To identify single-nucleotide polymorphisms (SNPs) associated with central serous chorioretinopathy (CSCR) by a systematic review and meta-analysis, and to compare the association profiles between CSCR, neovascular age-related macular degeneration (nAMD) […]» Read more
Uveal melanoma (UM) is a rare but aggressive cancer, which is the most common primary intraocular malignancy in adults. We aimed to develop and validate a competing risk nomogram to […]» Read more
Evaluation of intravitreal topotecan dose levels, toxicity and efficacy for retinoblastoma vitreous seeds: a preclinical and clinical study.
Current melphalan-based intravitreal regimens for retinoblastoma (RB) vitreous seeds cause retinal toxicity. We assessed the efficacy and toxicity of topotecan monotherapy compared with melphalan in our rabbit model and patient […]» Read more
Partial lamellar sclerouvectomy surgery for anteriorly located uveal tumour resection: a 20-year experience.
To investigate the results of partial lamellar sclerouvectomy (PLSU) for anteriorly located uveal tumours.We reviewed the tumour features, histopathologic findings, complications, visual acuity outcomes, eye preservation, metastasis, and mortality data […]» Read more
The clinical utility of most antiretinal antibodies (retina antibodies) currently available for testing remains unclear and unproven. Despite this, the presence of retinal antibodies is included in current diagnostic autoimmune […]» Read more
Long term outcomes of transcutaneous non-image guided bleomycin sclerotherapy in orbital/adnexal lymphatic malformations: a protocol-based management in 69 eyes.
To study the efficacy and the long-term outcomes of treating micro and macrocystic orbital and/or adnexal lymphatic malformations (OA-LM) with protocol-based bleomycin sclerotherapy.A retrospective interventional study of 69 eyes having […]» Read more
Risk factors leading to trabeculectomy surgery of glaucoma patient using Japanese nationwide administrative claims data: a retrospective non-interventional cohort study.
Early recognition and management of baseline risk factors may play an important role in reducing glaucoma surgery burdens. However, no studies have investigated them using real-world data in Japan or […]» Read more
Conjunctival melanoma: outcomes based on tumour origin in 629 patients at a single ocular oncology centre.
To investigate clinical features and outcomes of conjunctival melanoma classified by tumour origin.Retrospective review of conjunctival melanoma patients at a single ocular oncology centre between April 18, 1974 and September […]» Read more
Epidemiological characteristics and clinical course of eyelid squamous cell carcinoma patients from a large tertiary centre between 2009 and 2020.
To assess epidemiological tumour features, risk factors, clinical management and outcome of eyelid squamous cell carcinoma (SCC) and changes thereof. Furthermore, we searched for validating predictors of the American Joint […]» Read more
Survival in small choroidal melanocytic lesions with risk factors managed by initial observation until detection of tumour growth.
Main objective was to describe metastatic and survival rates in patients with small choroidal melanocytic lesions initially managed by observation.Retrospective, observational study of consecutive cases recruited from 2001 through 2018, […]» Read more
Orbital exenteration for conjunctival melanoma: comparison of long-term outcome between individualised and conventional techniques.
Growing evidence supports an individualised approach rather than radical surgery for conjunctival melanoma (CM). This study aimed to compare the long-term outcome between individualised and conventional exenteration techniques.Our study retrospectively […]» Read more
To review recent advancements in the genetic understanding, diagnosis, prognosis, and treatment of uveal melanoma (UM).UM is a molecularly distinct melanocytic malignancy driven by mutations in GNAQ or GNA11, with […]» Read more
Optimising prediction of early metastasis-free survival in uveal melanoma using a four-category model incorporating gene expression profile and tumour size.
Largest basal diameter (LBD) appears to have independent prognostic value in uveal melanoma (UM).All patients undergoing plaque brachytherapy or enucleation for UM involving the choroid and/or ciliary body between 2012 […]» Read more
Choroidal metastases occur in many patients with systemic cancer and limit quality of life due to visual deterioration or pain. The limited prognosis of these patients demand treatment approaches that […]» Read more
Orbital aspergillosis is a rare sight- and life-threatening fungal infection affecting immunocompromised or otherwise healthy patients. It is often misdiagnosed due to its unspecific clinical and radiologic appearance. Therapeutic delay […]» Read more
Population-based frequency of ophthalmic adverse events in melanoma, other cancers, and after immune checkpoint inhibitor treatment.
