Honokiol inhibits proliferation of colorectal cancer cells by targeting Anoctamin 1/TMEM16A Ca2+ -activated Cl- channels.

Bookmark this %label%

Anoctamin 1 (Ano1, also named TMEM16A) Ca2+ -activated Cl- channels contribute to the pathogenesis of colorectal cancer. Honokiol is known to inhibit cell proliferation and tumor growth in colorectal cancer. […]

» Read more

Pharmacokinetic and tissue distribution study of ZCY-15, a novel compound against Alzheimer’s disease, in rats byliquid chromatography-tandem mass spectrometry.

Bookmark this %label%

ZCY-15, N-(3,5-dimethyladamatan-1-yl)-N-(3-methylphenyl) urea, is a candidate compound synthesized from the memantine structure and has been shown to be remarkably effective in treating Alzheimer’s disease. To elucidate the pharmacokinetics and tissue […]

» Read more

A mean-field approach for modeling the propagation of perturbations in biochemical reaction networks.

Bookmark this %label%

Often, the time evolution of a biochemical reaction network is crucial for determining the effects of combining multiple pharmaceuticals. Here we illustrate a mathematical framework for modeling the dominant temporal […]

» Read more

Nose-to-brain delivery of phenytoin and its hydrophilic prodrug fosphenytoin combined in a microemulsion – formulation development and in vivo pharmacokinetics.

Bookmark this %label%

Phenytoin is a low aqueous solubility antiepileptic drug, but its phosphate ester prodrug fosphenytoin is soluble, although less permeable. In a previous study, the intranasal administration of aqueous-based formulations of […]

» Read more

Scalable, highly stable Si-based metal-insulator-semiconductor photoanodes for water oxidation fabricated using thin-film reactions and electrodeposition.

Bookmark this %label%

Metal-insulator-semiconductor (MIS) structures are widely used in Si-based solar water-splitting photoelectrodes to protect the Si layer from corrosion. Typically, there is a tradeoff between efficiency and stability when optimizing insulator […]

» Read more

Case Report: Delayed Alemtuzumab-Induced Concurrent Neutropenia and Thrombocytopenia in Relapsing-Remitting Multiple Sclerosis.

Bookmark this %label%

Alemtuzumab is an anti-CD52 monoclonal antibody used to treat relapsing-remitting multiple sclerosis following failure of second-line medications. It is administered intravenously in 2 treatment sequences 1 year apart. This drug […]

» Read more

Impact of Anticipatory Batching of Pharmacy Compounded Sterile Products on Time to Nurse Administration.

Bookmark this %label%

Timely medication administration is integral to patient care, and operational delays can challenge timely administration. Within an inpatient pharmacy of an academic medical center, intravenous medications were historically compounded on […]

» Read more

In-Furnace Control of Arsenic Vapor Emissions Using Fe2O3 Microspheres with Good Sintering Resistance.

Bookmark this %label%

The addition of Fe2O3 into furnaces is a promising method for arsenic pollution control. Nevertheless, Fe2O3 particles undergo serious sintering under actual furnace temperatures. To improve its sintering resistance, Fe2O3 […]

» Read more

Multi-organ Targeting of HIV-1 Viral Reservoirs with Etravirine Loaded Nanostructured Lipid Carrier: An In-vivo Proof of Concept.

Bookmark this %label%

The inadequate bioavailability and toxicity potential of antiretroviral therapy limit their effectiveness in the complete eradication of HIV from viral reservoirs. The penetration of these drugs into the brain is […]

» Read more

Uncontrolled Extensions of Clinical Trials and the Use of External Controls – scoping opportunities and methods.

Bookmark this %label%

Increased interest in real-world evidence (RWE) for clinical and regulatory decision making and the need to evaluate long-term benefits and risks of pharmaceutical products raise the importance of understanding the […]

» Read more

Doing More With Less: Pragmatic Implementation of Vancomycin Area-Under-the-Curve (AUC) Monitoring.

Bookmark this %label%

Universal area-under-the-curve (AUC) guided vancomycin therapeutic drug monitoring (TDM) is resource-intensive, cost-prohibitive, and presents a paradigm shift that leaves institutions with the quandary of defining the preferred and most practical […]

» Read more

Crystalline Sponge Affinity Screening: A Fast Tool for Soaking Condition Optimization without the Need of X-ray Diffraction Analysis.

Bookmark this %label%

Structural elucidation of small molecules only available in low quantity (nanogram) is one of the big advantages of the crystalline sponge method. The optimization of various soaking parameters is crucial […]

» Read more

Patient-Specific Risk Factors Associated With the Development of Hyperchloremia in a Neurocritical Care Intensive Care Unit.

Bookmark this %label%

Hypertonic sodium chloride (HTS) is used in intensive care unit (ICU) settings to manage cerebral edema, intracranial hypertension, and for the treatment of severe hyponatremia. It has been associated with […]

» Read more

Contemporary Management and Prevention of Vaso-Occlusive Crises (VOCs) in Adults With Sickle Cell Disease.

Bookmark this %label%

Sickle cell disease (SCD) is a hematological disorder that primarily affects individuals of African descent from sub-Saharan Africa and along the mediterranean. The main complications leading to hospitalizations include vaso-occlusive […]

» Read more

Synthesis of multi-color fluorine and nitrogen co-doped graphene quantum dots for use in tetracycline detection, colorful solid fluorescent ink, and film.

Bookmark this %label%

Fluorine-doped graphene quantum dots have unique chemical bonds and charge distribution, which can bring unexpected properties compared to other common atom-doped graphene quantum dots. In the present work, fluorine and […]

» Read more

A semi-mechanistic pharmacokinetic model for depot medroxyprogesterone acetate and drug-drug interactions with antiretroviral and antituberculosis treatment.

Bookmark this %label%

Depot medroxyprogesterone acetate (DMPA) is an injectable hormonal contraceptive, widely used by women of childbearing potential living with HIV and/or tuberculosis. As medroxyprogesterone acetate (MPA) is a CYP3A4 substrate, drug-drug […]

» Read more

Development and verification of an endogenous PBPK model to inform hydrocortisone replacement dosing in children and adults with cortisol deficiency.

Bookmark this %label%

The goal of hormone replacement is to mirror physiology. Hydrocortisone granules and modified release formulations are being developed to optimise cortisol replacement in the rare disease of adrenal insufficiency. To […]

» Read more

Development of Gliclazide ionic liquid and the transdermal patches: an effective and noninvasive sustained release formulation to achieve hypoglycemic effects.

Bookmark this %label%

Ionic liquids (IL) technology provides a useful platform to achieve the topical delivery of therapeutic agents, because of its capability to improve skin permeability. While the majority of the researches […]

» Read more

Electrospun gold nanorods/graphene oxide loaded-core-shell nanofibers for local delivery of paclitaxel against lung cancer during photo-chemotherapy method.

Bookmark this %label%

The combinations of photothermal therapy (PTT) and chemotherapy (CHT) have attracted increasing attention for cancer therapy. In the present study, paclitaxel as an anticancer drug and graphene oxide/gold nanorods (GO/Au […]

» Read more
1 2 3 568