Embedding an Advanced Pharmacy Technician in an Adult Specialty Pulmonary Clinic to Complete Prior Authorizations Improves Efficiency and Provider Satisfaction.

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The purpose of this study is to assess the impact of a clinic embedded Medication Assistance Program (MAP) specialist on the prescription benefit prior authorization (PA) process and provider satisfaction […]

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Enoxaparin Use and Adverse Events in Outpatients With a Continuous Flow Left Ventricular Assist Device at a Single Institution.

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Patients with left ventricular assist devices (LVADs) are anticoagulated with warfarin and may receive enoxaparin bridging for a subtherapeutic international normalized ratio (INR). There is no guideline regarding enoxaparin bridging […]

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Medication Therapy Management for Texas MediCAID Patients With Asthma and Chronic Obstructive Pulmonary Disease-A Pilot Study.

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Pharmacists can play an important role in providing medication therapy management (MTM) services, which focus on appropriate medication use. This pilot study aimed to describe pharmacists’ MTM service provision, results/outcomes […]

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The Implementation and Effect of Weekend Pharmacy-Driven Antimicrobial Stewardship Services at a Large Academic Medical Center.

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In September 2018, pharmacy antimicrobial stewardship (AMS) services were expanded to include weekends at this academic medical center. Activities performed by AMS pharmacists on the weekends include blood culture rapid […]

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Antibody Conjugated Lipid Nanoparticles as a Targeted Drug Delivery System for Hydrophobic Pharmaceuticals.

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Cancer remains a significant health issue worldwide. The most common group of chemotherapeutic agents are small-molecule drugs, which often are associated with toxic side-effects and non-specific delivery, leading to limited […]

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Eating microRNAs: pharmacological opportunities for cross-kingdom regulation and implications in host gene and gut microbiota modulation.

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Cross-kingdom communication via non-coding RNAs is a recent discovery. Exogenous microRNAs (exog-miRNAs) mainly enter a host through diet. Generally considered unstable in the gastrointestinal (GI) tract, some exogenous RNAs may […]

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Exploring Porcine Gastric and Intestinal Fluids using Microscopic and Solubility Estimates: Impact of Placebo Self-Emulsifying Drug Delivery System Administration to Inform Bio-Predictive in vitro Tools.

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Validation and characterisation of in vitro and pre-clinical animal models to support bio-enabling formulation development is of paramount importance. In this work, post-mortem gastric and small intestinal fluids were collected […]

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Nuclear translocation of ATG5 induces DNA mismatch repair deficiency (MMR-D)/microsatellite instability (MSI) via interacting to Mis18α in colorectal cancer.

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It is well known that high microsatellite instability (MSI-H) is associated with 5-fluorouracil (5-FU) resistance in colorectal cancer (CRC). MSI-H is the phenotype of DNA mismatch repair deficiency (MMR-D), mostly […]

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Development of long-acting rivastigmine drug-in-adhesive patch utilizing ion-pair strategy and characterization of controlled release mechanism.

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The purpose of present study was to develop a long-acting drug-in-adhesive patch of rivastigmine (RVS) to achieve controlled release under high drug loading. Formulation factors including ion-pair, pressure sensitive adhesive […]

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Improved in Vitro and in Vivo Properties of Telmisartan in the Co-amorphous System with Hydrochlorothiazide: A Potential Drug-Drug Interaction Mechanism Prediction.

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The aim of this study is to improve in vitro and in vivo properties of an antihypertensive poorly soluble drug Telmisartan (TEL) by co-amorphization with a pharmacologically relevant drug Hydrochlorothiazide […]

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Multimodality labeling of NGR-functionalized hyaluronan for tumor targeting and radiotherapy.

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Hyaluronan (HA) is a negatively charged linear polysaccharide that can interact with cluster determinant 44 (CD44) overexpressed cancers. However, HA can also bind to excess substrates in the human body […]

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Systematic review and patient-level meta-analysis of SARS-CoV-2 viral dynamics to model response to antiviral therapies.

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SARS-CoV-2 viral loads change rapidly following symptom onset so to assess antivirals it is important to understand the natural history and patient factors influencing this. We undertook an individual patient-level […]

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Immunotherapy for breast cancer using EpCAM aptamer tumor-targeted gene knockdown.

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New strategies for cancer immunotherapy are needed since most solid tumors do not respond to current approaches. Here we used epithelial cell adhesion molecule EpCAM (a tumor-associated antigen highly expressed […]

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Using the CYP3A Activity Evaluation to Predict the Efficacy and Safety of Diazepam in Patients With Alcohol Withdrawal Syndrome.

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Diazepam is one of the most commonly prescribed tranquilizers for the therapy of alcohol withdrawal syndrome (AWS). Despite its popularity, there is currently no precise information on the effect of […]

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Impact of Multiple Prescriptions with Anticholinergic Properties on Adverse Clinical Outcomes in the Elderly: a Longitudinal Cohort Study in Taiwan.

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The cumulative effect of multiple pharmaceutics with anticholinergic properties, i.e., anticholinergic burden, can serve as an indicator of suboptimal prescribing in the elderly. Yet, no research is available concerning the […]

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Moving from Point-based Analysis to Systems-based modeling: Integration of Knowledge to Address Antimicrobial Resistance against MDR Bacteria.

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The emerging discipline of Quantitative Systems Pharmacology (QSP) enables the integration of quantitative experimental data describing the interactions between the various biological processes within the system using mathematical modeling to […]

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Physiologically based pharmacokinetic modelling to support the clinical management of drug-drug interactions with bictegravir.

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Bictegravir is equally metabolized by cytochrome P-450 (CYP)3A and uridine diphosphate-glucuronosyltransferase (UGT)1A1. Drug-drug interaction (DDI) studies were only conducted for strong inhibitors and inducers, leading to some uncertainty whether moderate […]

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Response similarity assessment between polyarticular juvenile idiopathic arthritis and adult rheumatoid arthritis for biologics.

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Poly-articular juvenile idiopathic arthritis (pJIA) is a pediatric chronic inflammatory arthritis, much like rheumatoid arthritis (RA) in adults. Drug development for pJIA can potentially be expedited by using extrapolation of […]

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Sustained inhibition of calcineurin activity with a Melt-Dose Once-daily Tacrolimus formulation in renal transplant recipients.

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Tacrolimus (Tac) is the cornerstone calcineurin inhibitor in transplantation. Extended-release Meltdose formulation (Tac-LCP) offers better bioavailability compared to immediate-release formulation (Tac-IR). We postulated that the less fluctuating pharmacokinetic profile of […]

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