Opioids: A ‘crisis’ of too much or not enough – or simply how rich you are and where you live?

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The ‘Opioid Crisis’, which originated in Western countries, has been misrepresented and is misinforming the global public. For 20 years, since the advent of the synthetic opioids, 25,000 Americans, on average, […]

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Age-Related Positivity Effect” in the Relationship Between Pain and Depression Among Chinese Community-Dwelling Older Adults: Sex Differences.

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To examine the “age-related positivity effect” and its sex differences in the pain-depression relationship among Chinese community-dwelling older adults.Cross-sectional design.The study was conducted with a sample of 1,913 older adults […]

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The relationship between adverse life events and endogenous inhibition of pain and spinal nociception: Findings from the Oklahoma Study of Native American Pain Risk (OK-SNAP).

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Adverse life events (ALEs) are a risk factor for chronic pain; however, mechanisms underlying this association are not understood. This study examined whether cumulative ALE exposure impairs endogenous inhibition of […]

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Children’s Opioid Use at Home After Laparoscopic Appendectomy.

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To combat the opioid epidemic, prescribers need accurate information about pediatric home opioid requirements to manage acute pain after surgery. Current opioid use estimates come from retrospective surveys; this study […]

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Specialized pro-resolving mediators reduce pro-nociceptive inflammatory mediator production in models of localized provoked vulvodynia.

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Localized provoked vulvodynia (LPV) is the most common cause of chronic dyspareunia in premenopausal women, characterized by pain with light touch to the vulvar vestibule surrounding the vaginal opening. The […]

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Reasons for Discontinuation of Acute Postoperative Pain Ketamine Infusions: A Retrospective Case-Control Study.

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The purpose of the study was to investigate factors associated with early discontinuation of low-dose ketamine infusions due to adverse drug events (ADEs).A retrospective, matched case-control study of surgical patients […]

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Adverse Childhood Experiences (ACEs) and internalizing mental health, pain, and quality of life in youth with chronic pain: A longitudinal examination.

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The aims of this longitudinal study were to 1) identify categories of adverse childhood experiences (ACEs) (i.e., neglect, abuse, household dysfunction in childhood) that increase risk for internalizing mental health […]

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Pain regulation during mindfulness meditation: phenomenological fingerprints in novices and experts practitioners.

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The way people respond to pain is based on psychological mechanisms, beliefs and expectations. Mindfulness meditation (MM) has been shown to regulate pain and mental suffering through different mechanisms such […]

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Lidocaine Continuous Subcutaneous Infusion for Neuropathic Pain in Hospice Patients: Safety and Efficacy.

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Lidocaine continuous subcutaneous infusion (L-CSCI) for neuropathic pain in hospice patients has limited evidence for its safety and efficacy, and guidelines are lacking. This study assesses a series of patients […]

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Low-Dose Ketamine Infusion as Adjuvant Therapy during an Acute Pain Crisis in Pediatric Patients.

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Recent studies in pediatric patients have suggested that ketamine, an N-methyl-D-aspartate receptor (NMDA) antagonist, given at sub-anesthetic doses can effectively decrease pain scores, provide analgesic effects, and in some cases, […]

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Antioxidants improve oxaliplatin-induced peripheral neuropathy in tumor-bearing mice model: role of spinal cord oxidative stress and inflammation.

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Chemotherapy-Induced Peripheral Neuropathy (CIPN) is a common, difficult-to-treat, and dose-limiting side effect associated with Oxaliplatin (OXA) treatment. In this study, we evaluated the effect of three antioxidants – namely N-acetylcysteine, […]

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Fibromyalgia Pain and Fatigue Symptoms in Spanish and U.S. Men.

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Fibromyalgia Syndrome (FMS) is a chronic centralized pain disorder characterized by widespread pain and fatigue. Of those affected by FMS, the majority are women, and minimal research exists involving men. […]

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The Impact of Guided Imagery on Pain and Anxiety in Hospitalized Adults.

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The use and impact of guided imagery in the acute care setting is limited.The purpose of this quality improvement project was to evaluate the feasibility of a guided imagery intervention […]

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Development and Description of a New Multifidus-Sparing Radiofrequency Neurotomy Technique for Facet Joint Pain.

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The technique of radiofrequency neurotomy (RFN) of the facet joints has been used for decades to treat persistent low back pain to good effect in carefully selected patients. Traditionally, the […]

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ECAP-Controlled Closed-Loop Spinal Cord Stimulation Efficacy and Opioid Reduction over 24-Months: Final Results of the Prospective, Multicenter, Open-Label Avalon Study.

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Chronic pain is a major public health concern, as is the associated use of opioid medications, highlighting the importance of alternative treatments such as spinal cord stimulation (SCS). Here we […]

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Structural Validity and Reliability of the Spanish Central Sensitization Inventory in Breast Cancer Survivors.

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One of the most widely used instruments to identify symptoms that may be related to central sensitization is the Central Sensitization Inventory (CSI). Although this instrument has been translated and […]

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Prospective Association between Dysmenorrhea and Chronic Pain Development in Community-Dwelling Women.

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Despite emerging evidence of associations between dysmenorrhea, enhanced pain sensitivity, and functional neuroimaging patterns consistent with chronic pain, it is unknown whether dysmenorrhea is prospectively associated with chronic pain development. […]

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Treatment of knee osteoarthritic pain with platelet-rich plasma: a systematic review of clinical studies.

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Introduction: Knee osteoarthritis is a degenerative joint disease that is secondary to degradation of articular cartilage, reformation of subchondral bone through degradation and proliferation as well as presence of synovitis. Materials […]

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‘Reassurance and health care seeking in people with persistent musculoskeletal low back pain consulting orthopaedic spine practitioners: A prospective cohort study’.

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Guidelines recommend self-management for most people living with persistent musculoskeletal low back pain (PMLBP) when surgery is ruled out. Conveying this message to patients can be challenging. This study examined […]

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Expanding frontiers in telehealth: video assisted at-home application of capsaicin 8% patch.

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In recent years, the delivery of health services has undergone a major paradigm shift towards expanded outpatient services and widespread use of telemedicine. Post herpetic neuralgia (PHN) is a treatment […]

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Visual illusions modulate body perception disturbance and pain in Complex Regional Pain Syndrome: A randomised trial.

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Effective treatment of longstanding Complex Regional Pain Syndrome (CRPS) is a challenge, as causal mechanisms remain elusive. People with CRPS frequently report distorted subjective perceptions of their affected limb. Evidence […]

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Outcomes of Interdisciplinary Pain Rehabilitation Across Subgroups of the Multidimensional Pain Inventory – A Study from the Swedish Quality Registry for Pain Rehabilitation (SQRP).

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The Multidimensional Pain Inventory (MPI) is frequently used in the assessment of chronic pain. Three subgroups have been derived from MPI: Adaptive Coper (AC), Dysfunctional (DYS) and Interpersonally Distressed (ID). […]

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