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Studies suggest an increased all-cause mortality among adults with asthma. We aimed to study the relationship between asthma in children and young adults and all-cause mortality, and investigate differences in […]
» Read moreInvasive mechanical ventilation is often initiated in the Emergency Department (ED), and mechanically ventilated patients may be kept in the ED for hours prior to intensive care unit (ICU) transfer. […]
» Read morePulmonary exacerbations (PEx) are significant life events in people with cystic fibrosis (CF), associated with declining lung function, reduced quality of life (QoL), hospitalisations and decreased survival. The adult CF […]
» Read moreOsimertinib is standard-of-care therapy for previously untreated epidermal growth factor receptor (EGFR) mutation-positive advanced non-small-cell lung cancer (NSCLC). The efficacy and safety of osimertinib as adjuvant therapy are unknown.In this […]
» Read moreThere is increasing interest in the effects of sleep and sleep disturbances on the brain, particularly in relation to aging and neurodegenerative processes. Parkinson’s disease (PD) is the second most […]
» Read moreEmotional intelligence (EI) has become widely appreciated as an important leadership attribute, in business, education and, increasingly, in healthcare. Defined as “the capacity to understand your own and others’ emotions […]
» Read moreWith the advancement of cardio-respiratory interventions, the survival rate among patients with Duchenne muscular dystrophy has increased. Subsequently, pneumothorax has become a significant problem in patients with prolonged ventilatory support.We […]
» Read moreThe coronavirus pandemic has disrupted clinical practice, healthcare organizations, and life. In the context that “a crisis is a terrible thing to waste,” as disruptive as the pandemic has been […]
» Read moreIn the context that leadership matters and that leadership competencies differ from those needed to practice medicine or conduct research, developing leadership competencies for physicians is important. Indeed, effective leadership […]
» Read moreThe prevalence of burnout and depressive symptoms is high among physician trainees.What is the burden of burnout and depressive symptoms among fellows training in pulmonary and critical care medicine (PCCM) […]
» Read moreNo therapies for targeting KRAS mutations in cancer have been approved. The KRAS p.G12C mutation occurs in 13% of non-small-cell lung cancers (NSCLCs) and in 1 to 3% of colorectal […]
» Read moreSepsis is a serious global health issue and a major cause of death and disability. The availability of a simple, community-based preventive strategy could substantially reduce the burden of sepsis. […]
» Read moreChronic tobacco smoke exposure results in a broad range of lung pathologies including emphysema, airway disease and parenchymal fibrosis as well as a multitude of extra-pulmonary comorbidities. Prior work using […]
» Read moreMalignant pleural mesothelioma (MPM) is an aggressive cancer, associated with poor prognosis. We assessed the feasibility of patient-derived cell cultures to serve as an ex vivo model of MPM. Patient-derived […]
» Read moreExposure to tobacco content in films is a cause of smoking uptake in young people. In an earlier study, we reported that tobacco content occurred in 70% of UK box […]
» Read moreSarcoidosis and tuberculosis are granulomatous pulmonary diseases characterised by heightened immune reactivity to Mycobacterium tuberculosis (M.tb.) antigens. We hypothesised that an unsupervised analysis comparing the molecular characteristics of granulomas formed […]
» Read moreAre long-term Household Air Pollutions (HAPs) associated with asthma and lung function decline in middle-aged adults, and whether these associations were modified by GST gene variants, ventilation and atopy.Prospective data […]
» Read moreIn patients with chronic fibrosing interstitial lung disease (ILD), a progressive fibrosing phenotype (PF-ILD) may develop, but information on the frequency and characteristics of this population outside clinical trials is […]
» Read moreObesity is a common co-morbidity in asthma and associated with poorer asthma control, more frequent/severe exacerbations, and reduced response to asthma pharmacotherapy.This review aims to compare use of all classes […]
» Read morePulmonary fibrosis is a devastating, progressive disease and carries a prognosis worse than most cancers. Despite ongoing research, the mechanism(s) which underlie disease pathogenesis remain only partially understood. However, the […]
» Read moreIschaemic stroke and myocardial infarction (MI) are common after pneumonia and are associated with long-term mortality. Aspirin may attenuate this risk and should be explored as a therapeutic option.We extracted […]
» Read moreSelf-reported tobacco pack-year history plays a large role in decisions about low-dose computed tomography (CT) lung cancer screening yet is challenging to measure accurately.To what extent does random measurement error […]
» Read moreCharacteristics of critically ill adults with coronavirus disease 2019 (COVID-19) in an academic safety net hospital and the effect of evidence-based practices in these patients are unknown.What are the outcomes […]
» Read moreLong-term oxygen therapy improves survival in patients with chronic obstructive pulmonary disease (COPD) and chronic severe daytime hypoxemia. However, the efficacy of oxygen therapy for the management of isolated nocturnal […]
» Read moreTo determine if the Food Standards Agency nutrient profiling system (FSAm-NPS), which grades the nutritional quality of food products and is used to derive the Nutri-Score front-of-packet label to guide […]
» Read morePulmonary hemodynamics during exercise may reveal early pulmonary vascular disease and be of clinical and prognostic relevance in systemic sclerosis (SSc). We aimed to assess the prognostic relevance of exercise […]
» Read moreHigher levels of physical activity have been associated with better asthma clinical control.Does a behaviour change intervention aimed at increasing physical activity change asthma clinical control, physical activity, sedentary time, […]
» Read moreCough is a defense mechanism that protects the airways and lungs in response to airway irritation. The sensory neurons involved in detecting airway irritants and the neural pathways mediating cough […]
» Read moreThe COVID-19 pandemic has severely impacted Intensive Care Units (ICUs) and Critical Care Healthcare Providers (HCPs) worldwide.How do regional differences and perceived lack of ICU resources affect critical care resource […]
» Read moreMillions of smartphones contain a photoplethysmography (PPG) bio-sensor (Maxim Integrated, San Jose CA) that accurately measures pulse oximetry. No clinical use of these embedded sensors is currently being made, despite […]
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