Adnexal Torsion Recurrence – Is the Adnexal Twist Degree a Risk Factor? A Retrospective Cohort Study.

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To evaluate whether the adnexal twist degree is related to torsion recurrence and whether there is a dose-dependent relationship.A retrospective cohort study SETTING: Single tertiary medical center POPULATION: The study […]

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Incidence and risk factors for severe preeclampsia, HELLP syndrome and eclampsia at preterm and term gestation: a population-based study.

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A majority of previous studies of severe preeclampsia, eclampsia and HELLP (hemolysis, elevated liver enzymes and low platelets) syndrome were hospital-based or included a relatively small number of women. Large […]

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Cost-effectiveness of mifepristone and misoprostol versus misoprostol alone for the management of missed miscarriage: an economic evaluation based on the MifeMiso Trial.

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To assess the cost-effectiveness of mifepristone and misoprostol (MifeMiso) compared with misoprostol only for the medical management of a missed miscarriage.Within-trial economic evaluation and model-based analysis to set the findings […]

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Early Pregnancy Prediction of Spontaneous Preterm Birth Prior to 32 Completed Weeks of Pregnancy Using Plasma RNA: Transcriptome Discovery and Initial Validation of an RNA Panel of Markers.

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Compare the second trimester plasma cell-free (PCF) transcriptome of women who delivered at term to women with spontaneous preterm birth (sPTB)≦32weeks and identify/validate PCF ribonucleic acid (RNA) markers present by […]

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Validation of cobas 4800 HPV assay in SurePath Papanicolaou specimens for cervical cancer screening.

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The cobas (Roche Diagnostics, Indianapolis, IN) HPV assay was approved by the US Food and Drug Administration for human papillomavirus (HPV) testing in SurePath (Becton Dickinson, Franklin Lakes, NJ) Papanicolaou […]

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The Recognition of Excessive blood loss At ChildbirTh (REACT) Study: A two-phase exploratory, sequential mixed methods inquiry using focus groups, interviews, and a pilot, randomised crossover study.

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To explore how childbirth-related blood loss is evaluated and excessive bleeding recognised; and develop and test a theory of postpartum haemorrhage (PPH) diagnosis.Two-phase, exploratory, sequential mixed methods design using focus […]

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Pre-incision Adjunctive Prophylaxis for Cesarean Sections: A Systematic Review and Meta-analysis.

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To systematically review the relative effectiveness of pre-incision cefazolin with or without adjunctive prophylaxis (macrolides or metronidazole), versus cefazolin alone, in decreasing the incidence of post-Cesarean surgical site infections.We performed […]

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Fetomaternal Hemorrhage: Evaluation of Recurrence Within a Large Integrated Health Care System.

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Fetomaternal hemorrhage is associated with severe fetal morbidity and mortality. The recurrence risk of fetomaternal hemorrhage is unknown.We sought to establish the recurrence rate of fetomaternal hemorrhage in a large […]

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Mini-commentary on: BJOG-20-1967.R2: Use of non-steroidal anti-inflammatory drugs in early pregnancy and preterm birth: Is the jury still out?

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When an analgesic or antipyretic is needed in pregnancy, nonsteroidal anti-inflammatory drugs (NSAIDs) are contraindicated at 20 weeks’ gestation (WG) or later1 . Nevertheless, NSAIDs are thought to be used […]

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Frequency of high grade squamous cervical lesions among women over age 65 years living with the human immunodeficiency virus.

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Current U.S. cervical cancer screening guidelines recommend a stop to screening at age 65 years provided women have adequate prior screening and no history of precancer. Women living with the […]

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Two-port, exteriorized uterus, fetoscopic meningomyelocele closure has fewer adverse neonatal outcomes than open hysterotomy closure.

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In-utero closure of meningomyelocele using an open hysterotomy approach is associated with preterm delivery and its attendant adverse neonatal outcomes.This study compares neonatal outcomes between in-utero closure of meningomyelocele using […]

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High-Dose Compared With Standard-Dose Oxytocin Regimens to Augment Labor in Nulliparous Women: A Randomized Controlled Trial.

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To evaluate whether a high-dose oxytocin regimen reduces the risk for primary cesarean birth and other obstetric morbidities when compared with standard dosing.In a double-blind randomized clinical trial of nulliparous […]

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Intravenous oxytocin dosing regimens for postpartum hemorrhage prevention at cesarean section: a systematic review and meta-analysis.

