Myocarditis and inflammatory cardiomyopathy: current evidence and future directions.

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Inflammatory cardiomyopathy, characterized by inflammatory cell infiltration into the myocardium and a high risk of deteriorating cardiac function, has a heterogeneous aetiology. Inflammatory cardiomyopathy is predominantly mediated by viral infection, […]

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Interventions to reduce contaminated aerosols produced during dental procedures for preventing infectious diseases.

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Many dental procedures produce aerosols (droplets, droplet nuclei and splatter) that harbour various pathogenic micro-organisms and may pose a risk for the spread of infections between dentist and patient. The […]

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The impact of COVID-19 on acute ischemic stroke admissions: Analysis from a community-based tertiary care center.

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To evaluate the impact of the COVID-19 pandemic on hospital admissions and outcomes in patients admitted with acute ischemic stroke.Single-center retrospective analysis of patients admitted to the hospital with acute […]

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Imposed mutational meltdown as an antiviral strategy.

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Following widespread infections of the most recent coronavirus known to infect humans, SARS-CoV-2, attention has turned to potential therapeutic options. With no drug or vaccine yet approved, one focal point […]

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Efficacy and safety outcomes of proposed randomized controlled trials investigating hydroxychloroquine and chloroquine during the early stages of the COVID-19 pandemic.

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To assess whether randomized clinical trials (RCTs) proposed to evaluate the treatment of patients with COVID-19 with hydroxychloroquine (HQ) or chloroquine early in the pandemic included plans to measure outcomes […]

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Pharmaconutrition revisited for critically ill patients with coronavirus disease 2019 (COVID-19): Does selenium have a place?

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Coronavirus disease 2019 (COVID-19) is a global pandemic causing one of the biggest challenges for critical care medicine. Mortality from COVID-19 is much greater in elderly men, many of whom […]

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Repositioning microbial biotechnology against COVID-19: the case of microbial production of flavonoids.

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Coronavirus-related disease 2019 (COVID-19) became a pandemic in February 2020, and worldwide researchers try to tackle the disease with approved drugs of all kinds, or to develop novel compounds inhibiting […]

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GB-2 inhibits ACE2 and TMPRSS2 expression: In vivo and in vitro studies.

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After the first case of Coronavirus disease 2019 (COVID-19) was reported in Wuhan, COVID-19 has rapidly spread to almost all parts of world. Angiotensin converting enzyme 2 (ACE2) receptor can […]

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Does Serum Vitamin D Level Affect COVID-19 Infection and Its Severity?-A Case-Control Study.

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As effective medication to treat COVID-19 is currently unavailable, preventive remedies may be particularly important.To examine the relationship between serum 25-hydroxy vitamin D (25(OH)D) level and COVID-19 infection, its severity, […]

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Viral replication of SARS-CoV-2 could be self-limitative – The role of the renin-angiotensin system on COVID-19 pathophysiology.

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Currently, the world is suffering with one of the biggest pandemics of recent history. Caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the coronavirus disease 2019 (COVID-19) is provoking […]

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Designing of cytotoxic and helper T cell epitope map provides insights into the highly contagious nature of the pandemic novel coronavirus SARS-CoV-2.

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Novel coronavirus, SARS-CoV-2, has emerged as one of the deadliest pathogens of this century, creating an unprecedented pandemic. Belonging to the betacoronavirus family, it primarily spreads through human contact via […]

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Uniform infection screening allowed safe head and neck surgery during the coronavirus disease 2019 pandemic in Japan.

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The purpose of this study was to determine whether a uniform infection screening protocol could be used to safely perform head and neck cancer surgery during the coronavirus disease 2019 […]

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Tele-health and Palliative Care for Cancer Patients: Implications for the COVID-19 Pandemic.

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Cancer patients have been found to have a higher incidence of COVID-19 infection and are at an increased risk of severe life-threatening complications of the disease. Increased transmission and poorer […]

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Intensive care for seriously ill patients affected by novel coronavirus sars – CoV – 2: Experience of the Crema Hospital, Italy.

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In this work, the survival and mortality data of 54 consecutive patients admitted to the Intensive Care Unit (ICU) and suffering from severe respiratory insufficiency imputable to viral SARS – […]

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Right Atrial Thrombus in Transient in a COVID-19 Patient: Clinical Echocardiographic Features-Case Report and Literature Review.

