The ‘Opioid Crisis’, which originated in Western countries, has been misrepresented and is misinforming the global public. For 20 years, since the advent of the synthetic opioids, 25,000 Americans, on average, […]» Read more
Age-Related Positivity Effect” in the Relationship Between Pain and Depression Among Chinese Community-Dwelling Older Adults: Sex Differences.
To examine the “age-related positivity effect” and its sex differences in the pain-depression relationship among Chinese community-dwelling older adults.Cross-sectional design.The study was conducted with a sample of 1,913 older adults […]» Read more
Chronic pain-related sickness absence is an enormous socioeconomic burden globally. Optimized interventions are reliant on a lucid understanding of the distribution of social insurance benefits and their predictors. This register-based […]» Read more
The relationship between adverse life events and endogenous inhibition of pain and spinal nociception: Findings from the Oklahoma Study of Native American Pain Risk (OK-SNAP).
Adverse life events (ALEs) are a risk factor for chronic pain; however, mechanisms underlying this association are not understood. This study examined whether cumulative ALE exposure impairs endogenous inhibition of […]» Read more
To combat the opioid epidemic, prescribers need accurate information about pediatric home opioid requirements to manage acute pain after surgery. Current opioid use estimates come from retrospective surveys; this study […]» Read more
Specialized pro-resolving mediators reduce pro-nociceptive inflammatory mediator production in models of localized provoked vulvodynia.
Localized provoked vulvodynia (LPV) is the most common cause of chronic dyspareunia in premenopausal women, characterized by pain with light touch to the vulvar vestibule surrounding the vaginal opening. The […]» Read more
Reasons for Discontinuation of Acute Postoperative Pain Ketamine Infusions: A Retrospective Case-Control Study.
The purpose of the study was to investigate factors associated with early discontinuation of low-dose ketamine infusions due to adverse drug events (ADEs).A retrospective, matched case-control study of surgical patients […]» Read more
Adverse Childhood Experiences (ACEs) and internalizing mental health, pain, and quality of life in youth with chronic pain: A longitudinal examination.
The aims of this longitudinal study were to 1) identify categories of adverse childhood experiences (ACEs) (i.e., neglect, abuse, household dysfunction in childhood) that increase risk for internalizing mental health […]» Read more
Pain regulation during mindfulness meditation: phenomenological fingerprints in novices and experts practitioners.
The way people respond to pain is based on psychological mechanisms, beliefs and expectations. Mindfulness meditation (MM) has been shown to regulate pain and mental suffering through different mechanisms such […]» Read more
Lidocaine Continuous Subcutaneous Infusion for Neuropathic Pain in Hospice Patients: Safety and Efficacy.
Lidocaine continuous subcutaneous infusion (L-CSCI) for neuropathic pain in hospice patients has limited evidence for its safety and efficacy, and guidelines are lacking. This study assesses a series of patients […]» Read more
Recent studies in pediatric patients have suggested that ketamine, an N-methyl-D-aspartate receptor (NMDA) antagonist, given at sub-anesthetic doses can effectively decrease pain scores, provide analgesic effects, and in some cases, […]» Read more
Together, neck pain and back pain are the first cause of disability worldwide, accounting for more than 10% of the total years lived with disability. In this context, chiropractic care […]» Read more
Fast-Track Cardiac Anesthesia Aids in the Early Diagnosis of Lower Extremity Compartment Syndrome: A Case Report.
A 21-year-old otherwise healthy male with severe asymptomatic mitral regurgitation underwent a mitral valve repair via right thoracotomy and right femoral cannulation for cardiopulmonary bypass. Due to his age and […]» Read more
Cryoneurolysis of Innervation to Sacroiliac Joints: Technical Description and Initial Results-A Case Series.
The sacroiliac joint (SIJ) is a common source of pain in patients with low back pain. Untreated pain from the SIJ can lead to prolonged discomfort and financial burden. Interventional […]» Read more
Opioid-induced hyperalgesia (OIH) occurs when opioids paradoxically enhance the pain they are prescribed to ameliorate. To address a lack of perioperative awareness, we present an educational review of clinically relevant aspects […]» Read more
Antioxidants improve oxaliplatin-induced peripheral neuropathy in tumor-bearing mice model: role of spinal cord oxidative stress and inflammation.
