ECG classification is a key technology in intelligent ECG monitoring. In the past, traditional machine learning methods such as SVM and KNN have been used for ECG classification, but with […]» Read more
A drug is granted a license for use after a thorough assessment of risks and benefits based on high quality scientific proof of its efficacy and safety. Many drugs that […]» Read more
Launched in 2002, adalimumab (Humira) is the top revenue-generating drug in the US. Between 2016 and 2019, the US Food and Drug Administration tentatively approved 5 adalimumab biosimilars, yet none […]» Read more
The human leukocyte antigen (HLA) system is the most polymorphic in the human genome that has been associated with protection and predisposition to a broad array of infectious, autoimmune, and […]» Read more
Creatinine clearance is an important tool to describe the renal elimination of drugs in pharmacokinetic evaluations and clinical practice. In critically ill patients, unstable kidney function invalidates the steady state […]» Read more
Improved efficacy and safety of low doses of benznidazole-loaded multiparticulate delivery systems in experimental Chagas disease therapy.
Benznidazole (BZ) is a first-line drug for the treatment of Chagas disease; however, it presents several disadvantages that could hamper its therapeutic success. Multiparticulate drug delivery systems (MDDS) are promising […]» Read more
In situ antitumor vaccines have been widely explored as an effective strategy to inhibit tumor growth by stimulating antitumor immune responses. Herein, we reported a simple and effective in situ […]» Read more
Since the start of the coronavirus SARS-Cov-2 pandemic, a disease that has become one of the world’s greatest global health challenges, the role of the immune system has been at […]» Read more
Flow Structure and Particle Deposition Analyses for Optimization of a Pressurized Metered Dose Inhaler (pMDI) in a Model of Tracheobronchial Airway.
Inhalation therapy plays an important role in management or treatment of respiratory diseases such asthma and chronic obstructive pulmonary diseases (COPDs). For decades, pressurized metered dose inhalers (pMDIs) have been […]» Read more
Hospital Pharmacy Response to Covid-19 Pandemic in Italy: What We Learned From the First Outbreak Wave.
When COVID-19 pandemic started, Italian hospital pharmacists faced multiple challenges and change their work practices.The aim of this study was to describe the impact of COVID-19 emergency on pharmaceutical care […]» Read more
Opioid use disorder is a worldwide societal problem and public health burden. Strategies for treating opioid use disorder can be divided those that target the opioid receptor system and those […]» Read more
A high proportion of depressed patients fail to respond to antidepressant drug treatment. Treatment-resistant depression (TRD) is a major challenge for the psychopharmacology of mood disorders. Only in the past […]» Read more
Pharmacogenetics (PGx) research over the past two decades has produced extensive evidence for the influence of genetic factors on the efficacy and tolerability of antipsychotic treatment. However, the application of […]» Read more
QbD-driven development of dissolving microneedle patch loaded with Ultradeformable liposomes encapsulated Noopept: Exploring a patient friendly, once-daily option to manage Dementia.
Noopept (NPT), a potent neuroprotective agent, suffers the problem of poor oral bioavailability (∼10 %) and thus demands exploration of ways of bioavailability improvement. Present work focuses on confronting this […]» Read more
Continuous downstream processing of milled electrospun fibers to tablets monitored by near-infrared and Raman spectroscopy.
Electrospinning is a technology for manufacture of nano- and micro-sized fibers, which can enhance the dissolution properties of poorly water-soluble drugs. Tableting of electrospun fibers have been demonstrated in several […]» Read more
Formulation of olopatadine hydrochloride viscous eye drops – physicochemical, biopharmaceutical and efficacy assessment using in vitro and in vivo approaches.
The aim of this work was the formulation and the comprehensive evaluation of the viscous eye drops using vehicles containing medium chain chitosan (0.5% w/v), hydroxypropyl guar gum (0.25% w/v) […]» Read more
Medication errors during treatment with new oral anticancer agents: consequences for clinical practice based on the AMBORA study.
