Activation of Trace Amine-Associated Receptor 1 Selectively Attenuates the Reinforcing Effects of Morphine.

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Trace amine-associated receptor 1 (TAAR1) plays a critical role in regulating dopamine transmission. Previous studies showed that pharmacologically or genetically manipulating the activity of TAAR1 modulates addiction-like behaviors associated with […]

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Stimulation of soluble guanylate cyclase by riociguat attenuates heart failure and pathological cardiac remodelling.

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Heart failure (HF) is associated with an impaired NO-soluble guanylate cyclase (sGC)-cyclic guanosine monophosphate (cGMP) pathway, and its augmentation is thought to be beneficial in HF therapy. We hypothesized that […]

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Photostability studies of GarKS peptides for topical formulation development.

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There is a growing interest in the use of antimicrobial peptides (AMPs) as potent alternatives for conventional antibiotics, especially in chronic infected wounds. The development of a suitable topical formulation […]

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A novel G protein-biased agonist at the μ opioid receptor induces substantial receptor desensitization through G protein-coupled receptor kinase.

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G protein-biased μ opioid receptor (MOPr) agonists have the potential to induce less receptor desensitization and tolerance than balanced opioids. Here we demonstrate that the cyclic endomorphin analogue Tyr-c[D-Lys-Phe-Tyr-Gly] (Compound […]

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Drug-Drug Interaction Surveillance Study: Comparing Self-controlled Designs in Five Empirical Examples in Real-world Data.

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Self-controlled designs, specifically the case-crossover (CCO) and the self-controlled case series (SCCS), are increasingly utilized to generate real-world evidence (RWE) on drug-drug interactions (DDIs). While these designs share the advantages […]

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Public Workshop Summary Report on FY2021 Generic Drug Regulatory Science Initiatives: Data analysis and model-based bioequivalence.

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On May 4, 2020, the U.S. Food and Drug Administration (FDA) hosted an online public workshop titled “FY 2020 Generic Drug Regulatory Science Initiatives Public Workshop” to provide an overview […]

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Identification of MHC Class I bound peptides of Francisella tularensis Live Vaccine Strain using mass spectrometry.

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Tularemia, a zoonosis generally prevalent in the northern half of the globe, is caused by Francisella tularensis. Among various Francisella tularensis species, subspecies tularensis is the most pathogenic to humans […]

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Rationally engineered nanosensors: A novel strategy for the detection of heavy metal ions in the environment.

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Heavy metal ions (HMIs) have been mainly originated from natural and anthropogenic agents. It has become one of biggest societal issues due to their recognised accumulative and toxic effects in […]

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Glaucoma: Management and Future Perspectives for Nanotechnology-Based Treatment Modalities.

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Glaucoma, being asymptomatic for relatively late stage, is recognized as a worldwide cause of irreversible vision loss. The eye is an impervious organ that exhibits natural anatomical and physiological barriers […]

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Particle properties and drug metastable solubility of simvastatin containing PVP matrix particles prepared by electrospraying technique.

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In this work the preparation of drug loaded polymeric nanoparticles using electrospraying method and their subsequent characterization is presented. Our purpose was to incorporate the drug with extremely low solubility […]

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Protective effect of suppressor of cytokine signalling 1-based therapy in experimental abdominal aortic aneurysm.

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Abdominal aortic aneurysm (AAA) is a multifactorial disease characterized by chronic inflammation, oxidative stress, and proteolytic activity in the aortic wall. Targeting Janus kinase/signal transducer and activator of transcription (JAK/STAT) […]

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PAR2 induces ovarian cancer cell motility by merging three signalling pathways to transactivate EGFR.

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Specific cellular functions mediated by G protein-coupled receptors (GPCR) are often associated with signaling through a particular G protein or β-arrestin. Here we examine signalling through a GPCR, protease-activated receptor […]

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Field-programmable biological circuits and configurable (bio)logic blocks for distributed biological computing.

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Synthetic biology applications often require engineered computing structures, which can be programmed to process the information in a given way. However, programming of these structures usually requires significant amount of […]

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Field-programmable biological circuits and configurable (bio)logic blocks for distributed biological computing.

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Synthetic biology applications often require engineered computing structures, which can be programmed to process the information in a given way. However, programming of these structures usually requires significant amount of […]

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18F-Radiolabeling and Preliminary Evaluation of a HSP90 ligand.

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With the ambition of improving the management of pancreatic neuroendocrine tumors (P-NETs), we developed and preliminary validated a novel fluorine-18 labelled HSP90 ligand.A precursor containing methoxymethyl ethers protecting groups and […]

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Enhancing anti-melanoma outcomes in mice using novel chitooligosaccharide nanoparticles loaded with therapeutic survivin-targeted siRNA.

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Melanoma anti-tumor therapy remains a challenge. SiRNA-based therapies provide a powerful means, but limitations remain in its pharmaceutical applications owing to the lack of highly efficient delivery systems. In this […]

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Safety, Tolerability and Pharmacokinetics of Bencycloquidium Bromide, a Novel Inhaled Anticholinergic Bronchodilator, in Healthy Subjects: Results from Phase I Studies.

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Bencycloquidium bromide (BCQB) is a novel inhaled anticholinergic bronchodilator with high selectivity for muscarinic M3 receptor. BCQB’s potential utility of for therapy in Chronic obstructive pulmonary disease (COPD) has been […]

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The Evidence REVEAL study: exploring the use of real-world evidence and complex clinical trial design by the European pharmaceutical industry.

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The rapid evolution of science and technology allows innovative approaches to generate new types of evidence about the effectiveness of medical product development so as to speed up patients’ access […]

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How Does the Dissimilarity of Screw Geometry Impact Twin-screw Melt Granulation?

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Using a model formulation of 80% gabapentin and 20% hydroxypropyl cellulose (KlucelTM), we investigate how differences in the geometry of mixing elements in the Leistritz Nano-16 and Micro-18 extruders affect […]

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Repurposing existing drugs for the treatment of COVID-19/SARS-CoV-2 infection: A review describing drug mechanisms of action.

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The outbreak of a novel coronavirus (SARS-CoV-2) has caused a major public health concern across the globe. SARS-CoV-2 is the seventh coronavirus that is known to cause human disease. As […]

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COVID-19 Infection in Men on Testosterone Replacement Therapy.

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Men who contract coronavirus disease 2019 (COVID-19) appear to have worse clinical outcomes compared with women which raises the possibility of androgen-dependent effects.We sought to determine if testosterone replacement therapy […]

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