An increase in pulmonary artery pressure is a common observation in adult mammals exposed to global alveolar hypoxia. It is considered a maladaptive response that places an increased workload on […]» Read more
The effect of reduced gastric acid secretion on the gastrointestinal disposition of a ritonavir amorphous solid dispersion in fasted healthy volunteers: an in vivo – in vitro investigation.
This paper summarizes efforts to (i) better understand the behavior of amorphous solid dispersions (ASDs) under real-life dosing conditions and (ii) evaluate the capability of in vitro methodologies to capture […]» Read more
Converting a batch based high-shear granulation process to a continuous dry granulation process; a demonstration with ketoprofen tablets.
When one wishes to convert a batch based manufacturing process of an existing tablet product to a continuous process, there are several available strategies which can be adopted. Theoretically, the […]» Read more
6-hydroxydopamine lesion and levodopa treatment modify the effect of buspirone in the substantia nigra pars reticulata.
Abnormal involuntary movements known as L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID) are considered a major complication of the pharmacological treatment in Parkinson’s disease (PD). Serotonin (5-HT)-based drugs such as buspirone, a 5-HT1A […]» Read more
Prediction of drug exposure in critically ill encephalopathic neonates treated with therapeutic hypothermia based on a pooled population pharmacokinetic analysis of seven drugs and five metabolites.
Drug dosing in encephalopathic neonates treated with therapeutic hypothermia is challenging; exposure is dependent on body size and maturation but can also be influenced by factors related to disease and […]» Read more
How to Transition from Single Gene Pharmacogenetic Testing to Preemptive Panel-Based Testing: A Tutorial.
There have been significant advancements in precision medicine and approaches to medication selection based on pharmacogenetic results. With the availability of direct-to-consumer genetic testing and growing awareness of genetic inter-individual […]» Read more
Intestinal P-gp and Putative Hepatic OATP1B Induction: ITC Perspective on Drug Development Implications.
There is an increasing interest in transporter induction (i.e., decreased systemic drug exposure due to increased efflux-limited absorption or transporter-mediated clearance) as a mechanism of drug-drug interactions (DDIs), although evidence […]» Read more
Interpretation of Cytochrome P-450 Inhibition and Induction Effects from Clinical Data: Current Standards and Recommendations for Implementation.
Agents that modify cytochrome P-450 (CYP) enzyme activity are characterized as strong, moderate, or weak inhibitors or inducers based on the magnitude of their impact on substrate exposure in clinical […]» Read more
Genetic association of co-trimoxazole-induced severe cutaneous adverse reactions is phenotype-specific: HLA class I genotypes and haplotypes.
Co-trimoxazole (CTX) causes various forms of severe cutaneous adverse reactions (SCARs). This case-control study was conducted to investigate the involvement between genetic variants of human leukocyte antigen (HLA) and CYP2C9 […]» Read more
Most drug labels do not contain dosing recommendations for a significant portion of real world patients for whom the drug is prescribed. Current label recommendations predominately reflect the population studied […]» Read more
Nifekalant is a class III antiarrhythmic drug, and its major adverse effect is prolongation of the QT interval. This study analysed data generated from a pharmacokinetic (PK) study to develop […]» Read more
Radiotherapy has a high cure rate for early nasopharyngeal carcinoma(NPC). However, the radiation resistance of poorly differentiated NPC cells impacts the effectiveness of treatment of early-stage NPC patients. Here, we […]» Read more
Safety and Effectiveness of Sedation With Adjunctive Ketamine Versus Nonketamine Sedation in the Medical Intensive Care Unit.
Ketamine, an N-methyl-d-aspartate receptor antagonist with sedative and analgesic properties, is becoming more popular as an adjunctive sedative in the critically ill patients.We conducted a single center, retrospective cohort study […]» Read more
Improved surface adhesion and wound healing effect of madecassoside liposomes modified by temperature-responsive PEG-PCL-PEG copolymers.
Madecassoside (MA) exhibits excellent therapeutic effects in wound healing and scar management. However, its high hydrophilic nature and low permeability through skin tissue limits its topical application. Liposomes are widely […]» Read more
REGULATION OF GENE EXPRESSION BY MF63, A SELECTIVE INHIBITOR OF INDUCIBLE PROSTAGLANDIN E SYNTHASE-1 (mPGES-1) IN HUMAN OSTEOARTHRITIC CHONDROCYTES.
mPGES-1 catalyzes the production of prostaglandin E2 (PGE2 ), the most abundant prostanoid related to inflammation and pain in arthritis. mPGES-1 is suggested to be a safer and more selective […]» Read more
Pyridine and quinoline molecules as crucial protagonists in the never-stopping discovery of new agents against tuberculosis.
