Long-Lasting Dissociation of Esophageal Eosinophilia and Symptoms Following Dilation in Adults with Eosinophilic Esophagitis.

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Esophageal dilation improves dysphagia but not inflammation in eosinophilic esophagitis (EoE) patients. We investigated if dilation modifies the association between symptoms and esophageal eosinophil count (eos/hpf).Adults enrolled in a multisite, […]

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Management of the patient with esophagogastric junction outflow obstruction.

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Esophagogastric junction outflow obstruction (EGJOO), defined as elevated integrated residual pressure (IRP) with preservation of esophageal peristalsis, is a common finding on high-resolution esophageal manometry.The recent Chicago classification version 4.0 […]

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Long-Lasting Dissociation of Esophageal Eosinophilia and Symptoms Following Dilation in Adults with Eosinophilic Esophagitis.

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Esophageal dilation improves dysphagia but not inflammation in eosinophilic esophagitis (EoE) patients. We investigated if dilation modifies the association between symptoms and esophageal eosinophil count (eos/hpf).Adults enrolled in a multisite, […]

» Read more

Management of the patient with esophagogastric junction outflow obstruction.

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Esophagogastric junction outflow obstruction (EGJOO), defined as elevated integrated residual pressure (IRP) with preservation of esophageal peristalsis, is a common finding on high-resolution esophageal manometry.The recent Chicago classification version 4.0 […]

» Read more

Psychiatric comorbidities are highly prevalent in non-esophageal eosinophilic gastrointestinal diseases.

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The prevalence of psychiatric comorbidity in non-esophageal eosinophilic gastrointestinal disorders (EGIDs) has not been studied. We aimed to ascertain the prevalence of psychiatric diagnoses and psychiatric medication use in children, […]

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GREATER OVERLAP OF ROME IV DISORDERS OF GUT-BRAIN INTERACTIONS LEADS TO INCREASED DISEASE SEVERITY AND POORER QUALITY OF LIFE.

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Conditions such as irritable bowel syndrome (IBS), functional dyspepsia and functional constipation are among the prevalent gastrointestinal disorders classified as disorders of gut brain interaction (DGBI), which can adversely affect […]

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Distinct Clinical Physiologic Phenotypes of Patients with Laryngeal Symptoms Referred for Reflux Evaluation.

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Heterogeneous presentations and disease mechanisms among patients with laryngeal symptoms account for misdiagnosis of laryngopharyngeal reflux (LPR), variations in testing and suboptimal outcomes. We aimed to derive phenotypes of patients […]

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The optimal age to stop endoscopic surveillance of Barrett’s esophagus patients based on sex and comorbidity: a comparative cost-effectiveness analysis.

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Current guidelines recommend surveillance for non-dysplastic Barrett’s esophagus (NDBE) patients but do not include a recommended age for discontinuing surveillance. This study aimed to determine the optimal age for last […]

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Surveillance of patients with cirrhosis remains suboptimal in the United States.

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Regular monitoring/surveillance for liver complications is crucial in the management of patients with cirrhosis to reduce morbidity and mortality. Recommendations from professional societies are available but adherence is not well […]

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Esophageal afferent innervation and its role in gastro-esophageal reflux disease symptoms.

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Despite the wide prevalence of gastro-esophageal reflux disease (GERD), the neurophysiological mechanisms underlying heartburn perception in the esophagus of patients with GERD remains incompletely understood. Recent studies have highlighted the […]

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The role of magnetic sphincter augmentation in the treatment of gastroesophageal reflux disease.

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Magnetic sphincter augmentation (MSA) has been designed as a less disruptive and more standardized laparoscopic surgical procedure than fundoplication for patients with early stage gastroesophageal reflux disease (GERD). We analyzed […]

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Impact of bariatric surgery on gastroesophageal reflux disease and esophageal motility.

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Obesity is rapidly increasing in prevalence, and bariatric surgery has become a popular treatment option that can improve all-cause mortality in obese individuals. Gastroesophageal reflux disease (GERD) and esophageal motility […]

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Bacterial infections in patients with acute variceal bleeding in the era of antibiotic prophylaxis.

