Rationale and design of the OPTIMIZE trial: OPen label multicenter randomized trial comparing standard IMmunosuppression with tacrolimus and mycophenolate mofetil with a low exposure tacrolimus regimen In combination with everolimus in de novo renal transplantation in Elderly patients.

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In 2019, more than 30 % of all newly transplanted kidney transplant recipients in The Netherlands were above 65 years of age. Elderly patients are less prone to rejection, and death […]

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Intervening on health literacy by knowledge translation processes in kidney transplantation: A feasibility study.

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Patients awaiting kidney transplantation need to be prepared ahead of the upcoming transplantation by developing targeted pre- and post-transplant knowledge. On this background, we designed a new health literacy intervention, […]

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Protein energy wasting and long-term outcomes in nondialysis dependent chronic kidney disease.

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Nutritional status and protein energy wasting (PEW) is prevalent in patients with nondialysis-dependent chronic kidney disease (CKD). The relationship between PEW and long-term development of clinically important outcomes remains to […]

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Dialysis Facility Profit Status and Early Steps in Kidney Transplantation in the Southeastern United States.

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Dialysis facilities in the United States play a key role in access to kidney transplantation. Previous studies reported that patients treated at for-profit facilities are less likely to be waitlisted […]

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Performance versus Risk Factor-Based Approaches to Coronary Artery Disease Screening in Waitlisted Kidney Transplant Candidates.

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Current screening algorithms for coronary artery disease (CAD) before kidney transplantation result in many tests but few interventions.The aim of this study was to study the utility of 6-minute walk […]

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First and second morning spot urine protein measurements for the assessment of proteinuria: a diagnostic accuracy study in kidney transplant recipients.

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Quantification of proteinuria in kidney transplant recipients is important for diagnostic and prognostic purposes. Apart from correlation tests, there have been few evaluations of spot urine protein measurements in kidney […]

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Transplant Options for Patients With Diabetes and Advanced Kidney Disease: A Review.

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Optimal glycemic control in kidney transplant recipients with diabetes is associated with improved morbidity, mortality and allograft survival. Transplant options for patients with diabetes requiring insulin therapy and chronic kidney […]

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Kidney transplant in patients with atypical hemolytic uremic syndrome in the anti-C5 era: single-center experience with tailored Eculizumab.

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Patients with atypical hemolytic uremic syndrome (aHUS) have long been considered ineligible for kidney transplantation (KTx) in several centers due to the high risk of disease recurrence, graft loss and […]

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Pharmacist-Led Mobile Health Intervention and Transplant Medication Safety: A Randomized Controlled Clinical Trial.

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Medication safety events are predominant contributors to suboptimal graft outcomes in kidney transplant recipients. The goal of this study was to examine the efficacy of improving medication safety through a […]

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Urinary Cell mRNA Profiles Predictive of Human Kidney Allograft Status.

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Immune monitoring of kidney allograft recipients and personalized therapeutics may help reach the aspirational goal of “one transplant for life.” The invasive kidney biopsy procedure, the diagnostic tool of choice, […]

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Donor type and 3-month hospital readmission following kidney transplantation: results from the Netherlands organ transplant registry.

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Hospital readmission after transplantation is common in kidney transplant recipients (KTRs). In this study, we aim to compare the risk of 3-month hospital readmission after kidney transplantation with different donor […]

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Differences in physical symptoms between those with and without kidney disease: a comparative study across disease stages in a UK population.

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Those living with kidney disease (KD) report extensive symptom burden. However, research into how symptoms change across stages is limited. The aims of this study were to 1) describe symptom […]

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Targeting Sedentary Behavior in CKD: A Pilot and Feasibility Randomized Controlled Trial.

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We tested the feasibility of reducing sedentary behavior common in CKD.We carried out a Sit Less, Interact, Move More intervention in a 24-week parallel-group, randomized controlled trial in patients with […]

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Long-Term Infectious Complications of Kidney Transplantation.

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Infections remain a common complication of solid-organ transplantation. Most infections in the first month after transplant are typically health care-associated infections, whereas late infections, beyond 6-12 months, are community-acquired infections. […]

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Recipient Obesity and Kidney Transplant Outcomes: A Mate-Kidney Analysis.

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The impact of extreme recipient obesity on long-term kidney transplant outcomes has been controversial. This study sought to evaluate the association of various levels of recipient obesity on kidney transplantation […]

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Biopsy findings after detection of de novo donor-specific antibodies in renal transplant recipients: a single center experience.

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De novo donor-specific antibodies (DSA) are associated with an increased risk of antibody-mediated rejection and a substantial reduction of allograft survival. We hypothesized that detection of DSA should prompt a […]

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Long-Term Immunosuppression Management: Opportunities and Uncertainties.

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The long-term management of maintenance immunosuppression in kidney transplant recipients remains complex. The vast majority of patients are treated with the calcineurin inhibitor tacrolimus as the primary agent in combination […]

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C-terminal and intact FGF23 in kidney transplant recipients and their associations with overall graft survival.

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Increased fibroblast growth factor 23 (FGF23) is a risk factor for mortality, cardiovascular disease, and progression of chronic kidney disease. Limited data exist comparing the association of either c-terminal FGF23 […]

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