Globally, nearly 10% of the population has chronic kidney disease (CKD), defined as a glomerular filtration rate less than 60 mL/min/1.73 m2 and/or a urinary albumin to creatinine ratio greater than 30 mg/g […]» Read more
To investigate the risk of major adverse cardiac and cerebrovascular events (MACCEs) and all-cause death of patients with controlled hypertension and suggest the benefits of physical activity in their prognosis.People […]» Read more
Impact of Baseline Right Bundle Branch Block on Outcomes after Pulmonary Vein Isolation in Patients with Atrial Fibrillation.
Right bundle branch block (RBBB) is one of the most frequent alterations of the electrocardiogram. Several studies have shown that RBBB is a risk factor of cardiovascular diseases. However, the […]» Read more
Pulmonary Arterial Hypertension in Hospitalized Patients with Polycythemia Vera (From the National Inpatient Database).
The prevalence and pathophysiology of pulmonary arterial hypertension (PAH) in myeloproliferative neoplasms (MPN) is poorly understood and have not been evaluated on larger scale studies. These reports generally focus on […]» Read more
Variations in knowledge, awareness and treatment of hypertension and stroke risk by country income level.
Hypertension is the most important modifiable risk factor for stroke globally. We hypothesised that country-income level variations in knowledge, detection and treatment of hypertension may contribute to variations in the […]» Read more
Epidemiological evidence on the relationship between lipid profile and cardiovascular disease (CVD) events in young adults remains insufficient. Thus, we sought to explore the association of lipid profile with subsequent […]» Read more
Systolic and diastolic hypertension independently predict the risk of adverse cardiovascular events. It remains unclear how systolic pressure, diastolic pressure, and other patient characteristics influence the initial diagnosis of hypertension. […]» Read more
The role of G protein-coupled receptor kinase 4 in cardiomyocyte injury after myocardial infarction.
G protein-coupled receptor kinase 4 (GRK4) has been reported to play an important role in hypertension, but little is known about its role in cardiomyocytes and myocardial infarction (MI). The […]» Read more
Prolonged Elevation of Tricuspid Regurgitation Pressure Gradient after Exercise in Patients with Exercise-Induced Pulmonary Hypertension.
It is necessary to measure the peak tricuspid regurgitation pressure gradient (TRPG) that is recorded at maximum exercise intensity when diagnosing exercise-induced pulmonary hypertension (ePH) on exercise stress echocardiography (ESE). […]» Read more
Can the Absence of Hypertension Refine the Risk Assessment of Older Adults for Future Cardiovascular Events?: Nanna et al.: Hypertension in Older Adults.
We sought to determine if the absence of hypertension in older adults can be used to identify those at lower risk of atherosclerotic cardiovascular disease (ASCVD). We identified participants ≥75 […]» Read more
Secondary (functional) mitral regurgitation (SMR) most commonly arises secondary to left ventricular (LV) dilation/dysfunction. The concept of disproportionately severe SMR was proposed to help explain the different results of two […]» Read more
Midlife blood pressure is associated with the severity of white matter hyperintensities: analysis of the UK Biobank cohort study.
White matter hyperintensities (WMH) progress with age and hypertension, but the key period of exposure to elevated blood pressure (BP), and the relative role of systolic BP (SBP) vs. diastolic […]» Read more
Standardized exercise training is feasible, safe, and effective in pulmonary arterial and chronic thromboembolic pulmonary hypertension: results from a large European multicentre randomized controlled trial.
This prospective, randomized, controlled, multicentre study aimed to evaluate efficacy and safety of exercise training in patients with pulmonary arterial (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH).For the first time […]» Read more
Prognostic importance of the transmitral pressure gradient in mitral annular calcification with associated mitral valve dysfunction.
The aim of this study was to define the natural history of patients with mitral annular calcification (MAC)-related mitral valve dysfunction and to assess the prognostic importance of mean transmitral […]» Read more
Screening for High Blood Pressure in Children and Adolescents: US Preventive Services Task Force Recommendation Statement.
Prevalence of hypertension (both primary and secondary) in children and adolescents in the US ranges from 3% to 4%. Primary hypertension in children and adolescents occurs primarily in children older […]» Read more
Comparison of Prevalence, Presentation and Prognosis of Acute Coronary Syndromes in ≤35 years, 36 – 54 years, and ≥ 55 years Patients.
