Lidocaine Continuous Subcutaneous Infusion for Neuropathic Pain in Hospice Patients: Safety and Efficacy.

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Lidocaine continuous subcutaneous infusion (L-CSCI) for neuropathic pain in hospice patients has limited evidence for its safety and efficacy, and guidelines are lacking. This study assesses a series of patients […]

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Expanding frontiers in telehealth: video assisted at-home application of capsaicin 8% patch.

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In recent years, the delivery of health services has undergone a major paradigm shift towards expanded outpatient services and widespread use of telemedicine. Post herpetic neuralgia (PHN) is a treatment […]

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The Diagnostic Value of Magnetic Resonance Imaging in Posttraumatic Trigeminal Neuropathic Pain.

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To evaluate the diagnostic value of non-nerve-selective MRI sequences in posttraumatic trigeminal neuropathic pain (PTNP).This study retrospectively analyzed all MRI protocols performed between February 2, 2012 and June 20, 2018 […]

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Health-related quality of life and pain interference in two patient cohorts with neuropathic pain: breast cancer survivors and HIV patients.

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Persistent pain is common in HIV patients and breast cancer (BC) survivors. The aim of this study was to compare two patient groups with neuropathic pain (NP) regarding several psychological […]

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Feasibility Randomized-Controlled Trial of Online Acceptance and Commitment Therapy for Painful Peripheral Neuropathy in People Living with HIV: The OPEN Study.

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Neuropathic pain negatively affects quality of life among people living with HIV (PLWH). This study examined the feasibility of conducting a full-scale randomized-controlled trial of online acceptance and commitment therapy […]

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Role of the endocannabinoid system in a mouse model of Fragile X undergoing neuropathic pain.

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Neuropathic pain is a complex condition characterized by sensory, cognitive and affective symptoms that magnify the perception of pain. The underlying pathogenic mechanisms are largely unknown and there is an […]

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Medical Cannabis for Chronic Noncancer Pain: A Systematic Review of Health Care Recommendations.

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Medical cannabis for patients with chronic noncancer pain (CNCP) has been the focus of numerous health care recommendations. We conducted a systematic review to identify and summarize the currently available […]

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Central endothelin-1 confers analgesia by triggering spinal neuronal histone deacetylase 5 (HDAC5) nuclear exclusion in peripheral neuropathic pain in mice.

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The rationale of spinal administration of endothelin-1(ET-1) mediated anti-nociceptive effect has not been elucidated. ET-1 is reported to promote nuclear effluxion of histone deacetylase 5 (HDAC5) in myocytes, and spinal […]

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Primary sensorimotor cortex is modified by a 6 week graded motor imagery training in chronic CRPS patients: a randomized trial.

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Complex regional pain syndrome (CRPS) is a neuropathic pain condition that is difficult to treat. For behavioral interventions, graded motor imagery (GMI) showed relevant effects, but underlying neural substrates in […]

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Characteristics of pain in patients with pituitary adenomas: a cross-sectional study.

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This study determines the prevalence and particularities of headache and pain with neuropathic characteristics (NC) in a large French group of patients with pituitary adenoma (PA).Analysis of validated self-administered questionnaires, […]

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Dorsal Root Ganglion Stimulation Normalizes Measures of Pain Processing in Patients with Chronic Low Back Pain: A Prospective Pilot Study using Quantitative Sensory Testing.

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Dorsal root ganglion stimulation (DRG-S) is used as a treatment for chronic low back pain (CLBP), although its underlying mechanisms remain elusive. CLBP patients have been found to have reduced […]

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Cannabis for Chronic Pain: A Rapid Systematic Review of Randomized Control Trials.

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The high prevalence of inadequately managed chronic pain indicates the need for alternative and multimodal treatment options. Use of cannabinoids in medicine is becoming a growing area of interest, specifically […]

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Oral or topical pain therapy – how would patients decide? A discrete choice experiment in patients with peripheral neuropathic pain (pNP).

