Pragmatic language skills form the foundation for conversational competence, whereas deficits in this area are associated with behavioral problems and low literacy skills. Children who are deaf or hard of […]» Read more
Intracranial injuries on computed tomography head scans in infants investigated for suspected physical abuse: a retrospective review.
UK national guidelines recommend that investigation of infants (aged <12 months) with suspected physical abuse should always include CT head scans. Such imaging carries small but recognised risks from radiation […]» Read more
Puberty suppression (PS) is a cornerstone of treatment in youth experiencing gender dysphoria. In this study, we aim to inform prescribing professionals on the long-term effects of PS treatment on […]» Read more
Cross-cultural adaptation of the Participation and Environment Measure for Children and Youth (PEM-CY) into German: a qualitative study in three countries.
Concepts such as participation and environment may differ across cultures. Consequently, to use a measure like the Participation and Environment Measure for Children and Youth (PEM-CY) in other than the […]» Read more
Autism spectrum disorder (ASD) is the most common disability-causing neurodevelopmental disorder in childhood. Although inborn errors of metabolism (IEM) are rare causes of ASD, they are significant for several reasons, […]» Read more
RSV prophylaxis use in high-risk infants in Western Australia, 2002-2013: a record linkage cohort study.
The monoclonal antibody, palivizumab is licensed for use in high-risk infants to prevent severe illness caused by respiratory syncytial virus (RSV). The level of its use and compliance with current […]» Read more
Blood transfusions in the neonatal patient population are common, but there are no established guidelines regarding transfusion thresholds. Little is known about postoperative outcomes in neonates who receive preoperative blood […]» Read more
Deferred cord clamping (DCC) saves lives. It reduces extremely preterm infants’ mortality by 30%, yet a minority of eligible infants receive it. This may in part be due to lack […]» Read more
There is no globally accepted definition for dosing error in adult or pediatric practice. The definition of pediatric dosing error varies greatly in the literature. The objective of this study […]» Read more
The SIOP-Renal Tumour Study Group consensus statement on flank target volume delineation for highly conformal radiotherapy.
For decades, radiotherapy with two opposing photon beams has been the standard technique used to cover the flank target volume in paediatric patients with renal tumours. Nowadays, many institutes are […]» Read more
Prevalence of gout and asymptomatic hyperuricemia in the pediatric population: a cross-sectional study of a Japanese health insurance database.
Although gout is rare in children, chronic sustained hyperuricemia can lead to monosodium urate deposits progressing to gout, just as in adults. This study assessed prevalence and characteristics of gout […]» Read more
Given the risks associated with antibiotics, efforts to reduce unnecessary antibiotic use in the NICU have become increasingly urgent. In 2016, a comprehensive 3-year quality improvement (QI) initiative was conducted […]» Read more
No consensus has been reached on capillary blood reference intervals for platelet parameters in full-term neonates. We aimed to establish neonatal capillary blood reference intervals for platelet parameters and evaluate […]» Read more
A sex/gender perspective on interventions to promote children’s and adolescents’ overall physical activity: results from genEffects systematic review.
To evaluate the effects of interventions on children’s and adolescents’ overall physical activity (PA) for boys and girls separately and to appraise the extent to which the studies haven taken […]» Read more
To describe the practice of high-flow nasal cannula (HFNC) use in the pediatric ward setting across North America.A survey was distributed through the Pediatric Research in Inpatient Settings Network, which […]» Read more
Improving infant sleep safety via electronic health record communication: a randomized controlled trial.
With increased use of telehealth, interventions to improve infant sleep environments have not been explored. This study sought to assess the feasibility and efficacy of using electronic health record patient […]» Read more
A scoping review of physical activity and screen time guidelines for use in Outside School Hours Care.
Globally, millions of children attend Outside School Hours Care. Children’s activity in this setting is critical to meeting daily physical activity recommendations. Guidelines are evidence-based statements intended to optimise practice. […]» Read more
New guidelines support using interferon-γ release assays (IGRAs) in children ≥2 years for diagnosis of latent tuberculosis infection (LTBI). However, lack of experience in young children and concern that IGRAs […]» Read more
Rett syndrome (RTT) is a severe neurodevelopmental disorder with complex medical comorbidities extending beyond the nervous system requiring the attention of health professionals. There is no peer-reviewed, consensus-based therapeutic guidance […]» Read more
Clinical practice guideline on the prevention and management of neonatal extravasation injury: a before-and-after study design.
Extravasation injury resulting from intravenous therapies delivered via peripheral intravenous catheters or umbilical and peripherally inserted central venous catheters is a common iatrogenic complication occurring in neonatal intensive care units. […]» Read more
Adolescents with problematic substance use (SU) are at risk for far-reaching adverse outcomes.Synthesize the evidence regarding the effects of brief behavioral interventions for adolescents (12-20 years) with problematic SU.We conducted […]» Read more
Positive End-Expiratory Pressure in Newborn Resuscitation Around Term: A Randomized Controlled Trial.
International guidelines for resuscitation recommend using positive end-expiratory pressure (PEEP) during ventilation of preterm newborns. Reliable PEEP-valves for self-inflating bags have been lacking, and effects of PEEP during resuscitation of […]» Read more
A qualitative study reporting maternal perceptions of the importance of play for healthy growth and development in the first two years of life.
In order for infants and toddlers to meet recommended movement guidelines, their caregivers need to encourage play daily. This study used a qualitative approach to understand how mothers perceive and […]» Read more
The increase in neonatal abstinence syndrome (NAS) has underscored the need for NAS surveillance programs, but many rely on passive surveillance using unverified diagnosis codes. Few studies have evaluated the […]» Read more
Family-based lifestyle interventions are recommended for adolescent obesity treatment, yet the optimal role of parents in treatment is unclear.To examine systematically the evidence from prospective randomized controlled and/or clinical trials […]» Read more
Feeding practices in 6-24-month-old children with chronic cholestatic liver diseases: a mixed-method study.
Children with chronic cholestatic liver diseases have a high risk of malnutrition. However, nutritional management in China has received little attention, and there has been limited evidence regarding improving these […]» Read more
Postnatal length of hospital stay has reduced internationally but evidence-based policies to support earlier discharge are lacking.To determine the effects of early postnatal discharge on infant outcomes.CENTRAL (Cochrane Central Register […]» Read more
Despite little evidence, the practice of routine gastric residual volume (GRV) measurement to guide enteral feeding in neonatal units is widespread. Due to increased interest in this practice, and to […]» Read more
Admission platelet count and indices as predictors of outcome in children with severe Sepsis: a prospective hospital-based study.
Sepsis is still one of the main causes of infants and children mortality especially in developing, economically challenged countries with limited resources. Our objective in this study was to determine, […]» Read more
Acute kidney injury (AKI) may lead to short- and long-term consequences in children, but its epidemiology has not been well described at a population level and outside of ICU settings.In […]» Read more