Comparison of the effects of corticosteroid and hyaluronic acid-carboxylmethylcellulose (HA-CMC) solution on selective nerve root block (SNRB) for lumbar radiculopathy: A prospective, double-blind, randomized controlled clinical trial.

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SNRB was shown to effectively control radiating pain and reduce the need for surgical intervention. However, repetitive injections may trigger corticosteroid-induced side effects (hypercorticism, hyperglycemia, or fluid retention). This study […]

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Surgery and opioids: evidence-based expert consensus guidelines on the perioperative use of opioids in the United Kingdom.

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There are significant concerns regarding prescription and misuse of prescription opioids in the perioperative period. The Faculty of Pain Medicine at the Royal College of Anaesthetists have produced this evidence-based […]

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Self-reported prognostic factors in adults reporting neck or low back pain: An umbrella review.

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Numerous systematic reviews have attempted to synthesise evidence on prognostic factors for predicting future outcomes such as pain, disability and return-to-work/work absence in neck and low back pain populations. An […]

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Dorsal Root Ganglion Stimulation for Refractory Post-Herpetic Neuralgia.

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Post-herpetic neuralgia is a chronic neuropathic pain disorder that is the sequela of the varicella zoster virus reactivation in the dorsal root ganglion. A variety of treatment modalities have been […]

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Non-Surgical Interventions for Lumbar Spinal Stenosis Leading To Neurogenic Claudication: A Clinical practice guideline.

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Lumbar spinal stenosis (LSS) causing neurogenic claudication (NC) is increasingly common with an aging population and can be associated with significant symptoms and functional limitations. We developed this guideline to […]

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When do we not face our fears? Investigating the boundary conditions of costly pain-related avoidance generalization.

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Excessive generalization of fear and avoidance are hallmark symptoms of chronic pain disability, yet research focusing on the mechanisms underlying generalization of avoidance specifically, is scarce. Two experiments investigated the […]

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Single Subcutaneous Ketamine Dose Followed by Oral Ketamine for Depression Symptoms in Hospice Patients: A Case Series.

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Management of depression symptoms in hospice patients is complicated by the fact that an appropriate trial of antidepressant therapy requires 4-6 weeks and most hospice patients receive hospice services for less […]

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Modulating Brain Rhythms of Pain using Transcranial Alternating Current Stimulation (tACS) – A Sham-controlled Study in Healthy Human Participants.

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Chronic pain is a major health care problem. A better mechanistic understanding and new treatment approaches are urgently needed. In the brain, pain has been associated with neural oscillations at […]

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Pain Interference with Daily Living Activities and Dependency Level of Patients Undergoing CABG Surgery.

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Postoperative pain is one of the most intensive problems experienced by patients undergoing coronary artery bypass graft surgery. The severity of pain after surgery hinders general activity, sleep, deep breathing, […]

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Prevalence of musculoskeletal chest pain in the emergency department: a systematic review and meta-analysis.

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Our objective was to systematically review and meta-analyse relevant studies to determine the prevalence of musculoskeletal chest pain in the emergency department.This review was constructed while confirming to the preferred […]

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Sleep disturbance in patients attending specialized chronic pain clinics in Denmark: a longitudinal study examining the relationship between sleep and pain outcomes.

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Sleep disturbances are highly prevalent in patients with chronic pain. However, the majority of studies to date examining sleep disturbances in patients with chronic pain have been population-based cross-sectional studies. […]

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The challenge of recognizing severe pain and autonomic abnormalities for early diagnosis of CRPS.

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Complex regional pain syndrome (CRPS) is a disabling usually post-traumatic pain condition. International guidelines emphasize early diagnosis for treatment and improved outcome. Early intense and persistent pain along with features […]

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The Diagnostic Value of an X-ray based scoring system for degeneration of the cervical spine: A Reproducibility and Validation study.

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In interventional pain medicine cervical facet joint (CFJ) pain is commonly treated with CFJ denervation techniques, almost automatically assuming degeneration of the CFJs as an important cause of CFJ pain. […]

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A Cross-Sectional Review of Pain Management Interventions Used for Painful Pediatric Blood Draw Procedures in Hospital.

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Hospitalized children continue to experience procedural pain due to inconsistent implementation of readily available, evidence-based pain interventions.To explore the prevalence of painful blood-testing procedures, pain management interventions, child-caregiver perceptions of […]

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Long-term postoperative opioid prescription after cholecystectomy or gastric by-pass surgery: a retrospective observational study.

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Opioids are commonly prescribed post-surgery. We investigated the proportion of patients who were prescribed any opioids 6-12 months after two common surgeries – laparoscopic cholecystectomy and gastric by-pass (GBP) surgery. A secondary […]

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Multisystem Spinal Cord Stimulation Trialing: A Single Center, Retrospective, Observational Study.

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Spinal cord stimulation is a well established modality for the treatment of chronic intractable pain. The safety and efficacy of various stimulation therapy designs have been demonstrated in multiple randomized […]

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Neural activity during cognitive reappraisal in chronic low back pain: a preliminary study.

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Chronic pain patients often report higher levels of negative emotions, suggesting reduced ability to regulate emotions effectively, however, little is known of the underlying neural cognitive mechanisms. Therefore, the aim […]

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Effects of Propofol versus Sevoflurane on Postoperative Pain and Neuroendocrine Stress Response in Oocyte Pickup Patients.

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Pain aggravates the autonomic response to stress and raises neuroendocrine stress hormone levels. We compared the effects of propofol and sevoflurane on postoperative pain and neuroendocrine stress hormones. A prospective, […]

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Broadening the scope of pediatric intensive interdisciplinary pain treatment to promote future resilience and psychological flexibility.

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This journal recently published a paper by Wager and colleagues, entitled “Long-term outcomes of children with severe chronic pain: Comparison of former patients with a community sample” (Wager et al., […]

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High-frequency spinal cord stimulation as rescue therapy for chronic pain patients with failure of conventional spinal cord stimulation.

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This study aims to evaluate the efficacy of 10-kHz high-frequency (HF10) devices as a rescue treatment in patients with failure of conventional spinal cord stimulation (SCS) therapy for chronic pain […]

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Blockade of Erythropoietin-Producing Human Hepatocellular Carcinoma Receptor B1 in Spinal Dorsal Horn Alleviates Visceral Pain in Rats.

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This experiment was designed to determine whether erythropoietin-producing human hepatocellular carcinoma (Eph) receptors were involved in the development of visceral pain.Adult male Sprague-Dawley rats were randomly divided into three groups […]

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