Safety and efficacy of MD1003 (high-dose biotin) in patients with progressive multiple sclerosis (SPI2): a randomised, double-blind, placebo-controlled, phase 3 trial.

Bookmark this %label%

There is an unmet need to develop therapeutic interventions directed at the neurodegeneration that underlies progression in multiple sclerosis. High-dose, pharmaceutical-grade biotin (MD1003) might enhance neuronal and oligodendrocyte energetics, resulting […]

» Read more

Repetitive transcranial magnetic stimulation for post-stroke depression: a randomised trial with neurophysiological insight.

Bookmark this %label%

Despite high incidence of depression after stroke, few trials have investigated the therapeutic efficacy of repetitive transcranial magnetic stimulation (rTMS). Here, we aimed to evaluate clinical benefit of delivering a […]

» Read more

Clinical features which predict neuronal surface autoantibodies in new-onset focal epilepsy: implications for immunotherapies.

Bookmark this %label%

To generate a score which clinically identifies surface-directed autoantibodies in adults with new-onset focal epilepsy, and evaluate the value of immunotherapy in this clinical setting.Prospective clinical and autoantibody evaluations in […]

» Read more

Fully automated cognitive screening tool based on assessment of speech and language.

Bookmark this %label%

Recent years have seen an almost sevenfold rise in referrals to specialist memory clinics. This has been associated with an increased proportion of patients referred with functional cognitive disorder (FCD), […]

» Read more

Neuromyelitis optica spectrum disorder: pregnancy-related attack and predictive risk factors.

Bookmark this %label%

To investigate the influence of pregnancy on patients with neuromyelitis optica spectrum disorder (NMOSD) and to identify risk factors that predict pregnancy-related attack.From January 2015 to April 2019, 418 female […]

» Read more

Anti-MOG antibody-associated disorders: differences in clinical profiles and prognosis in Japan and Germany.

Bookmark this %label%

Neurological disorders with IgG antibodies against myelin-oligodendrocyte glycoprotein (MOG-IgG) have been increasingly recognised as a new type of neuroinflammatory disorder.The study aimed to identify regional and ethnic differences in clinical […]

» Read more

Serum vitamin D, vitamin D receptor and binding protein genes polymorphisms in restless legs syndrome.

Bookmark this %label%

Several studies showed lower serum 25-hydroxyvitamin D levels in patients with idiopathic restless legs syndrome (RLS) compared with matched controls, and a single study showed an association between the rs731236 […]

» Read more

Cognitive impairment in temporal lobe epilepsy: contributions of lesion, localization and lateralization.

Bookmark this %label%

Cognitive impairment is an important comorbidity of refractory temporal lobe epilepsy (TLE). We aimed to explore the impact of (i) specific lesions, such as dysembryoplastic neuroepithelial tumor (DNET), dysplasia, or hippocampal sclerosis, […]

» Read more

Long-term safety and efficacy of patisiran for hereditary transthyretin-mediated amyloidosis with polyneuropathy: 12-month results of an open-label extension study.

Bookmark this %label%

Hereditary transthyretin-mediated amyloidosis is a rare, inherited, progressive disease caused by mutations in the transthyretin (TTR) gene. We assessed the safety and efficacy of long-term treatment with patisiran, an RNA […]

» Read more

Neuroinflammation in intracerebral haemorrhage: immunotherapies with potential for translation.

Bookmark this %label%

Intracerebral haemorrhage is inadequately controlled by current treatments, requiring new solutions to improve the prognosis. Following the primary injury, a proinflammatory cascade in the perihaematomal region, composed of activated resident […]

» Read more

The “hype” of hydrops in classifying vestibular disorders: a narrative review.

Bookmark this %label%

Classifying and diagnosing peripheral vestibular disorders based on their symptoms is challenging due to possible symptom overlap or atypical clinical presentation. To improve the diagnostic trajectory, gadolinium-based contrast-enhanced magnetic resonance […]

» Read more

Myelin oligodendrocyte glycoprotein-antibody-associated disorder: a new inflammatory CNS demyelinating disorder.

Bookmark this %label%

Myelin oligodendrocyte glycoprotein (MOG) is an oligodendrocytopathy resulting in demyelination. We aimed to determine the frequency of MOG-associated disorders (MOGAD), its various clinical phenotypes, and imaging characteristics.All patients with MOGAD […]

» Read more

Cumulative health deficits, APOE genotype, and risk for later-life mild cognitive impairment and dementia.

Bookmark this %label%

To determine whether health-deficit accumulation is associated with the risks of mild cognitive impairment (MCI) and dementia independently of APOE genotype.A frailty index was calculated using the deficit-accumulation approach in […]

» Read more

Fluid biomarkers in frontotemporal dementia: past, present and future.

Bookmark this %label%

The frontotemporal dementia (FTD) spectrum of neurodegenerative disorders includes a heterogeneous group of conditions. However, following on from a series of important molecular studies in the early 2000s, major advances […]

» Read more

Systematic approach to selecting licensed drugs for repurposing in the treatment of progressive multiple sclerosis.

Bookmark this %label%

To establish a rigorous, expert-led, evidence-based approach to the evaluation of licensed drugs for repurposing and testing in clinical trials of people with progressive multiple sclerosis (MS).We long-listed licensed drugs […]

» Read more

Serum BDNF discriminates Parkinson’s disease patients with depression from without depression and reflect motor severity and gender differences.

Bookmark this %label%

To evaluate the diagnostic value of serum Brain-derived neurotrophic factor (BDNF) levels for discriminating PD with depression from without depression, and to investigate whether serum BDNF levels were associated with […]

» Read more

Central retina changes in Parkinson’s disease: a systematic review and meta-analysis.

Bookmark this %label%

Central retina imaging is important for early Parkinson’s disease (PD) recognition. We aimed to investigate central retina changes using spectral domain-optical coherence tomography (SD-OCT) in PD patients.We systematically searched PubMed […]

» Read more

Spinocerebellar ataxia type 23 (SCA23): a review.

Bookmark this %label%

Spinocerebellar ataxias (SCAs), formerly known as autosomal dominant cerebellar ataxias (ADCAs), are a group of hereditary heterogeneous neurodegenerative diseases. Gait, progressive ataxia, dysarthria, and eye movement disorder are common symptoms of […]

» Read more

Underdiagnosis and diagnostic delay in chronic inflammatory demyelinating polyneuropathy.

Bookmark this %label%

The frequency and causes of underdiagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP) are uncertain. We aimed to assess the frequency and electroclinical features of pre-referral CIDP underdiagnosis and the duration of […]

» Read more

Middle-age dementia risk scores and old-age cognition: a quasi-experimental population-based twin study with over 20-year follow-up.

Bookmark this %label%

Middle-age risk scores predict cognitive impairment, but it is not known if these associations are evident when controlling for shared genetic and environmental factors. Using two risk scores, self-report educational-occupational […]

» Read more

Efficacy of spoken word comprehension therapy in patients with chronic aphasia: a cross-over randomised controlled trial with structural imaging.

Bookmark this %label%

The efficacy of spoken language comprehension therapies for persons with aphasia remains equivocal. We investigated the efficacy of a self-led therapy app, ‘Listen-In’, and examined the relation between brain structure […]

» Read more
1 2 3 50