In vivo neuroinflammation and cerebral small vessel disease in mild cognitive impairment and Alzheimer’s disease.

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Associations between cerebral small vessel disease (SVD) and inflammation have been largely examined using peripheral blood markers of inflammation, with few studies measuring inflammation within the brain. We investigated the […]

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Dyslexia and cognitive impairment in adult patients with myotonic dystrophy type 1: a clinical prospective analysis.

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Cognitive impairments in patients with myotonic dystrophy type 1 (DM1) have often been described, however, there are only few studies differentiating between partial performance disorders and mental retardation in common. […]

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The European Physiotherapy Guideline for Parkinson’s Disease: translation for non-English speaking countries.

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The use of the European Physiotherapy Guideline for Parkinson’s Disease is limited in countries where the official language is not English.To provide practical steps on how to translate the European […]

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Occupational therapy consensus recommendations for functional neurological disorder.

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People with functional neurological disorder (FND) are commonly seen by occupational therapists; however, there are limited descriptions in the literature about the type of interventions that are likely to be […]

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Use of a symptom-based questionnaire to screen for the presence of significant voiding dysfunction in patients with multiple sclerosis and lower urinary tract symptoms: a pilot study.

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Lower urinary tract dysfunction is common in people with multiple sclerosis, leading to overactive bladder symptoms, voiding difficulties or a combination. First-line medications for overactive bladder symptoms are effective. Current […]

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Treatment of MOG antibody associated disorders: results of an international survey.

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While monophasic and relapsing forms of myelin oligodendrocyte glycoprotein antibody associated disorders (MOGAD) are increasingly diagnosed world-wide, consensus on management is yet to be developed.To survey the current global clinical […]

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Balance and coordination training for patients with genetic degenerative ataxia: a systematic review.

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The group of genetic degenerative ataxias shares the same feature of gradual deterioration in balance and coordination. However, no cure is yet available for this group of disorders, while rehabilitation […]

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Using patient-reported symptoms of dyspnea for screening reduced respiratory function in patients with motor neuron diseases.

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Poor monitoring of respiratory function may lead to late initiation of non-invasive ventilation (NIV) in patients with motor neuron diseases (MND). Monitoring could be improved by remotely assessing hypoventilation symptoms […]

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Systematic clinical approach for diagnosing upper limb tremor.

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Tremor is the most common movement disorder worldwide, but diagnosis is challenging. In 2018, the task force on tremor of the International Parkinson and Movement Disorder Society published a consensus […]

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Understanding multifactorial brain changes in type 2 diabetes: a biomarker perspective.

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People with type 2 diabetes are at an increased risk of cognitive impairment and dementia (including Alzheimer’s disease), as well as subtle forms of cognitive dysfunction. Current diabetes guidelines recommend […]

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The IN-DEEP project “INtegrating and Deriving Evidence, Experiences, Preferences”: a web information model on magnetic resonance imaging for people with multiple sclerosis.

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The IN-DEEP project aims to provide people with multiple sclerosis (PwMS) with evidence-based information on magnetic resonance imaging (MRI) in diagnosis and monitoring the disease through a website, and to […]

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Utriculo-ocular pathway dysfunction is more frequent in vestibular migraine than probable vestibular migraine.

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Abnormal vestibular function has been reported in patients with vestibular migraine (VM). However, it is unclear whether the proportion of patients with vestibular dysfunction differs between the diagnoses of VM […]

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Expert opinion: use of valproate in girls and women of childbearing potential with epilepsy: recommendations and alternatives based on a review of the literature and clinical experience-a European perspective.

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Valproate is a broad-spectrum antiepileptic drug (AED) of particular interest in pediatric epilepsy syndromes and idiopathic generalized epilepsy, as it is relatively more effective in these syndromes than other AEDs. […]

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Visual hallucinations in neurological and ophthalmological disease: pathophysiology and management.

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Visual hallucinations are common in older people and are especially associated with ophthalmological and neurological disorders, including dementia and Parkinson’s disease. Uncertainties remain whether there is a single underlying mechanism […]

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Factors delaying intravenous thrombolytic therapy in acute ischaemic stroke: a systematic review of the literature.

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This review examined factors that delay thrombolysis and what management strategies are currently employed to minimise this delay, with the aim of suggesting future directions to overcome bottlenecks in treatment […]

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Differential response to pallidal deep brain stimulation among monogenic dystonias: systematic review and meta-analysis.

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Genetic subtypes of dystonia may respond differentially to deep brain stimulation of the globus pallidus pars interna (GPi DBS). We sought to compare GPi DBS outcomes among the most common […]

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Primary lateral sclerosis: consensus diagnostic criteria.

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Primary lateral sclerosis (PLS) is a neurodegenerative disorder of the adult motor system. Characterised by a slowly progressive upper motor neuron syndrome, the diagnosis is clinical, after exclusion of structural, […]

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Clonidine GH stimulation test to differentiate MSA from idiopathic late onset cerebellar ataxia: a prospective, controlled study.

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Despite the consensus criteria for multiple system atrophy (MSA), the diagnosis of MSA of cerebellar type (MSA-C) may be difficult in the early stage of the disease. There are several […]

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Brain MRI of multiple system atrophy of cerebellar type: a prospective study with implications for diagnosis criteria.

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The second consensus statement for the diagnosis of multiple system atrophy type cerebellar (MSA-C) includes pons and middle cerebellar peduncle (MCP) atrophy as MRI features. However, other MRI abnormalities such […]

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Expert consensus recommendations to improve diagnosis of ATTR amyloidosis with polyneuropathy.

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Amyloid transthyretin (ATTR) amyloidosis with polyneuropathy (PN) is a progressive, debilitating, systemic disease wherein transthyretin protein misfolds to form amyloid, which is deposited in the endoneurium. ATTR amyloidosis with PN […]

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Haematoma evacuation in cerebellar intracerebral haemorrhage: systematic review.

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Guidelines regarding recommendations for surgical treatment of spontaneous cerebellar intracerebral haemorrhage (ICH) differ. We aimed to systematically review the literature to assess treatment strategies and outcomes.We searched PubMed and Embase […]

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Antihypertensive medications and risk for incident dementia and Alzheimer’s disease: a meta-analysis of individual participant data from prospective cohort studies.

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Dementia is a major health concern for which prevention and treatment strategies remain elusive. Lowering high blood pressure with specific antihypertensive medications (AHMs) could reduce the burden of disease. We […]

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