Testing, Monitoring, and Treatment of Thyroid Dysfunction in Pregnancy.

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Both hyperthyroidism and hypothyroidism can have adverse effects in pregnancy. The most common causes of thyrotoxicosis in pregnancy are gestational transient thyrotoxicosis and Graves’ disease. It is important to distinguish […]

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Maternal health, in-utero, and perinatal exposures and risk of thyroid cancer in offspring: a Nordic population-based nested case-control study.

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Thyroid cancer tends to be diagnosed at a younger age (median age 51 years) compared with most other malignancies (such as breast cancer [62 years] or lung cancer [71 years]). […]

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MorbiNet study. Hypothyroidism comorbidity networks in the adult general population.

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Multimorbidity impacts quality of life. We constructed hypothyroidism comorbidity networks to identify positive and negative associations with other prevalent diseases.We analyzed data of 285,342 patients with hypothyroidism from 3,135,948 adults […]

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Effects of thyroid status on regional brain volumes: a diagnostic and genetic imaging study in UK Biobank.

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Thyroid hormone is essential for optimal human neurodevelopment and may modify the risk of attention-deficit hyperactivity disorder (ADHD). However, the brain structures involved are unknown and it is unclear if […]

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Relationship of TSH levels with cardiometabolic risk factors in US youth and reference percentiles for thyroid function.

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Thyroid hormones play an important role in the metabolic homeostasis and higher levels have been associated with cardiometabolic risk.To examine the association of cardiometabolic risk factors with TSH levels in […]

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Cognitive and motor outcome in patients with early-detected central congenital hypothyroidism compared with siblings.

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Early treatment of primary congenital hypothyroidism (CH) prevents irreversible brain damage. Contrary to primary CH, outcome studies on central CH are scarce. Most central CH patients have multiple pituitary hormone […]

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Proteinuria in severe hypothyroidism: A prospective study.

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Hypothyroidism is associated with reversible decline in kidney function as measured by estimated glomerular filtration rate (eGFR). eGFR and proteinuria are most important markers for clinical assessment of kidney function. […]

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Severity of Proteinuria is Directly Associated with Risk of Hypothyroidism in Adults.

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Proteinuria can cause or exacerbate hypothyroidism, possibly due to urinary loss of protein-bound thyroid hormone. However, the precise relationship between proteinuria and hypothyroidism remains unclear.Determine the prevalence of hypothyroidism in […]

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Early Detection of Abnormal Growth Associated with Juvenile Acquired Hypothyroidism.

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Development of the typical growth phenotype of juvenile acquired hypothyroidism (JHT), the faltering linear growth with increasing weight, has not been thoroughly characterized.To describe longitudinal growth pattern in children developing […]

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The Hypothalamic-Pituitary-Thyroid Axis in Cushing Syndrome before and after Curative Surgery.

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We do not fully understand how hypercortisolism causes central hypothyroidism or what factors influence recovery of the hypothalamic-pituitary-thyroid axis. We evaluated thyroid function during and after cure of Cushing’s syndrome […]

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Multiple endocrine deficiencies are common in Hypoparathyroidism-Retardation-Dysmorphism (HRD) Syndrome.

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The rare syndrome of hypoparathyroidism, retardation, and dysmorphism (OMIM #241410) is caused by the mutated tubulin chaperone E (TBCE) gene. This gene encodes a critical protein in the microtubule assembly […]

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Newborn screening for congenital hypothyroidism: the benefit of using differential TSH cutoffs in a two-screen program.

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Analysis of a two-screen program for congenital hypothyroidism (CH) using differential blood TSH (bTSH) cutoffs of 10 mU/L at first screening (all infants) and 5 mU/L at second screening (selected […]

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Weight gain after thyroidectomy: a systematic review and meta-analysis.

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Weight gain is a major driver of dissatisfaction and decreased quality of life in patients with hypothyroidism. Data on the changes in body weight following thyroidectomy are conflicting.To perform a […]

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Association of Thyroid Hormone Therapy with Mortality in Subclinical Hypothyroidism: A Systematic Review and Meta-analysis.

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Benefits of thyroid hormone therapy on mortality in adults with subclinical hypothyroidism remain undetermined.To summarize the impact of thyroid hormone therapy on mortality in adults with subclinical hypothyroidism.PubMed, Embase, Scopus, […]

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Inactivation of a Frameshift TSH Receptor Variant Val711Phefs*18 is Due to Acquisition of a Hydrophobic Degron.

