Patterns of clinicopathological features and outcome in epithelial ovarian cancer patients: 35 years of prospectively collected data.

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Investigate the clinical landscape of ovarian carcinoma(OC) over time.Register-based prospectively collected data.South-East Scotland SAMPLE: 2805 OC patients diagnosed 1981-2015.Survival times were visualised using the Kaplan-Meier method; median survival, 5-year survival […]

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Risk assessment of endometrial cancer and endometrial intraepithelial neoplasia in women with abnormal bleeding and implications for clinical management algorithms.

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Most endometrial cancer cases are preceded by abnormal uterine bleeding, offering a potential opportunity for early detection and cure of endometrial cancer. While clinical guidelines exist for diagnostic workup of […]

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Important insights for non-molar choriocarcinoma.

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Although gestational trophoblastic neoplasia (GTN) is a rare event, particularly after a non-molar pregnancy, the true incidence of GTN is difficult to establish with certainty because data regarding the incidence […]

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Black and Hispanic women are less likely than White women to receive guideline-concordant endometrial cancer treatment.

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Differences in receipt of guideline-concordant treatment might underlie well-established racial disparities in endometrial cancer mortality.Using the National Cancer Database, we assessed the hypothesis that among women with endometrioid endometrial cancer, […]

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Demographics, Natural History and Treatment Outcomes of Non-Molar Gestational Choriocarcinoma; A UK population study.

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To investigate the demographics, natural history and treatment outcomes of non-molar gestational choriocarcinoma.A retrospective national population-based study SETTING: UK 1995-2015 POPULATION: A total of 234 women with a diagnosis of […]

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Atypical endometrial polyps and the incidence of endometrial cancer: a retrospective cohort study.

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The aim of this study is to evaluate the incidence of endometrial carcinoma, proven after hysterectomy, in patients diagnosed with atypical endometrial hyperplasia confined to a polyp. A secondary aim […]

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Impact of Quality of Care on Racial Disparities in Survival for Endometrial Cancer.

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Black women experience poorer survival compared to white women across all endometrial cancer stages and histologies. The incidence of endometrial cancer is 30% lower in black women compared to white […]

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Radical hysterectomy for cervical cancer: reducing ureteric injuries.

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Ureteric injury during radical hysterectomies for cervical cancer is a well-known complication requiring some form of intervention to redress the damage. The incidence is reported at approximately 2%. Direct ureteric […]

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Association Between Genetically Proxied Inhibition of HMG-CoA Reductase and Epithelial Ovarian Cancer.

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Preclinical and epidemiological studies indicate a potential chemopreventive role of statins in epithelial ovarian cancer risk.To evaluate the association of genetically proxied inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (ie, […]

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Recurrence Rates in Patients With Cervical Cancer Treated With Abdominal Versus Minimally Invasive Radical Hysterectomy: A Multi-Institutional Retrospective Review Study.

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To compare the disease-free survival (DFS) between open and minimally invasive radical hysterectomies (RH) performed in academic medical institutions.Retrospective multi-institutional review of patients undergoing RH for stage IA1 (with lymphovascular […]

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Occult Tubal Carcinoma After Risk-Reducing Salpingo-oophorectomy: A Systematic Review.

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To perform a systematic review of the literature to estimate the prevalence and outcomes of occult tubal carcinoma in BRCA mutation carriers and high-risk patients undergoing risk-reducing salpingo-oophorectomy.A search was […]

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Phase II study of treatment of advanced ovarian cancer with folate-receptor-targeted therapeutic (vintafolide) and companion SPECT-based imaging agent (99mTc-etarfolatide).

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This report examines 99mTc-etarfolatide imaging to identify the presence of folate receptor (FR) on tumors of women with recurrent/refractory ovarian or endometrial cancer and correlates expression with response to FR-targeted […]

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Sam68 expression and cytoplasmic localization is correlated with lymph node metastasis as well as prognosis in patients with early-stage cervical cancer.

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This study was aimed at investigating the role and molecular mechanism of Sam68 in cervical cancer lymph node metastasis.Sam68 expression profile was detected by quantitative polymerase chain reaction, western blotting […]

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Carboplatin and pegylated liposomal doxorubicin versus carboplatin and paclitaxel in partially platinum-sensitive ovarian cancer patients: results from a subset analysis of the CALYPSO phase III trial.

