Salpingectomy versus tubal ligation for sterilization: a systematic review and meta-analysis.

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Following strong evidence and major organizations recommending salpingectomy over tubal ligation, we sought to perform a systematic review and meta-analysis comparing the intraoperative attributes and complication rates associated with these […]

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Outcomes after the regionalization of care for high-grade endometrial cancers: a population-based study.

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In June 2013, Ontario Health – Cancer Care Ontario (CCO), the agency responsible for advancing cancer care in Ontario, Canada, published practice guidelines recommending that Gynaecologic Oncologists (GOs) at tertiary […]

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Role of carbon nanoparticle suspension in sentinel lymph node biopsy for early-stage cervical cancer: a prospective study.

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To evaluate the clinical diagnostic validity of carbon nanoparticle suspension (CNS) in sentinel lymph node biopsy (SLNB) for assessing lymphatic spread of early-stage cervical cancer.A prospective study.356 cases.We enrolled 356 […]

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Occupational Exposure to Human Papillomavirus and Vaccination for Health Care Workers.

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Multiple studies suggest that health care workers treating human papillomavirus (HPV)-associated conditions may experience occupational exposure to the virus. Case reports describe the development of cancer and other disease in […]

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Occupational Exposure to Human Papillomavirus and Vaccination for Health Care Workers.

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Multiple studies suggest that health care workers treating human papillomavirus (HPV)-associated conditions may experience occupational exposure to the virus. Case reports describe the development of cancer and other disease in […]

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The impact of surgical learning curve on survival – reopening the door for minimally invasive surgery in the management of cervical cancer?

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Minimally invasive surgery has been widely adopted in gynaecologic oncology with a significant surge the past decade associated with the introduction of robot-assisted surgery. Up until 2018, virtually all testimonials […]

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The impact of surgical learning curve on survival – reopening the door for minimally invasive surgery in the management of cervical cancer?

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Minimally invasive surgery has been widely adopted in gynaecologic oncology with a significant surge the past decade associated with the introduction of robot-assisted surgery. Up until 2018, virtually all testimonials […]

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Recommendations for the use of next-generation sequencing (NGS) for patients with metastatic cancers: A report from the ESMO Precision Medicine Working Group.

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Next-generation sequencing (NGS) allows sequencing a high number of nucleotides in a short time frame at an affordable cost. While this technology has been widely implemented, there are no recommendations […]

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Ovarian cancer prognosis in women with endometriosis. A retrospective nationwide cohort study of 32,419 women.

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Contradicting results regarding ovarian cancer prognosis in women with endometriosis have been reported in the literature. Due to the small sample size of previous studies, larger studies are required to […]

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A combination of cytokeratin 5/6, p63, p40 and MUC5AC are useful for distinguishing squamous cell carcinoma from adenocarcinoma of the cervix.

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Squamous cell carcinomas and adenocarcinomas are the most common types of cervical cancer. Compared to squamous cell carcinomas, adenocarcinomas are more common in younger women and have a poorer prognosis. […]

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Report of NCI and NICHD-Sponsored Workshop: Gynecology and Women’s Health-Benign Conditions and Cancer.

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The Division of Cancer Prevention and the Division of Cancer Biology at the National Cancer Institute, and the Gynecologic Health and Disease Branch in the National Institute of Child Health […]

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Endometrial biomarkers in premenopausal obese women: an at-risk cohort.

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Obesity is a well-known risk factor for endometrial cancer, yet mechanisms of obesity-related carcinogenesis are not well-defined, particularly for premenopausal women. With the continuing obesity epidemic, increases in endometrial cancer […]

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Robot-Assisted Surgery for Noncancerous Gynecologic Conditions: ACOG COMMITTEE OPINION, Number 810.

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For noncancerous conditions, such as hysterectomy, a minimally invasive approach to gynecologic surgery has well-documented advantages-including faster return to normal activities, decreased length of stay, and better quality of life-compared […]

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Anorectal Disorders: Clinical Updates in Women’s Health Care Primary and Preventive Care Review.

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Anorectal disorders can have overlapping symptoms, which sometimes can make it difficult to establish a diagnosis. Obtaining a detailed history and performing a physical examination are vital to establish the […]

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Robot-Assisted Surgery for Noncancerous Gynecologic Conditions: ACOG COMMITTEE OPINION SUMMARY, Number 810.

