Case Series: Evidence of Borderzone Ischemia in Critically-Ill COVID-19 Patients Who “Do Not Wake Up”.

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This article describes the clinical course, radiological findings, and outcome of two patients with the novel 2019 coronavirus disease (COVID-19) who remained comatose for a prolonged duration following discontinuation of […]

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Practical Considerations for the Management of Cushing’s Disease and COVID-19: A Case Report.

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Introduction: Italy, since the end of February 2020, is experiencing the corona virus disease 2019 (COVID-19) pandemic that may present as an acute respiratory infection. We report on COVID-19 pneumonia […]

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Endothelial dysfunction contributes to COVID-19-associated vascular inflammation and coagulopathy.

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Great attention has been paid to endothelial dysfunction (ED) in coronavirus disease 2019 (COVID-19). There is growing evidence to suggest that the angiotensin converting enzyme 2 receptor (ACE2 receptor) is […]

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Current targets and drug candidates for prevention and treatment of SARS-CoV-2 (COVID-19) infection.

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Angiotensin-converting enzyme 2 (ACE2), the host cell-binding site for SAR-CoV-2, poses two-fold drug development problems. First, the role of ACE2 itself is still a matter of investigation, and no specific […]

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Critical complications of COVID-19: A descriptive meta-analysis study.

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The coronavirus disease 2019 (COVID-19) is a novel coronavirus infection that has rapidly spread worldwide, causing a pandemic. The main objective of this meta-analysis was to evaluate the prevalence of […]

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Effect of heart failure on the outcome of COVID-19 – A meta analysis and systematic review.

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Several comorbidities have been associated with an increased risk of severity and mortality in coronavirus disease 2019 (COVID-19), including hypertension, diabetes, cerebrovascular disease, chronic kidney disease, and chronic obstructive pulmonary […]

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Can Traditional Chinese Medicine provide insights into controlling the COVID-19 pandemic: Serpentinization-induced lithospheric long-wavelength magnetic anomalies in Proterozoic bedrocks in a weakened geomagnetic field mediate the aberrant transformation of biogenic molecules in COVID-19 via magnetic catalysis.

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Thoracic organs, namely, the lungs and kidneys in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated coronavirus disease 2019 (COVID-19), exhibit silicate/glass-like (hyaline) and iron oxides-like deposits, which are like serpentinization-induced […]

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Factors associated with the poor outcomes in diabetic patients with COVID-19.

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Diabetic’s patients are supposed to experience higher rates of COVID-19 related poor outcomes. We aimed to determine factors predicting poor outcomes in hospitalized diabetic patients with COVID-19.This retrospective cohort study […]

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Cardiorenal tissues express SARS-CoV-2 entry genes and basigin (BSG/CD147) increases with age in endothelial cells.

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Vascular/cardiovascular inflammation and thrombosis occur in severe COVID-19. Advancing age is the most significant risk factor for severe COVID-19. Using transcriptomic databases, we found: (i) cardiovascular tissues/endothelial cells express putative […]

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Pathogenesis-Directed Therapy of 2019 Novel Coronavirus Disease.

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The 2019 novel coronavirus disease (COVID-19) now is considered a global public health emergency. One of the unprecedented challenges is defining optimal therapy for those patients with severe pneumonia and […]

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COVID-19 infection in kidney transplant recipients at the epicenter of pandemics.

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We investigated the prevalence and clinical outcomes of COVID-19 in recipients of kidney transplants in the Bronx, New York, one of the epicenters of the pandemic. Between March 16 and […]

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Safety, efficacy and patterns of failure after single fraction stereotactic body radiotherapy (SBRT) for oligometastases.

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Fewer attendances for radiotherapy results in increased efficiency and less foot traffic within a radiotherapy department. We investigated outcomes after single fraction (SF) SBRT in patients with oligometastatic disease.Between February […]

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Global impact of COVID-19 infection requiring admission to the intensive care unit: a systematic review and meta-analysis.

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The COVID-19 pandemic has placed unprecedented burden on the delivery of intensive care services worldwide.What is the global point estimate of mortality and risk factors for patients admitted to intensive […]

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Sex differences in clinical phenotype and transitions of care among individuals dying of COVID-19 in Italy.