Tuberculosis (TB) disease remains to be an alarming infection worldwide with nearly 1.6 million deaths per year ranking above HIV/AIDS. Although Mycobacterium tuberculosis (Mtb), which causes TB, was identified more […]» Read more
To describe clinical pharmacy services provided in a rural North Carolina primary care clinic and assess the impact of these services on systolic and diastolic blood pressures in patients with […]» Read more
Chemotherapy induced immune-suppression is a common, but potential detrimental, adverse reaction in patients undergoing treatment for cancer, and strategies with capacity to boost the immune cell populations are needed. Physical […]» Read more
Acid-Sensing Ion Channels Contribute to Type III Adenylyl Cyclase-Independent Acid Sensing of Mouse Olfactory Sensory Neurons.
Acids can disturb the ecosystem of wild animals through altering their olfaction and olfaction-related survival behaviors. It is known that the main olfactory epithelia (MOE) of mammals rely on odorant […]» Read more
Mucoadhesive emulgel systems containing curcumin for oral squamous cell carcinoma treatment: from pre-formulation to cytotoxicity in tissue-engineering oral mucosa.
Current oral squamous cell carcinoma chemotherapies demonstrate off-target toxicity, which could be reduced by local delivery. Curcumin acts via many cellular targets to give anti-cancer properties; however the bioavailability is […]» Read more
Exploring MicroRNAs in Diabetic Chronic Cutaneous Ulcers: Regulatory Mechanisms and Therapeutic Potentials.
Diabetic chronic cutaneous ulcers (DCU) is one of the serious complications of diabetes mellitus, which mainly occurs in diabetic patients with peripheral neuropathy. Recent studies have indicated that microRNAs (miRNAs/miRs) […]» Read more
The special issue “Ion Channels of Nociception” contains 13 articles published by 73 authors from different countries united by the main focusing on the peripheral mechanisms of pain. The content […]» Read more
Enhancing the oral bioavailability of simvastatin with silica-lipid hybrid particles: The effect of supersaturation and silica geometry.
Silica-lipid hybrid (SLH) microparticles are a solidified lipid-based drug delivery system under investigation for their aptitude to enhance the oral bioavailability of poorly water-soluble drugs. The cholesterol-lowering agent, simvastatin (SIM), […]» Read more
From real-world patient data to individualized treatment effects using machine learning: Current and future methods to address underlying challenges.
Clinical decision making needs to be supported by evidence that treatments are beneficial to individual patients. While randomized control trials are the gold standard for testing and introducing new drugs, […]» Read more
Physiologically based pharmacokinetic model outputs depend on dissolution data and their input: case examples glibenclamide and dipyridamole.
A plethora of dissolution tests exists for oral dosage forms, with variations in selection of the dissolution medium, the hydrodynamics and the dissolution equipment. This work aimed at determining the […]» Read more
Effect of Selective IK,ACh Inhibition by XAF-1407 in an Equine Model of Tachypacing-induced Persistent Atrial Fibrillation (AF).
Inhibition of the G-protein gated acetylcholine-activated inward rectifier potassium (K+ ) current, IK,ACh , may be an effective atrial selective treatment strategy for atrial fibrillation. Therefore, the anti-arrhythmic and electrophysiological […]» Read more
N-benzhydryl quinuclidine (NBQN) compounds are a potent and Src kinase-independent inhibitor of NALCN channels.
NALCN is a Na+ leak, G-protein-coupled receptor (GPCR)-activated channel that regulates the resting membrane potential and neuronal excitability. Despite numerous possible roles for NALCN in both normal physiology and disease […]» Read more
A physiologically based pharmacokinetic – pharmacodynamic modelling approach to predict incidence of neutropenia as a result of drug-drug interactions of paclitaxel in cancer patients.
Paclitaxel is the backbone of standard chemotherapeutic regimens used in a number of malignancies and is frequently given with concomitant medications. Newly developed oncolytic agents, including tyrosine kinase inhibitors are […]» Read more
Peptide-based cancer therapy has been of great interest due to the unique advantages of peptides, such as the low molecular weight, the ability to specifically target tumor cells, easy availability […]» Read more