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For noncancerous conditions, such as hysterectomy, a minimally invasive approach to gynecologic surgery has well-documented advantages-including faster return to normal activities, decreased length of stay, and better quality of life-compared […]

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MILO/ENGOT-ov11: Binimetinib Versus Physician’s Choice Chemotherapy in Recurrent or Persistent Low-Grade Serous Carcinomas of the Ovary, Fallopian Tube, or Primary Peritoneum.

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Low-grade serous ovarian carcinomas (LGSOCs) have historically low chemotherapy responses. Alterations affecting the MAPK pathway, most commonly KRAS/BRAF, are present in 30%-60% of LGSOCs. The purpose of this study was […]

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CD70 antibody-drug conjugate as a potential therapeutic agent for uterine leiomyosarcoma.

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Uterine leiomyosarcoma is a rare and aggressive gynecologic malignancy originating in the myometrium of the uterine corpus that tends to recur even after complete surgical excision. Current therapeutic agents have […]

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Cost of Care for the Initial Management of Cervical Cancer in Women with Commercial Insurance.

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Women with newly diagnosed cervical cancer are often treated with extensive, multimodal therapy that may include a combination of surgery, radiation, and chemotherapy. Little is known about the cost of […]

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Benefit and burden in the Dutch cytology-based versus high-risk human papillomavirus-based cervical cancer screening program.

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In 2017, the Dutch cervical cancer screening program has replaced primary cytology-based screening by primary high-risk human papillomavirus based screening, including the opportunity to participate through self-sampling. Evaluation and balancing […]

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Prospective Phase II Trial of Levonorgestrel Intrauterine Device: Non-Surgical Approach for Complex Atypical Hyperplasia and Early Endometrial Cancer.

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The incidence of complex atypical hyperplasia and early stage endometrioid endometrial cancer is increasing, in part due to the epidemic of obesity, a risk factor tightly linked to development of […]

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Attitudes towards risk-reducing early salpingectomy with delayed oophorectomy for ovarian cancer prevention: a cohort study.

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To determine risk-reducing early salpingectomy and delayed oophorectomy (RRESDO) acceptability and effect of surgical prevention on menopausal sequelae/satisfaction/regret in women at increased ovarian cancer (OC) risk.Multicentre, cohort, questionnaire study (IRSCTN:12310993).United […]

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PARP Inhibitors in the Management of Ovarian Cancer: ASCO Guideline.

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To provide recommendations on the use of poly(ADP-ribose) polymerase inhibitors (PARPis) for management of epithelial ovarian, tubal, or primary peritoneal cancer (EOC).Randomized, controlled, and open-labeled trials published from 2011 through […]

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Impact of Medicaid expansion on women with gynecologic cancer: A difference-in-difference analysis.

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Women with gynecologic cancer face socioeconomic disparities in care that impact survival outcomes. The Affordable Care Act offered states the option to expand Medicaid enrollment eligibility criteria as a means […]

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Olaparib and durvalumab in patients with germline BRCA-mutated metastatic breast cancer (MEDIOLA): an open-label, multicentre, phase 1/2, basket study.

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Poly (ADP-ribose) polymerase inhibitors combined with immunotherapy have shown antitumour activity in preclinical studies. We aimed to assess the safety and activity of olaparib in combination with the PD-L1-inhibitor, durvalumab, […]

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Human papillomavirus vaccine effectiveness within a cervical cancer screening programme: cohort study.

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To assess the effectiveness of an HPV vaccination programme in reducing the risk of cervical abnormalities identified at subsequent screening.Retrospective cohort study using administrative health data.General population of Ferrara Province, […]

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Front-line ovarian cancer maintenance therapy: PARP inhibitors for all?

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Poly (ADP-ribose) polymerase inhibitors (PARPi) have enjoyed enormous recent success in the treatment of ovarian cancer, a deadly and difficult to treat disease. In recent years, PARPi have gained approvals […]

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Radical Trachelectomy for the Treatment of Early-Stage Cervical Cancer: A Systematic Review.

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To assess surgical, oncologic, and pregnancy outcomes in patients undergoing radical vaginal, abdominal, or laparoscopic trachelectomy for the treatment of early-stage cervical cancer, using a methodic review of published literature.PubMed, […]

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