The optimal vasopressor management for septic patients with left ventricular (LV) dysfunction has not been well established, and current evidence is conflicting regarding the optimal vasopressor discontinuation order.The objective was […]» Read more
Cost-sharing increase, medication adherence and hospitalizations in schizophrenia patients: a natural experiment.
Increases in medication cost-sharing rates remain a controversial system-wide cost-containment measure for chronic mental health patients. The objective was to investigate the effects of cost-sharing increases on adherence to prescribed […]» Read more
Inactivation of sGC in living cells proceeds without heme loss and involves heterodimer dissociation as a common step.
Nitric oxide (NO) activates sGC for cGMP production, but in disease sGC becomes insensitive toward NO activation. What changes occur to sGC during its inactivation in cells is not clear.We […]» Read more
Inhaled bacteriophage therapy in a porcine model of pneumonia caused by Pseudomonas aeruginosa during mechanical ventilation.
Pseudomonas aeruginosa is a main cause of ventilator-associated pneumonia (VAP) with drug-resistant bacteria. Bacteriophage therapy has experienced resurgence to compensate for the limited development of novel antibiotics. However, phage therapy […]» Read more
Lorlatinib Exposure-Response Analyses for Safety and Efficacy in a Phase 1/2 Trial to Support Benefit-Risk Assessment in Non-Small Cell Lung Cancer.
Lorlatinib is a small molecule inhibitor of anaplastic lymphoma kinase (ALK) and c-ROS oncogene 1 (ROS1) tyrosine kinases and is approved for the treatment of patients with ALK-positive advanced non-small […]» Read more
Normalisation of glucose metabolism by Exendin-4 in the chronic phase after stroke promotes functional recovery in male diabetic mice.
Glucagon-like peptide-1 receptor (GLP-1R) activation decreases stroke risk in people with type 2 diabetes (T2D) while animal studies have shown the efficacy of this strategy to counteract stroke-induced acute brain […]» Read more
Cardiac fibrosis (scarring), characterised by an increased deposition of extracellular matrix (ECM) proteins, is a hallmark of most types of cardiovascular disease and plays an essential role in heart failure […]» Read more
Uncovering the signaling, structure and function of the 20-HETE-GPR75 pairing: Identifying CCL5 as a negative regulator of GPR75.
The G-protein coupled receptor GPR75 (Gq) and its ligand, the cytochrome P450-derived vasoactive eicosanoid 20-hydroxyeicosatetraenoic acid (20-HETE), are implicated in the activation of pro-inflammatory and hypertensive signaling cascades contributing to […]» Read more
The Role of the Pharmacist in Optimizing Cancer Immunotherapy: A Retrospective Study of Nivolumab Adverse Events.
Immune checkpoint inhibitors (ICIs) are an emerging treatment in cancer therapy for prolonging life, minimizing symptoms, and selectively targeting cancer. Program death 1 (PD-1) inhibitors, such as nivolumab, fall within […]» Read more
Development and Evaluation of a Pharmacist-Driven Screening Tool to Identify Patients Presenting to the Emergency Department Who Are Eligible for Outpatient Treatment of Deep Vein Thrombosis.
Deep vein thrombosis (DVT) is a critical and costly health issue. Treatment in the outpatient setting is preferred compared to the inpatient setting. However, there is a lack of evidence […]» Read more
In vitro and in vivo combinatorial anticancer effects of oxaliplatin- and resveratrol-loaded N,O-carboxymethyl chitosan nanoparticles against colorectal cancer.
Oxaliplatin (OXE) combined with other chemotherapy drugs against colorectal cancer had been reported in the literature before, however, the efficacy of oxaliplatin combined with natural compounds was elusive. In addition, […]» Read more
Angiotensin II augments renal vascular smooth muscle sGC expression via an AT1 R – FoxO transcription factor signaling axis.
Reduced renal blood flow triggers activation of the renin-angiotensin-aldosterone system (RAAS) leading to renovascular hypertension. Renal vascular smooth muscle expression of the nitric oxide (NO) receptor, soluble guanylyl cyclase (sGC), […]» Read more
The Impact of Cocaine Exposure in Adolescence: Behavioral Effects and Neuroplastic Mechanisms in Experimental Models.
Drug addiction is a devastating disorder with a huge economic and social burden for modern society. While an individual may slip into drug abuse throughout his/her life, adolescents are at […]» Read more
Discovery of Non-racemic Amisulpride to Maximize Benefit/Risk of 5-HT7 and D2 Receptor Antagonism for the Treatment of Mood Disorders.
