Both hyperthyroidism and hypothyroidism can have adverse effects in pregnancy. The most common causes of thyrotoxicosis in pregnancy are gestational transient thyrotoxicosis and Graves’ disease. It is important to distinguish […]» Read more
Maternal health, in-utero, and perinatal exposures and risk of thyroid cancer in offspring: a Nordic population-based nested case-control study.
Thyroid cancer tends to be diagnosed at a younger age (median age 51 years) compared with most other malignancies (such as breast cancer [62 years] or lung cancer [71 years]). […]» Read more
Multimorbidity impacts quality of life. We constructed hypothyroidism comorbidity networks to identify positive and negative associations with other prevalent diseases.We analyzed data of 285,342 patients with hypothyroidism from 3,135,948 adults […]» Read more
Effects of thyroid status on regional brain volumes: a diagnostic and genetic imaging study in UK Biobank.
Thyroid hormone is essential for optimal human neurodevelopment and may modify the risk of attention-deficit hyperactivity disorder (ADHD). However, the brain structures involved are unknown and it is unclear if […]» Read more
Relationship of TSH levels with cardiometabolic risk factors in US youth and reference percentiles for thyroid function.
Thyroid hormones play an important role in the metabolic homeostasis and higher levels have been associated with cardiometabolic risk.To examine the association of cardiometabolic risk factors with TSH levels in […]» Read more
Cognitive and motor outcome in patients with early-detected central congenital hypothyroidism compared with siblings.
Early treatment of primary congenital hypothyroidism (CH) prevents irreversible brain damage. Contrary to primary CH, outcome studies on central CH are scarce. Most central CH patients have multiple pituitary hormone […]» Read more
Hypothyroidism is associated with reversible decline in kidney function as measured by estimated glomerular filtration rate (eGFR). eGFR and proteinuria are most important markers for clinical assessment of kidney function. […]» Read more
Proteinuria can cause or exacerbate hypothyroidism, possibly due to urinary loss of protein-bound thyroid hormone. However, the precise relationship between proteinuria and hypothyroidism remains unclear.Determine the prevalence of hypothyroidism in […]» Read more
Development of the typical growth phenotype of juvenile acquired hypothyroidism (JHT), the faltering linear growth with increasing weight, has not been thoroughly characterized.To describe longitudinal growth pattern in children developing […]» Read more
We do not fully understand how hypercortisolism causes central hypothyroidism or what factors influence recovery of the hypothalamic-pituitary-thyroid axis. We evaluated thyroid function during and after cure of Cushing’s syndrome […]» Read more
Amiodarone is a class III antiarrhythmic drug containing 37% iodine by weight, with a structure similar to that of thyroid hormones. Deiodination of amiodarone releases large amounts of iodine that […]» Read more
Multiple endocrine deficiencies are common in Hypoparathyroidism-Retardation-Dysmorphism (HRD) Syndrome.
The rare syndrome of hypoparathyroidism, retardation, and dysmorphism (OMIM #241410) is caused by the mutated tubulin chaperone E (TBCE) gene. This gene encodes a critical protein in the microtubule assembly […]» Read more
Newborn screening for congenital hypothyroidism: the benefit of using differential TSH cutoffs in a two-screen program.
Analysis of a two-screen program for congenital hypothyroidism (CH) using differential blood TSH (bTSH) cutoffs of 10 mU/L at first screening (all infants) and 5 mU/L at second screening (selected […]» Read more
Weight gain is a major driver of dissatisfaction and decreased quality of life in patients with hypothyroidism. Data on the changes in body weight following thyroidectomy are conflicting.To perform a […]» Read more
Association of Thyroid Hormone Therapy with Mortality in Subclinical Hypothyroidism: A Systematic Review and Meta-analysis.
Benefits of thyroid hormone therapy on mortality in adults with subclinical hypothyroidism remain undetermined.To summarize the impact of thyroid hormone therapy on mortality in adults with subclinical hypothyroidism.PubMed, Embase, Scopus, […]» Read more
Inactivation of a Frameshift TSH Receptor Variant Val711Phefs*18 is Due to Acquisition of a Hydrophobic Degron.
Inactivating variants of TSH receptor (TSHR) cause congenital hypothyroidism. More than 60 such variants have been reported so far, most of which were located in the extracellular or transmembrane domain.We […]» Read more
Subclinical hypothyroidism as an independent determinant of left atrial dysfunction in the general population.