Patients treated with oral anticancer agents (e.g. kinase inhibitors) are a high-risk population for medication errors due to e.g. polymedication, age, and limited adherence. Systematic evaluations regarding frequencies and causes […]» Read more
Nondestructive Investigation of the Agglomeration Process for Nanosuspensions via NMR Relaxation of Water Molecules.
This study investigated an agglomeration of nanoparticles in a suspension using nuclear magnetic resonance (NMR) relaxation. The nanosuspension was prepared by wet bead milling using indomethacin and polyvinylpyrrolidone as an […]» Read more
A 99-year-old African-American male presented to the hospital with severe sepsis secondary to a urinary tract infection. Upon initial presentation he was tachycardic, hypotensive and had leukocytosis. While he had […]» Read more
A Portable Wireless Urine Detection System with Power-Efficient Electrochemical Readout ASIC and ABTS-CNT Biosensor for UACR Detection.
This work presents a portable wireless urine detection system which consists of an electrochemical readout application specific integrated circuit (ASIC) and a biosensor composed of 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) and carbon nanotube […]» Read more
An in-memory computing architecture based on two-dimensional semiconductors for multiply-accumulate operations.
In-memory computing may enable multiply-accumulate (MAC) operations, which are the primary calculations used in artificial intelligence (AI). Performing MAC operations with high capacity in a small area with high energy […]» Read more
Characterization of Prophylactic Antimicrobial Therapy Practices for Patients With Marine-Associated Injuries in the Emergency Department.
Centers for Disease Control and Prevention (CDC) recommendations for the treatment of marine-associated wound infections include empiric coverage for Vibrio species with a combination of a third-generation cephalosporin and doxycycline. […]» Read more
Evaluation of Weight-Based Dose During Transition From Immediate-Release to Extended-Release Tacrolimus in Kidney Transplant Recipients.
Manufacturer recommendations for conversion from immediate-release to extended-release tacrolimus, Envarsus XR®, suggests 80% of the total daily dose of the immediate-release formulation. This conversion has not consistently achieved therapeutic levels […]» Read more
The evidence for pharmacogenetics has grown rapidly in recent decades. However, the strength of evidence required for the clinical implementation of pharmacogenetics is highly debated. Therefore, the purpose of this […]» Read more
The drug supply chain has suffered many interruptions over the past decade. The COVID-19 pandemic exacerbated an already fragile infrastructure for supplying critical medications to hospitals and health-systems. The purpose […]» Read more
The pathophysiology for Coronavirus Disease 2019 (COVID-19) infection is characterized by cytokine oxidative stress and endothelial dysfunction. Intravenous (IV) vitamin C has been utilized as adjuvant therapy in critically ill […]» Read more
How does pressure affect the molecular dynamics, intramolecular interactions, and the relationship between structural (α) and secondary (JG-β) relaxation above and below the glass transition temperature in binary mixtures of H-bonded API – probucol and acetylated saccharides?
In this paper, the molecular dynamics as well as inter- and intramolecular interactions in the homogenous solid dispersions (SDs) of active pharmaceutical ingredient – probucol (PRO) with acetylated glucose (acGLU), […]» Read more
Flash memory has become a ubiquitous solid-state memory device widely used in portable digital devices, computers and enterprise applications. The development of the information age has demanded improvements in memory […]» Read more
Comparative efficacy evaluation of different penetration enhancement strategies for dermal delivery of poorly soluble drugs – a case with sertaconazole nitrate.
The aim of this study was to compare the efficacy of different approaches for enhancement of dermal availability of the highly lipophilic antifungal model drug – sertaconazole nitrate (SN). For […]» Read more
Physiologically based modelling of tranexamic acid pharmacokinetics following intravenous, intramuscular, sub-cutaneous and oral administration in healthy volunteers.
Tranexamic acid (TXA) is an antifibrinolytic drug that reduces surgical blood loss and death due to bleeding after trauma and post-partum haemorrhage. Treatment success is dependent on early intervention and […]» Read more