Differential effects of sex on longitudinal patterns of cognitive decline in Parkinson’s disease.

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Cognitive impairment is an important and diverse symptom of Parkinson’s disease (PD). Sex is a purported risk variable for cognitive decline in PD, but has not been comprehensively investigated.This cross-sectional […]

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Characterization of gait variability in multiple system atrophy and Parkinson’s disease.

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Gait impairment is a pivotal feature of parkinsonian syndromes and increased gait variability is associated with postural instability and a higher risk of falls.We compared gait variability at different walking […]

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Randomized Trial of Focused Ultrasound Subthalamotomy for Parkinson’s Disease.

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The subthalamic nucleus is the preferred neurosurgical target for deep-brain stimulation to treat cardinal motor features of Parkinson’s disease. Focused ultrasound is an imaging-guided method for creating therapeutic lesions in […]

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Levodopa-carbidopa intrajejunal infusion in Parkinson’s disease: untangling the role of age.

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Levodopa-Carbidopa Intrajejunal gel (LCIG) infusion is an effective intervention for people with advanced Parkinson’s disease (PD). Although age may not be a limiting factor for LCIG implant, no data are […]

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Genetic determinants of survival in progressive supranuclear palsy: a genome-wide association study.

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The genetic basis of variation in the progression of primary tauopathies has not been determined. We aimed to identify genetic determinants of survival in progressive supranuclear palsy (PSP).In stage one […]

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Investigating the 1-year decline in midbrain-to-pons ratio in the differential diagnosis of PSP and IPD.

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A reliable measure of PSP-specific midbrain atrophy, the midbrain-to-pons ratio (MTPR) has been reported to support the differential diagnosis of progressive supranuclear palsy (PSP) from idiopathic Parkinson’s disease (IPD). Since […]

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The erythrocyte sedimentation rate in male adolescents and subsequent risk of Parkinson’s disease: an observational study.

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Systemic inflammation may be implicated in the pathophysiology of Parkinson’s disease (PD). Since PD occurs usually in later life, most studies of causal factors are conducted in older populations, so […]

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Late onset depression: dopaminergic deficit and clinical features of prodromal Parkinson’s disease: a cross-sectional study.

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Late onset depression (LOD) may precede the diagnosis of Parkinson’s disease (PD) or dementia with Lewy bodies (DLB). We aimed to determine the rate of clinical and imaging features associated […]

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Serum BDNF discriminates Parkinson’s disease patients with depression from without depression and reflect motor severity and gender differences.

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To evaluate the diagnostic value of serum Brain-derived neurotrophic factor (BDNF) levels for discriminating PD with depression from without depression, and to investigate whether serum BDNF levels were associated with […]

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Central retina changes in Parkinson’s disease: a systematic review and meta-analysis.

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Central retina imaging is important for early Parkinson’s disease (PD) recognition. We aimed to investigate central retina changes using spectral domain-optical coherence tomography (SD-OCT) in PD patients.We systematically searched PubMed […]

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Better quality of life and less caregiver strain in young-onset Parkinson’s disease: a multicentre retrospective cohort study.

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Parkinson’s disease (PD) is typically considered as a disease of the elderly. However, there is a sizeable subgroup of patients where PD starts at a younger age, known as young-onset […]

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Management of Parkinson’s disease patients after DBS by remote programming: preliminary application of single center during quarantine of 2019-nCoV.

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Deep brain stimulation (DBS) is an effective treatment for patients with Parkinson’s disease (PD). On time follow-up and timely programing of symptoms are important measures to maintain the effectiveness of […]

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Spinal cord stimulation therapy for gait dysfunction in progressive supranuclear palsy patients.

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There are no effective symptomatic treatments for progressive supranuclear palsy (PSP). Recent studies report benefits of spinal cord stimulation (SCS) for freezing of gait (FOG) and gait disorders in Parkinson’s […]

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Action fluency identifies different sex, age, global cognition, executive function and brain activation profile in non-demented patients with Parkinson’s disease.

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Patients with Parkinson’s disease (PD) have difficulties processing action words, which could be related to early cognitive decline. The action fluency test can be used to quickly and easily assess […]

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Kinematic but not clinical measures predict falls in Parkinson-related orthostatic hypotension.

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We sought to test the hypothesis that technology could predict the risk of falls in Parkinson’s disease (PD) patients with orthostatic hypotension (OH) with greater accuracy than in-clinic assessment.Twenty-six consecutive […]

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Longitudinal prediction of falls and near falls frequencies in Parkinson’s disease: a prospective cohort study.

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Several prediction models for falls/near falls in Parkinson’s disease (PD) have been proposed. However, longitudinal predictors of frequency of falls/near falls are poorly investigated. Therefore, we aimed to identify short- […]

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Eye movements and association with regional brain atrophy in clinical subtypes of progressive supranuclear palsy.

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To investigate oculomotor impairment in subtypes of progressive supranuclear palsy (PSP) and its associations with clinical features and regional brain volumes in PSP.We compared the video-oculography (VOG) findings of 123 […]

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Potential human transmission of amyloid β pathology: surveillance and risks.

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Studies in experimental animals show transmissibility of amyloidogenic proteins associated with prion diseases, Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases. Although these data raise potential concerns for public health, […]

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Assessment of Wearing Off in Parkinson’s disease using objective measurement.

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Development of “Wearing Off” (WO) of motor and non-motor function in Parkinson’s disease (PD) adversely affects quality of life. This suggest that identifying and treating WO is important. However, identification […]

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Parkinson’s disease determinants, prediction and gene-environment interactions in the UK Biobank.

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To systematically investigate the association of environmental risk factors and prodromal features with incident Parkinson’s disease (PD) diagnosis and the interaction of genetic risk with these factors. To evaluate whether […]

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Deep brain stimulation of the internal globus pallidus does not affect the limbic circuit in patients with Parkinson’s disease: a PET study.

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Internal globus pallidus (GPi) deep brain stimulation (DBS) is a safe and effective alternative treatment in Parkinson’s disease (PD) for patients with cognitive impairment. However, no study has yet investigated […]

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Dopaminergic therapy and prefrontal activation during walking in individuals with Parkinson’s disease: does the levodopa overdose hypothesis extend to gait?

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The “levodopa-overdose hypothesis” posits that dopaminergic replacement therapy (1) increases performance on tasks that depend on the nigrostriatal-pathway (e.g., motor-control circuits), yet (2) decreases performance on tasks that depend upon […]

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Parkinson’s disease laterality: a 11C-PE2I PET imaging study.

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Asymmetry of striatal dopaminergic deficits and motor symptoms is a typical characteristic of idiopathic Parkinson’s disease (PD). This study aims to characterise the trend of asymmetry in moderate-stage PD. We […]

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Vascular risk factors, white matter lesions and cognitive impairment in Parkinson’s disease: the PACOS longitudinal study.

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Vascular risk factors (VRFs) may be associated with cognitive decline in early Parkinson’s disease (PD) but results are inconclusive. The identification of modifiable risk factors is relevant for prevention and […]

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Towards early disease modification of Parkinson’s disease: a review of lessons learned in the Alzheimer field.

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Parkinson’s disease (PD) research is beginning to focus on early disease modification and prevention. The therapeutic pipeline includes a growing range of pharmacological interventions that could theoretically intervene with the […]

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