Differential effects of sex on longitudinal patterns of cognitive decline in Parkinson’s disease.

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Cognitive impairment is an important and diverse symptom of Parkinson’s disease (PD). Sex is a purported risk variable for cognitive decline in PD, but has not been comprehensively investigated.This cross-sectional […]

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Beta-synuclein in cerebrospinal fluid as an early diagnostic marker of Alzheimer’s disease.

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Synaptic loss plays a major role in Alzheimer’s disease (AD). However so far no neurochemical marker for synaptic loss has been introduced into clinical routine. By mass spectrometry beta-synuclein was […]

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Late onset depression: dopaminergic deficit and clinical features of prodromal Parkinson’s disease: a cross-sectional study.

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Late onset depression (LOD) may precede the diagnosis of Parkinson’s disease (PD) or dementia with Lewy bodies (DLB). We aimed to determine the rate of clinical and imaging features associated […]

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Plasma microRNA signature in presymptomatic and symptomatic subjects with C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis.

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To identify potential biomarkers of preclinical and clinical progression in chromosome 9 open reading frame 72 gene (C9orf72)-associated disease by assessing the expression levels of plasma microRNAs (miRNAs) in C9orf72 […]

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Long-term functional decline of spontaneous intracerebral haemorrhage survivors.

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To identify in patients who survived 6 months after a spontaneous intracerebral haemorrhage (ICH) baseline characteristics and new clinical events associated with functional decline.In a single-centre study, we prospectively included 6-month […]

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Metabolic brain changes across different levels of cognitive impairment in ALS: a 18F-FDG-PET study.

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To identify the metabolic changes related to the various levels of cognitive deficits in amyotrophic lateral sclerosis (ALS) using 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography (18F-FDG-PET) imaging.274 ALS patients underwent neuropsychological assessment […]

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Metabolic brain changes across different levels of cognitive impairment in ALS: a 18F-FDG-PET study.

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To identify the metabolic changes related to the various levels of cognitive deficits in amyotrophic lateral sclerosis (ALS) using 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography (18F-FDG-PET) imaging.274 ALS patients underwent neuropsychological assessment […]

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Fully automated cognitive screening tool based on assessment of speech and language.

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Recent years have seen an almost sevenfold rise in referrals to specialist memory clinics. This has been associated with an increased proportion of patients referred with functional cognitive disorder (FCD), […]

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Cumulative health deficits, APOE genotype, and risk for later-life mild cognitive impairment and dementia.

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To determine whether health-deficit accumulation is associated with the risks of mild cognitive impairment (MCI) and dementia independently of APOE genotype.A frailty index was calculated using the deficit-accumulation approach in […]

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Fluid biomarkers in frontotemporal dementia: past, present and future.

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The frontotemporal dementia (FTD) spectrum of neurodegenerative disorders includes a heterogeneous group of conditions. However, following on from a series of important molecular studies in the early 2000s, major advances […]

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Middle-age dementia risk scores and old-age cognition: a quasi-experimental population-based twin study with over 20-year follow-up.

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Middle-age risk scores predict cognitive impairment, but it is not known if these associations are evident when controlling for shared genetic and environmental factors. Using two risk scores, self-report educational-occupational […]

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SQSTM1 variant in disorders of the frontotemporal dementia-amyotrophic lateral sclerosis spectrum: identification of a novel heterozygous variant and a review of the literature.

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Accumulating evidence shows that SQSTM1 plays a vital role in the pathogenesis of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), which represent a neurodegenerative disease continuum. Here, we report […]

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Effects of intensive versus standard blood pressure control on domain-specific cognitive function: a substudy of the SPRINT randomised controlled trial.

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Results from the Systolic Blood Pressure Intervention Trial (SPRINT) showed that intensive control of systolic blood pressure significantly reduced the occurrence of mild cognitive impairment, but not probable dementia. We […]

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Amyloid-PET and 18F-FDG-PET in the diagnostic investigation of Alzheimer’s disease and other dementias.

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Various biomarkers are available to support the diagnosis of neurodegenerative diseases in clinical and research settings. Among the molecular imaging biomarkers, amyloid-PET, which assesses brain amyloid deposition, and 18F-fluorodeoxyglucose (18F-FDG) […]

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Trauma and depressive symptomatology in middle-aged persons at high risk of dementia: the PREVENT Dementia Study.

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Depression and trauma are associated with changes in brain regions implicated in Alzheimer’s disease. The present study examined associations between childhood trauma, depression, adult cognitive functioning and risk of dementia.Data […]

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Cognition and behaviour in frontotemporal dementia with and without amyotrophic lateral sclerosis.

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The precise relationship between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) is incompletely understood. The association has been described as a continuum, yet data suggest that this may be […]

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Association of Receipt of Palliative Care Interventions With Health Care Use, Quality of Life, and Symptom Burden Among Adults With Chronic Noncancer Illness: A Systematic Review and Meta-analysis.

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The evidence for palliative care exists predominantly for patients with cancer. The effect of palliative care on important end-of-life outcomes in patients with noncancer illness is unclear.To measure the association […]

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Peripheral immunophenotype in dementia with Lewy bodies and Alzheimer’s disease: an observational clinical study.

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Inflammation plays a key role in the aetiology and progression of Alzheimer’s disease (AD). However, the immunophenotype of the second most common neurodegenerative cause of dementia, dementia with Lewy bodies […]

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Inside minds, beneath diseases: social cognition in amyotrophic lateral sclerosis-frontotemporal spectrum disorder.

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To compare social cognition performance between patients with amyotrophic lateral sclerosis (ALS) and those patients with behavioural variant frontotemporal dementia (bvFTD).We included 21 participants with ALS, 20 with bvFTD and […]

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Potential human transmission of amyloid β pathology: surveillance and risks.

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Studies in experimental animals show transmissibility of amyloidogenic proteins associated with prion diseases, Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases. Although these data raise potential concerns for public health, […]

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Parkinson’s disease determinants, prediction and gene-environment interactions in the UK Biobank.

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To systematically investigate the association of environmental risk factors and prodromal features with incident Parkinson’s disease (PD) diagnosis and the interaction of genetic risk with these factors. To evaluate whether […]

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Comparison between plasma and cerebrospinal fluid biomarkers for the early diagnosis and association with survival in prion disease.

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To compare the diagnostic accuracy and the prognostic value of blood and cerebrospinal fluid (CSF) tests across prion disease subtypes.We used a single-molecule immunoassay to measure tau and neurofilament light […]

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Does pallidal neuromodulation influence cognitive decline in Huntington’s disease?

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Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder associated with motor, psychiatric and cognitive deterioration over time. To date, Continuous Electrical Neuromodulation (CEN) of the globus pallidus internus (GPi) […]

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Vascular risk factors, white matter lesions and cognitive impairment in Parkinson’s disease: the PACOS longitudinal study.

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Vascular risk factors (VRFs) may be associated with cognitive decline in early Parkinson’s disease (PD) but results are inconclusive. The identification of modifiable risk factors is relevant for prevention and […]

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