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To ensure an adequate pain therapy with high patient adherence, it is necessary to know and consider patient preferences. A discrete choice experiment (DCE) was used to obtain patients’ preferences […]

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Activation of the regeneration-associated gene STAT3 and functional changes in intact nociceptors after peripheral nerve damage in mice.

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In the context of neuropathic pain, the contribution of regeneration to the development of positive symptoms is not completely understood. Several efforts have been done to described changes in axotomized […]

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Cross-sectional study of prevalence, characterization and impact of chronic pain disorders in workers.

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Chronic pain prevention and treatment constitute a challenge for occupational health. The aim of this study was to provide data on workers in a variety of jobs and multiple contexts […]

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Eukaryotic initiation factor 4 gamma 2 contributes to neuropathic pain through downregulation of Kv1.2 and the mu opioid receptor in mouse primary sensory neurones.

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Nerve injury-induced changes in gene expression in the dorsal root ganglion (DRG) contribute to neuropathic pain genesis. Eukaryotic initiation factor 4 gamma 2 (eIF4G2) is a general repressor of cap-dependent […]

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Effect of Genetic Polymorphisms on Pain Sensitivity in the Orofacial Region: A Systematic Review.

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To systematically review the literature to assess whether genetic polymorphisms affect orofacial pain sensitivity in healthy individuals and in patients with chronic orofacial pain disorders.Electronic searches were conducted to identify […]

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Involvement of TACAN, a mechanotransducing ion channel, in inflammatory but not neuropathic hyperalgesia in the rat.

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TACAN (Tmem120A), a mechanotransducing ion channel highly expressed in a subset of nociceptors, has recently been shown to contribute to detection of noxious mechanical stimulation. In the present study we […]

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Analgesic Effects of Topical Amitriptyline in Patients with Chemotherapy-Induced Peripheral Neuropathy: Mechanistic Insights from Studies in Mice.

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Oral amitriptyline hydrochloride (amitriptyline) is ineffective against some forms of chronic pain and is often associated with dose-limiting adverse events. We evaluated the potential effectiveness of high-dose topical amitriptyline in […]

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Use of anticonvulsants and antidepressants for treatment of complex regional pain syndrome: a literature review.

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Complex regional pain syndrome (CRPS) is characterized by pain accompanied by symptoms including skin changes, sensory, motor, trophic changes and autonomic dysfunction. Anticonvulsants and antidepressants are commonly prescribed for neuropathic pain […]

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Sensory and pain modulation profiles of ongoing central neuropathic extremity pain in multiple sclerosis.

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Central neuropathic extremity pain (CNEP) is the most frequent type of pain in multiple sclerosis (MS). The aim of the present study was to evaluate sensory and pain modulation profiles […]

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The serotonin receptor 2A (HTR2A) rs6313 variant is associated with higher ongoing pain and signs of central sensitization in neuropathic pain patients.

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The serotonin receptor 2A (HTR2A) has been described as an important facilitation mediator of spinal nociceptive processing leading to central sensitization (CS) in animal models of chronic pain. However, whether […]

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Modulation of SI and ACC response to noxious and non-noxious electrical stimuli after the spared nerve injury model of neuropathic pain.

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The current knowledge on the role of SI and ACC in acute pain processing and how these contribute to the development of chronic pain is limited. Our objective was to […]

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Validation of the Questionnaire for Symptom Assessment in Pain disorders for Back pain patients (Q-SAP).

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Previous studies have shown that not only pain intensity, but also impairment of quality of life and functionality are important parameters for the evaluation of treatment of chronic low back […]

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Median nerve stimulation as a non-pharmacological approach to bypass analgesic tolerance to morphine: a proof-of-concept study in mice.

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Analgesic tolerance to opioids contributes to the opioid crisis by increasing the quantity of opioids prescribed and consumed. Thus, there is a need to develop non-opioid-based pain-relieving regimens as well […]

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