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To perform a subset analysis of patients with partially platinum-sensitive recurrent ovarian cancer (ROC) who received either CD [carboplatin-pegylated liposomal doxorubicin (PLD)] or CP (carboplatin-paclitaxel) in the CALYPSO trial.CALYPSO, an […]

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A randomized phase II study investigating the addition of the specific COX-2 inhibitor celecoxib to docetaxel plus carboplatin as first-line chemotherapy for stage IC to IV epithelial ovarian cancer, Fallopian tube or primary peritoneal carcinomas: the DoCaCel study.

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In ovarian cancer, cyclooxygenase-2 (COX-2) overexpression is prognostic for poor survival. We investigated the efficacy of celecoxib (C), a selective COX-2 inhibitor, added to docetaxel (Taxotere)/carboplatin (DC) in advanced ovarian […]

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Health-related quality of life in recurrent platinum-sensitive ovarian cancer-results from the CALYPSO trial.

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In the CALYPSO trial, carboplatin-pegylated liposomal doxorubicin (CD) demonstrated superior therapeutic index versus carboplatin-paclitaxel (CP) in patients with recurrent ovarian cancer. This paper reports the health-related quality of life (HRQoL) […]

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A phase II trial (AGO 2.11) in platinum-resistant ovarian cancer: a randomized multicenter trial with sunitinib (SU11248) to evaluate dosage, schedule, tolerability, toxicity and effectiveness of a multitargeted receptor tyrosine kinase inhibitor monotherapy.

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Recurrent platinum-resistant ovarian cancer usually has a poor outcome with conventional chemotherapeutic therapy and new treatment modalities are warranted. This phase II study was conducted to evaluate sunitinib, an oral […]

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A randomized phase III adjuvant study in high-risk cervical cancer: simultaneous radiochemotherapy with cisplatin (S-RC) versus systemic paclitaxel and carboplatin followed by percutaneous radiation (PC-R): a NOGGO-AGO Intergroup Study.

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Simultaneous adjuvant platinum-based radiochemotherapy in high-risk cervical cancer (CC) is an established treatment strategy. Sequential paclitaxel (Taxol) and platinum followed by radiotherapy may offer further advantages regarding toxicity.An open-labeled randomized […]

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Phase II study of bevacizumab with liposomal doxorubicin for patients with platinum- and taxane-resistant ovarian cancer.

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Suppression of neoangiogenesis and pegylated liposomal doxorubicin (PLD) each contribute to the management of platinum-resistant/refractory ovarian cancer. The aim of this study is to test the combination of bevacizumab and […]

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Trabectedin plus pegylated liposomal doxorubicin in the treatment of patients with partially platinum-sensitive ovarian cancer: current evidence and future perspectives.

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The effectiveness of platinum re-treatment in relapsed ovarian cancer depends on relapse-free/treatment-free intervals. Platinum agents can be effectively readministered to platinum-sensitive patients (relapsing >12 months after platinum), but efficacy is […]

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Maternal and fetal outcomes of taxane chemotherapy in breast and ovarian cancer during pregnancy: case series and review of the literature.

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The purpose of this study was to evaluate the use of taxane chemotherapy during pregnancy and compare maternal and neonatal outcomes with those in women who did not receive taxanes […]

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Incidence of endometrioid and clear-cell ovarian cancer in histological proven endometriosis. The ENOCA population-based cohort study.

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Several studies have suggested that endometriosis is associated with an increased risk of ovarian cancer, especially for clear-cell and endometrioid subtypes. However previous studies lack sufficient power or diagnostic certainty.To […]

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First line treatment with carboplatin-paclitaxel-bevacizumab in ovarian cancer: retrospective review of a single institute experience.

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Click here to read the full article @ Annals of oncology : official journal of the European Society for Medical Oncology

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ARIEL4: An international, randomised phase 3 study of rucaparib vs chemotherapy as treatment for BRCA1- or BRCA2-mutated, relapsed ovarian cancer.

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Click here to read the full article @ Annals of oncology : official journal of the European Society for Medical Oncology

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Assessing the risk of pelvic and para-aortic nodal involvement in apparent early-stage ovarian cancer: a predictors- and nomogram-based analyses.

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Click here to read the full article @ Annals of oncology : official journal of the European Society for Medical Oncology

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