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Among the unknowns posed by the coronavirus disease 2019 (COVID-19) outbreak, the role of biological sex to explain disease susceptibility and progression is still a matter of debate, with limited […]

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Development and immunogenic potentials of chitosan-saponin encapsulated DNA vaccine against avian infectious bronchitis coronavirus.

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Infectious bronchitis (IB) is an economically important disease of poultry that also serve as model for the understanding of other coronaviruses associated diseases. IB is considered as a major challenge […]

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AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19.

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AKI is a common sequela of coronavirus disease 2019 (COVID-19). However, few studies have focused on AKI treated with RRT (AKI-RRT).We conducted a multicenter cohort study of 3099 critically ill […]

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Impact of Coronavirus disease 2019 on organ donation and transplantation in France.

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With 187 919 cases and 30 265 deaths by July 31, 2020, France was severely affected by the COVID-19 pandemic, and the two-month confinement that began in mid-March. Although donor-to-recipient transmission and […]

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Serum Cystatin C and Coronavirus Disease 2019: A Potential Inflammatory Biomarker in Predicting Critical Illness and Mortality for Adult Patients.

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This study aimed at determining the relationship between baseline cystatin C levels and coronavirus disease 2019 (COVID-19) and investigating the potential prognostic value of serum cystatin C in adult patients […]

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End-Stage Renal Disease Patients on Chronic Hemodialysis Fare Better With COVID-19: A Retrospective Cohort Study From the New York Metropolitan Region.

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Introduction Several comorbid conditions have been identified as risk factors in patients with coronavirus disease 2019 (COVID-19). However, there is a dearth of data describing the impact of COVID-19 infection in patients […]

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SARS-CoV-2 Vaccine Development: An Overview and Perspectives.

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Coronavirus disease 2019, abbreviated as COVID-19, is caused by a new strain of coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It started in late December 2019 in Wuhan, […]

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Dipeptidyl Peptidase-4: A Potential Therapeutic Target in Diabetic Kidney Disease with SARS-CoV-2 Infection.

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Dipeptidyl peptidase-4 (DPP-4) is expressed ubiquitously in many tissues, including kidney, respiratory tract, and immune cells. Human DPP-4 has been identified as a functional receptor for the spike glycoprotein of […]

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Physiologic Response to Angiotensin II Treatment for Coronavirus Disease 2019-Induced Vasodilatory Shock: A Retrospective Matched Cohort Study.

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To assess the early physiologic response to angiotensin-II treatment in patients with coronavirus disease 2019-induced respiratory failure and distributive shock.Retrospective consecutive-sample cohort study.Three medical ICUs in New York during the […]

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Antiviral Dosing Modification for Coronavirus Disease 2019-Infected Patients Receiving Extracorporeal Therapy.

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Previous literature regarding coronavirus disease 2019 outlined a presence of organ dysfunction including acute respiratory distress syndrome and acute kidney injury that are linked to mortality. Several patients require extracorporeal […]

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Fecal occult blood and urinary cytology tests for rapid screening of inflammatory infection in the gastrointestinal and urological systems in patients with Coronavirus disease 2019.

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Gastrointestinal infections (GI) and urological infections (UI) have not been fully addressed in COVID-19 patients. We aimed to evaluate the values of routine fecal occult blood (FOB) test and urinary […]

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Disorders of sodium balance and its clinical implications in COVID-19 patients: a multicenter retrospective study.

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The worldwide spread of SARS-CoV-2 has infected millions of people leading to over 0.3 million mortalities. The disruption of sodium homeostasis, tends to be a common occurrence in patients with […]

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Comprehensive Analysis of the Glycan Complement of SARS-CoV-2 Spike Proteins Using Signature Ions-Triggered Electron-Transfer/Higher-Energy Collisional Dissociation (EThcD) Mass Spectrometry.

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a global pandemic of coronavirus disease 2019 (COVID-19). The spike protein expressed on the surface of this virus is highly […]

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Increased odds ratio for Covid 19 in patients with recurrent aphthous stomatitis.

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The ACE2 receptor, the binding sites for the Covid19, is expressed abundantly in the oral cavity, raising the question whether the mouth is a target for the virus in addition […]

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COVID-19 in Dialysis Patients: Outlasting and Outsmarting a Pandemic.

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COVID-19 has affected dialysis patients and dialysis patient care worldwide. In this issue of Kidney International, three reports highlight the disproportionately severe impact of COVID-19 on dialysis patients, noting its […]

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