Transient Elastography Accurately Screens for Compensated Advanced Chronic Liver Disease in Patients with Ongoing or Recent Alcohol Withdrawal.

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Liver stiffness measurement by transient elastography (TE) is a promising method for staging fibrosis in alcohol-related liver disease, but uncertainties remain regarding the influence of alcohol consumption and thus the […]

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Antiviral therapy in the palliative setting of HCC (BCLC B and C).

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The potential impact of direct-acting antivirals (DAAs) in patients with Barcelona Clinic Liver Cancer (BCLC)-B/C hepatocellular carcinoma (HCC) is understudied. HCC patients have been systematically excluded from randomised controlled trials […]

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Diagnosis and management of secondary causes of steatohepatitis.

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The term non-alcoholic liver disease (NAFLD) was originally coined to describe hepatic fat deposition as part of the metabolic syndrome. However, a variety of rare hereditary liver and metabolic diseases, […]

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The health impact of MAFLD, a novel disease cluster of NAFLD, is amplified by the integrated effect of fatty liver disease related genetic variants.

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Metabolic dysfunction-associated fatty liver disease (MAFLD) is a newly proposed disease category that derived from non-alcoholic fatty liver disease. The impact of MAFLD on health events has not been investigated.UK […]

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INTEGRATED MULTI-OMICS REVEALS GLUCOSE USE REPROGRAMMING AND IDENTIFIES A NOVEL HEXOKINASE IN ALCOHOLIC HEPATITIS.

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We recently demonstrated that alcoholic hepatitis (AH) is characterized by de-differentiation of hepatocytes and loss of mature functions. Glucose metabolism is tightly regulated in healthy hepatocytes. We hypothesize that AH […]

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Association of genetic variation with cirrhosis: a multi-trait genome-wide association and gene-environment interaction study.

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In contrast to most other common diseases, few genetic variants have been identified that impact risk of cirrhosis. We aimed to identify new genetic variants that predispose to cirrhosis, to […]

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The Association of Histologic and Non-invasive Tests with Adverse Clinical and Patient-Reported Outcomes in Patients with Advanced Fibrosis Due to Nonalcoholic Steatohepatitis (NASH).

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Fibrosis is an independent predictor of death in NASH. We assessed the associations between histologic and non-invasive (NITs) fibrosis tests with clinical and patient-reported outcomes (PROs) in advanced NASH.Patients with […]

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The Systemic Inflammation Hypothesis: Towards a New Paradigm of Acute Decompensation and Multiorgan Failure in Cirrhosis.

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Acute decompensation (AD) of cirrhosis is defined by the development of ascites, hepatic encephalopathy (HE) and/or variceal bleeding. Ascites is traditionally attributed to splanchnic arterial vasodilation and left-ventricular dysfunction, HE […]

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Metabolic and genetic risk factors are the strongest predictors of severity of alcohol-related liver fibrosis.

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Individual risk for developing alcohol-related liver disease (ALD) varies greatly. We hypothesized that metabolic risk factors and genetic polymorphisms predict severity of ALD.Biopsy-controlled, cross-sectional study in patients with a history […]

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Clinical course of porto-sinusoidal vascular disease (PSVD) is distinct from idiopathic non-cirrhotic portal hypertension (INCPH).

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Porto-sinusoidal vascular disease (PSVD) was recently proposed as novel clinical entity characterized by typical histological changes with or without portal hypertension (PH) in the absence of cirrhosis. Thus, we aimed […]

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Pan-PPAR agonist lanifibranor improves portal hypertension and hepatic fibrosis in experimental advanced chronic liver disease.

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In advanced chronic liver disease (ACLD), de-regulated hepatic necroinflammatory processes play a key role in the development of liver microvascular dysfunction, fibrogenesis, and increased hepatic vascular tone, resulting in progression […]

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Assessing the role of amino acids in systemic inflammation and organ failure in patients with ACLF.

