Parkinsonism as a late presentation of lymphomatosis cerebri following high-dose chemotherapy with autologous stem cell transplantation for primary central nervous system lymphoma.

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Primary central nervous system lymphoma is an aggressive form of non-Hodgkin lymphoma arising in the eyes, meninges, spinal cord, or brain. Treatment of primary CNS lymphoma with a combination of […]

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Serum neuronal exosomes predict and differentiate Parkinson’s disease from atypical parkinsonism.

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Parkinson’s disease is characterised neuropathologically by α-synuclein aggregation. Currently, there is no blood test to predict the underlying pathology or distinguish Parkinson’s from atypical parkinsonian syndromes. We assessed the clinical […]

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Initiation of pharmacological therapy in Parkinson’s disease: when, why, and how.

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Debate is ongoing regarding when, why, and how to initiate pharmacotherapy for Parkinson’s disease. Early initiation of dopaminergic therapies does not convey disease-modifying effects but does reduce disability. Concerns about […]

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Predictors of cognitive impairment in Parkinson’s disease: a systematic review and meta-analysis of prospective cohort studies.

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Cognitive impairment is a debilitating manifestation in Parkinson’s disease (PD). We sought to investigate predictors of PD-CI (PD with cognitive impairment).We systematically searched PubMed and Cochrane Library for prospective cohort […]

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Autonomic failure in Parkinson’s disease is associated with striatal dopamine deficiencies.

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Autonomic dysfunction is a common non-motor symptom in Parkinson’s disease (PD). Dopamine and serotonin are known to play a role in autonomic regulation, and, therefore, PD-related degeneration of serotonergic and […]

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Beneficial effect of 24-month bilateral subthalamic stimulation on quality of sleep in Parkinson’s disease.

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Subthalamic nucleus (STN) deep brain stimulation (DBS) improves quality of life (QoL), motor, and sleep symptoms in Parkinson’s disease (PD). However, the long-term effects of STN-DBS on sleep and its […]

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Differentiating tic electrophysiology from voluntary movement in the human thalamocortical circuit.

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Tourette syndrome is a neurodevelopmental disorder commonly associated with involuntary movements, or tics. We currently lack an ideal animal model for Tourette syndrome. In humans, clinical manifestation of tics cannot […]

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Brain iron deposition is linked with cognitive severity in Parkinson’s disease.

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Dementia is common in Parkinson’s disease (PD) but measures that track cognitive change in PD are lacking. Brain tissue iron accumulates with age and co-localises with pathological proteins linked to […]

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Long-term unsupervised mobility assessment in movement disorders.

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Mobile health technologies (wearable, portable, body-fixed sensors, or domestic-integrated devices) that quantify mobility in unsupervised, daily living environments are emerging as complementary clinical assessments. Data collected in these ecologically valid, […]

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Survival after traumatic brain injury improves with deployment of neurosurgeons: a comparison of US and UK military treatment facilities during the Iraq and Afghanistan conflicts.

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Traumatic brain injury (TBI) is the most common cause of death on the modern battlefield. In recent conflicts in Iraq and Afghanistan, the US typically deployed neurosurgeons to medical treatment […]

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Utility of the Parkinson’s disease-Cognitive Rating Scale for the screening of global cognitive status in Huntington’s disease.

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Cognitive impairment is an essential feature of Huntington’s disease (HD) and dementia is a predictable outcome in all patients. However, validated instruments to assess global cognitive performance in the field […]

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Subjects at risk of Parkinson’s disease in health checkup examinees: cross-sectional analysis of baseline data of the NaT-PROBE study.

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The present study aimed to survey the prevalence of prodromal symptoms of Parkinson’s disease (PD) in Japanese health checkup examinees, for identifying at-risk subjects.We conducted a questionnaire survey of annual […]

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Nonmotor symptoms of 820 Taiwanese patients with Parkinson’s disease: an exploratory-comparative study.

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Nonmotor symptoms (NMSs) severely affect the daily quality of life of patients with Parkinson’s disease (PD). Although many studies have documented the clinical characteristics of NMSs in PD patients, some […]

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Clonidine GH stimulation test to differentiate MSA from idiopathic late onset cerebellar ataxia: a prospective, controlled study.

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Despite the consensus criteria for multiple system atrophy (MSA), the diagnosis of MSA of cerebellar type (MSA-C) may be difficult in the early stage of the disease. There are several […]

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Use of MRI to predict symptomatic haemorrhagic transformation after thrombolysis for cerebral ischaemia.

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Predictors of symptomatic haemorrhagic transformation (s-HT) of cerebral ischaemia after intravenous recombinant tissue-plasminogen activator (rt-PA) were identified in studies using CT scans. We evaluated whether MRI can identify other predictors.We […]

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Precision medicine in Parkinson’s disease: emerging treatments for genetic Parkinson’s disease.

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In recent years, numerous clinical trials for disease modification in Parkinson’s disease (PD) have failed, possibly because of a “one-size-fits all” approach. Alternatively, a precision medicine approach, which customises treatments […]

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Quantity and quality of gait and turning in people with multiple sclerosis, Parkinson’s disease and matched controls during daily living.

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Clinical trials need to specify which specific gait characteristics to monitor as mobility measures for each neurological disorder. As a first step, this study aimed to investigate a set of […]

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Brain activity during lower limb movements in Parkinson’s disease patients with and without freezing of gait.

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In this study, we assessed brain functional MRI (fMRI) activity during a foot movement task in Parkinson’s disease patients with (PD-FoG) and without freezing of gait (PD-noFoG). Twenty-seven PD patients […]

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Dynamics of impulsive-compulsive behaviors in early Parkinson’s disease: a prospective study.

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Impulsive compulsive behaviors (ICBs) in Parkinson’s disease (PD) are debilitating disorders of repetitive, excessive, and compulsive nature affecting up to one third of PD patients. Objectives are to address clinical, […]

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Apomorphine sublingual film for off episodes in Parkinson’s disease: a randomised, double-blind, placebo-controlled phase 3 study.

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Many patients with Parkinson’s disease have potentially disabling off episodes that are not predictably responsive to levodopa. In this study, we assessed the safety and efficacy of apomorphine sublingual film […]

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