Travel burden and clinical presentation of retinoblastoma: analysis of 1024 patients from 43 African countries and 518 patients from 40 European countries.

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The travel distance from home to a treatment centre, which may impact the stage at diagnosis, has not been investigated for retinoblastoma, the most common childhood eye cancer. We aimed […]

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Adjuvant use of laser in eyes with macular retinoblastoma treated with primary intravenous chemotherapy.

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Adjuvant use of laser with systemic chemotherapy for treatment of retinoblastoma may reduce recurrence rates while also causing local side effects. Information is lacking on the effect of laser on […]

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Anterior Segment OCTA of Melanocytic Lesions of the Conjunctiva and Iris.

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To study the feasibility and diagnostic value of vascular imaging using OCT-Angiography (OCTA) of melanocytic lesions of the conjunctiva and iris. Design; Cross-sectional study.Twenty-five patients with an untreated conjunctival lesion […]

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Conjunctival melanoma treatment outcomes in 288 patients: a multicentre international data-sharing study.

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To relate conjunctival melanoma characteristics to local control.Retrospective, registry-based interventional study with data gathered from 10 ophthalmic oncology centres from 9 countries on 4 continents. Conjunctival melanoma patients diagnosed between […]

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Long term outcomes of small pigmented choroidal melanoma treated with primary photodynamic therapy.

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To report the long-term outcomes of patients with small, pigmented posteriorly located choroidal melanoma undergoing primary treatment using photodynamic therapy (PDT) with verteporfin at the London Ocular Oncology Service.Retrospective interventional […]

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Small choroidal melanoma: outcomes following apical height dose brachytherapy.

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To assess the outcomes of small choroidal melanoma following iodine-125 episcleral brachytherapy (apical height dose of 85 Gy).Patients with small choroidal melanoma that underwent iodine-125 episcleral brachytherapy between January 2004 and […]

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Retinal vasculometry associations with glaucoma; findings from the European Prospective Investigation of Cancer-Norfolk Eye study.

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To examine retinal vasculometry associations with different glaucomas in older British people.Cross-sectional study METHODS: 8,623 European Prospective Investigation into Cancer-Norfolk Eye study participants were examined, who underwent retinal imaging, ocular […]

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Bacillary Layer Detachment in Bilateral Diffuse Uveal Melanocytic Proliferation Masquerading as Neovascular AMD.

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Bilateral diffuse uveal melanocytic proliferation (BDUMP) is a rare and unusual paraneoplastic ocular syndrome with generally poor prognosis. The authors present a case of BDUMP in a patient with bladder […]

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How Telemedicine and Centralized Care Changed the Natural History of Retinoblastoma in a Developing Country: Analysis of 478 Patients.

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To evaluate the efficacy of integrating telemedicine-based twinning partnership and centralized care for Retinoblastoma (RB) on survival and eye salvage.A cohort of 478 RB patients from 2003 to 2019 treated […]

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Invasive conjunctival melanoma mimicking ocular surface squamous neoplasia: a case series.

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Conjunctival melanoma is the second most common conjunctival malignant tumour after squamous cell carcinoma, usually arising from primary acquired melanosis and less commonly from a conjunctival naevus or de novo. […]

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Iodine-125 interstitial brachytherapy for malignant lacrimal sac tumours: an innovative technique.

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Primary malignant tumours of the lacrimal sac are rare, surgery and radiotherapy may induce substantial side effects for patients. Here, this article reports an innovative technique of interstitial brachytherapy developed […]

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Primary photodynamic therapy for small amelanotic choroidal melanomas: consecutive case series of 69 patients with at least 24-month follow-up.

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To investigate the success and recurrence rates and visual outcomes in a large case series of amelanotic posterior choroidal melanomas treated by means of primary photodynamic therapy (PDT) with verteporfin.Retrospective […]

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Periorbital, conjunctival and primary intraorbital carcinomas: Survival and risk factors after orbital exenteration.

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This study aimed to analyse the disease-free survival (DFS), overall survival (OS) and risk factors after orbital exenteration in patients with periorbital, conjunctival and primary intraorbital carcinomas.Patients undergoing orbital exenteration […]

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OCT changes in peri-tumour normal retina following ruthenium-106 and proton beam radiotherapy for uveal melanoma.

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Uveal melanoma is most commonly treated with radiotherapy, destroying the tumour cells with adequate safety margins and limiting collateral damage to surrounding structures to preserve maximal vision. We used optical […]

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Vogt-Koyanagi-Harada disease-like uveitis following nivolumab administration treated with steroid pulse therapy: a case report.

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Immune checkpoint inhibitors can cause various adverse effects. Recently it has been shown that Vogt-Koyanagi-Harada (VKH) disease-like uveitis can occur in patients treated with nivolumab.A 69-year-old man developed bilateral panuveitis […]

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Profiling ocular surface responses to preserved and non-preserved topical glaucoma medications: a two-year randomised evaluation study.

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Use of topical glaucoma medications has been reported to cause ocular surface (OS) discomfort and inflammation. This study explores the profile of inflammatory cytokines and OS symptoms induced in response […]

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Artificial intelligence for anterior segment diseases: Emerging applications in ophthalmology.

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With the advancement of computational power, refinement of learning algorithms and architectures, and availability of big data, artificial intelligence (AI) technology, particularly with machine learning and deep learning, is paving […]

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Nuclear expression of BAP-1 in transvitreal incisional biopsies and subsequent enucleation of eyes with posterior choroidal melanoma.

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As a majority of patients with choroidal melanoma do not undergo enucleation, tumour tissue for prognostic testing has to be obtained with alternate methods. Transvitreal incisional biopsies enable histological examination […]

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Scleral concave pool trabeculectomy combined phacoemulsification in primary open-angle glaucoma with cataract.

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To investigate the safety and efficacy of scleral concave pool trabeculectomy (SCPT) combined phacoemulsification for eyes with coexisting cataract and primary open-angle glaucoma (POAG).This was a retrospective, controlled, interventional pilot […]

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