Telling friend from foe in emergency vertigo and dizziness: does season and daytime of presentation help in the differential diagnosis?

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Distinguishing between serious (e.g., stroke) and benign (e.g., benign paroxysmal positional vertigo, BPPV) disorders remains challenging in emergency consultations for vertigo and dizziness (VD). A number of clues from patient […]

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Repetitive transcranial magnetic stimulation as an alternative therapy for stroke with spasticity: a systematic review and meta-analysis.

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Repetitive transcranial magnetic stimulation (rTMS) and intermittent theta-burst stimulation (iTBS) can be used to manage post-stroke spasticity, but a meta-analysis of the recent randomized-controlled trials (RCTs) is lacking. Our aim […]

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Paternal exposure to antiepileptic drugs and offspring outcomes: a nationwide population-based cohort study in Sweden.

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To investigate the association between paternal use of antiepileptic drugs (AEDs) and adverse neurodevelopmental outcomes and major congenital malformations (MCM) in the offspring.Using nationwide Swedish registries, we included 1 144 […]

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Anti-CASPR2 clinical phenotypes correlate with HLA and immunological features.

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Antibodies against contactin-associated protein-like 2 (CASPR2-Abs) have been described in acquired neuromyotonia, limbic encephalitis (LE) and Morvan syndrome (MoS). However, it is unknown whether these constitute one sole spectrum of […]

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Discrete changes in brain volume after deep brain stimulation in patients with Parkinson’s disease.

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Deep brain stimulation (DBS), targeting the subthalamic nucleus (STN) and globus pallidus interna, is a surgical therapy with class 1 evidence for Parkinson’s disease (PD). Bilateral DBS electrodes may be […]

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Multimodal MRI for MRgFUS in essential tremor: post-treatment radiological markers of clinical outcome.

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MRI-guided focused ultrasound (MRgFUS) thalamotomy is a promising non-invasive treatment option for medication-resistant essential tremor. However, it has been associated with variable efficacy and a relatively high incidence of adverse […]

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Early functional MRI changes in a prodromal semantic variant of primary progressive aphasia: a longitudinal case report.

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To assess longitudinal patterns of brain functional MRI (fMRI) activity in a case of prodromal semantic variant of a primary progressive aphasia (svPPA).Clinical, cognitive and neuroimaging data (T1-weighted and task-based […]

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Apathy, but not depression, predicts all-cause dementia in cerebral small vessel disease.

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To determine whether apathy or depression predicts all-cause dementia in small vessel disease (SVD) patients.Analyses used two prospective cohort studies of SVD: St. George’s Cognition and Neuroimaging in Stroke (SCANS; […]

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Risk incidence of fractures and injuries: a multicenter video-EEG study of 626 generalized convulsive seizures.

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To evaluate the incidence and risk factors of generalized convulsive seizure (GCS)-related fractures and injuries during video-EEG monitoring.We analyzed all GCSs in patients undergoing video-EEG-monitoring between 2007 and 2019 at […]

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Deep brain stimulation reduces (nocturnal) dyskinetic exacerbations in patients with ADCY5 mutation: a case series.

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Mutations in the ADCY5 gene can cause a complex hyperkinetic movement disorder. Episodic exacerbations of dyskinesia are a particularly disturbing symptom as they occur predominantly during night and interrupt sleep. […]

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Targeted next-generation sequencing study in familial ALS-FTD Portuguese patients negative for C9orf72 HRE.

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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with clinical and etiological heterogeneity and a complex genetic contribution. Clinical, neuropathological, and genetic evidence revealed that ALS and frontotemporal dementia (FTD) […]

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Environmental exposure to phthalates and dementia with Lewy bodies: contribution of metabolomics.

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In neurodegenerative diseases, alongside genetic factors, the possible intervention of environmental factors in the pathogenesis is increasingly being considered. In particular, recent evidence suggests the intervention of a pesticide-like xenobiotic […]

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Clinical and radiological differences between patients with probable cerebral amyloid angiopathy and mixed cerebral microbleeds.

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The key imaging features of cerebral amyloid angiopathy (CAA) are lobar, cortical, or cortico-subcortical microbleeds, macrohaemorrhages and cortical superficial siderosis (cSS). In contrast, hypertensive angiopathy is characterized by (micro) haemorrhages […]

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Reduced accuracy of MRI deep grey matter segmentation in multiple sclerosis: an evaluation of four automated methods against manual reference segmentations in a multi-center cohort.

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Deep grey matter (DGM) atrophy in multiple sclerosis (MS) and its relation to cognitive and clinical decline requires accurate measurements. MS pathology may deteriorate the performance of automated segmentation methods. […]

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Neurogenic calf amyotrophy with CK elevation by entrapment radiculopathy; clinical, radiological, and pathological analyses of 18 cases.

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To characterize the clinical, radiological, and pathological manifestations of 18 cases showing neurogenic calf amyotrophy with creatine kinase (CK) elevation by entrapment radiculopathy (NCACKEER).We retrospectively reviewed and evaluated the medical […]

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