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To synthesize available evidence on intravenous (IV) oxytocin dosing regimens for the prevention of postpartum hemorrhage (PPH) at cesarean section (CS).We searched Medline/OVID, Embase, Global Index Medicus, CINAHL, CENTRAL, ClinicalTrials.gov, […]

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Mindfulness Effects in Obstetric and Gynecology Patients During the Coronavirus Disease 2019 (COVID-19) Pandemic: A Randomized Controlled Trial.

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To assess the effect of a consumer-based mobile meditation application (app) on wellness in outpatient obstetric and gynecology patients during the coronavirus disease 2019 (COVID-19) pandemic.We conducted a randomized controlled […]

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New insights in diagnostic thresholds for total serum bile acid (TSBA) in intrahepatic cholestasis of pregnancy (ICP).

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Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy specific liver disorder known to be associated with fetal adverse events, in particular stillbirth. At present, an effective treatment to reduce the […]

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Outcomes of the First Pregnancy After Fertility-Sparing Surgery for Early-Stage Ovarian Cancer.

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To evaluate the outcomes of the first pregnancy after fertility-sparing surgery in patients treated for early-stage ovarian cancer.We performed a retrospective study of women aged 18-45 years with a history […]

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Performance and Diagnostic Value of Genome-Wide Noninvasive Prenatal Testing in Multiple Gestations.

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To evaluate the accuracy and diagnostic value of genome-wide noninvasive prenatal testing (NIPT) for the detection of fetal aneuploidies in multiple gestations, with a focus on dichorionic-diamniotic twin pregnancies.We performed […]

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Are Newborn Outcomes Different for Term Babies Who Were Exposed to Antenatal Corticosteroids?

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Antenatal corticosteroids improve newborn outcomes for preterm infants. However, predicting which women presenting for threatened preterm labor will have preterm infants is inaccurate and many women receive antenatal corticosteroids but […]

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Primary cytoreductive surgery for advanced stage endometrial cancer: A systematic review and meta-analysis.

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Endometrial cancer uncommonly presents at an advanced stage, and little prospective evidence exists to guide management. We aimed to summarize evidence on primary cytoreductive surgery (PCS) in the treatment of […]

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Chorioamnionitis and Risk for Maternal and Neonatal Sepsis: A Systematic Review and Meta-analysis.

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To estimate the risk of maternal and neonatal sepsis associated with chorioamnionitis.PubMed, BIOSIS, and ClinicalTrials.gov databases were systematically searched for full-text articles in English from inception until May 11, 2020.We […]

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Privacy Risks in Prenatal Aneuploidy and Carrier Screening: What Obstetricians and Their Patients Need to Know.

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Modern prenatal genetic screening techniques such as cell-free fetal DNA and expanded carrier screening genotype substantial amounts of maternal and fetoplacental DNA. Although DNA can be deidentified by stripping protected […]

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Clobetasol Compared With Fractionated Carbon Dioxide Laser for Lichen Sclerosus: A Randomized Controlled Trial.

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To compare 6-month safety and efficacy outcomes of fractionated CO2 laser (laser) with topical clobetasol propionate (steroid) for treatment of symptomatic vulvar lichen sclerosus.We conducted a single-center randomized controlled trial […]

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Re-examining the optimal nuchal translucency cutoff for diagnostic testing in the cell-free DNA and microarray era: results from the Victorian Perinatal Record Linkage study.

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The American College of Obstetricians and Gynecologists and the Society for Maternal Fetal Medicine recently recommended offering genetic counselling and diagnostic testing for enlarged NT at > 3.0mm, regardless of […]

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Delivery Mode After Manual Rotation of Occiput Posterior Fetal Positions: A Randomized Controlled Trial.

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To evaluate whether manual rotation of fetuses in occiput posterior positions at full dilation increases the rate of spontaneous vaginal delivery.In an open, single-center, randomized controlled trial, patients with a […]

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Surgical Management of Symptomatic Apical Pelvic Organ Prolapse: A Systematic Review and Meta-analysis.

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To systematically review objective and subjective success and complications of apical suspensions for symptomatic uterine or vaginal vault pelvic organ prolapse (POP).MEDLINE, CENTRAL, ClinicalTrials.gov, and EMBASE (2002-2019) were searched using […]

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Differentiating Acute Rejection From Preeclampsia After Kidney Transplantation.

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To evaluate the clinical and laboratory characteristics in pregnancy that differentiate preeclampsia from acute renal allograft rejection and to investigate the maternal, neonatal, and graft sequelae of these diagnoses.We conducted […]

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