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Inactivating variants of TSH receptor (TSHR) cause congenital hypothyroidism. More than 60 such variants have been reported so far, most of which were located in the extracellular or transmembrane domain.We […]

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Subclinical hypothyroidism as an independent determinant of left atrial dysfunction in the general population.

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Although subclinical hypothyroidism (SCH) is a common clinical entity and carries independent risk for incident heart failure (HF), its possible association with subclinical cardiac dysfunction is unclear. Left ventricular global […]

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Phenotypic variability of patients with PAX8 variants presenting congenital hypothyroidism and eutopic thyroid.

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Thyroid dyshormonogenesis is a heterogeneous group of hereditary diseases produced by a total/partial blockage of the biochemical processes of thyroid-hormone synthesis and secretion. PAX8 is essential for thyroid morphogenesis and […]

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Patient satisfaction and quality of life in hypothyroidism: An online survey by the british thyroid foundation.

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Dissatisfaction with treatment and impaired quality of life (QOL) are reported amongst people with treated hypothyroidism. We aimed to gain insight into this.We conducted an online survey of individuals with […]

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Treatment of Thyroid Dysfunction and Serum Lipids: A Systematic Review and Meta-Analysis.

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Hyperthyroidism is associated with low levels of cholesterol and triglycerides, and hypothyroidism is associated with hypercholesterolemia and hypertriglyceridemia.The aim of this systematic review was to investigate the impact of therapy […]

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Effects of thyroid function on phosphodiester concentrations in skeletal muscle and liver: An in vivo NMRS study.

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Thyroid function is clinically evaluated by determination of circulating concentrations of TSH and fT4. However, a tissue-specific effector substrate of thyroid function is lacking. Energy-rich phosphorus-containing metabolites (PM) and phospholipids […]

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Missed diagnoses and health problems in adults with Prader-Willi syndrome – recommendations for screening and treatment.

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Prader-Willi syndrome (PWS) is a complex hypothalamic disorder, combining hyperphagia, hypotonia, intellectual disability and pituitary hormone deficiencies. Annual mortality of patients with PWS is high (3%). In half of the […]

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Central hypothyroidism improves with age in very young children with Prader-Willi syndrome.

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Abnormalities in the hypothalamic-pituitary-thyroid (HPT) axis have been implicated in Prader-Willi syndrome (PWS); however, limited information is currently available on age-dependent alterations in the HPT axis. We herein investigated age-dependent […]

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Impact of preconception treatment initiation for hypothyroidism on neurocognitive function in children.

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Levothyroxine treatment for hypothyroidism in early pregnancy has inconsistent outcomes.This study evaluated children’s cognitive function to ascertain the impact of preconception maternal hypothyroidism treatment on fetal neurodevelopment.Prospective cohort study.A single-center […]

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Congenital Hypothyroidism Due to Truncating PAX8 Mutations: A Case Series and Molecular Function Studies.

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PAX8 is a transcription factor required for thyroid development, and its mutation causes congenital hypothyroidism (CH). More than 20 experimentally verified loss-of-function PAX8 mutations have been described, and all but […]

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Maternal thyroid dysfunction during pregnancy and the risk of adverse outcomes in the offspring: a systematic review and meta-analysis.

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Previous studies suggested a potential link of maternal thyroid dysfunction with adverse neurocognitive outcomes and impaired development of internal organs in offspring.To review the association between maternal thyroid dysfunction and […]

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Maternal thyroid disease and adiposity in mother and child.

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Thyroid hormones are crucial developmental factors and thyroid disease in pregnant women is a concern. Overweight and obesity are also important health concerns, and we hypothesized that in utero exposure […]

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Is subacute thyroiditis an underestimated manifestation of SARS-CoV-2 infection? Insights from a case series.

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than 18 million people worldwide and the pandemic is still spreading. After the first case we reported, we observed 4 […]

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HDL Cholesterol Efflux Capacity is Impaired in Severe Short-Term Hypothyroidism Despite Increased HDL Cholesterol.

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Severe hypothyroidism has profound effects on lipoprotein metabolism including high-density lipoprotein (HDL) cholesterol elevations but effects on HDL function metrics are unknown.To determine the impact of severe short-term hypothyroidism on […]

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Effect of Levothyroxine on Left Ventricular Ejection Fraction in Patients With Subclinical Hypothyroidism and Acute Myocardial Infarction: A Randomized Clinical Trial.

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Thyroid hormones play a key role in modulating myocardial contractility. Subclinical hypothyroidism in patients with acute myocardial infarction is associated with poor prognosis.To evaluate the effect of levothyroxine treatment on […]

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