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Antibiotic prophylaxis reduces the risk of infection and mortality in cirrhotic patients with acute variceal bleeding (AVB). This study examines the incidence and risk factors of bacterial infections during hospitalization […]

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The Prevalence and Predictors of Missed Dysplasia on Index Barrett’s Esophagus Diagnosing Endoscopy in a Veteran Population.

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Limitations of endoscopic sampling may result in missed dysplasia at the diagnosis of Barrett’s esophagus (BE). However, the role of close follow-up endoscopy is unclear. The aim was to evaluate […]

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Adjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer.

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No adjuvant treatment has been established for patients who remain at high risk for recurrence after neoadjuvant chemoradiotherapy and surgery for esophageal or gastroesophageal junction cancer.We conducted CheckMate 577, a […]

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Updated strategies in the management of acute variceal haemorrhage.

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This article reviews the most recent studies regarding the management of acute esophageal variceal haemorrhage.New randomized control trials and meta-analyses confirmed the role of early transjugular intrahepatic portosystemic shunt (TIPS) […]

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Long-term outcomes after endoscopic treatment for Barrett’s neoplasia with radiofrequency ablation ± endoscopic resection: results from the national Dutch database in a 10-year period.

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Radiofrequency ablation (RFA)±endoscopic resection (ER) is the preferred treatment for early neoplasia in Barrett’s oesophagus (BE). We aimed to report short-term and long-term outcomes for all 1384 patients treated in […]

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Endoscopic radiofrequency ablation or surveillance in patients with Barrett’s oesophagus with confirmed low-grade dysplasia: a multicentre randomised trial.

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Due to an annual progression rate of Barrett’s oesophagus (BO) with low-grade dysplasia (LGD) between 9% and 13% per year endoscopic ablation therapy is preferred to surveillance. Since this recommendation […]

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Non-alcoholic fatty liver disease and increased risk of incident extrahepatic cancers: a meta-analysis of observational cohort studies.

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We performed a meta-analysis of observational studies to quantify the magnitude of the association between non-alcoholic fatty liver disease (NAFLD) and risk of extrahepatic cancers.We systematically searched PubMed, Scopus and […]

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Epidemiologic and Economic Burden of Achalasia in the United States.

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Achalasia is a debilitating chronic condition of the esophagus. Currently there are no national estimates on the epidemiologic and economic burden of disease. We sought to estimate trends in incidence […]

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UTILITY AND COST-EFFECTIVENESS OF A NON-ENDOSCOPIC APPROACH TO BARRETT’S ESOPHAGUS SURVEILLANCE AFTER ENDOSCOPIC THERAPY.

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A non-endoscopic approach to Barrett’s esophagus (BE) surveillance after radiofrequency ablation (RFA) would offer a less invasive method for monitoring. We assessed the test characteristics and cost-effectiveness of the Cytosponge® […]

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Validation of the Short Form Esophageal Hypervigilance and Anxiety Scale.

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Esophageal hypervigilance and anxiety are emerging as important drivers of dysphagia symptoms and reduced quality of life across esophageal diagnoses. The esophageal hypervigilance and anxiety scale (EHAS) is a validated […]

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Integrated genomic profiling and modelling for risk stratification in patients with advanced oesophagogastric adenocarcinoma.

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Prognosis of patients with advanced oesophagogastric adenocarcinoma (mEGAC) is poor and molecular determinants of shorter or longer overall survivors are lacking. Our objective was to identify molecular features and develop […]

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Integrated genomic profiling and modelling for risk stratification in patients with advanced oesophagogastric adenocarcinoma.

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Prognosis of patients with advanced oesophagogastric adenocarcinoma (mEGAC) is poor and molecular determinants of shorter or longer overall survivors are lacking. Our objective was to identify molecular features and develop […]

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Epigenetic alterations in the gastrointestinal tract: Current and emerging use for biomarkers of cancer.

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Colorectal cancer, liver cancer, stomach cancer, pancreatic cancer, and esophageal cancer are leading causes of cancer related deaths worldwide. A fundamental trait of virtually all gastrointestinal cancers is genomic and […]

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