The Effect of Tumor Size and Histology on Outcomes Following Segmentectomy vs. Lobectomy for Clinically Node-negative Non-small Cell Lung Cancer.

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The interaction between tumor size and the comparative prognosis of lobar and sublobar resection has been poorly defined.The purpose of this study was to characterize the relationship between tumor size […]

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Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts.

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Genetic factors influence chronic obstructive pulmonary disease (COPD) risk, but the individual variants that have been identified have small effects. We hypothesised that a polygenic risk score using additional variants […]

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Interstitial lung abnormalities detected incidentally on CT: a Position Paper from the Fleischner Society.

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The term interstitial lung abnormalities refers to specific CT findings that are potentially compatible with interstitial lung disease in patients without clinical suspicion of the disease. Interstitial lung abnormalities are […]

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Treatment of nontuberculous mycobacterial pulmonary disease: an official ATS/ERS/ESCMID/IDSA clinical practice guideline.

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Nontuberculous mycobacteria (NTM) represent over 190 species and subspecies, some of which can produce disease in humans of all ages and can affect both pulmonary and extrapulmonary sites. This guideline […]

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Impact of a multimodal telemonitoring intervention on CPAP adherence in symptomatic low-cardiovascular risk sleep apnea: a randomized controlled trial.

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One of the major challenges in treating obstructive sleep apnea (OSA) is to achieve adequate continuous positive airway pressure (CPAP) adherence. Telemonitoring has the potential to provide individualized management and […]

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Analysis of lung cancer risk model (PLCOM2012 and LLPv2) performance in a community-based lung cancer screening programme.

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Low-dose CT (LDCT) screening of high-risk smokers reduces lung cancer (LC) specific mortality. Determining screening eligibility using individualised risk may improve screening effectiveness and reduce harm. Here, we compare the […]

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EmPHasis-10 health-related quality of life score predicts outcomes in patients with idiopathic and connective tissue disease-associated pulmonary arterial hypertension: results from a UK multi-centre study.

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Health-related quality of life (HRQoL) scores assess symptom burden in pulmonary arterial hypertension (PAH) but data regarding their role in prognostication and risk stratification are limited. We assessed these relationships […]

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Incidence, risk factors, and effects on outcome of ventilator-associated pneumonia in patients with traumatic brain injury. Analysis of a large, multicenter, prospective, observational longitudinal study.

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No large prospective data are available on ventilator-associated pneumonia (VAP) in patients with traumatic brain injury (TBI).To evaluate the incidence, timing and risk factors of VAP after TBI and its […]

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Maintenance inhaler therapy preferences of patients with asthma or chronic obstructive pulmonary disease: a discrete choice experiment.

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A variety of maintenance inhaler therapies are available to treat asthma and COPD. Patient-centric treatment choices require understanding patient preferences for the alternative therapies.A self-completed web-based discrete choice experiment was […]

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Effect of antiviral therapy on the outcome of mechanically ventilated patients with herpes simplex virus type 1 in bronchoalveolar lavage fluid: a retrospective cohort study.

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Herpes simplex virus type 1 (HSV-1) is frequently detected in the bronchoalveolar lavage fluid (BAL) of mechanically ventilated patients.The aim of the study was to investigate whether antiviral therapy is […]

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Association between nocturnal hypoxemia and cancer incidence in patients investigated for obstructive sleep apnea. Data from a large multicenter French cohort.

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Previous studies have yielded inconsistent findings regarding the association between obstructive sleep apnea (OSA) and cancer in humans.Is there an association between indices of sleep-disordered breathing severity and cancer incidence […]

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Airway clearance techniques in bronchiectasis: Analysis from the United States Bronchiectasis and NTM Research Registry.

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In patients with bronchiectasis, airway clearance techniques (ACTs) are important management strategies.The primary objective was to describe differences in patients with bronchiectasis and productive cough who utilized ACTs and those […]

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Pulmonary arterial hypertension associated with primary Sjogren’s syndrome: a multi-centre cohort study from China.

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Primary Sjogren’s syndrome (pSS) is an important cause of pulmonary arterial hypertension (PAH), which remains insufficiently studied and needs attention. This study aimed to investigate the clinical characteristics, risk factors, […]

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SABRTOOTH: A randomised controlled feasibility study of Stereotactic Ablative Radiotherapy (SABR) with surgery in paTients with peripheral stage I nOn-small cell lung cancer (NSCLC) cOnsidered To be at Higher risk of complications from surgical resection.

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Stereotactic Ablative Radiotherapy (SABR) is a well-established treatment for medically inoperable peripheral stage I non-small cell lung cancer (NSCLC). Previous non-randomised evidence supports SABR as an alternative to surgery, but […]

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Vitamin C to Pregnant Smokers Persistently Improves Infant Airway Function to 12 Months of Age: A Randomised Trial.

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Vitamin C (500 mg·day-1) supplementation for pregnant smokers has been reported to increase newborn pulmonary function and infant forced expiratory flows (FEFs) at 3 months of age. Its effect on airway function […]

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