Efficacy and Safety of Continued Treatment with Mirikizumab in a Phase 2 Trial of Patients with Ulcerative Colitis.

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Mirikizumab is an antibody against the p19 subunit of interleukin 23 that has demonstrated clinical efficacy and was well tolerated following 12 weeks of induction treatment in a phase 2 […]

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Exploring the early phase of Crohn’s disease.

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The development of Crohn’s disease is characterized by a breakdown of homeostatic immune-bacterial communication, which takes place at the intestinal mucosa when environmental triggers impact genetically predisposed individuals. Converging lines […]

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Biologics for Inflammatory Bowel Disease and their Safety in Pregnancy: A Systematic Review and Meta-analysis.

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Biologics are routinely used in pregnant women with inflammatory bowel disease (IBD) but large-scale data reporting adverse pregnancy outcomes among biologic users are lacking. We sought to estimate the prevalence […]

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Histologic Features of Colon Biopsies (Geboes Score) Associated With Progression of Ulcerative Colitis for the First 36 Months After Biopsy.

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In addition to findings from endoscopy, histologic features of colon biopsies have been associated with outcomes of patients with ulcerative colitis (UC). We investigated associations between Geboes scores (a system […]

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Inflammatory bowel diseases among first-generation and second-generation immigrants in Denmark: a population-based cohort study.

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Our objective was to estimate the relative risk of IBD among first-generation and second-generation immigrants in Denmark compared with native Danes.Using national registries, we established a cohort of Danish residents […]

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Diagnostic Yield of Colonoscopy in Patients with Symptoms Compatible with Rome IV Functional Bowel Disorders.

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There is little data on the diagnostic yield of colonoscopy in patients with symptoms compatible with functional bowel disorders (FBDs). Previous studies have only focused on diagnostic outcomes of colonoscopy […]

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Host immune interactions in chronic inflammatory gastrointestinal conditions.

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We performed a literature review of the latest studies on the interactions between the host immune system and microbes in chronic intestinal inflammatory conditions.The mechanisms leading to celiac disease (CeD) […]

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Linking strain engraftment in fecal microbiota transplantation with maintenance of remission in Crohn’s disease.

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Crohn’s Disease (CD) is a chronic gastrointestinal disease resulting from the dysfunctional interplay between genetic susceptibility, the immune system and commensal intestinal microbiota. Emerging evidence suggests that treatment by suppression […]

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An International Multicentre Comparison of IBD Related Disability and Validation of the IBDDI.

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The IBD disability index (IBDDI) has been shown to be valid and reliable. We compared the distributional and predictive properties of the IBDDI, when collected from five populations of people […]

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An International Multicentre Comparison of IBD Related Disability and Validation of the IBDDI.

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The IBD disability index (IBDDI) has been shown to be valid and reliable. We compared the distributional and predictive properties of the IBDDI, when collected from five populations of people […]

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Relationship Between Combined Histologic and Endoscopic Endpoints and Efficacy of Ustekinumab Treatment in Patients With Ulcerative Colitis.

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Ustekinumab induces and maintains histologic improvement in patients with ulcerative colitis (UC). The clinical relevance of this endpoint alone, and in combination with endoscopic improvement, is unknown.Histologic disease activity were […]

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Opioid use among patients with inflammatory bowel disease: A systematic review and meta-analysis.

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Despite reported adverse effects of opioids in patients with inflammatory bowel disease (IBD), the burden of opioid use in this population appears to be high. We performed a systematic review […]

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The role of resilience in irritable bowel syndrome, other chronic gastrointestinal conditions and the general population.

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Resilience is the ability to adapt positively to stress and adversity. It is a potential therapeutic target as it is reduced in irritable bowel syndrome (IBS) compared to healthy controls […]

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Succinate Produced by Intestinal Microbes Promotes Specification of Tuft Cells to Suppress Ileal Inflammation.

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Countries endemic for parasitic infestations have a lower incidence of Crohn’s disease (CD) than non-endemic countries, and there have been anecdotal reports of the beneficial effects of helminths in CD […]

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Antibiotic use and the development of inflammatory bowel disease: a national case-control study in Sweden.