In contrast to the dose-occupancy relationship in the treatment of schizophrenia, the minimal effective level of dopamine receptor 2 (D2R) blockade for antipsychotics in the treatment of bipolar depression is […]» Read more
Macrophages regulate iron homeostasis in the liver and play important role in hepatic ischemia/reperfusion (I/R) injury. The aim of this study was to explore the role of macrophages in iron […]» Read more
Emerging data suggest that coagulopathy, cytokine storm, and acute respiratory distress syndrome are associated with the 2019 coronavirus disease (COVID-19). The prevalence of hypercoagulable state in these patients is unknown, […]» Read more
COVID-19 is a complex disease, and many difficulties are faced today especially in the proper choice of pharmacological treatments. The role of antiviral agents for COVID-19 is still being investigated […]» Read more
Preparation and in-vitro evaluation of mesoporous biogenic silica nanoparticles obtained from rice and wheat husk as a biocompatible carrier for anti-cancer drug delivery.
In this study, mesoporous silica nanocarriers were synthesized from natural sources such as rice and wheat husk for drug delivery application. First, the biogenic silica in cereals husk was extracted […]» Read more
Omega-3 fatty acids eicosapentaenoic acid (EPA) and docosehexaenoic acid (DHA), often found in fish oil supplements, have been linked to cardiovascular benefits in proper doses.Quantify serving sizes and EPA and […]» Read more
Evaluation of a Pharmacy-Driven Calcitonin Protocol for Treating Hypercalcemia in Hospitalized Patients: A Multisite Study.
The dramatic increase in the acquisition cost of injectable calcitonin led to creating a pharmacy-driven calcitonin protocol to improve the appropriate use of calcitonin and other treatment modalities for hypercalcemia.This […]» Read more
Exploration of in vitro drug release testing methods for saquinavir microenvironmental pH modifying buccal films.
Buccal films containing a pH modifying excipient may be able to increase bioavailability of drugs with pH-dependent solubility such as saquinavir. Access to suitable in vitro drug release testing methods […]» Read more
As an agonist of the classical nuclear receptors, ERα and ERβ, estrogen has been understood to inhibit the development of cardiovascular disease in pre-menopausal women. Indeed, reduced levels of estrogen […]» Read more
Paradoxical changes in brain reward status during oxycodone self-administration in a novel test of the negative reinforcement hypothesis.
The extra-medical use of, and addiction to, prescription opioid analgesics is a growing health problem. To characterize how prescription opioid abuse develops, this study investigated the affective consequences of escalating […]» Read more
Population Pharmacokinetics-Pharmacodynamics of Ceftazidime in Neonates and Young Infants: Dosing Optimization for Neonatal Sepsis.
Ceftazidime is a third-generation cephalosporin with high activity against many pathogens. But the ambiguity and diversity of the dosing regimens in neonates and young infants impair access to effective treatment. […]» Read more
cGMP signalling in dorsal root ganglia and the spinal cord: Various functions in development and adulthood.
Cyclic GMP (cGMP) is a second messenger that regulates numerous physiological and pathophysiological processes. In recent years, more and more studies have uncovered multiple roles of cGMP signalling pathways in […]» Read more
Muscarinic M4 and M5 receptor subtypes in the ventral subiculum differentially modulate alcohol seeking vs consumption in male alcohol preferring rats.
Muscarinic acetylcholine receptors (mAChRs) mediate alcohol consumption and seeking in rats, and while M4 and M5 mAChRs have recently been implicated to mediate these behaviours in the striatum, their role […]» Read more
Blocking metabotrobic glutamate receptor 5 by the negative allosteric modulator CTEP improves disease course of ALS in SOD1G93A mice.
The pathogenesis of amyotrophic lateral sclerosis (ALS) is not fully clarified, although excessive glutamate (Glu) transmission and the downstream cytotoxic cascades are major mechanisms for motor neuron death. One and […]» Read more
Gut microbiota contributes to the development of hypertension in a genetic mouse model of systemic lupus erythematosus.
Hypertension is an important cardiovascular risk factor that is prevalent in the systemic lupus erythematosus (SLE) patient population. Here, we have investigated whether intestinal microbiota is involved in hypertension in […]» Read more
Involvement of 3′,5’cyclic inosine monophosphate in cystathionine γ-lyase -dependent regulation of the vascular tone.
L-Cysteine or hydrogen sulfide (H2 S) donors induce a biphasic effect on pre-contracted isolated vessels. The contractile effect is displayed within a concentration range of 10nM-3μM followed by vasodilatation at […]» Read more
Oxytosis/ferroptosis is a form of non-apoptotic regulated cell death characterized by glutathione depletion and dysregulated production of mitochondrial reactive oxygen species that results in lethal lipid peroxidation. As the significance […]» Read more