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Intense systemic inflammatory responses and the existence of organ failures are the hallmarks of acute-on-chronic liver failure (ACLF) that complicates cirrhosis. Little is known about the role of amino acids […]

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Non-invasive stratification of hepatocellular carcinoma risk in non-alcoholic fatty liver using polygenic risk scores.

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Hepatocellular carcinoma (HCC) risk stratification in individuals with dysmetabolism is a major unmet need. Genetic predisposition contributes to non-alcoholic fatty liver disease (NAFLD). We aimed to exploit robust polygenic risk […]

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Screening is associated with a lower risk of hepatocellular carcinoma-related mortality in patients with chronic hepatitis B.

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Patients with chronic hepatitis B (CHB) infection routinely undergo screening for hepatocellular carcinoma (HCC), but the efficacy of screening remains unclear. We aimed to evaluate the impact of screening with […]

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Clinical outcomes following DAA therapy in patients with HCV-related cirrhosis depend on disease severity.

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HCV-infected patients with cirrhosis achieve high sustained virological response (SVR) rates with direct-acting antivirals (DAAs) even after hepatic decompensation. We aimed to assess the clinical outcome following DAAs among patients […]

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PREDICT identifies precipitating events associated with the clinical course of acutely decompensated cirrhosis.

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Acute decompensation (AD) of cirrhosis may present without acute-on-chronic liver failure (ACLF) (AD-No ACLF), or with ACLF phenotype (AD-ACLF) defined by organ failure(s). Precipitants may induce AD. This multicenter, prospective, […]

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IL-2 contributes to cirrhosis-associated immune dysfunction by impairing follicular T helper cells in advanced cirrhosis.

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Patients with decompensated liver cirrhosis suffer from recurrent infections and inadequate responses to prophylactic vaccinations. However, many patients present with hypergammaglobulinemia (HGG), indicating a sustained ability to generate antibody responses. […]

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Amelioration of systemic inflammation in advanced chronic liver disease upon beta-blocker therapy translates into improved clinical outcomes.

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Systemic inflammation promotes the development of clinical events in patients with advanced chronic liver disease (ACLD). We assessed whether (1) non-selective beta blocker (NSBB) treatment initiation impacts biomarkers of systemic […]

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Estimating the proportion of people with chronic hepatitis B virus infection eligible for hepatitis B antiviral treatment worldwide: a systematic review and meta-analysis.

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In 2016, of the estimated 257 million people living with chronic hepatitis B virus (HBV) infection worldwide, only a small proportion was diagnosed and treated. The insufficiency of information on […]

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Efficacy and Safety of Ornithine Phenylacetate for Treating Overt Hepatic Encephalopathy in a Randomized Trial.

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Hepatic encephalopathy (HE) is associated with increased morbidity, mortality, and healthcare resource use. In this phase 2b study, we evaluated the efficacy and safety of ornithine phenylacetate (OP), an ammonia […]

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Expert Panel Review on Non-Alcoholic Fatty Liver Disease in Persons with HIV.

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Non-alcoholic fatty liver disease (NAFLD) affects 25% of adults in the general population and is a disease spectrum ranging from steatosis to non-alcoholic steatohepatitis (NASH) to end-stage liver disease. NAFLD […]

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Guidelines on the management of ascites in cirrhosis.

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The British Society of Gastroenterology in collaboration with British Association for the Study of the Liver has prepared this document. The aim of this guideline is to review and summarise […]

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Agreement between wedged hepatic venous pressure and portal pressure in non-alcoholic steatohepatitis-related cirrhosis.

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Wedge hepatic vein pressure (WHVP) accurately estimates portal pressure (PP) in alcohol or viral hepatitis-related cirrhosis. Whether this also holds true in cirrhosis due to non-alcoholic steatohepatitis (NASH) is unknown. […]

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Increased Mortality Risk in Autoimmune Hepatitis: A Nationwide Population-based Cohort Study With Histopathology.

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Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease that may lead to cirrhosis and liver failure, but data on overall mortality in AIH are conflicting.This was a nationwide population-based […]

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