Effect of reductions in amyloid levels on cognitive change in randomized trials: instrumental variable meta-analysis.

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To evaluate trials of drugs that target amyloid to determine whether reductions in amyloid levels are likely to improve cognition.Instrumental variable meta-analysis.14 randomized controlled trials of drugs for the prevention […]

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Neural effects of antidepressant medication and psychological treatments: a quantitative synthesis across three meta-analyses.

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Influential theories predict that antidepressant medication and psychological therapies evoke distinct neural changes.To test the convergence and divergence of antidepressant- and psychotherapy-evoked neural changes, and their overlap with the brain’s […]

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[COVID-19 Pandemic and Psychiatry – How much have the Interests of People with Psychiatric Disorders been Considered in German Laws?]

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Official regulations during the first COVID-19 lockdown in Germany were analyzed concerning their impact on patients with psychiatric disorders.All regulations valid between March 1, 2020 and June 30, 2020 with […]

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Effect of Layperson-Delivered, Empathy-Focused Program of Telephone Calls on Loneliness, Depression, and Anxiety Among Adults During the COVID-19 Pandemic: A Randomized Clinical Trial.

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Loneliness is a risk factor for many clinical conditions, but there are few effective interventions deployable at scale.To determine whether a layperson-delivered, empathy-focused program of telephone calls could rapidly improve […]

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Efficacy and safety of the novel glycine transporter inhibitor BI 425809 once daily in patients with schizophrenia: a double-blind, randomised, placebo-controlled phase 2 study.

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Cognitive impairment associated with schizophrenia predicts poor functional outcomes, but currently no approved pharmacotherapy is available. This study investigated whether the glycine transporter-1 inhibitor BI 425809 improves cognition in patients […]

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Comparative efficacy and acceptability of psychological interventions for the treatment of adult outpatients with anorexia nervosa: a systematic review and network meta-analysis.

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No consistent first-option psychological interventions for adult outpatients with anorexia nervosa emerges from guidelines. We aimed to compare stand-alone psychological interventions for adult outpatients with anorexia nervosa with a specific […]

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Maintenance Treatment With Long-Acting Injectable Antipsychotics for People With Nonaffective Psychoses: A Network Meta-Analysis.

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This study compared relapse prevention and acceptability of long-acting injectable (LAI) antipsychotics in the maintenance treatment of adults with nonaffective psychoses.The authors searched MEDLINE, Embase, PsycINFO, CINAHL, CENTRAL, and online […]

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Contribution of birth weight to mental health, cognitive and socioeconomic outcomes: two-sample Mendelian randomisation.

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Low birth weight is associated with adult mental health, cognitive and socioeconomic problems. However, the causal nature of these associations remains difficult to establish owing to confounding.To estimate the contribution […]

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Clinical efficacy of a Decision Support Tool (Link-me) to guide intensity of mental health care in primary practice: a pragmatic stratified randomised controlled trial.

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The volume and heterogeneity of mental health problems that primary care patients present with is a substantial challenge for health systems, and both undertreatment and overtreatment are common. We developed […]

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A parent-sibling dyadic interview to explore how an individual with Autism Spectrum Disorder can impact family dynamics.

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Autism Spectrum Disorder (ASD) is a life-long condition which affects the individual and their family system. Little research understands the impact of an ASD upon families, how this may change […]

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Integrating youth mental health into cash transfer programmes in response to the COVID-19 crisis in low-income and middle-income countries.

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Social protection measures can play an important part in securing livelihoods and in mitigating short-term and long-term economic, social, and mental health impacts of the COVID-19 pandemic. In particular, cash […]

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The role of psychiatry in championing positive life outcomes for children and adults with neurodevelopmental disorders and their families.

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Children and adults with neurodevelopmental disorders make up an estimated 10% of the population. Addressing health inequalities and poorer life outcomes is essential to deliver better quality care. Two parent-carers […]

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Psychiatry and neurodevelopmental disorders: experts by experience, clinical care and research.

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People with neurodevelopmental disorders often present with challenging behaviours and psychiatric illnesses. Diagnosis and treatment require patients, families and healthcare professionals to work closely together in partnership, acknowledging their respective […]

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Autistic traits and mental health in women with the fragile-X premutation: maternal status versus genetic risk.

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Research on women with the fragile-X premutation (FX-p) has been underrepresented within the field of behavioural phenotypes.To understand whether the FX-p confers risk for autistic traits, depression and anxiety, independent […]

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Antipsychotic and antidepressant prescribing for 704 297 children and young people with and without intellectual disabilities: record linkage study.

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Psychotropics are overprescribed for adults with intellectual disabilities; there are few studies in children and young people.To investigate antipsychotic and antidepressant prescribing in children and young people with and without […]

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Effectiveness of exercise-based interventions in reducing depressive symptoms in people without clinical depression: systematic review and meta-analysis of randomised controlled trials.

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In most trials and systematic reviews that evaluate exercise-based interventions in reducing depressive symptoms, it is difficult to separate treatment from prevention.To evaluate the effectiveness of exercise-based interventions in reducing […]

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Effect of Behavioral Therapy With In-Clinic or Telephone Group Visits vs In-Clinic Individual Visits on Weight Loss Among Patients With Obesity in Rural Clinical Practice: A Randomized Clinical Trial.

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Rural populations have a higher prevalence of obesity and poor access to weight loss programs. Effective models for treating obesity in rural clinical practice are needed.To compare the Medicare Intensive […]

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Delusions beyond beliefs: a critical overview of diagnostic, aetiological, and therapeutic schizophrenia research from a clinical-phenomenological perspective.

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Delusions are commonly conceived as false beliefs that are held with certainty and which cannot be corrected. This conception of delusion has been influential throughout the history of psychiatry and […]

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The Importance of Conduct Disorder in the Treatment of Violence in Schizophrenia: Efficacy of Clozapine Compared With Olanzapine and Haloperidol.

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Treatment of violence in schizophrenia remains a challenging problem, especially in patients with conduct disorder. Previous clinical studies did not select patients on the basis of violence and did not […]

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The World Health Organization Risk Drinking Levels Measure of Alcohol Consumption: Prevalence and Health Correlates in Nationally Representative Surveys of U.S. Adults, 2001-2002 and 2012-2013.

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Little is known about change over time in the prevalence of World Health Organization (WHO) risk drinking levels (very high, high, moderate, low) and their association with health conditions, overall […]

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Multimodal Neuroimaging of Suicidal Thoughts and Behaviors in a U.S. Population-Based Sample of School-Age Children.

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Suicide deaths and suicidal thoughts and behaviors are considered a public health emergency, yet their underpinnings in the brain remain elusive. The authors examined the classification accuracy of individual, environmental, […]

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