Although subclinical hypothyroidism (SCH) is a common clinical entity and carries independent risk for incident heart failure (HF), its possible association with subclinical cardiac dysfunction is unclear. Left ventricular global […]» Read more
Phenotypic variability of patients with PAX8 variants presenting congenital hypothyroidism and eutopic thyroid.
Thyroid dyshormonogenesis is a heterogeneous group of hereditary diseases produced by a total/partial blockage of the biochemical processes of thyroid-hormone synthesis and secretion. PAX8 is essential for thyroid morphogenesis and […]» Read more
Patient satisfaction and quality of life in hypothyroidism: An online survey by the british thyroid foundation.
Dissatisfaction with treatment and impaired quality of life (QOL) are reported amongst people with treated hypothyroidism. We aimed to gain insight into this.We conducted an online survey of individuals with […]» Read more
Hyperthyroidism is associated with low levels of cholesterol and triglycerides, and hypothyroidism is associated with hypercholesterolemia and hypertriglyceridemia.The aim of this systematic review was to investigate the impact of therapy […]» Read more
Effects of thyroid function on phosphodiester concentrations in skeletal muscle and liver: An in vivo NMRS study.
Thyroid function is clinically evaluated by determination of circulating concentrations of TSH and fT4. However, a tissue-specific effector substrate of thyroid function is lacking. Energy-rich phosphorus-containing metabolites (PM) and phospholipids […]» Read more
Missed diagnoses and health problems in adults with Prader-Willi syndrome – recommendations for screening and treatment.
Prader-Willi syndrome (PWS) is a complex hypothalamic disorder, combining hyperphagia, hypotonia, intellectual disability and pituitary hormone deficiencies. Annual mortality of patients with PWS is high (3%). In half of the […]» Read more
Abnormalities in the hypothalamic-pituitary-thyroid (HPT) axis have been implicated in Prader-Willi syndrome (PWS); however, limited information is currently available on age-dependent alterations in the HPT axis. We herein investigated age-dependent […]» Read more
Impact of preconception treatment initiation for hypothyroidism on neurocognitive function in children.
Levothyroxine treatment for hypothyroidism in early pregnancy has inconsistent outcomes.This study evaluated children’s cognitive function to ascertain the impact of preconception maternal hypothyroidism treatment on fetal neurodevelopment.Prospective cohort study.A single-center […]» Read more
Congenital Hypothyroidism Due to Truncating PAX8 Mutations: A Case Series and Molecular Function Studies.
PAX8 is a transcription factor required for thyroid development, and its mutation causes congenital hypothyroidism (CH). More than 20 experimentally verified loss-of-function PAX8 mutations have been described, and all but […]» Read more
Maternal thyroid dysfunction during pregnancy and the risk of adverse outcomes in the offspring: a systematic review and meta-analysis.
Previous studies suggested a potential link of maternal thyroid dysfunction with adverse neurocognitive outcomes and impaired development of internal organs in offspring.To review the association between maternal thyroid dysfunction and […]» Read more
Thyroid hormones are crucial developmental factors and thyroid disease in pregnant women is a concern. Overweight and obesity are also important health concerns, and we hypothesized that in utero exposure […]» Read more
Is subacute thyroiditis an underestimated manifestation of SARS-CoV-2 infection? Insights from a case series.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than 18 million people worldwide and the pandemic is still spreading. After the first case we reported, we observed 4 […]» Read more
HDL Cholesterol Efflux Capacity is Impaired in Severe Short-Term Hypothyroidism Despite Increased HDL Cholesterol.
Severe hypothyroidism has profound effects on lipoprotein metabolism including high-density lipoprotein (HDL) cholesterol elevations but effects on HDL function metrics are unknown.To determine the impact of severe short-term hypothyroidism on […]» Read more
Effect of Levothyroxine on Left Ventricular Ejection Fraction in Patients With Subclinical Hypothyroidism and Acute Myocardial Infarction: A Randomized Clinical Trial.
Thyroid hormones play a key role in modulating myocardial contractility. Subclinical hypothyroidism in patients with acute myocardial infarction is associated with poor prognosis.To evaluate the effect of levothyroxine treatment on […]» Read more