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A 54-year-old male is admitted with COVID-19 pneumonia and received prophylactic anticoagulation. On day 8, the patient rapidly deteriorated requiring urgent endotracheal intubation. Transthoracic echocardiography revealed large right atrial thrombus […]

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Population pharmacokinetics of lopinavir/ritonavir in Covid-19 patients.

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To develop a population pharmacokinetic model for lopinavir boosted by ritonavir in coronavirus disease 2019 (Covid-19) patients.Concentrations of lopinavir/ritonavir were assayed by an accredited LC-MS/MS method. The population pharmacokinetics of […]

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Pentoxifylline, a drug with antiviral, anti-inflammatory and bronchodilatory effects may be a possible drug candidate for SARS-CoV-2.

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In December 2019, a new coronavirus, named SARS-CoV-2, has emerged from China causing pneumonia outbreaks first in the Wuhan region and have now spread worldwide but there are still no […]

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The impact of protocol-based high-intensity pharmacological thromboprophylaxis on thrombotic events in critically ill COVID-19 patients.

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The reported incidence rate of venous and arterial thrombotic events in critically ill patients with COVID-19 infections is high, ranging from 20-60%. We adopted a patient-tailored thromboprophylaxis protocol based on […]

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Cardiopulmonary resuscitation in prone position: A scoping review.

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The ongoing pandemic of COVID-19 brought to the fore prone positioning as treatment for patients with acute respiratory failure. With the increasing number of patients in prone position, both spontaneously […]

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What chances do children have against COVID-19? Is the answer hidden within the thymus?

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A new type of coronavirus named as SARS-CoV-2 pandemic has begun to threaten human health. As with other types of coronaviruses, SARS-CoV-2 affects children less frequently, and it has been […]

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Approval of Itolizumab for COVID-19: A Premature Decision or Need of The Hour?

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Itolizumab is a first-in-class anti-CD6 monoclonal antibody that was initially developed for various cancers and was later developed and approved in India for treatment of moderate to severe chronic plaque […]

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Use of high-flow nasal cannula and noninvasive ventilation in patients with COVID-19: A multicenter observational study.

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The use of high-flow nasal cannula (HFNC) and noninvasive ventilation (NIV) in patients with COVID-19 is debated.This study was performed in four hospitals of China from January to March 2020. […]

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Risk stratification and outreach to hematology/oncology patients during the COVID-19 pandemic.

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Cancer patients have many medical and psychosocial needs, which may increase during the COVID-19 pandemic. We sought to (1) risk-stratify hematology/oncology patients using general medicine and cancer-specific methods to identify […]

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Hydroxychloroquine and Maintenance Immunosuppression Use in Kidney Transplant Recipients: Analysis of Linked U.S. Registry and Claims Data.

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Hydroxychloroquine (HCQ) is an antimalarial drug with immunomodulatory effects used to treat systemic lupus erythematosus (SLE) and scleroderma. The antiviral effects of HCQ have raised attention in the context of […]

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Association of acute kidney injury with the severity and mortality of SARS-CoV-2 infection: A meta-analysis.

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we aimed to explore the relationship of acute kidney injury (AKI) with the severity and mortality of coronavirus disease 2019 (COVID-19).A systematic literature search was conducted in PubMed, EMBASE, Scopus, […]

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Nationwide COVID-19 survey of Italian parents reveals useful information on attitudes to school attendance, medical support, vaccines and drug trials.

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Children have tended to have milder symptoms during the COVID-19 pandemic than adults and multisystem inflammatory syndrome has been a rare complication. However, restrictions implemented to reduce transmission have directly […]

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The social and clinical impact of the Covid-19 epidemic on the Strasbourg lung transplant cohort – a single-center retrospective cohort study.

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The clinical and social impacts of the Covid-19 epidemic on lung transplant (LTx) recipients remains poorly known. We aimed to evaluate its social, clinical and behavioral consequences on the LTx […]

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An overview of viral infections of the nervous system in the immunosuppressed.

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Several viruses have the capacity to cause serious infections of the nervous system in patients who are immunosuppressed. Individuals may be immunosuppressed because of primary inherited immunodeficiency, secondary immunodeficiency due […]

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Dental care during COVID-19 pandemic: survey of experts’ opinion.

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The current COVID-19 outbreak in conjunction with the need to provide safe dental treatments, and the limited knowledge on the efficacy of protective measures has posed dentists into a challenging […]

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