To combat the opioid epidemic, prescribers need accurate information about pediatric home opioid requirements to manage acute pain after surgery. Current opioid use estimates come from retrospective surveys; this study […]» Read more
Reasons for Discontinuation of Acute Postoperative Pain Ketamine Infusions: A Retrospective Case-Control Study.
The purpose of the study was to investigate factors associated with early discontinuation of low-dose ketamine infusions due to adverse drug events (ADEs).A retrospective, matched case-control study of surgical patients […]» Read more
Recent studies in pediatric patients have suggested that ketamine, an N-methyl-D-aspartate receptor (NMDA) antagonist, given at sub-anesthetic doses can effectively decrease pain scores, provide analgesic effects, and in some cases, […]» Read more
Together, neck pain and back pain are the first cause of disability worldwide, accounting for more than 10% of the total years lived with disability. In this context, chiropractic care […]» Read more
The use and impact of guided imagery in the acute care setting is limited.The purpose of this quality improvement project was to evaluate the feasibility of a guided imagery intervention […]» Read more
In recent years, the delivery of health services has undergone a major paradigm shift towards expanded outpatient services and widespread use of telemedicine. Post herpetic neuralgia (PHN) is a treatment […]» Read more
Distraction tasks that place continuous, high demand on executive resources have been shown to reduce pain intensity and pain unpleasantness ratings in healthy adult samples. We examined the effects of […]» Read more
The bidirectional relationship between pain and working memory (WM) deficits is well-documented but poorly understood. Pain catastrophizing – exaggerated, negative cognitive and emotional responses toward pain – may contribute to […]» Read more
Combination of pain location and pain duration is associated with central sensitization related-symptoms in patients with musculoskeletal disorders: A cross-sectional study.
Increased evidence indicates that pain location affects central sensitization (CS)-related symptoms. In addition, pain location and pain duration may be intricately related to CS-related symptoms. However, these factors have been […]» Read more
During the outbreak of coronavirus disease 2019 (COVID-19), allocating intensive care beds to patients needing acute care surgery became a very difficult task. Moreover, since general anesthesia is an aerosol-generating […]» Read more
Iatrogenic Cushing syndrome following lumbar medial branch block in a patient with HIV on ritonavir and darunavir.
We present a case report of a 62-year old female with HIV and chronic facetogenic back pain who underwent bilateral L3-L4 and L4-L5 medial branch nerve blocks using triamcinolone acetonide 80 mg. 2 weeks […]» Read more
Sleep disturbance is thought to aggravate acute postoperative pain. The influence of preoperative sleep problems on pain control in the long-term and development of chronic postsurgical pain is largely unknown.This […]» Read more
Determination of equi-analgesic doses of inhaled methoxyflurane versus intravenous fentanyl using the cold pressor test in volunteers: a randomised, double-blinded, placebo-controlled crossover study.
Inhaled methoxyflurane for acute pain relief has demonstrated an analgesic effect superior to placebo. Data comparing methoxyflurane to an opioid are needed. The aim of this study was to determine […]» Read more
N-acylethanolamine-hydrolyzing acid amidase: a new potential target to treat paclitaxel-induced neuropathy.
Although paclitaxel is an effective chemotherapeutic agent used to treat multiple types of cancer (e.g., breast, ovarian, neck, and lung), it also elicits paclitaxel-induced peripheral neuropathy (PIPN), which represents a […]» Read more
Venipuncture is a common procedure in the neonatal intensive care unit (NICU) and causes significant pain for neonates.To evaluate the effect of maternal voice on pain caused by venipuncture (including […]» Read more
It is common practice to use pain quality indicators (QI) to accurately assess the medical care situation of patients. This literature review identifies the status quo of acute pain QI […]» Read more
Challenges and opportunities in translational pain research – An opinion paper of the working group on translational pain research of the European pain federation (EFIC).
For decades, basic research on the underlying mechanisms of nociception has held promise to translate into efficacious treatments for patients with pain. Despite great improvement in the understanding of pain […]» Read more
The experience of pain is a complex interaction of somatic, behavioral, affective, and cognitive components. Negative psychological states (e.g., anxiety, fear, and depression) are intertwined with pain and contribute to […]» Read more
A Prospective Randomized Comparison of Postoperative Pain and Complications after Thyroidectomy under Different Anesthetic Techniques: Volatile Anesthesia versus Total Intravenous Anesthesia.
While the postoperative outcome is favorable, post-thyroidectomy pain is considerable. Reducing the postoperative acute pain, therefore, is considered important. This study investigated whether the pain intensity and need for rescue […]» Read more
Identification of Neonatal Infant Pain Assessment Tools as a Possibility of Their Application in Clinical Practice in Croatia: An Integrative Literature Review.
This article presents an integrative review of the literature with the aim of identifying instruments already in existence for measuring neonatal infant pain with a view to exploring possibilities of […]» Read more
Predictors of Acute Postsurgical Pain following Gastrointestinal Surgery: A Prospective Cohort Study.
Several predictors have been shown to be independently associated with chronic postsurgical pain for gastrointestinal surgery, but few studies have investigated the factors associated with acute postsurgical pain (APSP). The […]» Read more
Acute pain elicits a well-known inhibitory effect on upper limb corticomotor excitability, whereas the temporal effects of lower-limb experimental pain and pain in a remote limb are less clear. The […]» Read more
Impaired Exercise-induced Hypoalgesia in Individuals Reporting an Increase in Low Back Pain During Acute Exercise.
Exercise therapy is recommended for low back pain (LBP) although the immediate effects on pain are highly variable. In 96 individuals with LBP this cross-sectional study explored 1) the magnitude […]» Read more
Rebound pain is a common, yet under-recognised acute increase in pain severity after a peripheral nerve block (PNB) has receded, typically manifesting within 24 h after the block was performed. This […]» Read more
Intra-accumbal dopaminergic system modulates the restraint stress-induced antinociceptive behaviors in persistent inflammatory pain.
Stress activates several neural pathways that inhibit pain sensation. Nucleus accumbens (NAc) as an important component of the mesolimbic dopaminergic system, has a major role in pain modulation and is […]» Read more
Multicentre randomised controlled clinical trial of electroacupuncture with usual care for patients with non-acute pain after back surgery.
The purpose of this study was to investigate the effectiveness and safety between electroacupuncture (EA) combined with usual care (UC) and UC alone for pain reduction and functional improvement in […]» Read more
The number of people managing chronic conditions is growing with the rapidly aging population. Visits to the emergency department are steadily rising, but little is known about the rationale of […]» Read more
Transcutaneous Electric Nerve Stimulation reduces acute postoperative pain and analgesic use after open inguinal hernia surgery: a randomized, double-blind, placebo-controlled trial.
In this randomized, double-blind, placebo-controlled trial, we evaluated the role of transcutaneous electrical nerve stimulation (TENS) in the multimodal treatment (non-opioid analgesics and kinesiotherapy) of postoperative pain following open inguinal […]» Read more
Qualitative evaluation of the influence of Acute Oxaliplatin-Induced Peripheral Neuropathy on Quality of Life and Activities of Daily Life.
Oxaliplatin often causes acute or chronic peripheral neuropathy in patients with an intestinal or pancreatic tumor, but in-depth insights in its influence on quality of life (QoL) are lacking. We […]» Read more
Migraine is a common and disabling disorder affecting approximately 1.02 billion people worldwide. Calcitonin gene-related peptide (CGRP) has been identified as playing an important role in the pathophysiology of migraine […]» Read more