Genetic associations of central serous chorioretinopathy: a systematic review and meta-analysis.

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To identify single-nucleotide polymorphisms (SNPs) associated with central serous chorioretinopathy (CSCR) by a systematic review and meta-analysis, and to compare the association profiles between CSCR, neovascular age-related macular degeneration (nAMD) […]

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Evaluation of intravitreal topotecan dose levels, toxicity and efficacy for retinoblastoma vitreous seeds: a preclinical and clinical study.

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Current melphalan-based intravitreal regimens for retinoblastoma (RB) vitreous seeds cause retinal toxicity. We assessed the efficacy and toxicity of topotecan monotherapy compared with melphalan in our rabbit model and patient […]

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Partial lamellar sclerouvectomy surgery for anteriorly located uveal tumour resection: a 20-year experience.

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To investigate the results of partial lamellar sclerouvectomy (PLSU) for anteriorly located uveal tumours.We reviewed the tumour features, histopathologic findings, complications, visual acuity outcomes, eye preservation, metastasis, and mortality data […]

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Long term outcomes of transcutaneous non-image guided bleomycin sclerotherapy in orbital/adnexal lymphatic malformations: a protocol-based management in 69 eyes.

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To study the efficacy and the long-term outcomes of treating micro and macrocystic orbital and/or adnexal lymphatic malformations (OA-LM) with protocol-based bleomycin sclerotherapy.A retrospective interventional study of 69 eyes having […]

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Risk factors leading to trabeculectomy surgery of glaucoma patient using Japanese nationwide administrative claims data: a retrospective non-interventional cohort study.

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Early recognition and management of baseline risk factors may play an important role in reducing glaucoma surgery burdens. However, no studies have investigated them using real-world data in Japan or […]

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Conjunctival melanoma: outcomes based on tumour origin in 629 patients at a single ocular oncology centre.

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To investigate clinical features and outcomes of conjunctival melanoma classified by tumour origin.Retrospective review of conjunctival melanoma patients at a single ocular oncology centre between April 18, 1974 and September […]

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Epidemiological characteristics and clinical course of eyelid squamous cell carcinoma patients from a large tertiary centre between 2009 and 2020.

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To assess epidemiological tumour features, risk factors, clinical management and outcome of eyelid squamous cell carcinoma (SCC) and changes thereof. Furthermore, we searched for validating predictors of the American Joint […]

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Survival in small choroidal melanocytic lesions with risk factors managed by initial observation until detection of tumour growth.

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Main objective was to describe metastatic and survival rates in patients with small choroidal melanocytic lesions initially managed by observation.Retrospective, observational study of consecutive cases recruited from 2001 through 2018, […]

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Orbital exenteration for conjunctival melanoma: comparison of long-term outcome between individualised and conventional techniques.

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Growing evidence supports an individualised approach rather than radical surgery for conjunctival melanoma (CM). This study aimed to compare the long-term outcome between individualised and conventional exenteration techniques.Our study retrospectively […]

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Optimising prediction of early metastasis-free survival in uveal melanoma using a four-category model incorporating gene expression profile and tumour size.

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Largest basal diameter (LBD) appears to have independent prognostic value in uveal melanoma (UM).All patients undergoing plaque brachytherapy or enucleation for UM involving the choroid and/or ciliary body between 2012 […]

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Population-based frequency of ophthalmic adverse events in melanoma, other cancers, and after immune checkpoint inhibitor treatment.

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To examine the frequency of ophthalmic immune-related adverse events (OirAEs) in melanoma, other cancers, and following immune checkpoint inhibitor (ICI) treatment.Retrospective clinical cohort study METHODS: This study identified patients diagnosed […]

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Proton beam irradiation of uveal melanoma involving the iris, ciliary body and anterior choroid without surgical localisation (light field).

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To assess treatment outcomes after proton beam irradiation (PBI) without surgical localisation of uveal melanomas involving the iris, ciliary body and anterior choroid.Retrospective chart review of 125 patients evaluated at […]

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Cascade screening for glaucoma in high-risk family members of African-Caribbean glaucoma patients in an urban population in London.

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Cascade screening has been used successfully in relatives of patients with inherited cancers and other genetic diseases to identify presymptomatic disease. This study was designed to examine if this approach […]

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Cancer risk in individuals with major birth defects: large Nordic population based case-control study among children, adolescents, and adults.

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To examine associations between birth defects and cancer from birth into adulthood.Population based nested case-control study.Nationwide health registries in Denmark, Finland, Norway, and Sweden.62 295 cancer cases (0-46 years) and 724 542 […]

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Clinical outcomes of Modified Collaborative Ocular Melanoma Study IRIS plaques for treatment of iris, iridociliary, and ciliary body melanoma.

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To report clinical outcomes of modified Collaborative Ocular Melanoma Study IRIS (COMS IRIS) plaques for treatment of iris, iridociliary, and ciliary body melanoma.Retrospective, single-centre cohort study of iris melanoma treated […]

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Association of Retinal Vascular Occlusion With Women Filling a Prescription for Female Hormone Therapy.

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Oral contraceptives have been associated with cardiovascular disease, ischemic stroke, venous thromboembolic disease, and breast cancer. Retinal vascular occlusions share the same risk factors as cardiovascular and cerebrovascular disease.To determine […]

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