Whether very young patients (≤35-year-old) differ in the prevalence, presentation and prognosis of ACS is not well known. Out of 43,446 patients who were referred to a tertiary care cardiac […]» Read more
Obstructive sleep apnoea, intermittent hypoxia and heart failure with a preserved ejection fraction.
Obstructive sleep apnoea (OSA) is recognised to be a potent risk factor for hypertension, coronary heart disease, strokes and heart failure with a reduced ejection fraction. However, the association between […]» Read more
RA is the most common inflammatory arthritis and is associated with increased risk of cardiovascular events and mortality. Evidence regarding outcomes following PCI is limited. This study aimed to assess […]» Read more
Incidental Thoracic Aortic Dilation On Chest Computed Tomography In Patients With Atrial Fibrillation.
Individuals with atrial fibrillation (AF) have risk factors that predispose to thoracic aneurysmal disease (TAD) and atherosclerosis. In this study in individuals with AF, we assessed the occurrence of incidental […]» Read more
Pregnancy in women with aortic coarctation (CoA) has an estimated moderately increased risk (mWHO II-III) of adverse cardiovascular, obstetric or fetal events, but prospective data to validate this risk classification […]» Read more
Hypertension attenuates the prognostic value of coronary artery calcification scoring in low-risk patients.
In outpatients with suspected ischaemic symptoms, we investigated the impact of risk factor profile on the prognostic value of coronary artery calcium scoring (CACS) and CT coronary angiography (CTCA).772 consecutive […]» Read more
Effect of Praliciguat on Peak Rate of Oxygen Consumption in Patients With Heart Failure With Preserved Ejection Fraction: The CAPACITY HFpEF Randomized Clinical Trial.
Heart failure with preserved ejection fraction (HFpEF) is often characterized by nitric oxide deficiency.To evaluate the efficacy and adverse effects of praliciguat, an oral soluble guanylate cyclase stimulator, in patients […]» Read more
We assessed the association of BMI with all-cause and cardiovascular (CV) mortality in a contemporary acute coronary syndrome (ACS) cohort. Patients from the Australian Cooperative National Registry of Acute Coronary […]» Read more
Incidence and Predictors of 30-day Acute Cerebrovascular Accidents Post Atrial Fibrillation Catheter Ablation (From the Nationwide Readmissions Database).
Catheter-based ablation is increasingly being used as first-line therapy for atrial fibrillation (AF). Cerebrovascular accidents (CVA) are a known complication. In this study, we investigate the 30-day incidence and predictors […]» Read more
Obstructive sleep apnea-hypopnea syndrome (OSA) compromises the efficacy of atrial fibrillation (AF) control strategies. Continuous positive airway pressure (CPAP) may ameliorate arrhythmia control especially in early AF stages (new-onset AF). […]» Read more
Frequency, Trends and Outcomes of Cerebrovascular Events Associated with Atrial Fibrillation Hospitalizations.
The main objective is to estimate the frequency, temporal trends, and outcomes of cerebrovascular events associated with AF hospitalization in the United States using the National Inpatient Sample (NIS) dataset. […]» Read more
Prevalence of pulmonary hypertension in adults after atrial switch and role of ventricular filling pressures.
To assess the prevalence of elevated systemic right ventricular (sRV) end-diastolic pressure and pulmonary arterial hypertension in adults with transposition of the great arteries (TGA) who have undergone atrial switch […]» Read more
Clinical and echocardiographic outcomes in heart failure associated with methamphetamine use and cessation.
Methamphetamine use is associated with systolic dysfunction, pulmonary arterial hypertension and may also be associated with diastolic dysfunction. The impact of methamphetamine cessation on methamphetamine-associated heart failure (MethHF) remains poorly […]» Read more
Data on emergency coronary artery bypass surgery (CABG) are limited. We studied patients undergoing isolated CABG at Mayo Clinic between 1993 and 2019. Baseline characteristics and in-hospital outcomes of emergent […]» Read more
Aortic stenosis (AS) is associated with significant morbidity and mortality, including sudden cardiac death (SCD). Anemia is a known risk factor for mortality in patients with AS. We sought to […]» Read more