Unsystematic review shows neither that early intervention in psychosis is cost-effective nor cost-minimising.
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School-based interventions to prevent anxiety and depression in children and young people: a systematic review and network meta-analysis.
Rates of anxiety and depression are increasing among children and young people. Recent policies have focused on primary prevention of mental disorders in children and young people, with schools at […]
» Read morePrevention versus intervention in school mental health.
Functional cognitive disorders: a systematic review.
Cognitive symptoms are common, and yet many who seek help for cognitive symptoms neither have, nor go on to develop, dementia. A proportion of these people are likely to have […]
» Read moreYoga for psychiatric disorders: from fad to evidence-based intervention?
There is growing evidence for yoga’s neurobiological effects in people with psychiatric disorders. Postulated mechanisms of action include: (a) modulation of the hypothalamic-pituitary-adrenal (HPA) axis; (b) enhancement of GABAergic neurotransmission; […]
» Read moreSuicide following presentation to hospital for non-fatal self-harm in the Multicentre Study of Self-harm: a long-term follow-up study.
Self-harm is the strongest risk factor for subsequent suicide, but risk may vary. We compared the risk of suicide following hospital presentation for self-harm according to patient characteristics, method of […]
» Read moreGlial cells in schizophrenia: a unified hypothesis.
The cellular neurobiology of schizophrenia remains poorly understood. We discuss neuroimaging studies, pathological findings, and experimental work supporting the idea that glial cells might contribute to the development of schizophrenia. […]
» Read moreWelfare and well-being: towards mental health-promoting welfare systems.
By protecting vulnerable people from poverty and debt, welfare systems can be powerful tools for promoting mental health. However, the details of how welfare systems are implemented determine whether they […]
» Read moreLate-adolescent risk factors for suicide and self-harm in middle-aged men: explorative prospective population-based study.
Recent reports show alarmingly high rates of suicide in middle-aged men, yet there are few long-term prospective studies that focus on suicidal behaviour in men in this age group.To prospectively […]
» Read moreInsight and psychosis: the next 30 years.
Academic interest in the concept of insight in psychosis has increased markedly over the past 30 years, prompting this selective appraisal of the current state of the art. Considerable progress […]
» Read morePreconception care in mental health services: planning for a better future.
It is increasingly recognised that the preconception period is a window of opportunity to intervene to improve outcomes for women and the next generation. The importance of preconception mental health […]
» Read moreRevisiting the one in four: the prevalence of psychiatric disorder in the population of England 2000-2014.
Mental health problems are often said to affect one in four people in Britain, although with no consistent explanation of what the figure includes. We used three English national population […]
» Read moreA possible role for sarcosine in the management of schizophrenia.
Sarcosine, which is freely sold as a dietary supplement, has pharmacological activity to boost functioning of the glutamatergic N-methyl-d-aspartate receptor (NMDAR) and hence it is a biologically rational treatment for […]
» Read moreSmoking cessation in severe mental illness: combined long-term quit rates from the UK SCIMITAR trials programme.
Smoking contributes to health inequalities for people with severe mental illness (SMI). Although smoking cessation interventions are effective in the short term, there are few long-term trial-based estimates of abstinence. […]
» Read morePsychiatry and the global drugs debate: what every psychiatrist needs to know.
There are few topics that divide public opinion as sharply as the use of psychoactive substances and it is easy to see why. Substance use is complex and can be […]
» Read moreUS Food and Drug Administration approval of esketamine and brexanolone.
Esketamine for treatment-resistant depression: seven concerns about efficacy and FDA approval.
Problems posed by the Werther effect as a ‘net effect’: a comment on recent scholarly work on the effects of 13 Reasons Why.
Recent research estimated that an additional 195 suicides among 10- to 17-year-old youths occurred following the release of the television series 13 Reasons Why. There is an underrecognised aspect in […]
» Read moreDeveloping Innovative and Novel Treatment Strategies.
Fulminant Onset of Valproate-Associated Hyperammonemic Encephalopathy.
Cannabis in psychiatric disorders: the cart before the horse?
Cannabinoids for the treatment of mental disorders and symptoms of mental disorders: a systematic review and meta-analysis.
Medicinal cannabinoids, including medicinal cannabis and pharmaceutical cannabinoids and their synthetic derivatives, such as tetrahydrocannabinol (THC) and cannabidiol (CBD), have been suggested to have a therapeutic role in certain mental […]
» Read moreWhither TMS: A One-Trick Pony or the Beginning of a Neuroscientific Revolution?
Psychiatry has been at the forefront of advancing clinical transcranial magnetic stimulation (TMS) since the mid-1990s, shortly after the invention of modern TMS in 1985 by Barker. Clinical TMS for […]
» Read moreAutoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin.
There is increasing recognition in the neurological and psychiatric literature of patients with so-called isolated psychotic presentations (ie, with no, or minimal, neurological features) who have tested positive for neuronal […]
» Read moreAdverse childhood experiences research: commonalities with similar, arguably identical, literatures and the need for integration.
Adverse childhood experiences (ACEs) and their impact cannot be clearly distinguished from other distressing life experiences. Much can be therefore be learned by integrating ACEs research with similar, well-established literatures. […]
» Read moreEthnic disparities in psychotic experiences explained by area-level syndemic effects.
Ethnic inequalities in health outcomes are often explained by socioeconomic status and concentrated poverty. However, ethnic disparities in psychotic experiences are not completely attenuated by these factors.We investigated whether disparities […]
» Read moreBuilding the social, economic, legal, and health-care foundations for “Contributing Lives and Thriving Communities”.
Social interventions: a new era for global mental health?
Omega-3 and polyunsaturated fat for prevention of depression and anxiety symptoms: systematic review and meta-analysis of randomised trials.
There is strong public belief that polyunsaturated fats protect against and ameliorate depression and anxiety.To assess effects of increasing omega-3, omega-6 or total polyunsaturated fat on prevention and treatment of […]
» Read moreEffect of Fluoxetine on Obsessive-Compulsive Behaviors in Children and Adolescents With Autism Spectrum Disorders: A Randomized Clinical Trial.
Selective serotonin receptor inhibitors are prescribed to reduce the severity of core behaviors of autism spectrum disorders, but their efficacy remains uncertain.To determine the efficacy of fluoxetine for reducing the […]
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