Acute exacerbation of rheumatoid arthritis-associated interstitial lung disease: clinical features and prognosis.

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RA-associated interstitial lung disease (RA-ILD) is commonly associated with acute exacerbations (ILD-AE). This study examined the clinical characteristics and risk factors of ILD-AE and mortality of RA-ILD.We retrospectively collected data […]

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THE IMPACT OF DIFFERENT (RHEUMATOID) ARTHRITIS PHENOTYPES ON PATIENTS’ LIVES.

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To compare patient-relevant outcome (PRO) domains between three arthritis phenotypes: namely undifferentiated arthritis (UA), autoantibody-negative (RA-) and positive rheumatoid arthritis (RA+), at diagnosis, after 2 years and over time.All UA(n = 130), […]

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Efficacy, pharmacokinetics and safety of subcutaneous versus intravenous CT-P13 in rheumatoid arthritis: a randomized phase I/III trial.

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To assess non-inferiority of s.c. to i.v. CT-P13 in RA.Patients with active RA and inadequate response to MTX participated in this phase I/III double-blind study at 76 sites. Patients received […]

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Deep phenotyping of synovial molecular signatures by integrative systems analysis in rheumatoid arthritis.

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RA encompasses a complex, heterogeneous and dynamic group of diseases arising from molecular and cellular perturbations of synovial tissues. The aim of this study was to decipher this complexity using […]

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Efficacy, pharmacokinetics and safety of subcutaneous versus intravenous CT-P13 in rheumatoid arthritis: a randomized phase I/III trial.

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To assess non-inferiority of s.c. to i.v. CT-P13 in RA.Patients with active RA and inadequate response to MTX participated in this phase I/III double-blind study at 76 sites. Patients received […]

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Deep phenotyping of synovial molecular signatures by integrative systems analysis in rheumatoid arthritis.

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RA encompasses a complex, heterogeneous and dynamic group of diseases arising from molecular and cellular perturbations of synovial tissues. The aim of this study was to decipher this complexity using […]

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Proinflammatory and bone protective role of calcitonin gene-related peptide alpha in collagen antibody-induced arthritis.

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Calcitonin gene-related peptide alpha (αCGRP) represents an immunomodulatory neuropeptide implicated in pain perception. αCGRP also functions as a critical regulator of bone formation and is overexpressed in patients with rheumatoid […]

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Peripheral blood mononuclear cells are hypomethylated in active rheumatoid arthritis and methylation correlates with disease activity.

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Epigenetic modifications are dynamic and influence cellular disease activity. The aim of this study was to investigate global DNA methylation in peripheral blood mononuclear cells (PBMCs) of RA patients to […]

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Efficacy of baricitinib in patients with moderate-to-severe rheumatoid arthritis with 3 years of treatment: results from a long-term study.

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To evaluate the long-term efficacy of once-daily baricitinib 4 mg in patients with active RA who were either naïve to DMARDs or who had inadequate response (IR) to MTX.Analyses of data […]

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Priorities for High Quality Care in Rheumatoid Arthritis: Results of Patient, Health Professional, and Policymaker Perspectives.

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To elucidate the essential elements of high-quality rheumatoid arthritis (RA) care in order to develop a vision statement and a set of strategic objectives for a national RA quality framework.Focus […]

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Relationship between Depression and Disease Activity in United States Veterans with Early Rheumatoid Arthritis Receiving Methotrexate.

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Depression is common in rheumatoid arthritis (RA) patients, exacerbates disease activity, and may decrease response to first-line disease-modifying antirheumatic drugs. This study aimed to determine if depression affects disease activity […]

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Including pain, fatigue and physical function when assessing patients with early rheumatoid arthritis provides a comprehensive picture of disease burden.

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To explore the possibility of integrating patient-important outcomes like pain, fatigue and physical function into the evaluation of disease status in early rheumatoid arthritis (ERA), without compromising correct disease activity […]

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Lifestyle and clinical risk factors for incident rheumatoid arthritis-associated interstitial lung disease.

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To determine the association between novel lifestyle factors on risk of rheumatoid arthritis-associated interstitial lung disease (RA-ILD), define the threshold at which smoking increases RA-ILD risk, and calculate the degree […]

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Concerns, healthcare use, and treatment interruptions in patients with common autoimmune rheumatic diseases during the COVID-19 pandemic.

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To assess concerns and healthcare-related behaviors of patients with autoimmune rheumatic diseases during the COVID-19 pandemic.Adults from the United States with rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), […]

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Tuberculosis risk with biologics by screening-guided preventive strategy in rheumatoid arthritis under intermediate tuberculosis burden.

