Improved efficacy and safety of low doses of benznidazole-loaded multiparticulate delivery systems in experimental Chagas disease therapy.

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Benznidazole (BZ) is a first-line drug for the treatment of Chagas disease; however, it presents several disadvantages that could hamper its therapeutic success. Multiparticulate drug delivery systems (MDDS) are promising […]

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Interface-sensitized prodrug nanoaggregate as an effective in situ antitumor vaccine.

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In situ antitumor vaccines have been widely explored as an effective strategy to inhibit tumor growth by stimulating antitumor immune responses. Herein, we reported a simple and effective in situ […]

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Flow Structure and Particle Deposition Analyses for Optimization of a Pressurized Metered Dose Inhaler (pMDI) in a Model of Tracheobronchial Airway.

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Inhalation therapy plays an important role in management or treatment of respiratory diseases such asthma and chronic obstructive pulmonary diseases (COPDs). For decades, pressurized metered dose inhalers (pMDIs) have been […]

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QbD-driven development of dissolving microneedle patch loaded with Ultradeformable liposomes encapsulated Noopept: Exploring a patient friendly, once-daily option to manage Dementia.

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Noopept (NPT), a potent neuroprotective agent, suffers the problem of poor oral bioavailability (∼10 %) and thus demands exploration of ways of bioavailability improvement. Present work focuses on confronting this […]

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Continuous downstream processing of milled electrospun fibers to tablets monitored by near-infrared and Raman spectroscopy.

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Electrospinning is a technology for manufacture of nano- and micro-sized fibers, which can enhance the dissolution properties of poorly water-soluble drugs. Tableting of electrospun fibers have been demonstrated in several […]

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Formulation of olopatadine hydrochloride viscous eye drops – physicochemical, biopharmaceutical and efficacy assessment using in vitro and in vivo approaches.

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The aim of this work was the formulation and the comprehensive evaluation of the viscous eye drops using vehicles containing medium chain chitosan (0.5% w/v), hydroxypropyl guar gum (0.25% w/v) […]

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Medication errors during treatment with new oral anticancer agents: consequences for clinical practice based on the AMBORA study.

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Patients treated with oral anticancer agents (e.g. kinase inhibitors) are a high-risk population for medication errors due to e.g. polymedication, age, and limited adherence. Systematic evaluations regarding frequencies and causes […]

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Nondestructive Investigation of the Agglomeration Process for Nanosuspensions via NMR Relaxation of Water Molecules.

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This study investigated an agglomeration of nanoparticles in a suspension using nuclear magnetic resonance (NMR) relaxation. The nanosuspension was prepared by wet bead milling using indomethacin and polyvinylpyrrolidone as an […]

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A Portable Wireless Urine Detection System with Power-Efficient Electrochemical Readout ASIC and ABTS-CNT Biosensor for UACR Detection.

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This work presents a portable wireless urine detection system which consists of an electrochemical readout application specific integrated circuit (ASIC) and a biosensor composed of 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) and carbon nanotube […]

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Characterization of Prophylactic Antimicrobial Therapy Practices for Patients With Marine-Associated Injuries in the Emergency Department.

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Centers for Disease Control and Prevention (CDC) recommendations for the treatment of marine-associated wound infections include empiric coverage for Vibrio species with a combination of a third-generation cephalosporin and doxycycline. […]

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Evaluation of Weight-Based Dose During Transition From Immediate-Release to Extended-Release Tacrolimus in Kidney Transplant Recipients.

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Manufacturer recommendations for conversion from immediate-release to extended-release tacrolimus, Envarsus XR®, suggests 80% of the total daily dose of the immediate-release formulation. This conversion has not consistently achieved therapeutic levels […]

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How does pressure affect the molecular dynamics, intramolecular interactions, and the relationship between structural (α) and secondary (JG-β) relaxation above and below the glass transition temperature in binary mixtures of H-bonded API – probucol and acetylated saccharides?

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In this paper, the molecular dynamics as well as inter- and intramolecular interactions in the homogenous solid dispersions (SDs) of active pharmaceutical ingredient – probucol (PRO) with acetylated glucose (acGLU), […]

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Comparative efficacy evaluation of different penetration enhancement strategies for dermal delivery of poorly soluble drugs – a case with sertaconazole nitrate.

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The aim of this study was to compare the efficacy of different approaches for enhancement of dermal availability of the highly lipophilic antifungal model drug – sertaconazole nitrate (SN). For […]

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Physiologically based modelling of tranexamic acid pharmacokinetics following intravenous, intramuscular, sub-cutaneous and oral administration in healthy volunteers.

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Tranexamic acid (TXA) is an antifibrinolytic drug that reduces surgical blood loss and death due to bleeding after trauma and post-partum haemorrhage. Treatment success is dependent on early intervention and […]

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