnosed with cystic fibrosis (CF) as adults represent a rare but growing subset of the CF population; there are limited studies describing their lung function trajectories.What is the overall […]

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Methodological Quality of Guidelines for Training or Competence Processes for Basic Point of Care Echocardiography in Critical Care – A Systematic Review of the Literature.

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The formulation of expert-opinion guidelines has several sources of bias that may adversely affect their quality. To minimize bias, guideline creators must employ rigorous methodology. There has been no appraisal […]

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Identification and Remediation of Environmental Exposures in Patients with Interstitial Lung Disease: Evidence Review and Practical Considerations.

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A relationship between inhalational exposure to materials in the environment and development of interstitial lung disease (ILD) is long recognized. Hypersensitivity pneumonitis (HP) is an environmentally induced diffuse parenchymal lung […]

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