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We aimed to compare tuberculosis (TB) risk during biologics treatment between patients with RA who did (prophylaxis) and did not (non-prophylaxis) undergo chemoprophylaxis following pre-biologic latent TB screening in Korea […]

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Changes in the illness perceptions of patients with rheumatoid arthritis over the first year of methotrexate therapy.

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To describe the illness perceptions of patients with RA over the first year of MTX treatment, and the association between illness perceptions and outcomes.Data came from the Rheumatoid Arthritis Medication […]

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Hypogammaglobulinemia after rituximab for rheumatoid arthritis is not rare and is related with good response: 13 years real-life experience.

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Rituximab (RTX) use in the treatment of RA can be complicated by decrease in IgG, IgM or IgA levels (hypogammaglobulinemia-HGG). The aim of this study was to define the frequency […]

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Is seronegative rheumatoid arthritis true rheumatoid arthritis? A nationwide cohort study.

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The classification of seronegative arthritides can be challenging. Our aim was to examine the incidence of SpA diagnosis among patients initially diagnosed as seronegative RA.Using nationwide Finnish registers from social […]

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Switching between Janus kinase inhibitor upadacitinib and adalimumab following insufficient response: efficacy and safety in patients with rheumatoid arthritis.

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To evaluate efficacy and safety of immediate switch from upadacitinib to adalimumab, or vice versa, in patients with rheumatoid arthritis with non-response or incomplete-response to the initial therapy.SELECT-COMPARE randomised patients […]

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Rheumatoid arthritis related interstitial lung disease – improving outcomes over 25 years: a large multicentre UK study.

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This study explores whether the prognosis of interstitial lung disease in rheumatoid arthritis (RA-ILD) has improved over time and assesses the potential influence of drug therapy in a large multicentre […]

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Regulatory eosinophils induce the resolution of experimental arthritis and appear in remission state of human rheumatoid arthritis.

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Eosinophils possess pro-inflammatory functions in asthma. However, our recent studies have suggested that innate lymphoid cells type 2 (ILC2s) and eosinophils have proresolving properties in rheumatoid arthritis (RA). Nothing is […]

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Impact of disease activity and treatments on ovarian reserve in patients with rheumatoid arthritis in the ESPOIR cohort.

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Patients with RA have a higher prevalence of infertility than the general population. This study sought to examine the impact of RA disease activity and treatments on ovarian reserve measured […]

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Parsing multiomics landscape of activated synovial fibroblasts highlights drug targets linked to genetic risk of rheumatoid arthritis.

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Synovial fibroblasts (SFs) are one of the major components of the inflamed synovium in rheumatoid arthritis (RA). We aimed to gain insight into the pathogenic mechanisms of SFs through elucidating […]

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Circulating Fibroblast Growth Factor-21 Levels in Rheumatoid Arthritis: Associations with Disease Characteristics, Body Composition, and Physical Functioning.

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This study evaluated associations between Fibroblast Growth Factor (FGF)-21, an adipokine associated with metabolic stress, and adverse longitudinal changes in body composition and physical functioning in patients with rheumatoid arthritis […]

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Does Etanercept biosimilar prescription in a rheumatology center bend the medication cost curve?

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The market entry of biosimilars is expected to bring budgetary relief. Our objective was to determine how the introduction of biosimilars influences medication cost in patients with rheumatoid arthritis and […]

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Dendritic cell integrin expression patterns regulate inflammation in the rheumatoid arthritis joint.

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Immune dysregulation contributes to the development of RA. Altered surface expression patterns of integrin adhesion receptors by immune cells is one mechanism by which this may occur. We investigated the […]

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The dysregulation of monocyte subpopulations in individuals at risk of developing rheumatoid arthritis.

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Individuals carrying antibodies against citrullinated proteins (ACPA) are at high risk of developing RA. EULAR provided a clinical definition of individuals with arthralgia suspicious for progression to RA (clinically suspect […]

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Safety profile of upadacitinib in rheumatoid arthritis: integrated analysis from the SELECT phase III clinical programme.

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This integrated analysis presents the safety profile of upadacitinib, a Janus kinase inhibitor, at 15 mg and 30 mg once daily in patients with moderately to severely active rheumatoid arthritis (RA).Treatment-emergent adverse […]

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Abatacept in interstitial lung disease associated with rheumatoid arthritis: national multicenter study of 263 patients.

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To assess the efficacy of abatacept (ABA) in RA patients with interstitial lung disease (ILD) (RA-ILD).This was an observational, multicentre study of RA-ILD patients treated with at least one dose […]

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