Once-Daily Vibegron 75 mg for Overactive Bladder: Long-Term Safety and Efficacy From a Double-Blind Extension Study of the International Phase 3 Trial (EMPOWUR).

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The long-term safety, tolerability, and efficacy of vibegron in adults with overactive bladder were evaluated in the 40-week phase 3 EMPOWUR extension study.Patients who completed 12 weeks of once-daily vibegron […]

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Long-term effectiveness and safety of open Burch colposuspension versus retropubic midurethral sling for stress urinary incontinence – results from a large comparative study.

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There are few adequately powered long-term trials comparing midurethral sling (MUS) and Burch colposuspension (BC). Recent concerns about synthetic mesh with new stringent clinical and research governance support the need […]

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Less-radical Surgery for Early Stage Cervical Cancer: A Systematic Review.

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A systematic review was performed to examine the outcomes of simple hysterectomy for women with low-risk, early-stage cervical cancer.MEDLINE, Embase, Web of Science, and ClinicalTrials.gov were searched from inception until […]

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The Modified Prone Jack-knife Position for the Excision of Female Urethral Diverticula.

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Female urethral diverticula (UD) are an uncommon and often overlooked aetiology in women presenting with lower urinary tract symptoms, urethral pain, and recurrent urinary tract infection. With increasing awareness, appropriate […]

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Concurrent Retropubic Midurethral Sling and OnabotulinumtoxinA for Mixed Urinary Incontinence: A Randomized Controlled Trial.

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To evaluate whether retropubic midurethral sling combined with onabotulinumtoxinA is more effective than sling alone in improving mixed urinary incontinence symptoms.We conducted a prospective, double-blind, randomized, controlled trial of women […]

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Constipation during and after pregnancy.

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Constipation during and after pregnancy is a neglected clinical problem. The association with pelvic floor disorders include both anal incontinence (Johannessen HH et al, BJOG, 2020, Vol 127(12):1499-1506) and urinary […]

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Systematic Review and Meta-Analysis of the Association Between Vitamin D Status and Lower Urinary Tract Symptoms.

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Cumulative studies have shown that vitamin D may be associated with lower urinary tract symptoms, but the findings have been inconsistent. The aim of this study was to systematically evaluate […]

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Mind/Body (Hypnotherapy) Treatment of Women with Urgency Urinary Incontinence: Changes in Brain Attentional Networks.

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Prior study of patients with urgency urinary incontinence by functional magnetic resonance imaging showed altered function in areas of the brain associated with interoception and salience and with attention. Our […]

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Hood Technique for Robotic Radical Prostatectomy-Preserving Periurethral Anatomical Structures in the Space of Retzius and Sparing the Pouch of Douglas, Enabling Early Return of Continence Without Compromising Surgical Margin Rates.

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A common side effect following radical prostatectomy is urinary incontinence. Here, we describe a novel surgical technique to reduce postoperative urinary incontinence and facilitate early return of continence.To describe the […]

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Racial differences in urinary incontinence prevalence, overactive bladder and associated bother among men: The Multi-Ethnic Study of Atherosclerosis.

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To examine the association of race/ethnicity with urinary incontinence subtypes and overactive bladder and associated bother in older men.This cross-sectional analysis utilized data from Multi-Ethnic Study of Atherosclerosis, an observational […]

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EARLY POSTPARTUM PHYSICAL ACTIVITY AND PELVIC FLOOR SUPPORT AND SYMPTOMS ONE YEAR POSTPARTUM.

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Risks of pelvic organ prolapse and urinary incontinence rise after the first vaginal delivery. During the early postpartum period, a time of active regeneration and healing of the pelvic floor, […]

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Characteristics Associated With Treatment Failure 1 Year After Midurethral Sling in Women With Mixed Urinary Incontinence.

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To evaluate characteristics associated with treatment failure 1 year after midurethral sling in women with mixed urinary incontinence.Four hundred three women who participated in a randomized trial that compared midurethral […]

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Comparison of Two Single Incision Slings on the Vagina in an Ovine Model.

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Stress Urinary Incontinence carries a significant healthcare burden for women worldwide. Single incision slings are minimally invasive mesh devices designed to treat stress urinary incontinence. For prolapse repair, meshes with […]

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Racial differences in urinary incontinence prevalence and associated bother: The Multi-Ethnic Study of Atherosclerosis.

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Urinary incontinence is influenced by multiple factors, and prevalence of urinary incontinence subtypes may differ by race/ethnicity.To determine prevalence of urinary incontinence subtypes and associated bother among women by race/ethnicity.This […]

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Pregnancy and Delivery in Women with Lower Urinary Tract Reconstruction: A National Multicenter Retrospective Study.

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Management of pregnancy and delivery in women with lower urinary tract reconstruction is challenging and the currently available literature is insufficient to guide clinical practice. The purpose of this study […]

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Assessing the Quality of Surgical Care for Clinically Localized Prostate Cancer: Results from the CEASAR Study.

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Prior studies suggest that nationally endorsed quality measures for prostate cancer care are not linked closely with outcomes. Using a prospective, population-based cohort, we sought to measure clinically relevant variation […]

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Retzius-sparing Robot-assisted Radical Prostatectomy Leads to Durable Improvement in Urinary Function and Quality of Life Versus Standard Robot-assisted Radical Prostatectomy Without Compromise on Oncologic Efficacy: Single-surgeon Series and Step-by-step Guide.

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Retzius-sparing robot-assisted radical prostatectomy (RS-RARP) has been shown to improve continence. However, questions remain regarding feasibility and generalizability of technique and outcomes.To compare the outcomes of 140 consecutive standard robot-assisted […]

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Better studies needed on LASER use in urinary incontinence.

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LASERs are frequently marketed as a complication-free treatment for vaginal atrophy (genital syndrome of menopause [GSM]) and urinary incontinence (UI). At the same time, the disadvantages and risks of the […]

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A Multicenter Retrospective Cohort Study Comparing Urethral Diverticulectomy with and without Pubovaginal Sling.

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The objective of this study was to compare the clinical presentation, outcomes, complications and diverticulum recurrence rates in women who underwent urethral diverticulectomy with versus without a concurrent pubovaginal sling.This […]

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Vitamin D and stress urinary incontinence in pregnancy: a cross-sectional study.

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To assess the association between levels of vitamin D and urinary incontinence (UI) in pregnancy.A cross-sectional study. Secondary analysis of a randomised controlled trial. Setting Two university hospitals in Norway. […]

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Grading Severity and Bother Using the IPSS and ICIQ-MLUTS Scores in Men Seeking Lower Urinary Tract Symptoms Therapy.

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To establish severity banding ranges, bother assessment and key item content in principal patient reported outcomes measures (PROMs) in men seeking therapy for lower urinary tract symptoms (LUTS).Data for International […]

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Bladder Bacterial Diversity Differs In Continent and Incontinent Women: A Cross-Sectional Study.

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Since the discovery of the bladder microbiome (urobiome), interest has grown in learning whether urobiome characteristics have a role in clinical phenotyping and/or provide opportunities for novel therapeutic approaches for […]

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LASER therapy for urinary incontinence and pelvic organ prolapse: a systematic review.

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LASER therapy is now being proposed for the treatment of pelvic organ prolapse (POP) and urinary incontinence (UI).To systematically review the available literature on LASER therapy for POP and UI.Pubmed, […]

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