Bronchial gene expression signature associated with rate of subsequent FEV1 decline in individuals with and at risk of COPD.

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COPD is characterised by progressive lung function decline. Leveraging prior work demonstrating bronchial airway COPD-associated gene expression alterations, we sought to determine if there are alterations associated with differences in […]

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Effect of Antimicrobial Therapy on Respiratory Hospitalization or Death in Adults With Idiopathic Pulmonary Fibrosis: The CleanUP-IPF Randomized Clinical Trial.

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Alteration in lung microbes is associated with disease progression in idiopathic pulmonary fibrosis.To assess the effect of antimicrobial therapy on clinical outcomes.Pragmatic, randomized, unblinded clinical trial conducted across 35 US […]

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The inflammatory profile of exacerbations in patients with severe refractory eosinophilic asthma receiving mepolizumab (the MEX study): a prospective observational study.

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Clinical trials with mepolizumab, a humanised monoclonal antibody against interleukin-5, show a 50% reduction in severe asthma exacerbations in people with severe eosinophilic asthma. Exacerbations in patients treated with mepolizumab […]

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Long-term safety of lumacaftor-ivacaftor in children aged 2-5 years with cystic fibrosis homozygous for the F508del-CFTR mutation: a multicentre, phase 3, open-label, extension study.

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A previous phase 3 study showed that lumacaftor-ivacaftor was generally safe and well tolerated over 24 weeks of treatment in children aged 2-5 years with cystic fibrosis homozygous for the […]

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Comparison of First Nations and non-First Nations children’s profiles with bronchiectasis over two five-year periods from the Northern Territory, Australia.

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Although the burden of bronchiectasis is globally recognised, there is limited paediatric data particularly on trends over the years. There is also no published data on whether vitamin D deficiency/insufficiency […]

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3-month, 6-month, 9-month, and 12-month respiratory outcomes in patients following COVID-19-related hospitalisation: a prospective study.

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The consequences of COVID-19 in those who recover from acute infection requiring hospitalisation have yet to be clearly defined. We aimed to describe the temporal trends in respiratory outcomes over […]

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Kidney function and obstructive lung disease: a bidirectional Mendelian randomisation study.

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Additional study is warranted to investigate the causal effects between kidney function and obstructive lung disease.This study was a bidirectional two-sample Mendelian randomisation (MR) analysis. The CKDGen genome-wide association study […]

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Transbronchial mediastinal cryobiopsy in the diagnosis of mediastinal lesions: a randomised trial.

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Guidelines recommend endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) as an initial investigation technique for mediastinal nodal staging in lung cancer. However, EBUS-TBNA can be limited by the inadequacy of intact […]

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CT Findings and Patterns of Electronic Cigarette or Vaping Product Use-Associated Lung Injury (EVALI), A Multicenter Cohort of 160 Cases.

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Electronic cigarette and vaping-induced lung injury (EVALI) causes a spectrum of CT lung injury patterns. Relative frequencies and associations with vaping behavior are unknown.What are the frequencies of imaging findings […]

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Performance of an Electronic Decision Support System as a Therapeutic Intervention During a Multicenter PICU Clinical Trial: Heart and Lung Failure-Pediatric Insulin Titration trial (HALF-PINT).

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The use of electronic clinical decision support (CDS) systems for pediatric critical care trials is rare. We sought to describe in detail the use of a CDS tool (Children’s Hospital […]

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Functional electrical stimulation-assisted cycle ergometry-based progressive mobility programme for mechanically ventilated patients: randomised controlled trial with 6 months follow-up.

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Functional electrical stimulation-assisted cycle ergometry (FESCE) enables in-bed leg exercise independently of patients’ volition. We hypothesised that early use of FESCE-based progressive mobility programme improves physical function in survivors of […]

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