Chronic joint pain 3 years after chikungunya virus infection largely characterized by relapsing-remitting symptoms.

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Abstract: To determine the frequency of chronic joint pain and stiffness 3 years after infection with chikungunya virus in a Latin American cohort.A cross-sectional follow-up of 120 patients from an […]

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Impact of flare on radiographic progression after etanercept continuation, tapering or withdrawal in patients with rheumatoid arthritis.

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Abstract: The structural consequences of flare after dose reduction/discontinuation of biologic DMARDs in patients with RA who achieve remission are unclear. We compared the incidence of radiographic progression in patients […]

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PIR-B expressing CD8+ T cells exhibit features of Tc1 and Tc17 in SKG mice.

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Abstract: In autoimmune arthritis, TCR signalling is attenuated by peripheral tolerance mechanisms. We have described previously a population of inhibitory receptor LIR-1 expressing autoreactive CD8+ T cells in rheumatoid arthritis. […]

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Effectiveness of different combinations of DMARDs and glucocorticoid bridging in early rheumatoid arthritis: two-year results of CareRA.

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Abstract: To investigate whether MTX should be combined with an additional DMARD and bridging glucocorticoids as initial treatment for patients with early RA to induce an effective long-term response.The Care […]

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Non-response to rituximab therapy in rheumatoid arthritis is associated with incomplete disruption of the B cell receptor repertoire.

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Abstract: To gain more insight into the dynamics of lymphocyte depletion and develop new predictors of clinical response to rituximab in rheumatoid arthritis (RA).RNA-based next-generation sequencing was used to analyse […]

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Arthritis self-efficacy beliefs and functioning among osteoarthritis and rheumatoid arthritis patients: a meta-analytic review.

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Abstract: The Arthritis Self-Efficacy Scale (ASES) is a widely used self-report measure of beliefs reflecting confidence in one’s capacity to function despite pain and control pain or other symptoms of […]

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Drug retention of biological DMARD in rheumatoid arthritis patients: the role of baseline characteristics and disease evolution.

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Abstract: To examine the association of the evolution in physician-reported and patient-reported outcomes with decision to stop biological DMARDs (bDMARDs) in RA. The contribution of baseline characteristics is well established, […]

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Orthopaedic Surgery Trend in Rheumatoid Arthritis – results of the National Registry of Hospitalised Patients (CMBD) over a 17 year period (1999-2015). TREND-AR Study.

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Abstract: Analyse the trend of orthopaedic surgery (OS) rates on patients with rheumatoid arthritis.Retrospective observational study based on information provided by the Spanish National System of Hospital Data Surveillance. All […]

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Does Abatacept Increase Postoperative Adverse Events in Rheumatoid Arthritis Compared with Conventional Synthetic Disease-modifying Drugs?

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Abstract: The aim of this study was to investigate whether abatacept (ABT) causes more adverse events than conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) after orthopedic surgery in patients with rheumatoid […]

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Correlates of Successful Rheumatoid Arthritis Flare Management: Clinician-driven Treatment, Home-based Strategies, & Medication Change.

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Abstract: Describe strategies used to manage rheumatoid arthritis (RA) flares that contribute to a successful post flare outcome.Data were collected from the BRASS registry, including clinical and patient reported outcomes, […]

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Initiating tocilizumab, with or without methotrexate, compared with starting methotrexate with prednisone within step-up treatment strategies in early rheumatoid arthritis: an indirect comparison of effectiveness and safety of the U-Act-Early and CAMERA-II treat-to-target trials.

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Abstract: Methotrexate (MTX), often combined with low moderately dosed prednisone, is still the cornerstone of initial treatment for early rheumatoid arthritis (RA). It is not known how this strategy compares […]

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Efficacy and safety of switching from rituximab to biosimilar CT-P10 in rheumatoid arthritis: 72-week data from a randomized Phase 3 trial.

