Beta-synuclein in cerebrospinal fluid as an early diagnostic marker of Alzheimer’s disease.

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Synaptic loss plays a major role in Alzheimer’s disease (AD). However so far no neurochemical marker for synaptic loss has been introduced into clinical routine. By mass spectrometry beta-synuclein was […]

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Fully automated cognitive screening tool based on assessment of speech and language.

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Recent years have seen an almost sevenfold rise in referrals to specialist memory clinics. This has been associated with an increased proportion of patients referred with functional cognitive disorder (FCD), […]

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Fluid biomarkers in frontotemporal dementia: past, present and future.

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The frontotemporal dementia (FTD) spectrum of neurodegenerative disorders includes a heterogeneous group of conditions. However, following on from a series of important molecular studies in the early 2000s, major advances […]

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Associations of APOE e2 genotype with cerebrovascular pathology: a postmortem study of 1275 brains.

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We assessed the association of apolipoprotein E (APOE) genotype with cerebrovascular disease (CVD) in a large neuropathological database maintained by the National Alzheimer’s Coordinating Center (NACC). Such a comprehensive investigation […]

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Cognitive effects and acceptability of non-invasive brain stimulation on Alzheimer’s disease and mild cognitive impairment: a component network meta-analysis.

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To compare cognitive effects and acceptability of repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) in patients with Alzheimer’s disease (AD) or mild cognitive impairment (MCI), and […]

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Amyloid-PET and 18F-FDG-PET in the diagnostic investigation of Alzheimer’s disease and other dementias.

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Various biomarkers are available to support the diagnosis of neurodegenerative diseases in clinical and research settings. Among the molecular imaging biomarkers, amyloid-PET, which assesses brain amyloid deposition, and 18F-fluorodeoxyglucose (18F-FDG) […]

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Trauma and depressive symptomatology in middle-aged persons at high risk of dementia: the PREVENT Dementia Study.

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Depression and trauma are associated with changes in brain regions implicated in Alzheimer’s disease. The present study examined associations between childhood trauma, depression, adult cognitive functioning and risk of dementia.Data […]

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Anti-Aβ agents for mild to moderate Alzheimer’s disease: systematic review and meta-analysis.

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To assess the efficacy and safety of Aβ-targeting agents for mild to moderate Alzheimer’s disease.The MEDLINE, Embase, Cochrane Central Register of Controlled Trials, PsycINFO, ClinicalTrials.gov and the WHO’s International Clinical […]

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Peripheral immunophenotype in dementia with Lewy bodies and Alzheimer’s disease: an observational clinical study.

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Inflammation plays a key role in the aetiology and progression of Alzheimer’s disease (AD). However, the immunophenotype of the second most common neurodegenerative cause of dementia, dementia with Lewy bodies […]

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Potential human transmission of amyloid β pathology: surveillance and risks.

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Studies in experimental animals show transmissibility of amyloidogenic proteins associated with prion diseases, Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative diseases. Although these data raise potential concerns for public health, […]

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In vivo neuroinflammation and cerebral small vessel disease in mild cognitive impairment and Alzheimer’s disease.

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Associations between cerebral small vessel disease (SVD) and inflammation have been largely examined using peripheral blood markers of inflammation, with few studies measuring inflammation within the brain. We investigated the […]

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Cortical diffusivity investigation in posterior cortical atrophy and typical Alzheimer’s disease.

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To investigate the global cortical and regional quantitative features of cortical neural architecture in the brains of patients with posterior cortical atrophy (PCA) and typical Alzheimer’s disease (tAD) compared with […]

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Mental health and suicide in former professional soccer players.

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There is growing recognition of an association between contact sports participation and increased risk of neurodegenerative disease, including Alzheimer’s disease and chronic traumatic encephalopathy. In addition to cognitive impairment, a […]

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Evidence-based prevention of Alzheimer’s disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials.

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Evidence on preventing Alzheimer’s disease (AD) is challenging to interpret due to varying study designs with heterogeneous endpoints and credibility. We completed a systematic review and meta-analysis of current evidence […]

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Environmental exposure to phthalates and dementia with Lewy bodies: contribution of metabolomics.

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In neurodegenerative diseases, alongside genetic factors, the possible intervention of environmental factors in the pathogenesis is increasingly being considered. In particular, recent evidence suggests the intervention of a pesticide-like xenobiotic […]

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Diagnostic and prognostic value of serum NfL and p-Tau181 in frontotemporal lobar degeneration.

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To assess the diagnostic and prognostic value of serum neurofilament light (NfL) and serum phospho-Tau181 (p-Tau181) in a large cohort of patients with frontotemporal lobar degeneration (FTLD).In this retrospective study, […]

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Regional hyperperfusion in cognitively normal APOE ε4 allele carriers in mid-life: analysis of ASL pilot data from the PREVENT-Dementia cohort.

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Regional cerebral hypoperfusion is characteristic of Alzheimer’s disease (AD). Previous studies report conflicting findings in cognitively normal individuals at high risk of AD. Understanding early preclinical perfusion alterations may improve […]

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Using amyloid PET imaging to diagnose Alzheimer’s disease in patients with multiple sclerosis.

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Cognitive dysfunction affects 40-60% of individuals with multiple sclerosis (MS). The neuropsychological profile commonly consists of a subcortical pattern of deficits, although a proportion of patients have a severe progressive […]

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A novel conversion prediction method of MCI to AD based on longitudinal dynamic morphological features using ADNI structural MRIs.

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Mild cognitive impairment (MCI) is a pre-existing state of Alzheimer’s disease (AD). An accurate prediction on the conversion from MCI to AD is of vital clinical significance for potential prevention […]

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Seizures in Alzheimer’s disease are highly recurrent and associated with a poor disease course.

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Seizures are an important comorbidity in Alzheimer’s disease (AD). Conflicting results regarding clinical parameters associated with seizures in AD were previously reported. Data on seizure recurrence risk, a crucial parameter […]

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Plasma neurofilament light chain in the presenilin 1 E280A autosomal dominant Alzheimer’s disease kindred: a cross-sectional and longitudinal cohort study.

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Neurofilament light chain (NfL) is a promising biomarker of active axonal injury and neuronal degeneration. We aimed to characterise cross-sectional and longitudinal plasma NfL measurements and determine the age at […]

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Exergames for balance dysfunction in neurological disability: a meta-analysis with meta-regression.

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To evaluate systematically the efficacy of exergames for balance dysfunction in neurological conditions and to identify factors of exergaming protocols that may influence their effects.We searched electronic databases for randomized […]

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Understanding multifactorial brain changes in type 2 diabetes: a biomarker perspective.

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People with type 2 diabetes are at an increased risk of cognitive impairment and dementia (including Alzheimer’s disease), as well as subtle forms of cognitive dysfunction. Current diabetes guidelines recommend […]

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A new tetra-plex fluorimetric assay for the quantification of cerebrospinal fluid β-amyloid42, total-tau, phospho-tau and α-synuclein in the differential diagnosis of neurodegenerative dementia.

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Differential diagnosis of neurodegenerative dementia is currently supported by biomarkers including cerebrospinal fluid (CSF) tests. Among them, CSF total-tau (t-tau), phosphorylated tau (p-tau) and β-amyloid42 (Aβ42) are considered core biomarkers […]

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Blood phosphorylated tau 181 as a biomarker for Alzheimer’s disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts.

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CSF and PET biomarkers of amyloid β and tau accurately detect Alzheimer’s disease pathology, but the invasiveness, high cost, and poor availability of these detection methods restrict their widespread use […]

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