Post-traumatic stress disorder as a risk factor for dementia: systematic review and meta-analysis.

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Post-traumatic stress disorder (PTSD) has been identified as a potential risk factor for developing dementia. There are currently, however, no meta-analyses quantifying this risk.To systematically review and quantify the risk […]

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Mild Cognitive Impairment in Retired Professional Football Players With a History of Mild Traumatic Brain Injury: A Pilot Investigation.

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Traumatic brain injury (TBI) is a known risk factor for neurodegenerative dementias such as Alzheimer disease (AD); however, the potential risk of mild cases of TBI, such as concussions, remains […]

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Real-world effectiveness, its predictors and onset of action of cholinesterase inhibitors and memantine in dementia: retrospective health record study.

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The efficacy of acetylcholinesterase inhibitors and memantine in the symptomatic treatment of Alzheimer’s disease is well-established. Randomised trials have shown them to be associated with a reduction in the rate […]

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Race, History of Abuse, and Homelessness Are Associated With Forced Medication Administration During Psychiatric Inpatient Care.

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Although previous research has suggested that racial disparities exist in the administration of forced medication (FM) in psychiatric inpatients, data remain scarce regarding other contributing variables. Therefore, this study examined […]

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Lowering dementia risk and slowing progression of disease: the role of cognitive reserve and cognitive training.

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Almeida-Meza et al found an inverse correlation between cognitive reserve (associated with educational level, complexity of occupations and leisure activities) and dementia incidence. We suggest clarifying studies using their data-set […]

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Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study.

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Concerns regarding potential neurological complications of COVID-19 are being increasingly reported, primarily in small series. Larger studies have been limited by both geography and specialty. Comprehensive characterisation of clinical syndromes […]

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Clinical Features of Late-onset Semantic Dementia.

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Semantic dementia (SD) is characterized by progressive semantic anomia extending to a multimodal loss of semantic knowledge. Although often considered an early-onset dementia, SD also occurs in later life, when […]

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An Array of Studies Addressing Cognition and Cognitively Defined Neuropsychiatric Conditions: Many More Connections Than You Might Think.

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Six articles in the June 2020 issue of the American Journal of Psychiatry address the overall construct of cognition. These articles have a broad connection to cognition, which is itself […]

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Association of Blood Pressure Lowering With Incident Dementia or Cognitive Impairment: A Systematic Review and Meta-analysis.

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The benefit of blood pressure lowering for the prevention of dementia or cognitive impairment is unclear.To determine the association of blood pressure lowering with dementia or cognitive impairment.Search of PubMed, […]

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Obsessive-Compulsive Disorder in Older Adults: A Comprehensive Literature Review.

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We reviewed English-language articles concerning obsessive-compulsive disorder (OCD) in older adults. PubMed was searched using key words that included obsessive-compulsive disorder, geriatric, elderly, aging, and older. Of the 644 articles […]

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Associations of Benzodiazepines, Z-Drugs, and Other Anxiolytics With Subsequent Dementia in Patients With Affective Disorders: A Nationwide Cohort and Nested Case-Control Study.

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Benzodiazepines and Z-drugs are two of the most prescribed agents worldwide. However, because of their cognitive side effects, the question of their influence on the risk of dementia has been […]

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Markers of cognitive reserve and dementia incidence in the English Longitudinal Study of Ageing.

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In the current climate of an ageing population, it is imperative to identify preventive measures for dementia.We implemented a multifaceted index of cognitive reserve markers and investigated dementia incidence over […]

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Social Cognition and White Matter: Connectivity and Cooperation.

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Humans are highly social animals whose survival and well-being depend on their capacity to cooperate in complex social settings. Advances in anthropology and psychology have demonstrated the importance of cooperation […]

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Effectiveness of Pharmacological Interventions for Symptoms of Behavioral Variant Frontotemporal Dementia: A Systematic Review.

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Clinical guidance on the symptomatic treatment of behavioral variant frontotemporal dementia (bvFTD) is limited.To provide a systematic review of pharmacological interventions for symptomatic treatment of bvFTD, based on the International […]

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Screening for Cognitive Impairment in Older Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.

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Early identification of cognitive impairment may improve patient and caregiver health outcomes.To systematically review the test accuracy of cognitive screening instruments and benefits and harms of interventions to treat cognitive […]

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Problem-Solving Therapy for Older Adults at Risk for Depression: A Qualitative Analysis of the Depression in Later Life Trial.

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As a sequel to the Depression in Later Life trial of lay counselor-delivered problem-solving therapy for depression prevention among older adults in Goa, India, this qualitative study aimed to explore […]

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Cognitive symptoms of Alzheimer’s disease: clinical management and prevention.

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Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by the accumulation of amyloid β in the form of extracellular plaques and by intracellular neurofibrillary tangles, with eventual neurodegeneration and […]

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Differential Effect of Demographics, Processing Speed, and Depression on Cognitive Function in 755 Non-demented Community-dwelling Elderly Individuals.

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Several factors may account for inter- and intra-individual variability in cognitive functions, including age, gender, education level, information processing speed, and mood.To evaluate the combined contribution of demographic factors, information […]

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Incidence of ischaemic heart disease and stroke among people with psychiatric disorders: retrospective cohort study.

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Psychiatric disorders are associated with increased risk of ischaemic heart disease (IHD) and stroke, but it is not known whether the associations or the role of sociodemographic factors have changed […]

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A possible role for sarcosine in the management of schizophrenia.

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Sarcosine, which is freely sold as a dietary supplement, has pharmacological activity to boost functioning of the glutamatergic N-methyl-d-aspartate receptor (NMDAR) and hence it is a biologically rational treatment for […]

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Changing prevalence and treatment of depression among older people over two decades.

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Abstract: Depression is a leading cause of disability, with older people particularly susceptible to poor outcomes.To investigate whether the prevalence of depression and antidepressant use have changed across two decades […]

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Effects of a Mixed Reality-based Cognitive Training System Compared to a Conventional Computer-assisted Cognitive Training System on Mild Cognitive Impairment: A Pilot Study.

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Abstract: Mixed reality (MR) technology, which combines the best features of augmented reality and virtual reality, has recently emerged as a promising tool in cognitive rehabilitation therapy.To investigate the effectiveness […]

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The individual course of neuropsychiatric symptoms in people with Alzheimer’s and Lewy body dementia: 12-year longitudinal cohort study.

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Abstract: Understanding the natural course of neuropsychiatric symptoms (NPS) in dementia is important for planning patient care and trial design, but few studies have described the long-term course of NPS […]

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