Safety and Efficacy of Tumor Necrosis Factor Antagonists in Older Patients With Ulcerative Colitis: Patient-Level Pooled Analysis of Data From Randomized Trials.

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Treatment of older patients (more than 60 years) with ulcerative colitis (UC) can be a challenge, because they might be more vulnerable to adverse events (AEs). We determined the effects […]

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Drug-Induced Colitis.

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Drug-induced colitis encompasses a wide spectrum of colon disorders that can manifest microscopically or macroscopically. Patients present with new-onset colitis or exacerbations of inflammatory bowel diseases; in some cases, colitis […]

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Ileal or Colonic Histologic Activity is Not Associated With Clinical Relapse in Patients With Crohn’s Disease in Endoscopic Remission.

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Goals of treatment for Crohn’s disease (CD) are clinical and endoscopic remission. It is not clear whether histologic markers of healing associate with endoscopic remission in patients with CD.We identified […]

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Infliximab Exposure Associates With Radiologic Evidence of Healing in Patients With Crohn’s Disease.

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Higher infliximab trough levels are associated with clinical and endoscopic remission in patients with Crohn’s disease (CD). We investigated pharmacodynamic features of infliximab and radiological healing.We performed a substudy of […]

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Colorectal Dysplasia and Cancer in Pediatric-onset Ulcerative Colitis Associated with Primary Sclerosing Cholangitis.

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Click here to read the full article @ Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

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Not all terminal ileitis is Crohn’s disease: Intestinal tuberculosis causing small bowel obstruction.

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Click here to read the full article @ Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

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Factors Associated With Development of Perianal Fistulas in Pediatric Patients With Crohn’s Disease.

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Click here to read the full article @ Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

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High-definition Chromoendoscopy Superior to High-definition White-light Endoscopy in Surveillance of Inflammatory Bowel Diseases in a Randomized Trial.

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& Aims: There is debate over the optimal method for colonoscopic surveillance of patients with inflammatory bowel diseases. Guidelines recommend chromoendoscopy, but the value of chromoendoscopy in high-definition colonoscopy has […]

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Baseline Clearance of Infliximab is Associated with Requirement for Colectomy in Patients with Acute Severe Ulcerative Colitis.

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Hospitalized patients with acute severe ulcerative colitis (ASUC) often require surgery. Although the tumor necrosis factor antagonist infliximab is an effective salvage therapy to prevent colectomy in patients with ASUC, […]

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Submission Title: Immune Checkpoint Inhibitor Induced Enterocolitis.

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Click here to read the full article @ Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

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Cost-effectiveness of Telemedicine-directed Specialized vs Standard Care for Patients With Inflammatory Bowel Diseases in a Randomized Trial.

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Telemedicine can be used to monitor determinants and outcomes of patients with chronic diseases, possibly increasing the quality and value of care. Telemedicine was found to reduce outpatient visits and […]

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Maintaining the quality standards of care for inflammatory bowel disease patients during the COVID-19 pandemic.

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Click here to read the full article @ Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

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Dietary Therapies Induce Rapid Response and Remission in Pediatric Patients With Active Crohn’s Disease.

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Dietary therapies based on exclusion of usual dietary elements induce remission in children with Crohn’s disease (CD), whereas re-exposure induces rebound inflammation. We investigated whether a short trial of dietary […]

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Level of Tumor Necrosis Factor Production by Stimulated Blood Mononuclear Cells Can be Used to Predict Response of Patients With Inflammatory Bowel Diseases to Infliximab.

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A substantial proportion patients with inflammatory bowel disease (IBD) have a primary non-response to infliximab; markers are needed to identify patients most likely to respond to treatment. We investigated whether […]

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Rates of Post-operative Recurrence of Crohn’s Disease and Effects of Immunosuppressive and Biologic Therapies.

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The Rutgeerts’ scoring system is used to evaluate patients with Crohn’s disease (CD) following ileocolic resection, based on endoscopic findings at the anastomosis and in the neoterminal ileum. We investigated […]

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Persistent Diarrhea in Patients With Crohn’s Disease After Mucosal Healing is Associated With Lower Diversity of the Intestinal Microbiome and Increased Dysbiosis.

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In patients with inflammatory bowel diseases (IBD), symptoms do not always associate with the severity of endoscopic inflammation and can persist after mucosal healing. We investigated whether symptoms in patients […]

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Alterations in Fecal Microbiomes and Serum Metabolomes of Fatigued Patients With Quiescent Inflammatory Bowel Diseases.

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Fatigue is frequent and disabling in patients with inflammatory bowel diseases (IBD) but its mechanisms are poorly understood. We investigated alterations in fecal microbiomes and serum metabolomes and proteomes in […]

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A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8+ T cells in mice.

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Gut microbiota have been linked to inflammatory bowel disease (IBD) and colorectal cancer (CRC). Akkermansia muciniphila (A. muciniphila) is a gram-negative anaerobic bacterium that is selectively decreased in the faecal […]

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Comparison between assays used for therapeutic drug monitoring of infliximab and adalimumab in inflammatory bowel disease.

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Click here to read the full article @ Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

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Healthy Lifestyle is Associated with Reduced Mortality in Patients with Inflammatory Bowel Diseases.

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It is not clear whether a healthy lifestyle affects mortality of patients with inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC).We collected data form the Nurses’ […]

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Progression of Elderly-Onset Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis of Population-based Cohort Studies.

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The incidence of inflammatory bowel diseases (IBD) in older adults is increasing. We performed a systematic review and meta-analysis to evaluate progression of elderly-onset (EO)-IBD in population-based cohorts and compared […]

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Association of trough vedolizumab levels with clinical, biological and endoscopic outcomes during maintenance therapy in inflammatory bowel disease.

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To establish the relationship between trough vedolizumab levels and outcomes during maintenance therapy.Cross-sectional service evaluation was performed on patients with inflammatory bowel disease (IBD) receiving maintenance vedolizumab therapy (minimum of […]

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Early real-world effectiveness of ustekinumab for Crohn’s disease.

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To understand the effectiveness of ustekinumab in treating Crohn’s disease (CD) in a UK real-world setting.Retrospective cohort study using prospectively maintained clinical records.Single UK inflammatory bowel disease centre.Adult patients with […]

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Endoscopic surveillance strategies for dysplasia in ulcerative colitis.

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Ulcerative colitis (UC) is a chronic inflammatory bowel disorder with an increased risk of colorectal cancer (CRC). This has led to the implementation of surveillance programmes to minimise this risk. […]

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High risk of microscopic colitis after Campylobacter concisus infection: population-based cohort study.

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Microscopic colitis (MC) encompasses the two histopathological distinct entities of collagenous colitis (CC) and lymphocytic colitis (LC). In this Danish population-based cohort study, we examined the risk of MC following […]

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Mitochondrial impairment drives intestinal stem cell transition into dysfunctional Paneth cells predicting Crohn’s disease recurrence.

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Reduced Paneth cell (PC) numbers are observed in inflammatory bowel diseases and impaired PC function contributes to the ileal pathogenesis of Crohn’s disease (CD). PCs reside in proximity to Lgr5+ […]

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Effectiveness of Ustekinumab Dose Escalation in Patients with Crohn’s Disease.

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A subset of patients with Crohn’s disease (CD) do not respond to ustekinumab at the standard dose of 90 mg every 8 weeks. Little is known about the efficacy of […]

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