Chemotherapy-Induced Peripheral Neuropathy (CIPN) is a common, difficult-to-treat, and dose-limiting side effect associated with Oxaliplatin (OXA) treatment. In this study, we evaluated the effect of three antioxidants – namely N-acetylcysteine, […]» Read more
Fibromyalgia Syndrome (FMS) is a chronic centralized pain disorder characterized by widespread pain and fatigue. Of those affected by FMS, the majority are women, and minimal research exists involving men. […]» Read more
The use and impact of guided imagery in the acute care setting is limited.The purpose of this quality improvement project was to evaluate the feasibility of a guided imagery intervention […]» Read more
Development and Description of a New Multifidus-Sparing Radiofrequency Neurotomy Technique for Facet Joint Pain.
The technique of radiofrequency neurotomy (RFN) of the facet joints has been used for decades to treat persistent low back pain to good effect in carefully selected patients. Traditionally, the […]» Read more
ECAP-Controlled Closed-Loop Spinal Cord Stimulation Efficacy and Opioid Reduction over 24-Months: Final Results of the Prospective, Multicenter, Open-Label Avalon Study.
Chronic pain is a major public health concern, as is the associated use of opioid medications, highlighting the importance of alternative treatments such as spinal cord stimulation (SCS). Here we […]» Read more
Structural Validity and Reliability of the Spanish Central Sensitization Inventory in Breast Cancer Survivors.
One of the most widely used instruments to identify symptoms that may be related to central sensitization is the Central Sensitization Inventory (CSI). Although this instrument has been translated and […]» Read more
Prospective Association between Dysmenorrhea and Chronic Pain Development in Community-Dwelling Women.
Despite emerging evidence of associations between dysmenorrhea, enhanced pain sensitivity, and functional neuroimaging patterns consistent with chronic pain, it is unknown whether dysmenorrhea is prospectively associated with chronic pain development. […]» Read more
Treatment of knee osteoarthritic pain with platelet-rich plasma: a systematic review of clinical studies.
Introduction: Knee osteoarthritis is a degenerative joint disease that is secondary to degradation of articular cartilage, reformation of subchondral bone through degradation and proliferation as well as presence of synovitis. Materials […]» Read more
‘Reassurance and health care seeking in people with persistent musculoskeletal low back pain consulting orthopaedic spine practitioners: A prospective cohort study’.
Guidelines recommend self-management for most people living with persistent musculoskeletal low back pain (PMLBP) when surgery is ruled out. Conveying this message to patients can be challenging. This study examined […]» Read more
In recent years, the delivery of health services has undergone a major paradigm shift towards expanded outpatient services and widespread use of telemedicine. Post herpetic neuralgia (PHN) is a treatment […]» Read more
As in other fields of medicine, development of new medications for management of neuropathic pain has been difficult since preclinical rodent models do not necessarily translate to the clinics. Aside […]» Read more
Visual illusions modulate body perception disturbance and pain in Complex Regional Pain Syndrome: A randomised trial.
Effective treatment of longstanding Complex Regional Pain Syndrome (CRPS) is a challenge, as causal mechanisms remain elusive. People with CRPS frequently report distorted subjective perceptions of their affected limb. Evidence […]» Read more
The purpose of the current study was to determine whether auditory prepulse inhibition (PPI) and/or prepulse facilitation (PPF) were altered in people with fibromyalgia (FM) when compared with controls. Eyeblink […]» Read more
Outcomes of Interdisciplinary Pain Rehabilitation Across Subgroups of the Multidimensional Pain Inventory – A Study from the Swedish Quality Registry for Pain Rehabilitation (SQRP).
The Multidimensional Pain Inventory (MPI) is frequently used in the assessment of chronic pain. Three subgroups have been derived from MPI: Adaptive Coper (AC), Dysfunctional (DYS) and Interpersonally Distressed (ID). […]» Read more
Distraction tasks that place continuous, high demand on executive resources have been shown to reduce pain intensity and pain unpleasantness ratings in healthy adult samples. We examined the effects of […]» Read more