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Abstract: To evaluate the efficacy and safety of CT-P10, a rituximab biosimilar after a single switch, during a multinational, randomized, double-blind Phase 3 trial involving patients with RA.Patients received 48 […]

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Fc-gamma receptors and S100A8/A9 cause bone erosion during rheumatoid arthritis. Do they act as partners in crime?

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Abstract: Bone erosion is one of the central hallmarks of RA and is caused by excessive differentiation and activation of osteoclasts. Presence of autoantibodies in seropositive arthritis is associated with […]

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PD-1+CXCR5-CD4+T cells are correlated with the severity of systemic lupus erythematosus.

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Abstract: PD-1+CXCR5-CD4+T peripheral helper (Tph) cells, a recently identified T cell subset, are proven to promote B cell responses and antibody production in rheumatoid arthritis, but their role in the […]

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Efficacy and safety of bimekizumab as add-on therapy for rheumatoid arthritis in patients with inadequate response to certolizumab pegol: a proof-of-concept study.

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Abstract: Evaluate the efficacy and safety of dual neutralisation of interleukin (IL)-17A and IL-17F with bimekizumab, a monoclonal IgG1 antibody, in addition to certolizumab pegol (CZP) in patients with rheumatoid […]

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Swollen, but not tender joints, are independently associated with ultrasound synovitis: results from a longitudinal observational study of patients with established rheumatoid arthritis.

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Abstract: Joint swelling and tenderness are considered a proxy for inflammation in patients with rheumatoid arthritis (RA). With ultrasound-detected inflammation as reference, our objectives were to explore on patient and […]

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Multi-dimensional analysis identified rheumatoid arthritis-driving pathway in human T cell.

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Abstract: Rheumatoid arthritis (RA) is an autoimmune disease accompanied by lymphocyte infiltration into joint synovium. While T cells are considered to be important for its pathogenesis, the features that are […]

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Predictors, demographics and frequency of sustained remission and low disease activity in anti-tumour necrosis factor-treated rheumatoid arthritis patients.

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Abstract: To investigate the frequency and predictors of sustained 28-joint DAS (DAS28) remission and low disease activity (LDA) in patients receiving anti-TNF therapy and changes in responses over a 12 […]

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Association of serum Tocilizumab trough concentrations with clinical disease activity index scores in adult rheumatoid arthritis patients.

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Abstract: To determine whether serum trough concentrations of tocilizumab (TCZ) administered as a fixed dose subcutaneous injection for the treatment of rheumatoid arthritis (RA), are associated with disease activity responses.We […]

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MRI Results Following Discontinuation of Methotrexate in Patients With Rheumatoid Arthritis Treated With Subcutaneous Tocilizumab: The COMP-ACT MRI Substudy.

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Abstract: To assess differences in joint damage and inflammation using magnetic resonance imaging (MRI) between patients with rheumatoid arthritis (RA) who achieved low disease activity with tocilizumab (TCZ) + methotrexate […]

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Long-term drug survival of tumor necrosis factor inhibitors in patients with rheumatoid arthritis.

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Abstract: Evaluate long-term drug survival (proportion of patients still receiving treatment) and discontinuation of etanercept, infliximab, adalimumab, certolizumab pegol, and golimumab using observational data from patients with rheumatoid arthritis.Following a […]

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Canadian Rheumatology Association Meeting Fairmont The Queen Elizabeth Montreal, Quebec, Canada February – March 2, 2019.

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Abstract: The 73rd Annual Meeting of The Canadian Rheumatology Association was held at the Fairmont The Queen Elizabeth, Montreal, Quebec, Canada February 27 – March 2, 2019. The program consisted […]

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Different classes of anti-modified protein antibodies are induced on exposure to antigens expressing only one type of modification.

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Abstract: Autoantibodies against post-translationally modified proteins (anti-modified protein antibodies or AMPAs) are a hallmark of rheumatoid arthritis (RA). A variety of classes of AMPAs against different modifications on proteins, such […]

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