To examine the frequency of ophthalmic immune-related adverse events (OirAEs) in melanoma, other cancers, and following immune checkpoint inhibitor (ICI) treatment.Retrospective clinical cohort study METHODS: This study identified patients diagnosed […]» Read more
Proton beam irradiation of uveal melanoma involving the iris, ciliary body and anterior choroid without surgical localisation (light field).
To assess treatment outcomes after proton beam irradiation (PBI) without surgical localisation of uveal melanomas involving the iris, ciliary body and anterior choroid.Retrospective chart review of 125 patients evaluated at […]» Read more
Cascade screening for glaucoma in high-risk family members of African-Caribbean glaucoma patients in an urban population in London.
Cascade screening has been used successfully in relatives of patients with inherited cancers and other genetic diseases to identify presymptomatic disease. This study was designed to examine if this approach […]» Read more
Cancer risk in individuals with major birth defects: large Nordic population based case-control study among children, adolescents, and adults.
To examine associations between birth defects and cancer from birth into adulthood.Population based nested case-control study.Nationwide health registries in Denmark, Finland, Norway, and Sweden.62 295 cancer cases (0-46 years) and 724 542 […]» Read more
Blood-brain barrier disruption (BBBD) is a systemic therapy for malignant central nervous system (CNS) tumors that has been linked to poorly understood pigmentary maculopathy.To examine the rate of and risk […]» Read more
Clinical outcomes of Modified Collaborative Ocular Melanoma Study IRIS plaques for treatment of iris, iridociliary, and ciliary body melanoma.
To report clinical outcomes of modified Collaborative Ocular Melanoma Study IRIS (COMS IRIS) plaques for treatment of iris, iridociliary, and ciliary body melanoma.Retrospective, single-centre cohort study of iris melanoma treated […]» Read more
Vismodegib, a hedgehog pathway inhibitor, has been used in the management of locally advanced basal cell carcinoma (BCC) not suitable for surgery or radiation therapy. We report our experience using […]» Read more
To test whether analyzing DEPArrayTM-isolated single B cells from the vitreous fluid can reveal crucial genomic and clinicopathological features to distinguish patients with VRL from those with chronic inflammation using […]» Read more
Idiopathic orbital pseudotumour is rare in children. We report a case of bilateral paediatric idiopathic orbital pseudotumour and review the characteristics of this case.A 14-year-old female patient presented at our […]» Read more
The objective of this study is to characterise the natural history of conjunctival naevi in a paediatric and adolescent population.All children and adolescents referred to Moorfields Ocular Oncology Service for […]» Read more
We aimed to study the clinical state and prognosis of patients with unilateral retinoblastoma who were being treated at a paediatric comprehensive cancer centre in a limited-resource country, to assess […]» Read more
To report a case of malignant acanthosis nigricans with two unusual aspects, including the patient’s young age and the development of filiform papillomas on the eyelid margins.A 30-year-old woman presented […]» Read more
Postoperative severe visual impairment: surgical outcome of 165 patients with orbital tumours in the muscle cone.
This study aimed to evaluate the risk factors of postoperative severe vision impairment (PSVI) for a primary orbital tumour in the muscle cone.A retrospective analysis of the patients who underwent […]» Read more
Association of Retinal Vascular Occlusion With Women Filling a Prescription for Female Hormone Therapy.
Oral contraceptives have been associated with cardiovascular disease, ischemic stroke, venous thromboembolic disease, and breast cancer. Retinal vascular occlusions share the same risk factors as cardiovascular and cerebrovascular disease.To determine […]» Read more
The purpose of this study is to evaluate tumour vasculature with optical coherence tomography angiography (OCTA) in malignant choroidal melanoma (CM).Patients with unilateral CM were included in this cross-sectional observational […]» Read more