Ustekinumab Pharmacokinetics and Exposure Response in a Phase 3 Randomized Trial of Patients With Ulcerative Colitis: Ustekinumab PK and exposure-response in UC.

The efficacy of antibody-based therapeutics depends on their pharmacokinetics. The pharmacokinetic and exposure response profiles of ustekinumab, a monoclonal antibody against interleukin 12/interleukin 23, are known in patients with Crohn’s […]

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Use of Cross-sectional Imaging for Tight Monitoring of Inflammatory Bowel Diseases.

A “treat-to-target” strategy with close monitoring of intestinal inflammation is recommended in inflammatory bowel disease (IBD). Ileocolonoscopy (CS) remains the gold-standard for assessing disease activity in IBD but is a […]

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Histologic Healing is More Strongly Associated with Clinical Outcomes in Ileal Crohn’s Disease than Endoscopic Healing.

Deep remission, based on clinical remission and evidence of healing during endoscopic evaluation, are goals of medical treatments for Crohn’s disease (CD). We investigated whether histologic healing is associated with […]

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Identifying Patients With Inflammatory Bowel Diseases at High vs Low Risk of Complications.

People with Crohn’s disease and ulcerative colitis have varying presentations and clinical consequences of their disease. Patients commonly ask about their prognosis, and what this diagnosis means for them. They […]

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Complete Endoscopic Healing Associated With Better Outcomes Than Partial Endoscopic Healing in Patients With Crohn’s Disease.

Mucosal healing (MH) has been associated with a good outcomes of patients with Crohn’s disease (CD). It is not clear what levels of endoscopic healing, based on CD endoscopic index […]

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Management of Inflammatory Bowel Diseases in Special Populations: Obese, Old or Obstetric.

The epidemiology of inflammatory bowel disease (IBD) is progressively evolving impacting the type of patients with IBD we will see in clinical practice. In this review, we discuss specific challenges […]

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Risk for Chronic Kidney Disease in Patients with Inflammatory Bowel Diseases Increases with Age but is not Associated with 5-aminosalicylate Use.

It is not clear what factors affect risk of chronic kidney disease (CKD) in patients with inflammatory bowel disease (IBD); increased risk has been inconsistently associated with use of 5-aminosalicylates […]

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Epstein-Barr Virus-Positive Mucocutaneous Ulcers Complicate Colitis Caused by Immune Checkpoint Regulator Therapy and Associate With Colon Perforation.

Abstract: Cancer therapy with immune checkpoint inhibitors can cause colitis and colon perforation. We investigated whether infection with Epstein Barr virus (EBV) associates with development and severity of colitis in […]

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Exposure-Response Analyses for Upadacitinib Efficacy and Safety in the Crohn’s Disease CELEST Study and Bridging to the Extended-Release Formulation.

Abstract: Upadacitinib plasma concentrations, efficacy, and safety data from 216 subjects with moderately-to-severely active Crohn’s disease (CD) from the 16-week induction period of CELEST study were analyzed to characterize upadacitinib […]

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Peri-operative and Post-operative Management of Patients with Crohn’s Disease and Ulcerative Colitis.

Abstract: Although the number of available therapies for the treatment of ulcerative colitis (UC) and Crohn’s disease (CD) continues to expand, a significant portion of patients with inflammatory bowel disease […]

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Association of Alterations in Intestinal Microbiota With Impaired Psychological Function in Patients With Inflammatory Bowel Diseases in Remission.

Abstract: Depression and anxiety are frequent comorbidities with inflammatory bowel diseases (IBD). Alterations to the intestinal microbiome promote not only intestinal inflammation but also psychologic function. We studied the interactions […]

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Discordance Between Patient-Reported Outcomes and Mucosal Inflammation in Patients With Mild to Moderate Ulcerative Colitis.

Abstract: Little is known about the association between rectal bleeding and increased stool frequency with endoscopic findings in patients with mild to moderate ulcerative colitis (UC). We evaluated the associations […]

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Features of Fecal and Colon Microbiomes Associate With Responses to Biologic Therapies for Inflammatory Bowel Diseases: a Systematic Review.

Abstract: We performed a systematic review of changes in fecal and colon microbiomes of patients with inflammatory bowel diseases (IBD) receiving treatment with monoclonal antibodies against tumor necrosis factor (TNF), […]

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