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Use of antibiotics in early life has been linked with childhood inflammatory bowel disease (IBD), but data for adults are mixed, and based on smaller investigations that did not compare […]

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Transcription and DNA Methylation patterns of blood derived CD8+ T cells are associated with age and Inflammatory Bowel Disease but do not predict prognosis.

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Gene expression patterns of CD8+ T cells have been reported to correlate with clinical outcomes of adults with inflammatory bowel diseases (IBD). We aimed at validating these findings in independent […]

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S100A8 and S100A9 are Important for Postnatal Development of Gut Microbiota and Immune System in Mice and Infants.

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After birth, the immune system matures via interactions with microbes in the gut. The S100 calcium binding proteins S100A8 and S100A9, and their extracellular complex form, S100A8-A9, are found in […]

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Diagnostic Accuracy of Fecal Calprotectin Concentration in Evaluating Therapeutic Outcomes of Patients With Ulcerative Colitis.

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Histologic features of inflammation (histologic inflammation) are associated with clinical relapse in patients with ulcerative colitis (UC). Concentration of fecal calprotectin (FC) can be used to identify patients with mucosal […]

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Variation in Provider Connectedness Associates with Outcomes of Inflammatory Bowel Diseases in an Analysis of Data from a National Health System.

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Inflammatory bowel diseases (IBD) often require multidisciplinary care with tight coordination among providers. Provider connectedness, a measure of the relationship among providers, is an important aspect of care coordination that […]

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Frailty is Independently Associated with Mortality and Readmission in Hospitalized Patients with Inflammatory Bowel Diseases.

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Old age must be considered in weighing the risks of complications vs benefits of treatment for patients with inflammatory bowel diseases (IBD). We conducted a nationally representative cohort study to […]

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The risk of extra-intestinal cancer in inflammatory bowel disease: a systematic review and meta-analysis of population-based cohort studies.

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Patients with Crohn’s disease (CD) and ulcerative colitis (UC) are at increased risk of developing intestinal cancer. However, less is known about the risk of extra-intestinal cancers (EICs). The aim […]

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Active margins, Plexitis, and Granulomas Increase Post-operative Crohn’s Recurrence: Systematic Review and Meta-analysis.

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Rates of post-operative Crohn’s disease (CD) recurrence remain high, although the ability to predict this risk of recurrence remains limited. As such, we aimed to determine the association of histological […]

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Normalization of Fecal Calprotectin Within 12 Months of Diagnosis is Associated with Reduced Risk of Disease Progression in Patients with Crohn’s Disease.

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The level of fecal calprotectin (FC) correlates with endoscopic evidence of inflammation in Crohn’s disease (CD). A treat-to-target algorithm for patients with CD, that incorporates FC, outperforms a treatment strategy […]

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Identification of the Most Effective Position for Ustekinumab in Treatment Algorithms for Crohn’s Disease.

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Ustekinumab is a monoclonal antibody against interleukin 12 and interleukin 23 that has been approved by the Food and Drug Administration for treatment of Crohn’s disease (CD). We sought to […]

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Evolution of endoscopic lesions in steroid-refractory acute severe ulcerative colitis responding to infliximab or cyclosporine.

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Few data on the evolution of endoscopic findings are available in patients with acute severe ulcerative colitis (ASUC). The aim of this study was to describe this evolution in a […]

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Accuracy of Ultrasound for Evaluation of Colorectal Segments in Patients With Inflammatory Bowel Diseases: a Systematic Review and Meta-analysis.

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The accuracy of ultrasound for evaluation of individual colorectal segments in patients with inflammatory bowel diseases (IBD) has not been evaluated in a systematic review. We evaluated the diagnostic accuracy […]

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A Phase 1b safety study of SER-287, a spore-based microbiome therapeutic, for active mild to moderate ulcerative colitis.

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Firmicutes bacteria produce metabolites that maintain the intestinal barrier and mucosal immunity. Firmicutes are reduced in the intestinal microbiota of patients with ulcerative colitis (UC). In a phase 1b trial […]

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